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Protein

Homeobox protein Hox-A4

Gene

HOXA4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi209 – 26860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A4
Alternative name(s):
Homeobox protein Hox-1.4
Short name:
Chox-1.4
Gene namesi
Name:HOXA4
Synonyms:CHOX-1.4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Homeobox protein Hox-A4PRO_0000200052Add
BLAST

Proteomic databases

PaxDbiP17277.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017984.

Structurei

3D structure databases

ProteinModelPortaliP17277.
SMRiP17277. Positions 182-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi188 – 1936Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 148111Pro-richAdd
BLAST

Domaini

The proline stretch works as a part of the transcriptional activation domain.

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG257177.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17277.
KOiK09304.
OMAiPRREPGY.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP
60 70 80 90 100
PPPPPHLHAA HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ
110 120 130 140 150
APSYPQAPYS YSSAGSAAPG PEQPPPGASP PPPPPAKGHP GPAQPLLPGH
160 170 180 190 200
ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG LKGKEPVVYP WMKKIHVSTV
210 220 230 240 250
NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI EIAHTLCLSE
260 270 280 290 300
RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD

GAAPNAAAL
Length:309
Mass (Da):33,478
Last modified:August 1, 1990 - v1
Checksum:i8898A41502319341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52670 mRNA. Translation: CAA36896.1.
X52747 mRNA. Translation: CAB57949.1.
PIRiS09257.
RefSeqiNP_001025517.1. NM_001030346.1.
XP_003640746.1. XM_003640698.2.
UniGeneiGga.4243.

Genome annotation databases

EnsembliENSGALT00000018006; ENSGALP00000017984; ENSGALG00000011055.
ENSGALT00000029853; ENSGALP00000029207; ENSGALG00000022622.
GeneIDi100858374.
395307.
KEGGigga:100858374.
gga:395307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52670 mRNA. Translation: CAA36896.1.
X52747 mRNA. Translation: CAB57949.1.
PIRiS09257.
RefSeqiNP_001025517.1. NM_001030346.1.
XP_003640746.1. XM_003640698.2.
UniGeneiGga.4243.

3D structure databases

ProteinModelPortaliP17277.
SMRiP17277. Positions 182-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017984.

Proteomic databases

PaxDbiP17277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000018006; ENSGALP00000017984; ENSGALG00000011055.
ENSGALT00000029853; ENSGALP00000029207; ENSGALG00000022622.
GeneIDi100858374.
395307.
KEGGigga:100858374.
gga:395307.

Organism-specific databases

CTDi3201.

Phylogenomic databases

eggNOGiNOG257177.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17277.
KOiK09304.
OMAiPRREPGY.

Miscellaneous databases

NextBioi20815392.
PROiP17277.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a."
    Sasaki H., Yokoyama E., Kuroiwa A.
    Nucleic Acids Res. 18:1739-1747(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and analysis of chick homeobox cDNA clones."
    Scotting P.J., Hewitt M., Keynes R.J.
    Nucleic Acids Res. 18:3999-3999(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-273.
    Strain: Comet Hubbard hybrid.

Entry informationi

Entry nameiHXA4_CHICK
AccessioniPrimary (citable) accession number: P17277
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 4, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.