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P17277 (HXA4_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A4
Alternative name(s):
Homeobox protein Hox-1.4
Short name=Chox-1.4
Gene names
Name:HOXA4
Synonyms:CHOX-1.4
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Subcellular location

Nucleus.

Domain

The proline stretch works as a part of the transcriptional activation domain.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Homeobox protein Hox-A4
PRO_0000200052

Regions

DNA binding209 – 26860Homeobox
Motif188 – 1936Antp-type hexapeptide
Compositional bias38 – 148111Pro-rich

Sequences

Sequence LengthMass (Da)Tools
P17277 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 8898A41502319341

FASTA30933,478
        10         20         30         40         50         60 
MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP PPPPPHLHAA 

        70         80         90        100        110        120 
HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ APSYPQAPYS YSSAGSAAPG 

       130        140        150        160        170        180 
PEQPPPGASP PPPPPAKGHP GPAQPLLPGH ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG 

       190        200        210        220        230        240 
LKGKEPVVYP WMKKIHVSTV NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI 

       250        260        270        280        290        300 
EIAHTLCLSE RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD 


GAAPNAAAL 

« Hide

References

[1]"Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a."
Sasaki H., Yokoyama E., Kuroiwa A.
Nucleic Acids Res. 18:1739-1747(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation and analysis of chick homeobox cDNA clones."
Scotting P.J., Hewitt M., Keynes R.J.
Nucleic Acids Res. 18:3999-3999(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-273.
Strain: Comet Hubbard hybrid.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52670 mRNA. Translation: CAA36896.1.
X52747 mRNA. Translation: CAB57949.1.
PIRS09257.
RefSeqNP_001025517.1. NM_001030346.1.
XP_003640746.1. XM_003640698.2.
UniGeneGga.4243.

3D structure databases

ProteinModelPortalP17277.
SMRP17277. Positions 182-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000017984.

Proteomic databases

PaxDbP17277.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000018006; ENSGALP00000017984; ENSGALG00000011055.
ENSGALT00000029853; ENSGALP00000029207; ENSGALG00000022622.
GeneID100858374.
395307.
KEGGgga:100858374.
gga:395307.

Organism-specific databases

CTD3201.

Phylogenomic databases

eggNOGNOG257177.
GeneTreeENSGT00750000117269.
HOGENOMHOG000231179.
HOVERGENHBG016849.
InParanoidP17277.
KOK09304.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815392.
PROP17277.

Entry information

Entry nameHXA4_CHICK
AccessionPrimary (citable) accession number: P17277
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries