Reviewed, UniProtKB/Swiss-Prot P17277 (HXA4_CHICK)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A4
Alternative name(s):
    Chox-1.4

Gene names

Name:	HOXA4
Synonyms:	CHOX-1.4

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
Subcellular location	Nucleus.
Domain	The proline stretch works as a part of the transcriptional activation domain.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Homeobox protein Hox-A4		PRO_0000200052
Regions
	DNA binding	209 – 268	60	Homeobox
	Motif	188 – 193	6	Antp-type hexapeptide
	Compositional bias	38 – 148	111	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	P17277-1 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 8898A41502319341	FASTA	309	33,478
	10 20 30 40 50 60 MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP PPPPPHLHAA 70 80 90 100 110 120 HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ APSYPQAPYS YSSAGSAAPG 130 140 150 160 170 180 PEQPPPGASP PPPPPAKGHP GPAQPLLPGH ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG 190 200 210 220 230 240 LKGKEPVVYP WMKKIHVSTV NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI 250 260 270 280 290 300 EIAHTLCLSE RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD GAAPNAAAL

References

[1]	"Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a." Sasaki H., Yokoyama E., Kuroiwa A. Nucleic Acids Res. 18:1739-1747(1990) [PubMed: 1970866] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and analysis of chick homeobox cDNA clones." Scotting P.J., Hewitt M., Keynes R.J. Nucleic Acids Res. 18:3999-3999(1990) [PubMed: 1973835] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-273. Strain: Comet Hubbard hybrid.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X52670 mRNA. Translation: CAA36896.1. X52747 mRNA. Translation: CAB57949.1.
IPI	IPI00593052.
PIR	S09257.
RefSeq	NP_001025517.1.
UniGene	Gga.4243
3D structure databases
SMR	P17277. Positions 210-269.
ModBase	Search...
Protein-protein interaction databases
STRING	P17277.
Genome annotation databases
Ensembl	ENSGALT00000018006; ENSGALP00000017984; ENSGALG00000011055; Gallus gallus. [Genome view]
GeneID	395307.
KEGG	gga:395307.
Organism-specific databases
CTD	395307.
Phylogenomic databases
HOGENOM	HBG715745.
HOVERGEN	P17277.
InParanoid	P17277.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA4_CHICK

Accession

Primary (citable) accession number: P17277

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	December 15, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)