SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17277

- HXA4_CHICK

UniProt

P17277 - HXA4_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homeobox protein Hox-A4

Gene
HOXA4, CHOX-1.4
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi209 – 26860HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A4
Alternative name(s):
Homeobox protein Hox-1.4
Short name:
Chox-1.4
Gene namesi
Name:HOXA4
Synonyms:CHOX-1.4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Homeobox protein Hox-A4PRO_0000200052Add
BLAST

Proteomic databases

PaxDbiP17277.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017984.

Structurei

3D structure databases

ProteinModelPortaliP17277.
SMRiP17277. Positions 182-269.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi188 – 1936Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 148111Pro-richAdd
BLAST

Domaini

The proline stretch works as a part of the transcriptional activation domain.

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG257177.
GeneTreeiENSGT00750000117269.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17277.
KOiK09304.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17277-1 [UniParc]FASTAAdd to Basket

« Hide

MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP    50
PPPPPHLHAA HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ 100
APSYPQAPYS YSSAGSAAPG PEQPPPGASP PPPPPAKGHP GPAQPLLPGH 150
ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG LKGKEPVVYP WMKKIHVSTV 200
NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI EIAHTLCLSE 250
RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD 300
GAAPNAAAL 309
Length:309
Mass (Da):33,478
Last modified:August 1, 1990 - v1
Checksum:i8898A41502319341
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52670 mRNA. Translation: CAA36896.1.
X52747 mRNA. Translation: CAB57949.1.
PIRiS09257.
RefSeqiNP_001025517.1. NM_001030346.1.
XP_003640746.1. XM_003640698.2.
UniGeneiGga.4243.

Genome annotation databases

EnsembliENSGALT00000018006; ENSGALP00000017984; ENSGALG00000011055.
ENSGALT00000029853; ENSGALP00000029207; ENSGALG00000022622.
GeneIDi100858374.
395307.
KEGGigga:100858374.
gga:395307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52670 mRNA. Translation: CAA36896.1 .
X52747 mRNA. Translation: CAB57949.1 .
PIRi S09257.
RefSeqi NP_001025517.1. NM_001030346.1.
XP_003640746.1. XM_003640698.2.
UniGenei Gga.4243.

3D structure databases

ProteinModelPortali P17277.
SMRi P17277. Positions 182-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000017984.

Proteomic databases

PaxDbi P17277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000018006 ; ENSGALP00000017984 ; ENSGALG00000011055 .
ENSGALT00000029853 ; ENSGALP00000029207 ; ENSGALG00000022622 .
GeneIDi 100858374.
395307.
KEGGi gga:100858374.
gga:395307.

Organism-specific databases

CTDi 3201.

Phylogenomic databases

eggNOGi NOG257177.
GeneTreei ENSGT00750000117269.
HOGENOMi HOG000231179.
HOVERGENi HBG016849.
InParanoidi P17277.
KOi K09304.

Miscellaneous databases

NextBioi 20815392.
PROi P17277.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a."
    Sasaki H., Yokoyama E., Kuroiwa A.
    Nucleic Acids Res. 18:1739-1747(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and analysis of chick homeobox cDNA clones."
    Scotting P.J., Hewitt M., Keynes R.J.
    Nucleic Acids Res. 18:3999-3999(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-273.
    Strain: Comet Hubbard hybrid.

Entry informationi

Entry nameiHXA4_CHICK
AccessioniPrimary (citable) accession number: P17277
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi