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P17277

- HXA4_CHICK

UniProt

P17277 - HXA4_CHICK

Protein

Homeobox protein Hox-A4

Gene

HOXA4

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi209 – 26860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A4
    Alternative name(s):
    Homeobox protein Hox-1.4
    Short name:
    Chox-1.4
    Gene namesi
    Name:HOXA4
    Synonyms:CHOX-1.4
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Homeobox protein Hox-A4PRO_0000200052Add
    BLAST

    Proteomic databases

    PaxDbiP17277.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000017984.

    Structurei

    3D structure databases

    ProteinModelPortaliP17277.
    SMRiP17277. Positions 182-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi188 – 1936Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi38 – 148111Pro-richAdd
    BLAST

    Domaini

    The proline stretch works as a part of the transcriptional activation domain.

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG257177.
    GeneTreeiENSGT00750000117269.
    HOGENOMiHOG000231179.
    HOVERGENiHBG016849.
    InParanoidiP17277.
    KOiK09304.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17277-1 [UniParc]FASTAAdd to Basket

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    MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP    50
    PPPPPHLHAA HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ 100
    APSYPQAPYS YSSAGSAAPG PEQPPPGASP PPPPPAKGHP GPAQPLLPGH 150
    ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG LKGKEPVVYP WMKKIHVSTV 200
    NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI EIAHTLCLSE 250
    RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD 300
    GAAPNAAAL 309
    Length:309
    Mass (Da):33,478
    Last modified:August 1, 1990 - v1
    Checksum:i8898A41502319341
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52670 mRNA. Translation: CAA36896.1.
    X52747 mRNA. Translation: CAB57949.1.
    PIRiS09257.
    RefSeqiNP_001025517.1. NM_001030346.1.
    XP_003640746.1. XM_003640698.2.
    UniGeneiGga.4243.

    Genome annotation databases

    EnsembliENSGALT00000018006; ENSGALP00000017984; ENSGALG00000011055.
    ENSGALT00000029853; ENSGALP00000029207; ENSGALG00000022622.
    GeneIDi100858374.
    395307.
    KEGGigga:100858374.
    gga:395307.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52670 mRNA. Translation: CAA36896.1 .
    X52747 mRNA. Translation: CAB57949.1 .
    PIRi S09257.
    RefSeqi NP_001025517.1. NM_001030346.1.
    XP_003640746.1. XM_003640698.2.
    UniGenei Gga.4243.

    3D structure databases

    ProteinModelPortali P17277.
    SMRi P17277. Positions 182-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000017984.

    Proteomic databases

    PaxDbi P17277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000018006 ; ENSGALP00000017984 ; ENSGALG00000011055 .
    ENSGALT00000029853 ; ENSGALP00000029207 ; ENSGALG00000022622 .
    GeneIDi 100858374.
    395307.
    KEGGi gga:100858374.
    gga:395307.

    Organism-specific databases

    CTDi 3201.

    Phylogenomic databases

    eggNOGi NOG257177.
    GeneTreei ENSGT00750000117269.
    HOGENOMi HOG000231179.
    HOVERGENi HBG016849.
    InParanoidi P17277.
    KOi K09304.

    Miscellaneous databases

    NextBioi 20815392.
    PROi P17277.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a."
      Sasaki H., Yokoyama E., Kuroiwa A.
      Nucleic Acids Res. 18:1739-1747(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and analysis of chick homeobox cDNA clones."
      Scotting P.J., Hewitt M., Keynes R.J.
      Nucleic Acids Res. 18:3999-3999(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-273.
      Strain: Comet Hubbard hybrid.

    Entry informationi

    Entry nameiHXA4_CHICK
    AccessioniPrimary (citable) accession number: P17277
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3