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Protein

Homeobox protein Hox-A4

Gene

HOXA4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi209 – 268HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A4
Alternative name(s):
Homeobox protein Hox-1.4
Short name:
Chox-1.4
Gene namesi
Name:HOXA4
Synonyms:CHOX-1.4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000521 – 309Homeobox protein Hox-A4Add BLAST309

Proteomic databases

PaxDbiP17277.

Expressioni

Gene expression databases

BgeeiENSGALG00000011055.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017984.

Structurei

3D structure databases

ProteinModelPortaliP17277.
SMRiP17277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi188 – 193Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 148Pro-richAdd BLAST111

Domaini

The proline stretch works as a part of the transcriptional activation domain.

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP17277.
KOiK09304.
OMAiYYAPRTA.
OrthoDBiEOG091G09XD.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P17277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP
60 70 80 90 100
PPPPPHLHAA HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ
110 120 130 140 150
APSYPQAPYS YSSAGSAAPG PEQPPPGASP PPPPPAKGHP GPAQPLLPGH
160 170 180 190 200
ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG LKGKEPVVYP WMKKIHVSTV
210 220 230 240 250
NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI EIAHTLCLSE
260 270 280 290 300
RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD

GAAPNAAAL
Length:309
Mass (Da):33,478
Last modified:August 1, 1990 - v1
Checksum:i8898A41502319341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52670 mRNA. Translation: CAA36896.1.
X52747 mRNA. Translation: CAB57949.1.
PIRiS09257.
RefSeqiNP_001025517.1. NM_001030346.1.
UniGeneiGga.4243.

Genome annotation databases

EnsembliENSGALT00000029853; ENSGALP00000029207; ENSGALG00000022622.
GeneIDi395307.
KEGGigga:395307.

Similar proteinsi

Entry informationi

Entry nameiHXA4_CHICK
AccessioniPrimary (citable) accession number: P17277
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 27, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families