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P17275 (JUNB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 156. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor jun-B
Gene names
Name:JUNB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Subunit structure

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). Ref.6

Subcellular location

Nucleus.

Induction

By growth factors.

Post-translational modification

Ubiquitinated by ITCH, leading to its degradation. Ref.6

Sequence similarities

Belongs to the bZIP family. Jun subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   PTMAcetylation
Phosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to calcium ion

Inferred from electronic annotation. Source: Ensembl

cellular response to hormone stimulus

Inferred from electronic annotation. Source: Ensembl

decidualization

Inferred from electronic annotation. Source: Ensembl

embryonic process involved in female pregnancy

Inferred from electronic annotation. Source: Ensembl

gene expression

Traceable author statement. Source: Reactome

labyrinthine layer blood vessel development

Inferred from electronic annotation. Source: Ensembl

osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

osteoblast proliferation

Inferred from electronic annotation. Source: Ensembl

osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Traceable author statement. Source: Reactome

regulation of cell cycle

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

response to cAMP

Inferred from electronic annotation. Source: Ensembl

response to corticosterone

Inferred from electronic annotation. Source: Ensembl

response to cytokine

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to light stimulus

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from electronic annotation. Source: Ensembl

transcription initiation from RNA polymerase II promoter

Traceable author statement. Source: Reactome

transcription, DNA-templated

Traceable author statement. Source: Reactome

transforming growth factor beta receptor signaling pathway

Traceable author statement. Source: Reactome

trophectodermal cell differentiation

Inferred from electronic annotation. Source: Ensembl

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentchromatin

Traceable author statement Ref.1. Source: ProtInc

nucleoplasm

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay. Source: HPA

   Molecular_functionDNA binding

Traceable author statement PubMed 10764760. Source: ProtInc

RNA polymerase II regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

double-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 16511568PubMed 20195357PubMed 21988832PubMed 24029232. Source: IntAct

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

transcription coactivator activity

Traceable author statement Ref.1. Source: ProtInc

transcription corepressor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Transcription factor jun-B
PRO_0000076438

Regions

Domain268 – 33164bZIP
Region268 – 29528Basic motif By similarity
Region296 – 32429Leucine-zipper By similarity

Amino acid modifications

Modified residue1021Phosphothreonine Ref.7
Modified residue1041Phosphothreonine Ref.7 Ref.9
Modified residue1171Phosphoserine Ref.7 Ref.9
Modified residue2401N6-acetyllysine By similarity
Modified residue2511Phosphoserine Ref.8 Ref.9
Modified residue2551Phosphothreonine Ref.8 Ref.9 Ref.10
Modified residue2591Phosphoserine Ref.8 Ref.10

Natural variations

Natural variant2301L → V. Ref.4
Corresponds to variant rs17880705 [ dbSNP | Ensembl ].
VAR_021081

Experimental info

Sequence conflict1241A → G in AAH09465. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P17275 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: DF8CD1CD4409C6BE

FASTA34735,879
        10         20         30         40         50         60 
MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL KAPGARGPGP 

        70         80         90        100        110        120 
EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT TTPTPPGQYF YPRGGGSGGG 

       130        140        150        160        170        180 
AGGAGGGVTE EQEGFADGFV KALDDLHKMN HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP 

       190        200        210        220        230        240 
VYTNLSSYSP ASASSGGAGA AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK 

       250        260        270        280        290        300 
EEPQTVPEAR SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV 

       310        320        330        340 
KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF 

« Hide

References

« Hide 'large scale' references
[1]"jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun."
Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J.
Cell 59:987-997(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Isolation of human cDNA clones of jun-related genes, jun-B and jun-D."
Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R.
Nucleic Acids Res. 18:3047-3048(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci."
Phinney D.G., Tseng S.W., Ryder K.
Genomics 28:228-234(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[4]NIEHS SNPs program
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-230.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[6]"Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation."
Yang C., Zhou W., Jeon M.S., Demydenko D., Harada Y., Zhou H., Liu Y.C.
Mol. Cell 21:135-141(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ITCH, UBIQUITINATION.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-102; THR-104 AND SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251; THR-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104; SER-117; SER-251 AND THR-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29039 Genomic DNA. Translation: AAA59198.1.
X51345 mRNA. Translation: CAA35738.1.
U20734 Genomic DNA. Translation: AAA74915.1.
AY751746 Genomic DNA. Translation: AAU43800.1.
BC004250 mRNA. Translation: AAH04250.1.
BC009465 mRNA. Translation: AAH09465.1.
BC009466 mRNA. Translation: AAH09466.1.
CCDSCCDS12280.1.
PIRTVHUJB. S10183.
RefSeqNP_002220.1. NM_002229.2.
UniGeneHs.25292.

3D structure databases

ProteinModelPortalP17275.
SMRP17275. Positions 272-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109929. 41 interactions.
DIPDIP-1052N.
IntActP17275. 26 interactions.
MINTMINT-205420.
STRING9606.ENSP00000303315.

PTM databases

PhosphoSiteP17275.

Polymorphism databases

DMDM135304.

Proteomic databases

MaxQBP17275.
PaxDbP17275.
PRIDEP17275.

Protocols and materials databases

DNASU3726.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302754; ENSP00000303315; ENSG00000171223.
GeneID3726.
KEGGhsa:3726.
UCSCuc002mvc.3. human.

Organism-specific databases

CTD3726.
GeneCardsGC19P012902.
HGNCHGNC:6205. JUNB.
HPACAB004464.
HPA019149.
MIM165161. gene.
neXtProtNX_P17275.
PharmGKBPA30007.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283376.
HOGENOMHOG000006648.
HOVERGENHBG001722.
InParanoidP17275.
KOK09028.
OMALNAYCPN.
OrthoDBEOG75MVXV.
PhylomeDBP17275.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_71. Gene Expression.
SignaLinkP17275.

Gene expression databases

ArrayExpressP17275.
BgeeP17275.
CleanExHS_JUNB.
GenevestigatorP17275.

Family and domain databases

Gene3D1.10.880.10. 1 hit.
InterProIPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSPR00043. LEUZIPPRJUN.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMSSF47454. SSF47454. 1 hit.
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiJUNB.
GenomeRNAi3726.
NextBio14587.
PROP17275.
SOURCESearch...

Entry information

Entry nameJUNB_HUMAN
AccessionPrimary (citable) accession number: P17275
Secondary accession number(s): Q96GH3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM