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Protein

Transcription factor jun-B

Gene

JUNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171223-MONOMER.
ReactomeiR-HSA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
SignaLinkiP17275.
SIGNORiP17275.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-B
Gene namesi
Name:JUNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6205. JUNB.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: ProtInc
  • nuclear chromatin Source: GO_Central
  • nucleoplasm Source: HPA
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3726.
OpenTargetsiENSG00000171223.
PharmGKBiPA30007.

Polymorphism and mutation databases

BioMutaiJUNB.
DMDMi135304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764381 – 347Transcription factor jun-BAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei102PhosphothreonineCombined sources1
Modified residuei104PhosphothreonineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei240N6-acetyllysine; alternateBy similarity1
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei251PhosphoserineCombined sources1
Modified residuei255PhosphothreonineCombined sources1
Modified residuei259PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by ITCH, leading to its degradation.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17275.
PaxDbiP17275.
PeptideAtlasiP17275.
PRIDEiP17275.

PTM databases

iPTMnetiP17275.
PhosphoSitePlusiP17275.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiENSG00000171223.
CleanExiHS_JUNB.
ExpressionAtlasiP17275. baseline and differential.
GenevisibleiP17275. HS.

Organism-specific databases

HPAiCAB004464.
HPA019149.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF2P153362EBI-748062,EBI-1170906
ATF3P188472EBI-748062,EBI-712767
ATF7P175442EBI-748062,EBI-765623
BATFQ165209EBI-748062,EBI-749503
BATF2Q8N1L93EBI-748062,EBI-742695
BATF3Q9NR552EBI-748062,EBI-10312707
C19orf68Q86XI82EBI-748062,EBI-2682158
FOSP011008EBI-748062,EBI-852851
FOSQ6FG414EBI-748062,EBI-10198738
FOSL1P154074EBI-748062,EBI-744510
FOSL2P154085EBI-748062,EBI-3893419
HBZP0C7462EBI-748062,EBI-10890294From a different organism.
MDV005Q9DGW52EBI-748062,EBI-10889526From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109929. 65 interactors.
DIPiDIP-1052N.
IntActiP17275. 40 interactors.
MINTiMINT-205420.
STRINGi9606.ENSP00000303315.

Structurei

3D structure databases

ProteinModelPortaliP17275.
SMRiP17275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 331bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 295Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni296 – 324Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
GeneTreeiENSGT00390000009929.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP17275.
KOiK09028.
OMAiPTPAHYL.
OrthoDBiEOG091G0N0L.
PhylomeDBiP17275.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029822. JunB.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF37. PTHR11462:SF37. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL
60 70 80 90 100
KAPGARGPGP EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT
110 120 130 140 150
TTPTPPGQYF YPRGGGSGGG AGGAGGGVTE EQEGFADGFV KALDDLHKMN
160 170 180 190 200
HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP VYTNLSSYSP ASASSGGAGA
210 220 230 240 250
AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK EEPQTVPEAR
260 270 280 290 300
SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV
310 320 330 340
KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF
Length:347
Mass (Da):35,879
Last modified:August 1, 1990 - v1
Checksum:iDF8CD1CD4409C6BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → G in AAH09465 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021081230L → V.1 PublicationCorresponds to variant rs17880705dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29039 Genomic DNA. Translation: AAA59198.1.
X51345 mRNA. Translation: CAA35738.1.
U20734 Genomic DNA. Translation: AAA74915.1.
AY751746 Genomic DNA. Translation: AAU43800.1.
BC004250 mRNA. Translation: AAH04250.1.
BC009465 mRNA. Translation: AAH09465.1.
BC009466 mRNA. Translation: AAH09466.1.
CCDSiCCDS12280.1.
PIRiS10183. TVHUJB.
RefSeqiNP_002220.1. NM_002229.2.
UniGeneiHs.25292.

Genome annotation databases

EnsembliENST00000302754; ENSP00000303315; ENSG00000171223.
GeneIDi3726.
KEGGihsa:3726.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29039 Genomic DNA. Translation: AAA59198.1.
X51345 mRNA. Translation: CAA35738.1.
U20734 Genomic DNA. Translation: AAA74915.1.
AY751746 Genomic DNA. Translation: AAU43800.1.
BC004250 mRNA. Translation: AAH04250.1.
BC009465 mRNA. Translation: AAH09465.1.
BC009466 mRNA. Translation: AAH09466.1.
CCDSiCCDS12280.1.
PIRiS10183. TVHUJB.
RefSeqiNP_002220.1. NM_002229.2.
UniGeneiHs.25292.

3D structure databases

ProteinModelPortaliP17275.
SMRiP17275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109929. 65 interactors.
DIPiDIP-1052N.
IntActiP17275. 40 interactors.
MINTiMINT-205420.
STRINGi9606.ENSP00000303315.

PTM databases

iPTMnetiP17275.
PhosphoSitePlusiP17275.

Polymorphism and mutation databases

BioMutaiJUNB.
DMDMi135304.

Proteomic databases

EPDiP17275.
PaxDbiP17275.
PeptideAtlasiP17275.
PRIDEiP17275.

Protocols and materials databases

DNASUi3726.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302754; ENSP00000303315; ENSG00000171223.
GeneIDi3726.
KEGGihsa:3726.

Organism-specific databases

CTDi3726.
DisGeNETi3726.
GeneCardsiJUNB.
HGNCiHGNC:6205. JUNB.
HPAiCAB004464.
HPA019149.
MIMi165161. gene.
neXtProtiNX_P17275.
OpenTargetsiENSG00000171223.
PharmGKBiPA30007.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
GeneTreeiENSGT00390000009929.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP17275.
KOiK09028.
OMAiPTPAHYL.
OrthoDBiEOG091G0N0L.
PhylomeDBiP17275.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171223-MONOMER.
ReactomeiR-HSA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
SignaLinkiP17275.
SIGNORiP17275.

Miscellaneous databases

ChiTaRSiJUNB. human.
GeneWikiiJUNB.
GenomeRNAii3726.
PROiP17275.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171223.
CleanExiHS_JUNB.
ExpressionAtlasiP17275. baseline and differential.
GenevisibleiP17275. HS.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029822. JunB.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF37. PTHR11462:SF37. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJUNB_HUMAN
AccessioniPrimary (citable) accession number: P17275
Secondary accession number(s): Q96GH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 181 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.