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P17275

- JUNB_HUMAN

UniProt

P17275 - JUNB_HUMAN

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Protein

Transcription factor jun-B

Gene

JUNB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. double-stranded DNA binding Source: Ensembl
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. transcription coactivator activity Source: ProtInc
  6. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. cellular response to calcium ion Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. decidualization Source: Ensembl
  4. embryonic process involved in female pregnancy Source: Ensembl
  5. gene expression Source: Reactome
  6. labyrinthine layer blood vessel development Source: Ensembl
  7. osteoblast differentiation Source: Ensembl
  8. osteoblast proliferation Source: Ensembl
  9. osteoclast differentiation Source: Ensembl
  10. positive regulation of cell differentiation Source: Ensembl
  11. positive regulation of transcription from RNA polymerase II promoter Source: Reactome
  12. regulation of cell cycle Source: Ensembl
  13. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  14. response to cAMP Source: Ensembl
  15. response to corticosterone Source: Ensembl
  16. response to cytokine Source: Ensembl
  17. response to drug Source: Ensembl
  18. response to light stimulus Source: Ensembl
  19. response to mechanical stimulus Source: Ensembl
  20. response to peptide hormone Source: Ensembl
  21. response to progesterone Source: Ensembl
  22. transcription, DNA-templated Source: Reactome
  23. transcription initiation from RNA polymerase II promoter Source: Reactome
  24. transforming growth factor beta receptor signaling pathway Source: Reactome
  25. trophectodermal cell differentiation Source: Ensembl
  26. vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
SignaLinkiP17275.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-B
Gene namesi
Name:JUNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6205. JUNB.

Subcellular locationi

GO - Cellular componenti

  1. chromatin Source: ProtInc
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Transcription factor jun-BPRO_0000076438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021Phosphothreonine1 Publication
Modified residuei104 – 1041Phosphothreonine2 Publications
Modified residuei117 – 1171Phosphoserine2 Publications
Modified residuei240 – 2401N6-acetyllysineBy similarity
Modified residuei251 – 2511Phosphoserine2 Publications
Modified residuei255 – 2551Phosphothreonine3 Publications
Modified residuei259 – 2591Phosphoserine2 Publications

Post-translational modificationi

Ubiquitinated by ITCH, leading to its degradation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP17275.
PaxDbiP17275.
PRIDEiP17275.

PTM databases

PhosphoSiteiP17275.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiP17275.
CleanExiHS_JUNB.
ExpressionAtlasiP17275. baseline and differential.
GenevestigatoriP17275.

Organism-specific databases

HPAiCAB004464.
HPA019149.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BATF2Q8N1L93EBI-748062,EBI-742695
C19orf68Q86XI82EBI-748062,EBI-2682158
FOSP011003EBI-748062,EBI-852851

Protein-protein interaction databases

BioGridi109929. 42 interactions.
DIPiDIP-1052N.
IntActiP17275. 27 interactions.
MINTiMINT-205420.
STRINGi9606.ENSP00000303315.

Structurei

3D structure databases

ProteinModelPortaliP17275.
SMRiP17275. Positions 272-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 33164bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 29528Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni296 – 32429Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG283376.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP17275.
KOiK09028.
OMAiLNAYCPN.
OrthoDBiEOG75MVXV.
PhylomeDBiP17275.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17275 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL
60 70 80 90 100
KAPGARGPGP EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT
110 120 130 140 150
TTPTPPGQYF YPRGGGSGGG AGGAGGGVTE EQEGFADGFV KALDDLHKMN
160 170 180 190 200
HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP VYTNLSSYSP ASASSGGAGA
210 220 230 240 250
AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK EEPQTVPEAR
260 270 280 290 300
SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV
310 320 330 340
KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF
Length:347
Mass (Da):35,879
Last modified:August 1, 1990 - v1
Checksum:iDF8CD1CD4409C6BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241A → G in AAH09465. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti230 – 2301L → V.1 Publication
Corresponds to variant rs17880705 [ dbSNP | Ensembl ].
VAR_021081

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29039 Genomic DNA. Translation: AAA59198.1.
X51345 mRNA. Translation: CAA35738.1.
U20734 Genomic DNA. Translation: AAA74915.1.
AY751746 Genomic DNA. Translation: AAU43800.1.
BC004250 mRNA. Translation: AAH04250.1.
BC009465 mRNA. Translation: AAH09465.1.
BC009466 mRNA. Translation: AAH09466.1.
CCDSiCCDS12280.1.
PIRiS10183. TVHUJB.
RefSeqiNP_002220.1. NM_002229.2.
UniGeneiHs.25292.

Genome annotation databases

EnsembliENST00000302754; ENSP00000303315; ENSG00000171223.
GeneIDi3726.
KEGGihsa:3726.
UCSCiuc002mvc.3. human.

Polymorphism databases

DMDMi135304.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29039 Genomic DNA. Translation: AAA59198.1 .
X51345 mRNA. Translation: CAA35738.1 .
U20734 Genomic DNA. Translation: AAA74915.1 .
AY751746 Genomic DNA. Translation: AAU43800.1 .
BC004250 mRNA. Translation: AAH04250.1 .
BC009465 mRNA. Translation: AAH09465.1 .
BC009466 mRNA. Translation: AAH09466.1 .
CCDSi CCDS12280.1.
PIRi S10183. TVHUJB.
RefSeqi NP_002220.1. NM_002229.2.
UniGenei Hs.25292.

3D structure databases

ProteinModelPortali P17275.
SMRi P17275. Positions 272-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109929. 42 interactions.
DIPi DIP-1052N.
IntActi P17275. 27 interactions.
MINTi MINT-205420.
STRINGi 9606.ENSP00000303315.

PTM databases

PhosphoSitei P17275.

Polymorphism databases

DMDMi 135304.

Proteomic databases

MaxQBi P17275.
PaxDbi P17275.
PRIDEi P17275.

Protocols and materials databases

DNASUi 3726.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302754 ; ENSP00000303315 ; ENSG00000171223 .
GeneIDi 3726.
KEGGi hsa:3726.
UCSCi uc002mvc.3. human.

Organism-specific databases

CTDi 3726.
GeneCardsi GC19P012902.
HGNCi HGNC:6205. JUNB.
HPAi CAB004464.
HPA019149.
MIMi 165161. gene.
neXtProti NX_P17275.
PharmGKBi PA30007.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283376.
HOGENOMi HOG000006648.
HOVERGENi HBG001722.
InParanoidi P17275.
KOi K09028.
OMAi LNAYCPN.
OrthoDBi EOG75MVXV.
PhylomeDBi P17275.

Enzyme and pathway databases

Reactomei REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
SignaLinki P17275.

Miscellaneous databases

GeneWikii JUNB.
GenomeRNAii 3726.
NextBioi 14587.
PROi P17275.
SOURCEi Search...

Gene expression databases

Bgeei P17275.
CleanExi HS_JUNB.
ExpressionAtlasi P17275. baseline and differential.
Genevestigatori P17275.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
InterProi IPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view ]
PRINTSi PR00043. LEUZIPPRJUN.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun."
    Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J.
    Cell 59:987-997(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D."
    Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R.
    Nucleic Acids Res. 18:3047-3048(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci."
    Phinney D.G., Tseng S.W., Ryder K.
    Genomics 28:228-234(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  4. NIEHS SNPs program
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-230.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. "Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation."
    Yang C., Zhou W., Jeon M.S., Demydenko D., Harada Y., Zhou H., Liu Y.C.
    Mol. Cell 21:135-141(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITCH, UBIQUITINATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-102; THR-104 AND SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251; THR-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104; SER-117; SER-251 AND THR-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-255 AND SER-259, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJUNB_HUMAN
AccessioniPrimary (citable) accession number: P17275
Secondary accession number(s): Q96GH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3