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P17275 (JUNB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor jun-B
Gene names
Name:JUNB
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Subunit structure

Binds DNA as an homodimer or as an heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). Ref.8

Subcellular location

Nucleus.

Induction

By growth factors.

Post-translational modification

Ubiquitinated by ITCH, leading to its degradation. Ref.8

Sequence similarities

Belongs to the bZIP family. Jun subfamily.

Contains 1 bZIP domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentchromatin

Traceable author statement. Source: ProtInc

nucleus

Inferred from direct assay. Source: HPA

   Molecular functionprotein dimerization activity

Inferred from electronic annotation. Source: InterPro

transcription coactivator activity

Traceable author statement. Source: ProtInc

transcription corepressor activity

Traceable author statement. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BATF2Q8N1L93EBI-748062,EBI-742695
C19orf68Q86XI82EBI-748062,EBI-2682158

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Transcription factor jun-B
PRO_0000076438

Regions

Domain296 – 32429Leucine-zipper
DNA binding273 – 29220Basic motif

Amino acid modifications

Modified residue1021Phosphothreonine Ref.9
Modified residue1041Phosphothreonine Ref.9
Modified residue1171Phosphoserine Ref.9
Modified residue2511Phosphoserine Ref.9 Ref.10
Modified residue2551Phosphothreonine Ref.7 Ref.9 Ref.10
Modified residue2591Phosphoserine Ref.6 Ref.7 Ref.9 Ref.10

Natural variations

Natural variant2301L → V. Ref.4
Corresponds to variant rs17880705 [ dbSNP | Ensembl ].
VAR_021081

Experimental info

Sequence conflict1241A → G in AAH09465. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P17275 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: DF8CD1CD4409C6BE

FASTA34735,879
        10         20         30         40         50         60 
MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL KAPGARGPGP 

        70         80         90        100        110        120 
EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT TTPTPPGQYF YPRGGGSGGG 

       130        140        150        160        170        180 
AGGAGGGVTE EQEGFADGFV KALDDLHKMN HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP 

       190        200        210        220        230        240 
VYTNLSSYSP ASASSGGAGA AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK 

       250        260        270        280        290        300 
EEPQTVPEAR SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV 

       310        320        330        340 
KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF 

« Hide

References

« Hide 'large scale' references
[1]"jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun."
Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J.
Cell 59:987-997(1989) [PubMed: 2513129] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Isolation of human cDNA clones of jun-related genes, jun-B and jun-D."
Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R.
Nucleic Acids Res. 18:3047-3048(1990) [PubMed: 2112242] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci."
Phinney D.G., Tseng S.W., Ryder K.
Genomics 28:228-234(1995) [PubMed: 8530030] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[4]NIEHS SNPs program
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-230.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[6]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[7]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-255 AND SER-259, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[8]"Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation."
Yang C., Zhou W., Jeon M.S., Demydenko D., Harada Y., Zhou H., Liu Y.C.
Mol. Cell 21:135-141(2006) [PubMed: 16387660] [Abstract]
Cited for: INTERACTION WITH ITCH, UBIQUITINATION.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-102; THR-104; SER-117; SER-251; THR-255 AND SER-259, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251; THR-255 AND SER-259, MASS SPECTROMETRY.
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29039 Genomic DNA. Translation: AAA59198.1.
X51345 mRNA. Translation: CAA35738.1.
U20734 Genomic DNA. Translation: AAA74915.1.
AY751746 Genomic DNA. Translation: AAU43800.1.
BC004250 mRNA. Translation: AAH04250.1.
BC009465 mRNA. Translation: AAH09465.1.
BC009466 mRNA. Translation: AAH09466.1.
IPIIPI00013439.
PIRTVHUJB. S10183.
RefSeqNP_002220.1. NM_002229.2.
UniGeneHs.25292.

3D structure databases

ProteinModelPortalP17275.
SMRP17275. Positions 272-329.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-1052N.
IntActP17275. 22 interactions.
MINTMINT-205420.
STRINGP17275.

PTM databases

PhosphoSiteP17275.

Polymorphism databases

DMDM135304.

Proteomic databases

PRIDEP17275.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302754; ENSP00000303315; ENSG00000171223.
GeneID3726.
KEGGhsa:3726.
UCSCuc002mvc.1. human.

Organism-specific databases

CTD3726.
GeneCardsGC19P012902.
H-InvDBHIX0014804.
HGNCHGNC:6205. JUNB.
HPACAB004464.
HPA019149.
MIM165161. gene.
neXtProtNX_P17275.
PharmGKBPA30007.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG17996.
HOGENOMHBG446073.
HOVERGENHBG001722.
InParanoidP17275.
OMANGCQLLL.
OrthoDBEOG4RV2RS.
PhylomeDBP17275.

Enzyme and pathway databases

Pathway_Interaction_DBnfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes.
tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway.
cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
il6_7pathway. IL6-mediated signaling events.

Gene expression databases

ArrayExpressP17275.
BgeeP17275.
CleanExHS_JUNB.
GenevestigatorP17275.
GermOnlineENSG00000171223. Homo sapiens.

Family and domain databases

InterProIPR004827. bZIP.
IPR011616. bZIP_1.
IPR008917. Euk_TF_DNA-bd.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
[Graphical view]
Gene3DG3DSA:1.10.880.10. G3DSA:1.10.880.10. 1 hit.
KOK09028.
PfamPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSPR00043. LEUZIPPRJUN.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMSSF47454. Euk_transcr_DNA. 1 hit.
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio14587.
SOURCESearch...

Entry information

Entry nameJUNB_HUMAN
AccessionPrimary (citable) accession number: P17275
Secondary accession number(s): Q96GH3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: January 25, 2012
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families