Reviewed,
UniProtKB/Swiss-Prot P17275 (JUNB_HUMAN)
Last modified
June 16, 2009.
Version 105.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transcription factor jun-B | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 347 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. |
| Subunit structure | Binds DNA as an homodimer or as an heterodimer with another member of the jun/fos family. |
| Subcellular location | |
| Induction | By growth factors. |
| Sequence similarities | Belongs to the bZIP family. Jun subfamily. Contains 1 bZIP domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 347 | 347 | Transcription factor jun-B | PRO_0000076438 | |||||
Regions | |||||||||
| Domain | 296 – 324 | 29 | Leucine-zipper | ||||||
| DNA binding | 273 – 292 | 20 | Basic motif | ||||||
Amino acid modifications | |||||||||
| Modified residue | 102 | 1 | Phosphothreonine Ref.8 | ||||||
| Modified residue | 104 | 1 | Phosphothreonine Ref.8 | ||||||
| Modified residue | 117 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 251 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 255 | 1 | Phosphothreonine Ref.8 Ref.7 | ||||||
| Modified residue | 259 | 1 | Phosphoserine Ref.8 Ref.7 Ref.6 | ||||||
Natural variations | |||||||||
| Natural variant | 230 | 1 | L → V: dbSNP rs17880705. Ref.4 | VAR_021081 | |||||
Experimental info | |||||||||
| Sequence conflict | 124 | 1 | A → G in AAH09465. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun." Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J. Cell 59:987-997(1989) [PubMed: 2513129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D." Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R. Nucleic Acids Res. 18:3047-3048(1990) [PubMed: 2112242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci." Phinney D.G., Tseng S.W., Ryder K. Genomics 28:228-234(1995) [PubMed: 8530030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta. |
| [4] | NIEHS SNPs program Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-230. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas. |
| [6] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, MASS SPECTROMETRY. Tissue: Epithelium. |
| [7] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-255 AND SER-259, MASS SPECTROMETRY. Tissue: Epithelium. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-102; THR-104; SER-117; SER-251; THR-255 AND SER-259, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M29039 Genomic DNA. Translation: AAA59198.1. X51345 mRNA. Translation: CAA35738.1. U20734 Genomic DNA. Translation: AAA74915.1. AY751746 Genomic DNA. Translation: AAU43800.1. BC004250 mRNA. Translation: AAH04250.1. BC009465 mRNA. Translation: AAH09465.1. BC009466 mRNA. Translation: AAH09466.1. | |
| IPI | IPI00013439. |
| PIR | TVHUJB. S10183. |
| RefSeq | NP_002220.1. |
| UniGene | Hs.25292 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FOS based on UniProtKB P05412. |
| SMR | P17275. Positions 269-329. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:1052N. |
| IntAct | P17275. 3 interactions. |
PTM databases | |
| PhosphoSite | P17275. |
Proteomic databases | |
| PRIDE | P17275. |
Genome annotation databases | |
| Ensembl | ENSG00000171223. Homo sapiens. [Contig view] |
| GeneID | 3726. |
| KEGG | hsa:3726. |
Organism-specific databases | |
| GeneCards | GC19P012763. |
| H-InvDB | HIX0014804. |
| HGNC | HGNC:6205. JUNB. |
| HPA | CAB004464. |
| MIM | 165161. gene. |
| PharmGKB | PA30007. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P17275. |
| HOVERGEN | P17275. |
| OMA | P17275. NGCQLLL. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes. tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway. cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells. il6_7pathway. IL6-mediated signaling events. |
Gene expression databases | |
| ArrayExpress | P17275. |
| Bgee | P17275. |
| CleanEx | HS_JUNB. |
| GermOnline | ENSG00000171223. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011616. bZIP_1. IPR005643. JNK. IPR002112. Leuzip_Jun. IPR004827. TF_bZIP. [Graphical view] |
| Pfam | PF00170. bZIP_1. 1 hit. PF03957. Jun. 1 hit. [Graphical view] |
| PRINTS | PR00043. LEUZIPPRJUN. |
| SMART | SM00338. BRLZ. 1 hit. [Graphical view] |
| PROSITE | PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 14587. |
| SOURCE | Search... |
Entry information
| Entry name | JUNB_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P17275 Secondary accession number(s): Q96GH3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


