ID   ERS1_YEAST              Reviewed;         260 AA.
AC   P17261; D6VR77;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-APR-2013, entry version 110.
DE   RecName: Full=Cystine transporter;
DE   AltName: Full=ERD suppressor;
DE   AltName: Full=Transmembrane protein ERS1;
GN   Name=ERS1; OrderedLocusNames=YCR075C; ORFNames=YCR75C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2186379; DOI=10.1093/nar/18.8.2177;
RA   Hardwick K., Pelham H.;
RT   "ERS1 a seven transmembrane domain protein from Saccharomyces
RT   cerevisiae.";
RL   Nucleic Acids Res. 18:2177-2177(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M.,
RA   Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W.,
RA   Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H.,
RA   Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V.,
RA   Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A.,
RA   de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H.,
RA   Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K.,
RA   Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B.,
RA   Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A.,
RA   Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y.,
RA   Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R.,
RA   Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G.,
RA   Tzermia M., Urrestarazu L.A., Valle G., Vetter I.,
RA   van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H.,
RA   Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C.,
RA   Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RG   Saccharomyces Genome Database;
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=15885099; DOI=10.1111/j.1742-4658.2005.04670.x;
RA   Gao X.-D., Wang J., Keppler-Ross S., Dean N.;
RT   "ERS1 encodes a functional homologue of the human lysosomal cystine
RT   transporter.";
RL   FEBS J. 272:2497-2511(2005).
CC   -!- FUNCTION: Transport cystine out of vacuoles/endodomes.
CC   -!- INTERACTION:
CC       P40975:PMP2; NbExp=1; IntAct=EBI-2058366, EBI-2043041;
CC       P87284:PMP3; NbExp=1; IntAct=EBI-2058366, EBI-13555;
CC       Q12270:RBD2; NbExp=1; IntAct=EBI-2058366, EBI-31471;
CC       P40107:VRG4; NbExp=1; IntAct=EBI-2058366, EBI-7764;
CC   -!- SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane
CC       protein. Vacuole membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the cystinosin family.
CC   -!- SIMILARITY: Contains 2 PQ-loop domains.
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DR   EMBL; X52468; CAA36706.1; -; Genomic_DNA.
DR   EMBL; X59720; CAA42264.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07546.1; -; Genomic_DNA.
DR   PIR; S22850; S22850.
DR   RefSeq; NP_010000.1; NM_001178784.1.
DR   ProteinModelPortal; P17261; -.
DR   DIP; DIP-8250N; -.
DR   IntAct; P17261; 1.
DR   MINT; MINT-1358453; -.
DR   STRING; 4932.YCR075C; -.
DR   TCDB; 2.A.43.2.1; lysosomal cystine transporter (LCT) family.
DR   EnsemblFungi; YCR075C; YCR075C; YCR075C.
DR   GeneID; 850438; -.
DR   KEGG; sce:YCR075C; -.
DR   CYGD; YCR075c; -.
DR   SGD; S000000671; ERS1.
DR   eggNOG; NOG266153; -.
DR   GeneTree; ENSGT00390000005338; -.
DR   HOGENOM; HOG000000908; -.
DR   KO; K12386; -.
DR   OMA; SASAISM; -.
DR   OrthoDB; EOG4K6KDF; -.
DR   NextBio; 966036; -.
DR   Genevestigator; P17261; -.
DR   GermOnline; YCR075C; Saccharomyces cerevisiae.
DR   GO; GO:0005768; C:endosome; IDA:SGD.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000324; C:fungal-type vacuole; IDA:SGD.
DR   GO; GO:0016021; C:integral to membrane; ISM:SGD.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015184; F:L-cystine transmembrane transporter activity; IGI:SGD.
DR   InterPro; IPR006603; CTNS.
DR   InterPro; IPR005282; LC_transporter.
DR   PANTHER; PTHR13131; PTHR13131; 1.
DR   SMART; SM00679; CTNS; 2.
DR   TIGRFAMs; TIGR00951; 2A43; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Endosome; Glycoprotein; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport; Vacuole.
FT   CHAIN         1    260       Cystine transporter.
FT                                /FTId=PRO_0000205519.
FT   TRANSMEM      7     28       Helical; (Potential).
FT   TRANSMEM     40     62       Helical; (Potential).
FT   TRANSMEM     81    102       Helical; (Potential).
FT   TRANSMEM    118    138       Helical; (Potential).
FT   TRANSMEM    151    175       Helical; (Potential).
FT   TRANSMEM    185    205       Helical; (Potential).
FT   TRANSMEM    227    247       Helical; (Potential).
FT   DOMAIN        1     67       PQ-loop 1.
FT   DOMAIN      162    212       PQ-loop 2.
FT   CARBOHYD    177    177       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   260 AA;  30116 MW;  BF9E129E44D20655 CRC64;
     MVSLDDILGI VYVTSWSISM YPPIITNWRH KSASAISMDF VMLNTAGYSY LVISIFLQLY
     CWKMTGDESD LGRPKLTQFD FWYCLHGCLM NVVLLTQVVA GARIWRFPGK GHRKMNPWYL
     RILLASLAIF SLLTVQFMYS NYWYDWHNSR TLAYCNNLFL LKISMSLIKY IPQVTHNSTR
     KSMDCFPIQG VFLDVTGGIA SLLQLIWQLS NDQGFSLDTF VTNFGKVGLS MVTLIFNFIF
     IMQWFVYRSR GHDLASEYPL
//