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Protein

Cystine transporter

Gene

ERS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transport cystine out of vacuoles/endodomes.1 Publication

GO - Molecular functioni

  • L-cystine transmembrane transporter activity Source: SGD

GO - Biological processi

  • L-cystine transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29374-MONOMER.
ReactomeiR-SCE-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.
R-SCE-5223345. Miscellaneous transport and binding events.

Protein family/group databases

TCDBi2.A.43.1.3. the lysosomal cystine transporter (lct) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystine transporter
Alternative name(s):
ERD suppressor
Transmembrane protein ERS1
Gene namesi
Name:ERS1
Ordered Locus Names:YCR075C
ORF Names:YCR75C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR075C.
SGDiS000000671. ERS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2822HelicalSequence analysisAdd
BLAST
Transmembranei40 – 6223HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10222HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Transmembranei151 – 17525HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endosome Source: SGD
  • endosome membrane Source: UniProtKB-SubCell
  • fungal-type vacuole Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Cystine transporterPRO_0000205519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PMP2P409751EBI-2058366,EBI-2043041
PMP3P872841EBI-2058366,EBI-13555
RBD2Q122701EBI-2058366,EBI-31471
VRG4P401071EBI-2058366,EBI-7764

Protein-protein interaction databases

BioGridi31050. 57 interactions.
DIPiDIP-8250N.
IntActiP17261. 4 interactions.
MINTiMINT-1358453.

Structurei

3D structure databases

ProteinModelPortaliP17261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6767PQ-loop 1Add
BLAST
Domaini162 – 21251PQ-loop 2Add
BLAST

Sequence similaritiesi

Belongs to the cystinosin family.Curated
Contains 2 PQ-loop domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000005338.
HOGENOMiHOG000000908.
InParanoidiP17261.
KOiK12386.
OMAiITIVFDI.
OrthoDBiEOG7JDR80.

Family and domain databases

InterProiIPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view]
PANTHERiPTHR13131. PTHR13131. 1 hit.
PfamiPF04193. PQ-loop. 2 hits.
[Graphical view]
SMARTiSM00679. CTNS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00951. 2A43. 1 hit.

Sequencei

Sequence statusi: Complete.

P17261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLDDILGI VYVTSWSISM YPPIITNWRH KSASAISMDF VMLNTAGYSY
60 70 80 90 100
LVISIFLQLY CWKMTGDESD LGRPKLTQFD FWYCLHGCLM NVVLLTQVVA
110 120 130 140 150
GARIWRFPGK GHRKMNPWYL RILLASLAIF SLLTVQFMYS NYWYDWHNSR
160 170 180 190 200
TLAYCNNLFL LKISMSLIKY IPQVTHNSTR KSMDCFPIQG VFLDVTGGIA
210 220 230 240 250
SLLQLIWQLS NDQGFSLDTF VTNFGKVGLS MVTLIFNFIF IMQWFVYRSR
260
GHDLASEYPL
Length:260
Mass (Da):30,116
Last modified:August 1, 1990 - v1
Checksum:iBF9E129E44D20655
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52468 Genomic DNA. Translation: CAA36706.1.
X59720 Genomic DNA. Translation: CAA42264.1.
BK006937 Genomic DNA. Translation: DAA07546.1.
PIRiS22850.
RefSeqiNP_010000.1. NM_001178784.1.

Genome annotation databases

EnsemblFungiiCAA42264; CAA42264; CAA42264.
YCR075C; YCR075C; YCR075C.
GeneIDi850438.
KEGGisce:YCR075C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52468 Genomic DNA. Translation: CAA36706.1.
X59720 Genomic DNA. Translation: CAA42264.1.
BK006937 Genomic DNA. Translation: DAA07546.1.
PIRiS22850.
RefSeqiNP_010000.1. NM_001178784.1.

3D structure databases

ProteinModelPortaliP17261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31050. 57 interactions.
DIPiDIP-8250N.
IntActiP17261. 4 interactions.
MINTiMINT-1358453.

Protein family/group databases

TCDBi2.A.43.1.3. the lysosomal cystine transporter (lct) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42264; CAA42264; CAA42264.
YCR075C; YCR075C; YCR075C.
GeneIDi850438.
KEGGisce:YCR075C.

Organism-specific databases

EuPathDBiFungiDB:YCR075C.
SGDiS000000671. ERS1.

Phylogenomic databases

GeneTreeiENSGT00390000005338.
HOGENOMiHOG000000908.
InParanoidiP17261.
KOiK12386.
OMAiITIVFDI.
OrthoDBiEOG7JDR80.

Enzyme and pathway databases

BioCyciYEAST:G3O-29374-MONOMER.
ReactomeiR-SCE-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.
R-SCE-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

PROiP17261.

Family and domain databases

InterProiIPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view]
PANTHERiPTHR13131. PTHR13131. 1 hit.
PfamiPF04193. PQ-loop. 2 hits.
[Graphical view]
SMARTiSM00679. CTNS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00951. 2A43. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ERS1 a seven transmembrane domain protein from Saccharomyces cerevisiae."
    Hardwick K., Pelham H.
    Nucleic Acids Res. 18:2177-2177(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "ERS1 encodes a functional homologue of the human lysosomal cystine transporter."
    Gao X.-D., Wang J., Keppler-Ross S., Dean N.
    FEBS J. 272:2497-2511(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiERS1_YEAST
AccessioniPrimary (citable) accession number: P17261
Secondary accession number(s): D6VR77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 8, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.