ID   PTHR_CHICK              Reviewed;         176 AA.
AC   P17251;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   24-JAN-2024, entry version 133.
DE   RecName: Full=Parathyroid hormone-related protein;
DE            Short=PTH-rP;
DE            Short=PTHrP;
DE   Contains:
DE     RecName: Full=Osteostatin;
DE     AltName: Full=PTHrP[107-139];
DE   Flags: Precursor;
GN   Name=PTHLH;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2349111; DOI=10.1093/nar/18.10.3062;
RA   Thiede M.A., Rutledge S.J.;
RT   "Nucleotide sequence of a parathyroid hormone-related peptide expressed by
RT   the 10 day chicken embryo.";
RL   Nucleic Acids Res. 18:3062-3062(1990).
RN   [2]
RP   STRUCTURE BY NMR OF 145-176.
RX   PubMed=10366729; DOI=10.1016/s0167-4838(99)00078-3;
RA   Cuthbertson R.M., Kemp B.E., Barden J.A.;
RT   "Structure study of osteostatin PTHrP[Thr107](107-139).";
RL   Biochim. Biophys. Acta 1432:64-72(1999).
CC   -!- FUNCTION: Neuroendocrine peptide which is a critical regulator of
CC       cellular and organ growth, development, migration, differentiation and
CC       survival and of epithelial calcium ion transport. {ECO:0000250}.
CC   -!- FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone
CC       resorption. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Secreted {ECO:0000250}.
CC   -!- PTM: There are several secretory forms, including osteostatin, arising
CC       from endoproteolytic cleavage of the initial translation product. Each
CC       of these secretory forms is believed to have one or more of its own
CC       receptors that mediates the normal paracrine, autocrine and endocrine
CC       actions (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the parathyroid hormone family. {ECO:0000305}.
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DR   EMBL; X52131; CAA36376.1; -; mRNA.
DR   PIR; S10202; S10202.
DR   RefSeq; NP_990669.2; NM_205338.2.
DR   AlphaFoldDB; P17251; -.
DR   SMR; P17251; -.
DR   STRING; 9031.ENSGALP00000069044; -.
DR   PaxDb; 9031-ENSGALP00000029396; -.
DR   Ensembl; ENSGALT00000079807; ENSGALP00000055214; ENSGALG00000017295.
DR   Ensembl; ENSGALT00010052512.1; ENSGALP00010031419.1; ENSGALG00010021622.1.
DR   Ensembl; ENSGALT00015019120; ENSGALP00015010684; ENSGALG00015007973.
DR   GeneID; 396281; -.
DR   CTD; 5744; -.
DR   VEuPathDB; HostDB:geneid_396281; -.
DR   eggNOG; ENOG502S3J9; Eukaryota.
DR   GeneTree; ENSGT00390000004933; -.
DR   HOGENOM; CLU_095189_0_0_1; -.
DR   InParanoid; P17251; -.
DR   OMA; LQRWFFA; -.
DR   Reactome; R-GGA-373080; Class B/2 (Secretin family receptors).
DR   Reactome; R-GGA-418555; G alpha (s) signalling events.
DR   PRO; PR:P17251; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000017295; Expressed in lung and 7 other cell types or tissues.
DR   ExpressionAtlas; P17251; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0030282; P:bone mineralization; IEA:InterPro.
DR   GO; GO:1903042; P:negative regulation of chondrocyte hypertrophy; IMP:AgBase.
DR   GO; GO:0002076; P:osteoblast development; IBA:GO_Central.
DR   GO; GO:0032330; P:regulation of chondrocyte differentiation; IBA:GO_Central.
DR   GO; GO:1902733; P:regulation of growth plate cartilage chondrocyte differentiation; IMP:AgBase.
DR   GO; GO:0003420; P:regulation of growth plate cartilage chondrocyte proliferation; IMP:AgBase.
DR   InterPro; IPR003626; PTH-rel.
DR   InterPro; IPR001415; PTH/PTH-rel.
DR   PANTHER; PTHR17223; PARATHYROID HORMONE-RELATED; 1.
DR   PANTHER; PTHR17223:SF0; PARATHYROID HORMONE-RELATED PROTEIN; 1.
DR   Pfam; PF01279; Parathyroid; 1.
DR   SMART; SM00087; PTH; 1.
DR   PROSITE; PS00335; PARATHYROID; 1.
PE   1: Evidence at protein level;
KW   Calcium; Cleavage on pair of basic residues; Cytoplasm; Hormone; Nucleus;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..37
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000023240"
FT   CHAIN           38..176
FT                   /note="Parathyroid hormone-related protein"
FT                   /id="PRO_0000023241"
FT   PEPTIDE         145..176
FT                   /note="Osteostatin"
FT                   /id="PRO_0000023242"
FT   REGION          76..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           109..130
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        76..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..141
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   176 AA;  20226 MW;  60C8AB30ACF5293B CRC64;
     MMFTKLFQQW SFAVFLLSYS VPSYGRSVEG ISRRLKRAVS EHQLLHDKGK SIQDLRRRIF
     LQNLIEGVNT AEIRATSEVS PNPKPATNTK NYPVRFGSED EGRYLTQETN KSQTYKEQPL
     KVSGKKKKAK PGKRKEQEKK KRRARSAWLN SGMYGSNVTE SPVLDNSVTT HNHILR
//