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Protein

Parathyroid hormone-related protein

Gene

PTHLH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport.By similarity
Osteostatin is a potent inhibitor of osteoclastic bone resorption.By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • negative regulation of chondrocyte hypertrophy Source: AgBase
  • osteoblast development Source: GO_Central
  • regulation of growth plate cartilage chondrocyte differentiation Source: AgBase
  • regulation of growth plate cartilage chondrocyte proliferation Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone-related protein
Short name:
PTH-rP
Short name:
PTHrP
Cleaved into the following chain:
Alternative name(s):
PTHrP[107-139]
Gene namesi
Name:PTHLH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000002324026 – 37By similarityAdd BLAST12
ChainiPRO_000002324138 – 176Parathyroid hormone-related proteinAdd BLAST139
PeptideiPRO_0000023242145 – 176OsteostatinAdd BLAST32

Post-translational modificationi

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP17251.

Expressioni

Gene expression databases

BgeeiENSGALG00000017295.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029396.

Structurei

3D structure databases

ProteinModelPortaliP17251.
SMRiP17251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi109 – 130Nuclear localization signalBy similarityAdd BLAST22

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW2I. Eukaryota.
ENOG41126XH. LUCA.
GeneTreeiENSGT00390000004933.
HOGENOMiHOG000115765.
HOVERGENiHBG003236.
InParanoidiP17251.
OrthoDBiEOG091G0SNZ.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFTKLFQQW SFAVFLLSYS VPSYGRSVEG ISRRLKRAVS EHQLLHDKGK
60 70 80 90 100
SIQDLRRRIF LQNLIEGVNT AEIRATSEVS PNPKPATNTK NYPVRFGSED
110 120 130 140 150
EGRYLTQETN KSQTYKEQPL KVSGKKKKAK PGKRKEQEKK KRRARSAWLN
160 170
SGMYGSNVTE SPVLDNSVTT HNHILR
Length:176
Mass (Da):20,226
Last modified:August 1, 1990 - v1
Checksum:i60C8AB30ACF5293B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52131 mRNA. Translation: CAA36376.1.
PIRiS10202.
UniGeneiGga.2626.

Genome annotation databases

EnsembliENSGALT00000079807; ENSGALP00000055214; ENSGALG00000017295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52131 mRNA. Translation: CAA36376.1.
PIRiS10202.
UniGeneiGga.2626.

3D structure databases

ProteinModelPortaliP17251.
SMRiP17251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029396.

Proteomic databases

PaxDbiP17251.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000079807; ENSGALP00000055214; ENSGALG00000017295.

Phylogenomic databases

eggNOGiENOG410IW2I. Eukaryota.
ENOG41126XH. LUCA.
GeneTreeiENSGT00390000004933.
HOGENOMiHOG000115765.
HOVERGENiHBG003236.
InParanoidiP17251.
OrthoDBiEOG091G0SNZ.

Miscellaneous databases

PROiP17251.

Gene expression databases

BgeeiENSGALG00000017295.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTHR_CHICK
AccessioniPrimary (citable) accession number: P17251
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.