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P17251

- PTHR_CHICK

UniProt

P17251 - PTHR_CHICK

Protein

Parathyroid hormone-related protein

Gene

PTHLH

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport.By similarity
    Osteostatin is a potent inhibitor of osteoclastic bone resorption.By similarity

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. endochondral ossification Source: Ensembl
    3. endoderm development Source: Ensembl
    4. epithelial cell differentiation Source: Ensembl
    5. lung alveolus development Source: Ensembl
    6. mammary gland bud elongation Source: Ensembl
    7. negative regulation of chondrocyte differentiation Source: Ensembl
    8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    9. nipple sheath formation Source: Ensembl
    10. osteoblast development Source: Ensembl
    11. positive regulation of cAMP biosynthetic process Source: Ensembl
    12. positive regulation of cell proliferation Source: Ensembl
    13. protein processing Source: Ensembl
    14. surfactant homeostasis Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone-related protein
    Short name:
    PTH-rP
    Short name:
    PTHrP
    Cleaved into the following chain:
    Alternative name(s):
    PTHrP[107-139]
    Gene namesi
    Name:PTHLH
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. Golgi apparatus Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 3712By similarityPRO_0000023240Add
    BLAST
    Chaini38 – 176139Parathyroid hormone-related proteinPRO_0000023241Add
    BLAST
    Peptidei145 – 17632OsteostatinPRO_0000023242Add
    BLAST

    Post-translational modificationi

    There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000029396.

    Structurei

    3D structure databases

    ProteinModelPortaliP17251.
    SMRiP17251. Positions 38-71, 104-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi109 – 13022Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the parathyroid hormone family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40343.
    HOGENOMiHOG000115765.
    HOVERGENiHBG003236.
    InParanoidiP17251.

    Family and domain databases

    InterProiIPR003626. PTH-rel.
    IPR001415. PTH/PTH-rel.
    [Graphical view]
    PANTHERiPTHR17223. PTHR17223. 1 hit.
    PfamiPF01279. Parathyroid. 1 hit.
    [Graphical view]
    SMARTiSM00087. PTH. 1 hit.
    [Graphical view]
    PROSITEiPS00335. PARATHYROID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17251-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMFTKLFQQW SFAVFLLSYS VPSYGRSVEG ISRRLKRAVS EHQLLHDKGK    50
    SIQDLRRRIF LQNLIEGVNT AEIRATSEVS PNPKPATNTK NYPVRFGSED 100
    EGRYLTQETN KSQTYKEQPL KVSGKKKKAK PGKRKEQEKK KRRARSAWLN 150
    SGMYGSNVTE SPVLDNSVTT HNHILR 176
    Length:176
    Mass (Da):20,226
    Last modified:August 1, 1990 - v1
    Checksum:i60C8AB30ACF5293B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52131 mRNA. Translation: CAA36376.1.
    PIRiS10202.
    UniGeneiGga.2626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52131 mRNA. Translation: CAA36376.1 .
    PIRi S10202.
    UniGenei Gga.2626.

    3D structure databases

    ProteinModelPortali P17251.
    SMRi P17251. Positions 38-71, 104-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000029396.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG40343.
    HOGENOMi HOG000115765.
    HOVERGENi HBG003236.
    InParanoidi P17251.

    Miscellaneous databases

    NextBioi 20816332.
    PROi P17251.

    Family and domain databases

    InterProi IPR003626. PTH-rel.
    IPR001415. PTH/PTH-rel.
    [Graphical view ]
    PANTHERi PTHR17223. PTHR17223. 1 hit.
    Pfami PF01279. Parathyroid. 1 hit.
    [Graphical view ]
    SMARTi SM00087. PTH. 1 hit.
    [Graphical view ]
    PROSITEi PS00335. PARATHYROID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a parathyroid hormone-related peptide expressed by the 10 day chicken embryo."
      Thiede M.A., Rutledge S.J.
      Nucleic Acids Res. 18:3062-3062(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure study of osteostatin PTHrP[Thr107](107-139)."
      Cuthbertson R.M., Kemp B.E., Barden J.A.
      Biochim. Biophys. Acta 1432:64-72(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 145-176.

    Entry informationi

    Entry nameiPTHR_CHICK
    AccessioniPrimary (citable) accession number: P17251
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3