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P17251 (PTHR_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parathyroid hormone-related protein

Short name=PTH-rP
Short name=PTHrP

Cleaved into the following chain:

  1. Osteostatin
    Alternative name(s):
    PTHrP[107-139]
Gene names
Name:PTHLH
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport By similarity.

Osteostatin is a potent inhibitor of osteoclastic bone resorption By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity.

Post-translational modification

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions By similarity.

Sequence similarities

Belongs to the parathyroid hormone family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
Secreted
   DomainSignal
   LigandCalcium
   Molecular functionHormone
   PTMCleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

endochondral ossification

Inferred from electronic annotation. Source: Ensembl

endoderm development

Inferred from electronic annotation. Source: Ensembl

epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

lung alveolus development

Inferred from electronic annotation. Source: Ensembl

mammary gland bud elongation

Inferred from electronic annotation. Source: Ensembl

negative regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

nipple sheath formation

Inferred from electronic annotation. Source: Ensembl

osteoblast development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

protein processing

Inferred from electronic annotation. Source: Ensembl

surfactant homeostasis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 3712 By similarity
PRO_0000023240
Chain38 – 176139Parathyroid hormone-related protein
PRO_0000023241
Peptide145 – 17632Osteostatin
PRO_0000023242

Regions

Motif109 – 13022Nuclear localization signal By similarity

Sequences

Sequence LengthMass (Da)Tools
P17251 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 60C8AB30ACF5293B

FASTA17620,226
        10         20         30         40         50         60 
MMFTKLFQQW SFAVFLLSYS VPSYGRSVEG ISRRLKRAVS EHQLLHDKGK SIQDLRRRIF 

        70         80         90        100        110        120 
LQNLIEGVNT AEIRATSEVS PNPKPATNTK NYPVRFGSED EGRYLTQETN KSQTYKEQPL 

       130        140        150        160        170 
KVSGKKKKAK PGKRKEQEKK KRRARSAWLN SGMYGSNVTE SPVLDNSVTT HNHILR 

« Hide

References

[1]"Nucleotide sequence of a parathyroid hormone-related peptide expressed by the 10 day chicken embryo."
Thiede M.A., Rutledge S.J.
Nucleic Acids Res. 18:3062-3062(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure study of osteostatin PTHrP[Thr107](107-139)."
Cuthbertson R.M., Kemp B.E., Barden J.A.
Biochim. Biophys. Acta 1432:64-72(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 145-176.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52131 mRNA. Translation: CAA36376.1.
PIRS10202.
UniGeneGga.2626.

3D structure databases

ProteinModelPortalP17251.
SMRP17251. Positions 38-71, 104-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000029396.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG40343.
HOGENOMHOG000115765.
HOVERGENHBG003236.
InParanoidP17251.

Family and domain databases

InterProIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERPTHR17223. PTHR17223. 1 hit.
PfamPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTSM00087. PTH. 1 hit.
[Graphical view]
PROSITEPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816332.
PROP17251.

Entry information

Entry namePTHR_CHICK
AccessionPrimary (citable) accession number: P17251
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families