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Protein

Parathyroid hormone-related protein

Gene

PTHLH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport.By similarity
Osteostatin is a potent inhibitor of osteoclastic bone resorption.By similarity

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. endochondral ossification Source: Ensembl
  3. endoderm development Source: Ensembl
  4. epithelial cell differentiation Source: Ensembl
  5. lung alveolus development Source: Ensembl
  6. mammary gland bud elongation Source: Ensembl
  7. negative regulation of chondrocyte differentiation Source: Ensembl
  8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  9. nipple sheath formation Source: Ensembl
  10. osteoblast development Source: Ensembl
  11. positive regulation of cAMP biosynthetic process Source: Ensembl
  12. positive regulation of cell proliferation Source: Ensembl
  13. protein processing Source: Ensembl
  14. surfactant homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_245585. Class B/2 (Secretin family receptors).
REACT_246971. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone-related protein
Short name:
PTH-rP
Short name:
PTHrP
Cleaved into the following chain:
Alternative name(s):
PTHrP[107-139]
Gene namesi
Name:PTHLH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. Golgi apparatus Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 3712By similarityPRO_0000023240Add
BLAST
Chaini38 – 176139Parathyroid hormone-related proteinPRO_0000023241Add
BLAST
Peptidei145 – 17632OsteostatinPRO_0000023242Add
BLAST

Post-translational modificationi

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Gene expression databases

ExpressionAtlasiP17251. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029396.

Structurei

3D structure databases

ProteinModelPortaliP17251.
SMRiP17251. Positions 38-71, 104-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 13022Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40343.
HOGENOMiHOG000115765.
HOVERGENiHBG003236.
InParanoidiP17251.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFTKLFQQW SFAVFLLSYS VPSYGRSVEG ISRRLKRAVS EHQLLHDKGK
60 70 80 90 100
SIQDLRRRIF LQNLIEGVNT AEIRATSEVS PNPKPATNTK NYPVRFGSED
110 120 130 140 150
EGRYLTQETN KSQTYKEQPL KVSGKKKKAK PGKRKEQEKK KRRARSAWLN
160 170
SGMYGSNVTE SPVLDNSVTT HNHILR
Length:176
Mass (Da):20,226
Last modified:August 1, 1990 - v1
Checksum:i60C8AB30ACF5293B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52131 mRNA. Translation: CAA36376.1.
PIRiS10202.
UniGeneiGga.2626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52131 mRNA. Translation: CAA36376.1.
PIRiS10202.
UniGeneiGga.2626.

3D structure databases

ProteinModelPortaliP17251.
SMRiP17251. Positions 38-71, 104-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG40343.
HOGENOMiHOG000115765.
HOVERGENiHBG003236.
InParanoidiP17251.

Enzyme and pathway databases

ReactomeiREACT_245585. Class B/2 (Secretin family receptors).
REACT_246971. G alpha (s) signalling events.

Miscellaneous databases

NextBioi20816332.
PROiP17251.

Gene expression databases

ExpressionAtlasiP17251. baseline.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a parathyroid hormone-related peptide expressed by the 10 day chicken embryo."
    Thiede M.A., Rutledge S.J.
    Nucleic Acids Res. 18:3062-3062(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure study of osteostatin PTHrP[Thr107](107-139)."
    Cuthbertson R.M., Kemp B.E., Barden J.A.
    Biochim. Biophys. Acta 1432:64-72(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 145-176.

Entry informationi

Entry nameiPTHR_CHICK
AccessioniPrimary (citable) accession number: P17251
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 4, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.