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P17224

- T1RP_ECOLX

UniProt

P17224 - T1RP_ECOLX

Protein

Type I restriction enzyme EcoprrI

Gene

prrD

Organism
Escherichia coli
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    • Comment

    Functioni

    Putative 'masking-agent' for the anticodon nuclease. Recognizes the double-stranded sequence 5'-CCAN7RTGC-3'.

    Catalytic activityi

    Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. Type I site-specific deoxyribonuclease activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Protein family/group databases

    REBASEi2541. EcoprrI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type I restriction enzyme EcoprrI (EC:3.1.21.3)
    Gene namesi
    Name:prrD
    OrganismiEscherichia coli
    Taxonomic identifieri562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Type I restriction enzyme EcoprrIPRO_0000077261Add
    BLAST

    Proteomic databases

    PRIDEiP17224.

    Structurei

    3D structure databases

    ProteinModelPortaliP17224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HsdR family.Curated

    Family and domain databases

    InterProiIPR007409. Restrct_endonuc_type1_HsdR_N.
    [Graphical view]
    PfamiPF04313. HSDR_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17224-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDCTKPIAE SNNFIILDKY NPDWKITESY QSEGDLEREL IQDLVNQGYE    50
    YLPTLNNTKA MLANVREQLQ NLNNVEFLEA EWRRFVETWM DKPSDGVVEK 100
    ARKIHDDYVH DFVFDDGRIQ NIYLLDRKNI LRNKVQVIKQ FEQAGTHANR 150
    YDVTILVNGL PLVQIELKKR GVAIREAFNQ IHRYSKESFN SENSLFKYLQ 200
    LFVISNGTDT RYFANTTKRD KNSFDFTMNW AKSDNTLIKD LKDFTATFFQ 250
    KHTLLNVLVN YSVFDSSQTL LVMRPYQIAA TERILWKIKS SFTSEELVKT 300
    GKRWVYLAHY RFW 313
    Length:313
    Mass (Da):37,036
    Last modified:August 1, 1990 - v1
    Checksum:iFB2628D6630ED828
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52284 Genomic DNA. Translation: CAA36528.1.
    PIRiS09628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52284 Genomic DNA. Translation: CAA36528.1 .
    PIRi S09628.

    3D structure databases

    ProteinModelPortali P17224.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 2541. EcoprrI.

    Proteomic databases

    PRIDEi P17224.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007409. Restrct_endonuc_type1_HsdR_N.
    [Graphical view ]
    Pfami PF04313. HSDR_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The optional E. coli prr locus encodes a latent form of phage T4-induced anticodon nuclease."
      Levitz R., Chapman D., Amitsur M., Green R., Snyder L., Kaufmann G.
      EMBO J. 9:1383-1389(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CTR5X.

    Entry informationi

    Entry nameiT1RP_ECOLX
    AccessioniPrimary (citable) accession number: P17224
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3