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P17224

- T1RP_ECOLX

UniProt

P17224 - T1RP_ECOLX

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Protein
Type I restriction enzyme EcoprrI
Gene
prrD
Organism
Escherichia coli
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Putative 'masking-agent' for the anticodon nuclease. Recognizes the double-stranded sequence 5'-CCAN7RTGC-3'.

Catalytic activityi

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. Type I site-specific deoxyribonuclease activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Protein family/group databases

REBASEi2541. EcoprrI.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I restriction enzyme EcoprrI (EC:3.1.21.3)
Gene namesi
Name:prrD
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Type I restriction enzyme EcoprrI
PRO_0000077261Add
BLAST

Proteomic databases

PRIDEiP17224.

Structurei

3D structure databases

ProteinModelPortaliP17224.

Family & Domainsi

Sequence similaritiesi

Belongs to the HsdR family.

Family and domain databases

InterProiIPR007409. Restrct_endonuc_type1_HsdR_N.
[Graphical view]
PfamiPF04313. HSDR_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17224-1 [UniParc]FASTAAdd to Basket

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MVDCTKPIAE SNNFIILDKY NPDWKITESY QSEGDLEREL IQDLVNQGYE    50
YLPTLNNTKA MLANVREQLQ NLNNVEFLEA EWRRFVETWM DKPSDGVVEK 100
ARKIHDDYVH DFVFDDGRIQ NIYLLDRKNI LRNKVQVIKQ FEQAGTHANR 150
YDVTILVNGL PLVQIELKKR GVAIREAFNQ IHRYSKESFN SENSLFKYLQ 200
LFVISNGTDT RYFANTTKRD KNSFDFTMNW AKSDNTLIKD LKDFTATFFQ 250
KHTLLNVLVN YSVFDSSQTL LVMRPYQIAA TERILWKIKS SFTSEELVKT 300
GKRWVYLAHY RFW 313
Length:313
Mass (Da):37,036
Last modified:August 1, 1990 - v1
Checksum:iFB2628D6630ED828
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52284 Genomic DNA. Translation: CAA36528.1.
PIRiS09628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52284 Genomic DNA. Translation: CAA36528.1 .
PIRi S09628.

3D structure databases

ProteinModelPortali P17224.
ModBasei Search...

Protein family/group databases

REBASEi 2541. EcoprrI.

Proteomic databases

PRIDEi P17224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007409. Restrct_endonuc_type1_HsdR_N.
[Graphical view ]
Pfami PF04313. HSDR_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The optional E. coli prr locus encodes a latent form of phage T4-induced anticodon nuclease."
    Levitz R., Chapman D., Amitsur M., Green R., Snyder L., Kaufmann G.
    EMBO J. 9:1383-1389(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CTR5X.

Entry informationi

Entry nameiT1RP_ECOLX
AccessioniPrimary (citable) accession number: P17224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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