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P17213

- BPI_HUMAN

UniProt

P17213 - BPI_HUMAN

Protein

Bactericidal permeability-increasing protein

Gene

BPI

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 4 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.2 Publications

    GO - Molecular functioni

    1. lipopolysaccharide binding Source: BHF-UCL

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW
    2. immune response Source: Ensembl
    3. negative regulation of interleukin-6 production Source: BHF-UCL
    4. negative regulation of interleukin-8 production Source: BHF-UCL
    5. negative regulation of macrophage activation Source: BHF-UCL
    6. negative regulation of tumor necrosis factor production Source: BHF-UCL

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial

    Protein family/group databases

    TCDBi1.C.40.1.1. the bactericidal permeability increasing protein (bpip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bactericidal permeability-increasing protein
    Short name:
    BPI
    Alternative name(s):
    CAP 57
    Gene namesi
    Name:BPI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:1095. BPI.

    Subcellular locationi

    Secreted. Cytoplasmic granule membrane
    Note: Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi49 – 491S → C: No impairment of secretion and increased propensity for dimer formation. 1 Publication
    Mutagenesisi163 – 1631C → A: No impairment of secretion and/or biological activity. Loss of dimer formation. 1 Publication
    Mutagenesisi166 – 1661C → S: Poorly secreted. Loss of LPS-binding and biological activity. 1 Publication
    Mutagenesisi206 – 2061C → A: Not secreted. 1 Publication

    Organism-specific databases

    PharmGKBiPA25403.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 31314 PublicationsAdd
    BLAST
    Chaini32 – 487456Bactericidal permeability-increasing proteinPRO_0000017154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi166 ↔ 206
    Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP17213.
    PRIDEiP17213.

    PTM databases

    PhosphoSiteiP17213.

    Expressioni

    Tissue specificityi

    Restricted to cells of the myeloid series.

    Gene expression databases

    ArrayExpressiP17213.
    BgeeiP17213.
    GenevestigatoriP17213.

    Interactioni

    Subunit structurei

    Monomer. Homodimer; disulfide-linked.1 Publication

    Structurei

    Secondary structure

    1
    487
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 417
    Helixi42 – 6019
    Beta strandi68 – 714
    Beta strandi75 – 795
    Beta strandi81 – 9313
    Beta strandi97 – 1026
    Turni103 – 1053
    Beta strandi106 – 12621
    Beta strandi129 – 15325
    Turni154 – 1574
    Beta strandi158 – 16912
    Beta strandi172 – 1765
    Helixi180 – 1823
    Helixi183 – 19210
    Helixi194 – 21522
    Helixi217 – 2215
    Beta strandi226 – 2294
    Beta strandi231 – 2333
    Beta strandi235 – 2373
    Beta strandi240 – 2423
    Beta strandi248 – 2558
    Beta strandi258 – 2603
    Beta strandi282 – 2909
    Helixi291 – 30313
    Beta strandi307 – 3126
    Helixi313 – 3153
    Helixi326 – 3305
    Beta strandi333 – 3353
    Helixi336 – 3394
    Beta strandi344 – 3507
    Beta strandi356 – 3605
    Beta strandi363 – 3675
    Beta strandi369 – 3779
    Beta strandi383 – 39210
    Beta strandi395 – 4017
    Beta strandi403 – 41210
    Beta strandi416 – 4249
    Helixi429 – 4324
    Helixi433 – 44311
    Helixi445 – 45410
    Beta strandi464 – 47411
    Beta strandi477 – 48610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BP1X-ray2.40A32-487[»]
    1EWFX-ray1.70A32-487[»]
    ProteinModelPortaliP17213.
    SMRiP17213. Positions 32-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17213.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni240 – 2456Cleavage sites for elastaseSequence Analysis

    Domaini

    The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.1 Publication

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG262970.
    HOVERGENiHBG002797.
    InParanoidiP17213.
    OMAiCSSHINS.
    PhylomeDBiP17213.
    TreeFamiTF315617.

    Family and domain databases

    InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017954. Lipid-bd_serum_glycop_CS.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view]
    PfamiPF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view]
    SMARTiSM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55394. SSF55394. 2 hits.
    PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17213-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRENMARGPC NAPRWASLMV LVAIGTAVTA AVNPGVVVRI SQKGLDYASQ    50
    QGTAALQKEL KRIKIPDYSD SFKIKHLGKG HYSFYSMDIR EFQLPSSQIS 100
    MVPNVGLKFS ISNANIKISG KWKAQKRFLK MSGNFDLSIE GMSISADLKL 150
    GSNPTSGKPT ITCSSCSSHI NSVHVHISKS KVGWLIQLFH KKIESALRNK 200
    MNSQVCEKVT NSVSSELQPY FQTLPVMTKI DSVAGINYGL VAPPATTAET 250
    LDVQMKGEFY SENHHNPPPF APPVMEFPAA HDRMVYLGLS DYFFNTAGLV 300
    YQEAGVLKMT LRDDMIPKES KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS 350
    ASTPPHLSVQ PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS 400
    AESNRLVGEL KLDRLLLELK HSNIGPFPVE LLQDIMNYIV PILVLPRVNE 450
    KLQKGFPLPT PARVQLYNVV LQPHQNFLLF GADVVYK 487
    Length:487
    Mass (Da):53,900
    Last modified:November 25, 2008 - v4
    Checksum:i30BC73B1B465B62D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51M → L in AAH40955. (PubMed:15489334)Curated
    Sequence conflicti53 – 531T → R AA sequence (PubMed:1937776)Curated
    Sequence conflicti355 – 3551P → S in AAG42844. 1 PublicationCurated
    Sequence conflicti375 – 3751F → L(PubMed:7517398)Curated
    Sequence conflicti411 – 4111K → R in AAG42844. 1 PublicationCurated
    Sequence conflicti433 – 4331Q → L in BAG37729. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121A → T.
    Corresponds to variant rs5743497 [ dbSNP | Ensembl ].
    VAR_049728
    Natural varianti12 – 121A → V.
    Corresponds to variant rs5743498 [ dbSNP | Ensembl ].
    VAR_049729
    Natural varianti16 – 161A → V.2 Publications
    Corresponds to variant rs1341023 [ dbSNP | Ensembl ].
    VAR_018401
    Natural varianti90 – 901R → C.
    Corresponds to variant rs5743500 [ dbSNP | Ensembl ].
    VAR_049730
    Natural varianti140 – 1401E → Q.
    Corresponds to variant rs5743506 [ dbSNP | Ensembl ].
    VAR_049732
    Natural varianti196 – 1961A → V.
    Corresponds to variant rs5743509 [ dbSNP | Ensembl ].
    VAR_018402
    Natural varianti216 – 2161E → K.3 Publications
    Corresponds to variant rs4358188 [ dbSNP | Ensembl ].
    VAR_018403
    Natural varianti280 – 2801A → V.
    Corresponds to variant rs5741804 [ dbSNP | Ensembl ].
    VAR_049733
    Natural varianti377 – 3771V → I.
    Corresponds to variant rs5743524 [ dbSNP | Ensembl ].
    VAR_049734
    Natural varianti404 – 4041N → D.2 Publications
    Corresponds to variant rs5741809 [ dbSNP | Ensembl ].
    VAR_049735
    Natural varianti451 – 4511K → E.
    Corresponds to variant rs5743542 [ dbSNP | Ensembl ].
    VAR_049736

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04739 mRNA. Translation: AAA51841.1.
    DQ414688 mRNA. Translation: ABD66755.1.
    AK315328 mRNA. Translation: BAG37729.1.
    AL359555 Genomic DNA. No translation available.
    AL391095 Genomic DNA. No translation available.
    AL499625 Genomic DNA. No translation available.
    AL583962 Genomic DNA. No translation available.
    BC040955 mRNA. Translation: AAH40955.1.
    AF322588 mRNA. Translation: AAG42844.1.
    CCDSiCCDS13303.1.
    PIRiA33850. A30909.
    RefSeqiNP_001716.2. NM_001725.2.
    UniGeneiHs.529019.

    Genome annotation databases

    EnsembliENST00000262865; ENSP00000262865; ENSG00000101425.
    GeneIDi671.
    KEGGihsa:671.
    UCSCiuc002xib.2. human.

    Polymorphism databases

    DMDMi215274242.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04739 mRNA. Translation: AAA51841.1 .
    DQ414688 mRNA. Translation: ABD66755.1 .
    AK315328 mRNA. Translation: BAG37729.1 .
    AL359555 Genomic DNA. No translation available.
    AL391095 Genomic DNA. No translation available.
    AL499625 Genomic DNA. No translation available.
    AL583962 Genomic DNA. No translation available.
    BC040955 mRNA. Translation: AAH40955.1 .
    AF322588 mRNA. Translation: AAG42844.1 .
    CCDSi CCDS13303.1.
    PIRi A33850. A30909.
    RefSeqi NP_001716.2. NM_001725.2.
    UniGenei Hs.529019.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BP1 X-ray 2.40 A 32-487 [» ]
    1EWF X-ray 1.70 A 32-487 [» ]
    ProteinModelPortali P17213.
    SMRi P17213. Positions 32-487.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.C.40.1.1. the bactericidal permeability increasing protein (bpip) family.

    PTM databases

    PhosphoSitei P17213.

    Polymorphism databases

    DMDMi 215274242.

    Proteomic databases

    PaxDbi P17213.
    PRIDEi P17213.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262865 ; ENSP00000262865 ; ENSG00000101425 .
    GeneIDi 671.
    KEGGi hsa:671.
    UCSCi uc002xib.2. human.

    Organism-specific databases

    CTDi 671.
    GeneCardsi GC20P036888.
    H-InvDB HIX0027669.
    HGNCi HGNC:1095. BPI.
    MIMi 109195. gene.
    neXtProti NX_P17213.
    PharmGKBi PA25403.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262970.
    HOVERGENi HBG002797.
    InParanoidi P17213.
    OMAi CSSHINS.
    PhylomeDBi P17213.
    TreeFami TF315617.

    Miscellaneous databases

    ChiTaRSi BPI. human.
    EvolutionaryTracei P17213.
    GenomeRNAii 671.
    NextBioi 2748.
    PROi P17213.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17213.
    Bgeei P17213.
    Genevestigatori P17213.

    Family and domain databases

    InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017954. Lipid-bd_serum_glycop_CS.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view ]
    Pfami PF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55394. SSF55394. 2 hits.
    PROSITEi PS00400. LBP_BPI_CETP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations."
      Gray P.W., Flaggs G., Leong S.R., Gumina R.J., Weiss J., Ooi C.E., Elsbach P.
      J. Biol. Chem. 264:9505-9509(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-68, FUNCTION, SUBCELLULAR LOCATION, DOMAIN, VARIANTS VAL-16 AND LYS-216.
    2. "Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation."
      Wilde C.G., Seilhamer J.J., McGrogan M., Ashton N., Snable J.L., Lane J.C., Leong S.R., Thornton M.B., Miller K.L., Scott R.W.
      J. Biol. Chem. 269:17411-17416(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "cDNA cloning and sequence analysis of human bactericidal/permeability protein."
      Ma H., Cao X., Sun Y., Lei W.
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-16.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-404.
      Tissue: Fetal heart.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-216.
      Tissue: Leukocyte.
    7. "Cloning of cDNA of human bactericidal/permeability-increasing protein."
      Xu J., Wang H.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-487, VARIANTS LYS-216 AND ASP-404.
    8. "Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa."
      Wasiluk K.R., Skubitz K.M., Gray B.H.
      Infect. Immun. 59:4193-4200(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-53, FUNCTION.
      Tissue: Leukocyte.
    9. Cited for: PROTEIN SEQUENCE OF 32-51.
    10. "A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein."
      Ooi C.E., Weiss J., Elsbach P., Frangione B., Mannion B.
      J. Biol. Chem. 262:14891-14894(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-48.
    11. "Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein."
      Horwitz A.H., Leigh S.D., Abrahamson S., Gazzano-Santoro H., Liu P.-S., Williams R.E., Carroll S.F., Theofan G.
      Protein Expr. Purif. 8:28-40(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-49; CYS-163; CYS-166 AND CYS-206.
    12. "Crystal structure of human BPI and two bound phospholipids at 2.4-A resolution."
      Beamer L.J., Carroll S.F., Eisenberg D.
      Science 276:1861-1864(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 32-487.

    Entry informationi

    Entry nameiBPI_HUMAN
    AccessioniPrimary (citable) accession number: P17213
    Secondary accession number(s): B2RCY2
    , Q1ZZU8, Q5JRW0, Q8IW58, Q9BYZ9, Q9H1L2, Q9H1M8, Q9H203, Q9UCT4, Q9UD65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 145 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3