POU domain, class 4, transcription factor 1

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Reviewed, UniProtKB/Swiss-Prot P17208 (PO4F1_MOUSE)

Last modified June 16, 2009. Version 83. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    POU domain, class 4, transcription factor 1
Alternative name(s):
    Brain-specific homeobox/POU domain protein 3A
      Short name=Brn-3A
    Brn-3.0

Gene names

Name:	Pou4f1
Synonyms:	Brn-3, Brn3, Brn3a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.
Subcellular location	Nucleus.
Tissue specificity	Brain, peripheral sensory nervous system and retina. In the adult nervous system BRN-3.0 predominates in the medial habenula, superficial gray of the superior colliculus, red nucleus, mesencephalic nucleus of the trigeminal ganglion, nucleus ambiguus, inferior olivary nucleus, and peripheral sensory ganglia.
Sequence similarities	Belongs to the POU transcription factor family. Class-4 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	cell migration in hindbrain Inferred from mutant phenotype. Source: MGI central nervous system neuron differentiation Inferred from mutant phenotype. Source: MGI peripheral nervous system neuron differentiation Inferred from mutant phenotype. Source: MGI positive regulation of apoptosis Inferred from genetic interaction. Source: MGI proprioception during equilibrioception Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from mutant phenotype. Source: MGI suckling behavior Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: MGI
Molecular function	protein binding Inferred from physical interaction. Source: MGI sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from mutant phenotype. Source: MGI
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 421

421

POU domain, class 4, transcription factor 1

PRO_0000100737

Regions

Domain

262 – 339

POU-specific

DNA binding

357 – 416

Homeobox

Motif

57 – 66

POU-IV box

Compositional bias

100 – 108

Poly-His

Compositional bias

130 – 187

Gly-rich

Compositional bias

205 – 258

Ala-rich

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Sequences

Sequence

Length

Mass (Da)

Tools

P17208-1 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 34EC99D789EBE939
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FASTA

421

42,781

        10         20         30         40         50         60 
MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL DETLLARAEA 

        70         80         90        100        110        120 
LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH HHHHHHHHQA LEPGDLLDHI 

       130        140        150        160        170        180 
SSPSLALMAG AGGAGAAGGG GGAHDGPGGG GGPGGGGGPG GGGPGGGGGG GGPGGGGGAP 

       190        200        210        220        230        240 
GGGLLGGSAH PHPHMHGLGH LSHPAAAAAM NMPSGLPHPG LVAAAAHHGA AAAAAAAAAG 

       250        260        270        280        290        300 
QVAAASAAAA VVGAAGLASI CDSDTDPREL EAFAERFKQR RIKLGVTQAD VGSALANLKI 

       310        320        330        340        350        360 
PGVGSLSQST ICRFESLTLS HNNMIALKPI LQAWLEEAEG AQREKMNKPE LFNGGEKKRK 

       370        380        390        400        410        420 
RTSIAAPEKR SLEAYFAVQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT 


Y

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References

[1]	"Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes." Theil T., Zechner U., Klett C., Adolph S., Moeroey T. Cytogenet. Cell Genet. 66:267-271(1994) [PubMed: 8162704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning and sequencing of POU-boxes expressed in mouse testis." Goldsborough A., Ashworth A., Willison K.R. Nucleic Acids Res. 18:1634-1634(1990) [PubMed: 1970171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-401. Strain: T6 / TW1. Tissue: Testis.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	S69350 Genomic DNA. Translation: AAB30577.2. X51959 mRNA. Translation: CAA36218.1.
IPI	IPI00136852.
UniGene	Mm.246550
3D structure databases
HSSP	HSSP built from PDB template 1CQT based on UniProtKB P14859.
ModBase	Search...
PTM databases
PhosphoSite	P17208.
Proteomic databases
PRIDE	P17208.
Genome annotation databases
Ensembl	ENSMUSG00000048349. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:102525. Pou4f1.
Phylogenomic databases
HOGENOM	P17208.
HOVERGEN	P17208.
Gene expression databases
ArrayExpress	P17208.
Bgee	P17208.
CleanEx	MM_POU4F1.
GermOnline	ENSMUSG00000048349. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR013847. POU. IPR015584. POU_4_related. IPR000327. POU_specific. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PANTHER	PTHR11636:SF10. POU_4_related. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. [Graphical view]
PRINTS	PR00028. POUDOMAIN.
ProDom	PD000010. Homeobox. 1 hit. PD000583. POU. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. SM00352. POU. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

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Entry information

Entry name

PO4F1_MOUSE

Accession

Primary (citable) accession number: P17208

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents