Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P17208

- PO4F1_MOUSE

UniProt

P17208 - PO4F1_MOUSE

Protein

POU domain, class 4, transcription factor 1

Gene

Pou4f1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi357 – 41660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: BHF-UCL
    5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    6. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    7. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cell migration in hindbrain Source: MGI
    2. central nervous system neuron differentiation Source: MGI
    3. habenula development Source: MGI
    4. innervation Source: MGI
    5. mesoderm development Source: MGI
    6. negative regulation of neuron apoptotic process Source: BHF-UCL
    7. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    8. nervous system development Source: MGI
    9. neuron differentiation Source: MGI
    10. neuron fate specification Source: BHF-UCL
    11. peripheral nervous system neuron development Source: BHF-UCL
    12. peripheral nervous system neuron differentiation Source: MGI
    13. positive regulation of apoptotic process Source: MGI
    14. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    15. proprioception involved in equilibrioception Source: MGI
    16. regulation of neurogenesis Source: MGI
    17. regulation of transcription, DNA-templated Source: MGI
    18. sensory system development Source: BHF-UCL
    19. suckling behavior Source: MGI
    20. transcription from RNA polymerase II promoter Source: GOC
    21. trigeminal nerve development Source: BHF-UCL
    22. ventricular compact myocardium morphogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 4, transcription factor 1
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 3A
    Short name:
    Brain-3A
    Short name:
    Brn-3A
    Brn-3.0
    Gene namesi
    Name:Pou4f1
    Synonyms:Brn-3, Brn3, Brn3a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:102525. Pou4f1.

    Subcellular locationi

    GO - Cellular componenti

    1. neuron projection Source: MGI
    2. nuclear chromatin Source: BHF-UCL
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421POU domain, class 4, transcription factor 1PRO_0000100737Add
    BLAST

    Proteomic databases

    PaxDbiP17208.

    PTM databases

    PhosphoSiteiP17208.

    Expressioni

    Tissue specificityi

    Brain, peripheral sensory nervous system and retina. In the adult nervous system BRN-3.0 predominates in the medial habenula, superficial gray of the superior colliculus, red nucleus, mesencephalic nucleus of the trigeminal ganglion, nucleus ambiguus, inferior olivary nucleus, and peripheral sensory ganglia.

    Gene expression databases

    BgeeiP17208.
    CleanExiMM_POU4F1.
    GenevestigatoriP17208.

    Interactioni

    Protein-protein interaction databases

    BioGridi202310. 2 interactions.
    STRINGi10090.ENSMUSP00000060798.

    Structurei

    3D structure databases

    ProteinModelPortaliP17208.
    SMRiP17208. Positions 266-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini262 – 33978POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi57 – 6610POU-IV box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi100 – 1089Poly-His
    Compositional biasi130 – 18758Gly-richAdd
    BLAST
    Compositional biasi205 – 25854Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG289030.
    GeneTreeiENSGT00750000117482.
    HOGENOMiHOG000116305.
    HOVERGENiHBG031829.
    InParanoidiP17208.
    KOiK09366.
    OMAiHLSHQAM.
    OrthoDBiEOG7RV9G7.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL    50
    DETLLARAEA LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH 100
    HHHHHHHHQA LEPGDLLDHI SSPSLALMAG AGGAGAAGGG GGAHDGPGGG 150
    GGPGGGGGPG GGGPGGGGGG GGPGGGGGGP GGGLLGGSAH PHPHMHGLGH 200
    LSHPAAAAAM NMPSGLPHPG LVAAAAHHGA AAAAAAAAAG QVAAASAAAA 250
    VVGAAGLASI CDSDTDPREL EAFAERFKQR RIKLGVTQAD VGSALANLKI 300
    PGVGSLSQST ICRFESLTLS HNNMIALKPI LQAWLEEAEG AQREKMNKPE 350
    LFNGGEKKRK RTSIAAPEKR SLEAYFAVQP RPSSEKIAAI AEKLDLKKNV 400
    VRVWFCNQRQ KQKRMKFSAT Y 421
    Length:421
    Mass (Da):42,767
    Last modified:July 27, 2011 - v3
    Checksum:i64EC98E5C0CF79E2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791G → A in AAB30577. (PubMed:8162704)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69350 Genomic DNA. Translation: AAB30577.2.
    AC121997 Genomic DNA. No translation available.
    X51959 mRNA. Translation: CAA36218.1.
    CCDSiCCDS27319.1.
    RefSeqiNP_035273.3. NM_011143.4.
    XP_006518768.1. XM_006518705.1.
    XP_006518769.1. XM_006518706.1.
    UniGeneiMm.246550.

    Genome annotation databases

    EnsembliENSMUST00000053016; ENSMUSP00000060798; ENSMUSG00000048349.
    GeneIDi18996.
    KEGGimmu:18996.
    UCSCiuc007uxb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69350 Genomic DNA. Translation: AAB30577.2 .
    AC121997 Genomic DNA. No translation available.
    X51959 mRNA. Translation: CAA36218.1 .
    CCDSi CCDS27319.1.
    RefSeqi NP_035273.3. NM_011143.4.
    XP_006518768.1. XM_006518705.1.
    XP_006518769.1. XM_006518706.1.
    UniGenei Mm.246550.

    3D structure databases

    ProteinModelPortali P17208.
    SMRi P17208. Positions 266-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202310. 2 interactions.
    STRINGi 10090.ENSMUSP00000060798.

    PTM databases

    PhosphoSitei P17208.

    Proteomic databases

    PaxDbi P17208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053016 ; ENSMUSP00000060798 ; ENSMUSG00000048349 .
    GeneIDi 18996.
    KEGGi mmu:18996.
    UCSCi uc007uxb.2. mouse.

    Organism-specific databases

    CTDi 5457.
    MGIi MGI:102525. Pou4f1.

    Phylogenomic databases

    eggNOGi NOG289030.
    GeneTreei ENSGT00750000117482.
    HOGENOMi HOG000116305.
    HOVERGENi HBG031829.
    InParanoidi P17208.
    KOi K09366.
    OMAi HLSHQAM.
    OrthoDBi EOG7RV9G7.
    TreeFami TF316413.

    Miscellaneous databases

    NextBioi 295398.
    PROi P17208.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17208.
    CleanExi MM_POU4F1.
    Genevestigatori P17208.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes."
      Theil T., Zechner U., Klett C., Adolph S., Moeroey T.
      Cytogenet. Cell Genet. 66:267-271(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Cloning and sequencing of POU-boxes expressed in mouse testis."
      Goldsborough A., Ashworth A., Willison K.R.
      Nucleic Acids Res. 18:1634-1634(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-401.
      Strain: T6 / TW1.
      Tissue: Testis.

    Entry informationi

    Entry nameiPO4F1_MOUSE
    AccessioniPrimary (citable) accession number: P17208
    Secondary accession number(s): E9QPT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3