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P17208 (PO4F1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 4, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 3A
Short name=Brain-3A
Short name=Brn-3A
Brn-3.0
Gene names
Name:Pou4f1
Synonyms:Brn-3, Brn3, Brn3a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Subcellular location

Nucleus.

Tissue specificity

Brain, peripheral sensory nervous system and retina. In the adult nervous system BRN-3.0 predominates in the medial habenula, superficial gray of the superior colliculus, red nucleus, mesencephalic nucleus of the trigeminal ganglion, nucleus ambiguus, inferior olivary nucleus, and peripheral sensory ganglia.

Sequence similarities

Belongs to the POU transcription factor family. Class-4 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration in hindbrain

Inferred from mutant phenotype PubMed 8955272. Source: MGI

central nervous system neuron differentiation

Inferred from mutant phenotype PubMed 8876243PubMed 8955272. Source: MGI

habenula development

Inferred from mutant phenotype PubMed 19906978. Source: MGI

innervation

Inferred from mutant phenotype PubMed 19906978. Source: MGI

mesoderm development

Inferred from mutant phenotype PubMed 19877281. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 20096094. Source: BHF-UCL

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19877281. Source: BHF-UCL

nervous system development

Inferred from direct assay PubMed 12810599. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 16040009. Source: MGI

neuron fate specification

Inferred from mutant phenotype PubMed 19877281PubMed 20096094. Source: BHF-UCL

peripheral nervous system neuron development

Inferred from mutant phenotype PubMed 17239249PubMed 19877281PubMed 20096094. Source: BHF-UCL

peripheral nervous system neuron differentiation

Inferred from mutant phenotype PubMed 8876243PubMed 8955272. Source: MGI

positive regulation of apoptotic process

Inferred from genetic interaction PubMed 15492043. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18368538. Source: UniProtKB

proprioception involved in equilibrioception

Inferred from mutant phenotype PubMed 8876243PubMed 8955272. Source: MGI

regulation of neurogenesis

Inferred from mutant phenotype PubMed 19877281. Source: MGI

regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 12810599PubMed 19906978. Source: MGI

sensory system development

Inferred from mutant phenotype PubMed 20096094. Source: BHF-UCL

suckling behavior

Inferred from mutant phenotype PubMed 8876243PubMed 8955272. Source: MGI

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 20096094. Source: GOC

trigeminal nerve development

Inferred from mutant phenotype PubMed 19877281. Source: BHF-UCL

ventricular compact myocardium morphogenesis

Inferred from mutant phenotype PubMed 18368538. Source: UniProtKB

   Cellular_componentneuron projection

Inferred from direct assay PubMed 19906978. Source: MGI

nuclear chromatin

Inferred from direct assay PubMed 17196582PubMed 20096094. Source: BHF-UCL

nucleus

Inferred from direct assay PubMed 7623109. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12810599PubMed 15492043. Source: MGI

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from direct assay PubMed 18368538. Source: UniProtKB

RNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 17196582PubMed 20096094. Source: BHF-UCL

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 20096094. Source: BHF-UCL

protein binding

Inferred from physical interaction PubMed 15492043. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype PubMed 12810599. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421POU domain, class 4, transcription factor 1
PRO_0000100737

Regions

Domain262 – 33978POU-specific
DNA binding357 – 41660Homeobox
Motif57 – 6610POU-IV box
Compositional bias100 – 1089Poly-His
Compositional bias130 – 18758Gly-rich
Compositional bias205 – 25854Ala-rich

Experimental info

Sequence conflict1791G → A in AAB30577. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P17208 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 64EC98E5C0CF79E2

FASTA42142,767
        10         20         30         40         50         60 
MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL DETLLARAEA 

        70         80         90        100        110        120 
LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH HHHHHHHHQA LEPGDLLDHI 

       130        140        150        160        170        180 
SSPSLALMAG AGGAGAAGGG GGAHDGPGGG GGPGGGGGPG GGGPGGGGGG GGPGGGGGGP 

       190        200        210        220        230        240 
GGGLLGGSAH PHPHMHGLGH LSHPAAAAAM NMPSGLPHPG LVAAAAHHGA AAAAAAAAAG 

       250        260        270        280        290        300 
QVAAASAAAA VVGAAGLASI CDSDTDPREL EAFAERFKQR RIKLGVTQAD VGSALANLKI 

       310        320        330        340        350        360 
PGVGSLSQST ICRFESLTLS HNNMIALKPI LQAWLEEAEG AQREKMNKPE LFNGGEKKRK 

       370        380        390        400        410        420 
RTSIAAPEKR SLEAYFAVQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT 


Y 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes."
Theil T., Zechner U., Klett C., Adolph S., Moeroey T.
Cytogenet. Cell Genet. 66:267-271(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Cloning and sequencing of POU-boxes expressed in mouse testis."
Goldsborough A., Ashworth A., Willison K.R.
Nucleic Acids Res. 18:1634-1634(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-401.
Strain: T6 / TW1.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S69350 Genomic DNA. Translation: AAB30577.2.
AC121997 Genomic DNA. No translation available.
X51959 mRNA. Translation: CAA36218.1.
CCDSCCDS27319.1.
RefSeqNP_035273.3. NM_011143.4.
XP_006518768.1. XM_006518705.1.
XP_006518769.1. XM_006518706.1.
UniGeneMm.246550.

3D structure databases

ProteinModelPortalP17208.
SMRP17208. Positions 266-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202310. 2 interactions.
STRING10090.ENSMUSP00000060798.

PTM databases

PhosphoSiteP17208.

Proteomic databases

PaxDbP17208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000053016; ENSMUSP00000060798; ENSMUSG00000048349.
GeneID18996.
KEGGmmu:18996.
UCSCuc007uxb.2. mouse.

Organism-specific databases

CTD5457.
MGIMGI:102525. Pou4f1.

Phylogenomic databases

eggNOGNOG289030.
GeneTreeENSGT00750000117482.
HOGENOMHOG000116305.
HOVERGENHBG031829.
InParanoidP17208.
KOK09366.
OMAHLSHQAM.
OrthoDBEOG7RV9G7.
TreeFamTF316413.

Gene expression databases

BgeeP17208.
CleanExMM_POU4F1.
GenevestigatorP17208.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295398.
PROP17208.
SOURCESearch...

Entry information

Entry namePO4F1_MOUSE
AccessionPrimary (citable) accession number: P17208
Secondary accession number(s): E9QPT6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot