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P17208

- PO4F1_MOUSE

UniProt

P17208 - PO4F1_MOUSE

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Protein

POU domain, class 4, transcription factor 1

Gene
Pou4f1, Brn-3, Brn3, Brn3a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi357 – 41660HomeoboxAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: BHF-UCL
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  6. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell migration in hindbrain Source: MGI
  2. central nervous system neuron differentiation Source: MGI
  3. habenula development Source: MGI
  4. innervation Source: MGI
  5. mesoderm development Source: MGI
  6. negative regulation of neuron apoptotic process Source: BHF-UCL
  7. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  8. nervous system development Source: MGI
  9. neuron differentiation Source: MGI
  10. neuron fate specification Source: BHF-UCL
  11. peripheral nervous system neuron development Source: BHF-UCL
  12. peripheral nervous system neuron differentiation Source: MGI
  13. positive regulation of apoptotic process Source: MGI
  14. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  15. proprioception involved in equilibrioception Source: MGI
  16. regulation of neurogenesis Source: MGI
  17. regulation of transcription, DNA-templated Source: MGI
  18. sensory system development Source: BHF-UCL
  19. suckling behavior Source: MGI
  20. transcription from RNA polymerase II promoter Source: GOC
  21. trigeminal nerve development Source: BHF-UCL
  22. ventricular compact myocardium morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 3A
Short name:
Brain-3A
Short name:
Brn-3A
Brn-3.0
Gene namesi
Name:Pou4f1
Synonyms:Brn-3, Brn3, Brn3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:102525. Pou4f1.

Subcellular locationi

GO - Cellular componenti

  1. neuron projection Source: MGI
  2. nuclear chromatin Source: BHF-UCL
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421POU domain, class 4, transcription factor 1PRO_0000100737Add
BLAST

Proteomic databases

PaxDbiP17208.

PTM databases

PhosphoSiteiP17208.

Expressioni

Tissue specificityi

Brain, peripheral sensory nervous system and retina. In the adult nervous system BRN-3.0 predominates in the medial habenula, superficial gray of the superior colliculus, red nucleus, mesencephalic nucleus of the trigeminal ganglion, nucleus ambiguus, inferior olivary nucleus, and peripheral sensory ganglia.

Gene expression databases

BgeeiP17208.
CleanExiMM_POU4F1.
GenevestigatoriP17208.

Interactioni

Protein-protein interaction databases

BioGridi202310. 2 interactions.
STRINGi10090.ENSMUSP00000060798.

Structurei

3D structure databases

ProteinModelPortaliP17208.
SMRiP17208. Positions 266-416.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini262 – 33978POU-specificAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi57 – 6610POU-IV box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 1089Poly-His
Compositional biasi130 – 18758Gly-richAdd
BLAST
Compositional biasi205 – 25854Ala-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289030.
GeneTreeiENSGT00750000117482.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiP17208.
KOiK09366.
OMAiHLSHQAM.
OrthoDBiEOG7RV9G7.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17208-1 [UniParc]FASTAAdd to Basket

« Hide

MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL    50
DETLLARAEA LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH 100
HHHHHHHHQA LEPGDLLDHI SSPSLALMAG AGGAGAAGGG GGAHDGPGGG 150
GGPGGGGGPG GGGPGGGGGG GGPGGGGGGP GGGLLGGSAH PHPHMHGLGH 200
LSHPAAAAAM NMPSGLPHPG LVAAAAHHGA AAAAAAAAAG QVAAASAAAA 250
VVGAAGLASI CDSDTDPREL EAFAERFKQR RIKLGVTQAD VGSALANLKI 300
PGVGSLSQST ICRFESLTLS HNNMIALKPI LQAWLEEAEG AQREKMNKPE 350
LFNGGEKKRK RTSIAAPEKR SLEAYFAVQP RPSSEKIAAI AEKLDLKKNV 400
VRVWFCNQRQ KQKRMKFSAT Y 421
Length:421
Mass (Da):42,767
Last modified:July 27, 2011 - v3
Checksum:i64EC98E5C0CF79E2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791G → A in AAB30577. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S69350 Genomic DNA. Translation: AAB30577.2.
AC121997 Genomic DNA. No translation available.
X51959 mRNA. Translation: CAA36218.1.
CCDSiCCDS27319.1.
RefSeqiNP_035273.3. NM_011143.4.
XP_006518768.1. XM_006518705.1.
XP_006518769.1. XM_006518706.1.
UniGeneiMm.246550.

Genome annotation databases

EnsembliENSMUST00000053016; ENSMUSP00000060798; ENSMUSG00000048349.
GeneIDi18996.
KEGGimmu:18996.
UCSCiuc007uxb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S69350 Genomic DNA. Translation: AAB30577.2 .
AC121997 Genomic DNA. No translation available.
X51959 mRNA. Translation: CAA36218.1 .
CCDSi CCDS27319.1.
RefSeqi NP_035273.3. NM_011143.4.
XP_006518768.1. XM_006518705.1.
XP_006518769.1. XM_006518706.1.
UniGenei Mm.246550.

3D structure databases

ProteinModelPortali P17208.
SMRi P17208. Positions 266-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202310. 2 interactions.
STRINGi 10090.ENSMUSP00000060798.

PTM databases

PhosphoSitei P17208.

Proteomic databases

PaxDbi P17208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053016 ; ENSMUSP00000060798 ; ENSMUSG00000048349 .
GeneIDi 18996.
KEGGi mmu:18996.
UCSCi uc007uxb.2. mouse.

Organism-specific databases

CTDi 5457.
MGIi MGI:102525. Pou4f1.

Phylogenomic databases

eggNOGi NOG289030.
GeneTreei ENSGT00750000117482.
HOGENOMi HOG000116305.
HOVERGENi HBG031829.
InParanoidi P17208.
KOi K09366.
OMAi HLSHQAM.
OrthoDBi EOG7RV9G7.
TreeFami TF316413.

Miscellaneous databases

NextBioi 295398.
PROi P17208.
SOURCEi Search...

Gene expression databases

Bgeei P17208.
CleanExi MM_POU4F1.
Genevestigatori P17208.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes."
    Theil T., Zechner U., Klett C., Adolph S., Moeroey T.
    Cytogenet. Cell Genet. 66:267-271(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Cloning and sequencing of POU-boxes expressed in mouse testis."
    Goldsborough A., Ashworth A., Willison K.R.
    Nucleic Acids Res. 18:1634-1634(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-401.
    Strain: T6 / TW1.
    Tissue: Testis.

Entry informationi

Entry nameiPO4F1_MOUSE
AccessioniPrimary (citable) accession number: P17208
Secondary accession number(s): E9QPT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi