Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P17202 (BADH_SPIOL)

Last modified June 16, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Betaine aldehyde dehydrogenase, chloroplastic
      Short name=BADH
    EC=1.2.1.8
OrganismSpinacia oleracea (Spinach)
Taxonomic identifier3562 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Amaranthaceae › Spinacia

Hide | Top

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Subunit structure

Homodimer.

Subcellular location

Plastid › chloroplast.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Hide | Top

Ontologies

Keywords
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 77Chloroplast Potential
Chain8 – 497490Betaine aldehyde dehydrogenase, chloroplastic
PRO_0000007182

Regions

Nucleotide binding235 – 2406NAD By similarity

Sites

Active site2571Proton acceptor By similarity
Active site2911Nucleophile By similarity
Site1591Transition state stabilizer By similarity

Amino acid modifications

Modified residue81Blocked amino end (Arg)

Experimental info

Sequence conflict4241S → F in AAB41696. Ref.2

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P17202-1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 55088240E635B22F

FASTA49754,270
        10         20         30         40         50         60 
MAFPIPARQL FIDGEWREPI KKNRIPVINP STEEIIGDIP AATAEDVEVA VVAARRAFRR 

        70         80         90        100        110        120 
NNWSATSGAH RATYLRAIAA KITEKKDHFV KLETIDSGKP FDEAVLDIDD VASCFEYFAG 

       130        140        150        160        170        180 
QAEALDGKQK APVTLPMERF KSHVLRQPLG VVGLISPWNY PLLMATWKIA PALAAGCTAV 

       190        200        210        220        230        240 
LKPSELASVT CLEFGEVCNE VGLPPGVLNI LTGLGPDAGA PLVSHPDVDK IAFTGSSATG 

       250        260        270        280        290        300 
SKVMASAAQL VKPVTLELGG KSPIVVFEDV DIDKVVEWTI FGCFWTNGQI CSATSRLLVH 

       310        320        330        340        350        360 
ESIAAEFVDK LVKWTKNIKI SDPFEEGCRL GPVISKGQYD KIMKFISTAK SEGATILYGG 

       370        380        390        400        410        420 
SRPEHLKKGY YIEPTIVTDI STSMQIWKEE VFGPVLCVKT FSSEDEAIAL ANDTEYGLAA 

       430        440        450        460        470        480 
AVFSNDLERC ERITKALEVG AVWVNCSQPC FVQAPWGGIK RSGFGRELGE WGIQNYLNIK 

       490 
QVTQDISDEP WGWYKSP

« Hide

Hide | Top

References

[1]"Molecular cloning of a plant betaine-aldehyde dehydrogenase, an enzyme implicated in adaptation to salinity and drought."
Weretilnyk E.A., Hanson A.D.
Proc. Natl. Acad. Sci. U.S.A. 87:2745-2749(1990) [PubMed: 2320587] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: cv. Savoy hybrid 612.
[2]Shu W., Ai W., Chen S.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

M31480 mRNA. Translation: AAA34025.1.
U69142 Genomic DNA. Translation: AAB41696.1.
PIRA35994.
T51173.

3D structure databases

HSSPHSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.2.1.8. 286.

Family and domain databases

InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameBADH_SPIOL
AccessionPrimary (citable) accession number: P17202
Secondary accession number(s): P93555
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents