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P17181

- INAR1_HUMAN

UniProt

P17181 - INAR1_HUMAN

Protein

Interferon alpha/beta receptor 1

Gene

IFNAR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 3 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. type I interferon receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. cytokine-mediated signaling pathway Source: Reactome
    3. defense response to virus Source: Ensembl
    4. JAK-STAT cascade Source: ProtInc
    5. positive regulation of interferon-gamma production Source: Ensembl
    6. regulation of type I interferon-mediated signaling pathway Source: Reactome
    7. response to virus Source: ProtInc
    8. T cell activation Source: Ensembl
    9. type I interferon biosynthetic process Source: Ensembl
    10. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.
    SignaLinkiP17181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha/beta receptor 1
    Short name:
    IFN-R-1
    Short name:
    IFN-alpha/beta receptor 1
    Alternative name(s):
    Cytokine receptor class-II member 1
    Cytokine receptor family 2 member 1
    Short name:
    CRF2-1
    Type I interferon receptor 1
    Gene namesi
    Name:IFNAR1
    Synonyms:IFNAR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:5432. IFNAR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29670.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 557530Interferon alpha/beta receptor 1PRO_0000011001Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi58 – 581N-linked (GlcNAc...)1 Publication
    Disulfide bondi79 ↔ 871 Publication
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
    Glycosylationi172 – 1721N-linked (GlcNAc...)1 Publication
    Disulfide bondi199 ↔ 2201 Publication
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi283 ↔ 2911 Publication
    Glycosylationi313 – 3131N-linked (GlcNAc...)1 Publication
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi403 ↔ 426By similarity
    Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Lipidationi463 – 4631S-palmitoyl cysteine1 Publication
    Modified residuei466 – 4661Phosphotyrosine; by TYK21 Publication
    Modified residuei481 – 4811Phosphotyrosine; by TYK21 Publication
    Modified residuei495 – 4951Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.2 Publications
    Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP17181.
    PRIDEiP17181.

    PTM databases

    PhosphoSiteiP17181.

    Expressioni

    Tissue specificityi

    IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.1 Publication

    Gene expression databases

    ArrayExpressiP17181.
    BgeeiP17181.
    CleanExiHS_IFNAR1.
    GenevestigatoriP17181.

    Organism-specific databases

    HPAiHPA018015.

    Interactioni

    Subunit structurei

    Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FBXW11Q9UKB18EBI-1547250,EBI-355189
    STAT2P526304EBI-1547250,EBI-1546963

    Protein-protein interaction databases

    BioGridi109676. 13 interactions.
    DIPiDIP-57N.
    IntActiP17181. 7 interactions.
    MINTiMINT-107953.
    STRINGi9606.ENSP00000270139.

    Structurei

    Secondary structure

    1
    557
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi37 – 415
    Beta strandi44 – 485
    Beta strandi60 – 6910
    Beta strandi80 – 889
    Beta strandi100 – 1078
    Beta strandi112 – 1165
    Helixi122 – 1254
    Beta strandi132 – 1376
    Beta strandi142 – 1476
    Beta strandi164 – 1718
    Turni172 – 1743
    Beta strandi178 – 1836
    Beta strandi186 – 1894
    Beta strandi197 – 20610
    Helixi207 – 2093
    Beta strandi219 – 2224
    Beta strandi233 – 2408
    Beta strandi243 – 2497
    Beta strandi251 – 2544
    Beta strandi256 – 2638
    Helixi264 – 2674
    Helixi281 – 2833
    Beta strandi286 – 2949
    Helixi295 – 2973
    Beta strandi300 – 31011
    Beta strandi322 – 3254

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3S98X-ray1.90A30-332[»]
    3SE3X-ray4.00A28-436[»]
    3SE4X-ray3.50A28-436[»]
    4PO6X-ray1.99B478-507[»]
    ProteinModelPortaliP17181.
    SMRiP17181. Positions 33-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17181.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 436409ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini458 – 557100CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 12695Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini127 – 227101Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 32999Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini331 – 432102Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43815.
    HOVERGENiHBG052126.
    InParanoidiP17181.
    KOiK05130.
    OMAiVYCVKAR.
    OrthoDBiEOG73FQMD.
    PhylomeDBiP17181.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR016669. Interferon_alpha/beta_rcpt-1.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view]
    PfamiPF09294. Interfer-bind. 2 hits.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016567. IFN_alpha/beta_recept-1. 1 hit.
    SMARTiSM00060. FN3. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 4 hits.
    PROSITEiPS50853. FN3. 4 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P17181-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN    50
    RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI 100
    KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT 150
    KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL 200
    KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY 250
    TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK 300
    GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI 350
    GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT 400
    VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL 450
    PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE 500
    KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE 550
    ELQQDFV 557
    Length:557
    Mass (Da):63,525
    Last modified:March 7, 2006 - v3
    Checksum:i24A01779DB7F356F
    GO
    Isoform 2 (identifier: P17181-2) [UniParc]FASTAAdd to Basket

    Also known as: Sol-1, Soluble form 1

    The sequence of this isoform differs from the canonical sequence as follows:
         428-434: KTKPGNT → NISLNSH
         435-557: Missing.

    Note: Incomplete sequence.

    Show »
    Length:434
    Mass (Da):49,547
    Checksum:i4744EF06968FD2EA
    GO
    Isoform 3 (identifier: P17181-3) [UniParc]FASTAAdd to Basket

    Also known as: Sol-2, Soluble form 2

    The sequence of this isoform differs from the canonical sequence as follows:
         414-421: Missing.
         428-480: Missing.

    Note: Incomplete sequence.

    Show »
    Length:496
    Mass (Da):56,718
    Checksum:i16984A61FE2BF41C
    GO
    Isoform 4 (identifier: P17181-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-69: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:488
    Mass (Da):56,046
    Checksum:i29AF6E22379E2E7C
    GO

    Sequence cautioni

    The sequence AAH02590.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171A → G in AAA52730. (PubMed:2153461)Curated
    Sequence conflicti59 – 591V → M in BAD96532. 1 PublicationCurated
    Sequence conflicti279 – 2791Q → R in BAD96532. 1 PublicationCurated
    Sequence conflicti344 – 3441D → G in BAG35516. (PubMed:14702039)Curated
    Sequence conflicti479 – 4791D → N in BAD96532. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti168 – 1681V → L.3 Publications
    Corresponds to variant rs2257167 [ dbSNP | Ensembl ].
    VAR_002717
    Natural varianti307 – 3071V → I.1 Publication
    Corresponds to variant rs17875833 [ dbSNP | Ensembl ].
    VAR_020502
    Natural varianti359 – 3591T → M.1 Publication
    Corresponds to variant rs17875834 [ dbSNP | Ensembl ].
    VAR_020503

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6969Missing in isoform 4. 1 PublicationVSP_055322Add
    BLAST
    Alternative sequencei414 – 4218Missing in isoform 3. 1 PublicationVSP_029928
    Alternative sequencei428 – 48053Missing in isoform 3. 1 PublicationVSP_029929Add
    BLAST
    Alternative sequencei428 – 4347KTKPGNT → NISLNSH in isoform 2. 1 PublicationVSP_029930
    Alternative sequencei435 – 557123Missing in isoform 2. 1 PublicationVSP_029931Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03171 mRNA. Translation: AAA52730.1.
    X60459 Genomic DNA. Translation: CAA42992.1.
    AK298051 mRNA. Translation: BAG60345.1.
    AK312631 mRNA. Translation: BAG35516.1.
    AK222770 mRNA. Translation: BAD96490.1.
    AK222812 mRNA. Translation: BAD96532.1.
    AY654286 Genomic DNA. Translation: AAT49100.1.
    AF039907 Genomic DNA. No translation available.
    AP000296 Genomic DNA. No translation available.
    AP000297 Genomic DNA. No translation available.
    AP000298 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09837.1.
    CH471079 Genomic DNA. Translation: EAX09839.1.
    BC002590 mRNA. Translation: AAH02590.1. Sequence problems.
    BC021825 mRNA. Translation: AAH21825.1.
    CCDSiCCDS13624.1. [P17181-1]
    PIRiA32694.
    S41602.
    RefSeqiNP_000620.2. NM_000629.2. [P17181-1]
    XP_005261021.1. XM_005260964.1.
    UniGeneiHs.529400.

    Genome annotation databases

    EnsembliENST00000270139; ENSP00000270139; ENSG00000142166. [P17181-1]
    GeneIDi3454.
    KEGGihsa:3454.
    UCSCiuc002yrn.3. human. [P17181-1]

    Polymorphism databases

    DMDMi90110827.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03171 mRNA. Translation: AAA52730.1 .
    X60459 Genomic DNA. Translation: CAA42992.1 .
    AK298051 mRNA. Translation: BAG60345.1 .
    AK312631 mRNA. Translation: BAG35516.1 .
    AK222770 mRNA. Translation: BAD96490.1 .
    AK222812 mRNA. Translation: BAD96532.1 .
    AY654286 Genomic DNA. Translation: AAT49100.1 .
    AF039907 Genomic DNA. No translation available.
    AP000296 Genomic DNA. No translation available.
    AP000297 Genomic DNA. No translation available.
    AP000298 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09837.1 .
    CH471079 Genomic DNA. Translation: EAX09839.1 .
    BC002590 mRNA. Translation: AAH02590.1 . Sequence problems.
    BC021825 mRNA. Translation: AAH21825.1 .
    CCDSi CCDS13624.1. [P17181-1 ]
    PIRi A32694.
    S41602.
    RefSeqi NP_000620.2. NM_000629.2. [P17181-1 ]
    XP_005261021.1. XM_005260964.1.
    UniGenei Hs.529400.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3S98 X-ray 1.90 A 30-332 [» ]
    3SE3 X-ray 4.00 A 28-436 [» ]
    3SE4 X-ray 3.50 A 28-436 [» ]
    4PO6 X-ray 1.99 B 478-507 [» ]
    ProteinModelPortali P17181.
    SMRi P17181. Positions 33-433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109676. 13 interactions.
    DIPi DIP-57N.
    IntActi P17181. 7 interactions.
    MINTi MINT-107953.
    STRINGi 9606.ENSP00000270139.

    Chemistry

    ChEMBLi CHEMBL1887.
    DrugBanki DB00034. Interferon Alfa-2a, Recombinant.
    DB00105. Interferon Alfa-2b, Recombinant.
    DB00011. Interferon alfa-n1.
    DB00018. Interferon alfa-n3.
    DB00069. Interferon alfacon-1.
    DB00068. Interferon beta-1b.
    DB00008. Peginterferon alfa-2a.
    DB00022. Peginterferon alfa-2b.
    GuidetoPHARMACOLOGYi 1723.

    PTM databases

    PhosphoSitei P17181.

    Polymorphism databases

    DMDMi 90110827.

    Proteomic databases

    PaxDbi P17181.
    PRIDEi P17181.

    Protocols and materials databases

    DNASUi 3454.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270139 ; ENSP00000270139 ; ENSG00000142166 . [P17181-1 ]
    GeneIDi 3454.
    KEGGi hsa:3454.
    UCSCi uc002yrn.3. human. [P17181-1 ]

    Organism-specific databases

    CTDi 3454.
    GeneCardsi GC21P034696.
    HGNCi HGNC:5432. IFNAR1.
    HPAi HPA018015.
    MIMi 107450. gene.
    neXtProti NX_P17181.
    PharmGKBi PA29670.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43815.
    HOVERGENi HBG052126.
    InParanoidi P17181.
    KOi K05130.
    OMAi VYCVKAR.
    OrthoDBi EOG73FQMD.
    PhylomeDBi P17181.

    Enzyme and pathway databases

    Reactomei REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.
    SignaLinki P17181.

    Miscellaneous databases

    ChiTaRSi IFNAR1. human.
    EvolutionaryTracei P17181.
    GeneWikii IFNAR1.
    GenomeRNAii 3454.
    NextBioi 13606.
    PROi P17181.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17181.
    Bgeei P17181.
    CleanExi HS_IFNAR1.
    Genevestigatori P17181.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR016669. Interferon_alpha/beta_rcpt-1.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view ]
    Pfami PF09294. Interfer-bind. 2 hits.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016567. IFN_alpha/beta_recept-1. 1 hit.
    SMARTi SM00060. FN3. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 4 hits.
    PROSITEi PS50853. FN3. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA."
      Uze G., Lutfalla G., Gresser I.
      Cell 60:225-234(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-168.
    2. "The structure of the human interferon alpha/beta receptor gene."
      Lutfalla G., Gardiner K., Proudhon D., Vielh E., Uze G.
      J. Biol. Chem. 267:2802-2809(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-168.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Lung.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-168.
      Tissue: Liver.
    5. SeattleSNPs variation discovery resource
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-307 AND MET-359.
    6. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Ovary.
    9. "Identification of mRNAs encoding two different soluble forms of the human interferon alpha-receptor."
      Abramovich C., Ratovitski E., Lundgren E., Revel M.
      FEBS Lett. 338:295-300(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 398-514 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 419-557 (ISOFORM 2), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
      Tissue: Myeloma.
    10. "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase."
      Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J.
      Mol. Cell. Biol. 14:8133-8142(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY TYK2.
    11. "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling."
      Li X., Leung S., Kerr I.M., Stark G.R.
      Mol. Cell. Biol. 17:2048-2056(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STAT1 AND STAT2.
    12. "Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation."
      Russell-Harde D., Wagner T.C., Perez H.D., Croze E.
      Biochem. Biophys. Res. Commun. 255:539-544(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IFNAR2.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha."
      Claudinon J., Gonnord P., Beslard E., Marchetti M., Mitchell K., Boularan C., Johannes L., Eid P., Lamaze C.
      J. Biol. Chem. 284:24328-24340(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-463.
    15. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58; ASN-110 AND ASN-313.
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Structural linkage between ligand discrimination and receptor activation by type I interferons."
      Thomas C., Moraga I., Levin D., Krutzik P.O., Podoplelova Y., Trejo A., Lee C., Yarden G., Vleck S.E., Glenn J.S., Nolan G.P., Piehler J., Schreiber G., Garcia K.C.
      Cell 146:621-632(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 28-436 IN COMPLEX WITH IFNAR2 AND IFNW1, DISULFIDE BONDS, GLYCOSYLATION AT ASN-172.

    Entry informationi

    Entry nameiINAR1_HUMAN
    AccessioniPrimary (citable) accession number: P17181
    Secondary accession number(s): B2R6L9
    , B4DNT3, D3DSF0, Q53GW9, Q53H11, Q6PKD7, Q7M4L2, Q8WTZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 142 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3