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Protein

Interferon alpha/beta receptor 1

Gene

IFNAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).By similarity1 Publication6 Publications

GO - Molecular functioni

  • type I interferon binding Source: UniProtKB
  • type I interferon receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142166-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
SignaLinkiP17181.
SIGNORiP17181.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha/beta receptor 1
Short name:
IFN-R-1
Short name:
IFN-alpha/beta receptor 1
Alternative name(s):
Cytokine receptor class-II member 1
Cytokine receptor family 2 member 1
Short name:
CRF2-1
Type I interferon receptor 1
Gene namesi
Name:IFNAR1
Synonyms:IFNAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:5432. IFNAR1.

Subcellular locationi

Isoform 1 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 436ExtracellularSequence analysisAdd BLAST409
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 557CytoplasmicSequence analysisAdd BLAST100

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • late endosome Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB-SubCell
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi466Y → F: Impairs internalization in response to interferon. 1 Publication1
Mutagenesisi491 – 492LL → AA: Impairs interaction with TYK2. 1 Publication2
Mutagenesisi496 – 497EE → AA: Impairs interaction with TYK2. 1 Publication2
Mutagenesisi500E → A: Impairs interaction with TYK2. 1 Publication1
Mutagenesisi501K → R: Mildly reduces ubiquitination. Nearly abolishes ubiquitination and subsequent degradation; when associated with 525-R-R-526. 1 Publication1
Mutagenesisi525 – 526KK → RR: Reduces ubiquitination. Nearly abolishes ubiquitination and subsequent degradation; when associated with R-501. 1 Publication2
Mutagenesisi535S → A: Abolishes interaction with FBXW11 and decreases ubiquitination. 2 Publications1
Mutagenesisi535S → A: Abolishes phosphorylation at this site and interaction with SHMT2. 1 Publication1
Mutagenesisi539S → A: Abolishes interaction with FBXW11 and decreases ubiquitination. 1 Publication1

Organism-specific databases

DisGeNETi3454.
OpenTargetsiENSG00000142166.
PharmGKBiPA29670.

Chemistry databases

ChEMBLiCHEMBL1887.
DrugBankiDB00011. Interferon alfa-n1.
DB00018. Interferon alfa-n3.
DB00069. Interferon alfacon-1.
DB00060. Interferon beta-1a.
DB00068. Interferon beta-1b.
DB05258. Natural alpha interferon.
DB00008. Peginterferon alfa-2a.
DB00022. Peginterferon alfa-2b.
GuidetoPHARMACOLOGYi1723.

Polymorphism and mutation databases

BioMutaiIFNAR1.
DMDMi90110827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001100128 – 557Interferon alpha/beta receptor 1Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi58N-linked (GlcNAc...)1 Publication1
Disulfide bondi79 ↔ 87Combined sources1 Publication
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)1 Publication1
Glycosylationi172N-linked (GlcNAc...)Combined sources1 Publication1
Disulfide bondi199 ↔ 220Combined sources1 Publication
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi283 ↔ 291Combined sources1 Publication
Glycosylationi313N-linked (GlcNAc...)1 Publication1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1
Glycosylationi376N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi403 ↔ 426By similarity
Glycosylationi416N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Lipidationi463S-palmitoyl cysteine1 Publication1
Modified residuei466Phosphotyrosine; by TYK21 Publication1
Modified residuei481Phosphotyrosine; by TYK21 Publication1
Modified residuei495PhosphoserineCombined sources1
Cross-linki501Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki525Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki526Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei535Phosphoserine4 Publications1

Post-translational modificationi

Ubiquitinated, leading to its internalization and degradation (PubMed:14532120, PubMed:15337770). Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation (PubMed:18056411). The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex (PubMed:24075985).4 Publications
Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120, PubMed:15337770, PubMed:24075985). Phosphorylated on tyrosine residues by TYK2 tyrosine kinase (PubMed:7526154). Phosphorylated on tyrosine residues in response to interferon (PubMed:10049744).4 Publications
Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP17181.
PaxDbiP17181.
PeptideAtlasiP17181.
PRIDEiP17181.

PTM databases

iPTMnetiP17181.
PhosphoSitePlusiP17181.
SwissPalmiP17181.

Expressioni

Tissue specificityi

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.1 Publication

Gene expression databases

BgeeiENSG00000142166.
CleanExiHS_IFNAR1.
ExpressionAtlasiP17181. baseline and differential.
GenevisibleiP17181. HS.

Organism-specific databases

HPAiHPA018015.
HPA029226.

Interactioni

Subunit structurei

Heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466 (PubMed:9121453). Interacts with TYK2 (PubMed:7526154, PubMed:15337770, PubMed:24704786). Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:14532120, PubMed:15337770, PubMed:18056411). Interacts with SHMT2; this promotes interaction with FAM175B and the BRISC complex (PubMed:24075985).10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FBXW11Q9UKB18EBI-1547250,EBI-355189
STAT1P422242EBI-1547250,EBI-1057697
STAT2P526305EBI-1547250,EBI-1546963

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109676. 15 interactors.
DIPiDIP-57N.
IntActiP17181. 8 interactors.
MINTiMINT-107953.
STRINGi9606.ENSP00000270139.

Chemistry databases

BindingDBiP17181.

Structurei

Secondary structure

1557
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 41Combined sources5
Beta strandi44 – 48Combined sources5
Beta strandi60 – 69Combined sources10
Beta strandi80 – 88Combined sources9
Beta strandi100 – 107Combined sources8
Beta strandi112 – 116Combined sources5
Helixi122 – 125Combined sources4
Beta strandi132 – 137Combined sources6
Beta strandi142 – 147Combined sources6
Beta strandi164 – 171Combined sources8
Turni172 – 174Combined sources3
Beta strandi178 – 183Combined sources6
Beta strandi186 – 189Combined sources4
Beta strandi197 – 206Combined sources10
Helixi207 – 209Combined sources3
Beta strandi219 – 222Combined sources4
Beta strandi233 – 240Combined sources8
Beta strandi243 – 249Combined sources7
Beta strandi251 – 254Combined sources4
Beta strandi256 – 263Combined sources8
Helixi264 – 267Combined sources4
Helixi281 – 283Combined sources3
Beta strandi286 – 294Combined sources9
Helixi295 – 297Combined sources3
Beta strandi300 – 310Combined sources11
Beta strandi322 – 325Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S98X-ray1.90A30-332[»]
3SE3X-ray4.00A28-436[»]
3SE4X-ray3.50A28-436[»]
4PO6X-ray1.99B478-507[»]
ProteinModelPortaliP17181.
SMRiP17181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17181.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 126Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini127 – 227Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101
Domaini231 – 329Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST99
Domaini331 – 432Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni491 – 500Important for interaction with TYK21 Publication10

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIP. Eukaryota.
ENOG4111QEU. LUCA.
GeneTreeiENSGT00530000063449.
HOVERGENiHBG052126.
InParanoidiP17181.
KOiK05130.
OMAiVYCVKAR.
OrthoDBiEOG091G04H5.
PhylomeDBiP17181.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
IPR016669. Interferon_alpha/beta_rcpt-1.
[Graphical view]
PfamiPF09294. Interfer-bind. 2 hits.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
PIRSFiPIRSF016567. IFN_alpha/beta_recept-1. 1 hit.
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17181-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN
60 70 80 90 100
RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI
110 120 130 140 150
KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT
160 170 180 190 200
KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL
210 220 230 240 250
KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY
260 270 280 290 300
TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK
310 320 330 340 350
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI
360 370 380 390 400
GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT
410 420 430 440 450
VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL
460 470 480 490 500
PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE
510 520 530 540 550
KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE

ELQQDFV
Length:557
Mass (Da):63,525
Last modified:March 7, 2006 - v3
Checksum:i24A01779DB7F356F
GO
Isoform 2 (identifier: P17181-2) [UniParc]FASTAAdd to basket
Also known as: Sol-1, Soluble form 1

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: KTKPGNT → NISLNSH
     435-557: Missing.

Note: Incomplete sequence.
Show »
Length:434
Mass (Da):49,547
Checksum:i4744EF06968FD2EA
GO
Isoform 3 (identifier: P17181-3) [UniParc]FASTAAdd to basket
Also known as: Sol-2, Soluble form 2

The sequence of this isoform differs from the canonical sequence as follows:
     414-421: Missing.
     428-480: Missing.

Note: Incomplete sequence.
Show »
Length:496
Mass (Da):56,718
Checksum:i16984A61FE2BF41C
GO
Isoform 4 (identifier: P17181-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Note: No experimental confirmation available.
Show »
Length:488
Mass (Da):56,046
Checksum:i29AF6E22379E2E7C
GO

Sequence cautioni

The sequence AAH02590 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17A → G in AAA52730 (PubMed:2153461).Curated1
Sequence conflicti59V → M in BAD96532 (Ref. 4) Curated1
Sequence conflicti279Q → R in BAD96532 (Ref. 4) Curated1
Sequence conflicti344D → G in BAG35516 (PubMed:14702039).Curated1
Sequence conflicti479D → N in BAD96532 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002717168V → L.3 PublicationsCorresponds to variant rs2257167dbSNPEnsembl.1
Natural variantiVAR_020502307V → I.1 PublicationCorresponds to variant rs17875833dbSNPEnsembl.1
Natural variantiVAR_020503359T → M.1 PublicationCorresponds to variant rs17875834dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553221 – 69Missing in isoform 4. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_029928414 – 421Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_029929428 – 480Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_029930428 – 434KTKPGNT → NISLNSH in isoform 2. 1 Publication7
Alternative sequenceiVSP_029931435 – 557Missing in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03171 mRNA. Translation: AAA52730.1.
X60459 Genomic DNA. Translation: CAA42992.1.
AK298051 mRNA. Translation: BAG60345.1.
AK312631 mRNA. Translation: BAG35516.1.
AK222770 mRNA. Translation: BAD96490.1.
AK222812 mRNA. Translation: BAD96532.1.
AY654286 Genomic DNA. Translation: AAT49100.1.
AF039907 Genomic DNA. No translation available.
AP000296 Genomic DNA. No translation available.
AP000297 Genomic DNA. No translation available.
AP000298 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09837.1.
CH471079 Genomic DNA. Translation: EAX09839.1.
BC002590 mRNA. Translation: AAH02590.1. Sequence problems.
BC021825 mRNA. Translation: AAH21825.1.
CCDSiCCDS13624.1. [P17181-1]
PIRiA32694.
S41602.
RefSeqiNP_000620.2. NM_000629.2. [P17181-1]
XP_005261021.1. XM_005260964.2. [P17181-4]
UniGeneiHs.529400.

Genome annotation databases

EnsembliENST00000270139; ENSP00000270139; ENSG00000142166. [P17181-1]
GeneIDi3454.
KEGGihsa:3454.
UCSCiuc002yrn.4. human. [P17181-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03171 mRNA. Translation: AAA52730.1.
X60459 Genomic DNA. Translation: CAA42992.1.
AK298051 mRNA. Translation: BAG60345.1.
AK312631 mRNA. Translation: BAG35516.1.
AK222770 mRNA. Translation: BAD96490.1.
AK222812 mRNA. Translation: BAD96532.1.
AY654286 Genomic DNA. Translation: AAT49100.1.
AF039907 Genomic DNA. No translation available.
AP000296 Genomic DNA. No translation available.
AP000297 Genomic DNA. No translation available.
AP000298 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09837.1.
CH471079 Genomic DNA. Translation: EAX09839.1.
BC002590 mRNA. Translation: AAH02590.1. Sequence problems.
BC021825 mRNA. Translation: AAH21825.1.
CCDSiCCDS13624.1. [P17181-1]
PIRiA32694.
S41602.
RefSeqiNP_000620.2. NM_000629.2. [P17181-1]
XP_005261021.1. XM_005260964.2. [P17181-4]
UniGeneiHs.529400.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S98X-ray1.90A30-332[»]
3SE3X-ray4.00A28-436[»]
3SE4X-ray3.50A28-436[»]
4PO6X-ray1.99B478-507[»]
ProteinModelPortaliP17181.
SMRiP17181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109676. 15 interactors.
DIPiDIP-57N.
IntActiP17181. 8 interactors.
MINTiMINT-107953.
STRINGi9606.ENSP00000270139.

Chemistry databases

BindingDBiP17181.
ChEMBLiCHEMBL1887.
DrugBankiDB00011. Interferon alfa-n1.
DB00018. Interferon alfa-n3.
DB00069. Interferon alfacon-1.
DB00060. Interferon beta-1a.
DB00068. Interferon beta-1b.
DB05258. Natural alpha interferon.
DB00008. Peginterferon alfa-2a.
DB00022. Peginterferon alfa-2b.
GuidetoPHARMACOLOGYi1723.

PTM databases

iPTMnetiP17181.
PhosphoSitePlusiP17181.
SwissPalmiP17181.

Polymorphism and mutation databases

BioMutaiIFNAR1.
DMDMi90110827.

Proteomic databases

MaxQBiP17181.
PaxDbiP17181.
PeptideAtlasiP17181.
PRIDEiP17181.

Protocols and materials databases

DNASUi3454.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270139; ENSP00000270139; ENSG00000142166. [P17181-1]
GeneIDi3454.
KEGGihsa:3454.
UCSCiuc002yrn.4. human. [P17181-1]

Organism-specific databases

CTDi3454.
DisGeNETi3454.
GeneCardsiIFNAR1.
HGNCiHGNC:5432. IFNAR1.
HPAiHPA018015.
HPA029226.
MIMi107450. gene.
neXtProtiNX_P17181.
OpenTargetsiENSG00000142166.
PharmGKBiPA29670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKIP. Eukaryota.
ENOG4111QEU. LUCA.
GeneTreeiENSGT00530000063449.
HOVERGENiHBG052126.
InParanoidiP17181.
KOiK05130.
OMAiVYCVKAR.
OrthoDBiEOG091G04H5.
PhylomeDBiP17181.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142166-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
SignaLinkiP17181.
SIGNORiP17181.

Miscellaneous databases

ChiTaRSiIFNAR1. human.
EvolutionaryTraceiP17181.
GeneWikiiIFNAR1.
GenomeRNAii3454.
PROiP17181.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142166.
CleanExiHS_IFNAR1.
ExpressionAtlasiP17181. baseline and differential.
GenevisibleiP17181. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
IPR016669. Interferon_alpha/beta_rcpt-1.
[Graphical view]
PfamiPF09294. Interfer-bind. 2 hits.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
PIRSFiPIRSF016567. IFN_alpha/beta_recept-1. 1 hit.
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINAR1_HUMAN
AccessioniPrimary (citable) accession number: P17181
Secondary accession number(s): B2R6L9
, B4DNT3, D3DSF0, Q53GW9, Q53H11, Q6PKD7, Q7M4L2, Q8WTZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 164 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.