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P17181

- INAR1_HUMAN

UniProt

P17181 - INAR1_HUMAN

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Protein

Interferon alpha/beta receptor 1

Gene

IFNAR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

GO - Molecular functioni

  1. type I interferon receptor activity Source: ProtInc

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. cytokine-mediated signaling pathway Source: Reactome
  3. defense response to virus Source: Ensembl
  4. JAK-STAT cascade Source: ProtInc
  5. positive regulation of interferon-gamma production Source: Ensembl
  6. positive regulation of interleukin-1 beta secretion Source: Ensembl
  7. regulation of type I interferon-mediated signaling pathway Source: Reactome
  8. response to virus Source: ProtInc
  9. T cell activation Source: Ensembl
  10. type I interferon biosynthetic process Source: Ensembl
  11. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.
SignaLinkiP17181.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha/beta receptor 1
Short name:
IFN-R-1
Short name:
IFN-alpha/beta receptor 1
Alternative name(s):
Cytokine receptor class-II member 1
Cytokine receptor family 2 member 1
Short name:
CRF2-1
Type I interferon receptor 1
Gene namesi
Name:IFNAR1
Synonyms:IFNAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:5432. IFNAR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 436409ExtracellularSequence AnalysisAdd
BLAST
Transmembranei437 – 45721HelicalSequence AnalysisAdd
BLAST
Topological domaini458 – 557100CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 557530Interferon alpha/beta receptor 1PRO_0000011001Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi58 – 581N-linked (GlcNAc...)1 Publication
Disulfide bondi79 ↔ 871 Publication
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Glycosylationi172 – 1721N-linked (GlcNAc...)1 Publication
Disulfide bondi199 ↔ 2201 Publication
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi283 ↔ 2911 Publication
Glycosylationi313 – 3131N-linked (GlcNAc...)1 Publication
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi403 ↔ 426By similarity
Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Lipidationi463 – 4631S-palmitoyl cysteine1 Publication
Modified residuei466 – 4661Phosphotyrosine; by TYK21 Publication
Modified residuei481 – 4811Phosphotyrosine; by TYK21 Publication
Modified residuei495 – 4951Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.2 Publications
Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP17181.
PaxDbiP17181.
PRIDEiP17181.

PTM databases

PhosphoSiteiP17181.

Expressioni

Tissue specificityi

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.1 Publication

Gene expression databases

BgeeiP17181.
CleanExiHS_IFNAR1.
ExpressionAtlasiP17181. baseline and differential.
GenevestigatoriP17181.

Organism-specific databases

HPAiHPA018015.

Interactioni

Subunit structurei

Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FBXW11Q9UKB18EBI-1547250,EBI-355189
STAT2P526304EBI-1547250,EBI-1546963

Protein-protein interaction databases

BioGridi109676. 13 interactions.
DIPiDIP-57N.
IntActiP17181. 7 interactions.
MINTiMINT-107953.
STRINGi9606.ENSP00000270139.

Structurei

Secondary structure

1
557
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 415Combined sources
Beta strandi44 – 485Combined sources
Beta strandi60 – 6910Combined sources
Beta strandi80 – 889Combined sources
Beta strandi100 – 1078Combined sources
Beta strandi112 – 1165Combined sources
Helixi122 – 1254Combined sources
Beta strandi132 – 1376Combined sources
Beta strandi142 – 1476Combined sources
Beta strandi164 – 1718Combined sources
Turni172 – 1743Combined sources
Beta strandi178 – 1836Combined sources
Beta strandi186 – 1894Combined sources
Beta strandi197 – 20610Combined sources
Helixi207 – 2093Combined sources
Beta strandi219 – 2224Combined sources
Beta strandi233 – 2408Combined sources
Beta strandi243 – 2497Combined sources
Beta strandi251 – 2544Combined sources
Beta strandi256 – 2638Combined sources
Helixi264 – 2674Combined sources
Helixi281 – 2833Combined sources
Beta strandi286 – 2949Combined sources
Helixi295 – 2973Combined sources
Beta strandi300 – 31011Combined sources
Beta strandi322 – 3254Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S98X-ray1.90A30-332[»]
3SE3X-ray4.00A28-436[»]
3SE4X-ray3.50A28-436[»]
4PO6X-ray1.99B478-507[»]
ProteinModelPortaliP17181.
SMRiP17181. Positions 33-433.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17181.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12695Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini127 – 227101Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini231 – 32999Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini331 – 432102Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43815.
GeneTreeiENSGT00530000063449.
HOVERGENiHBG052126.
InParanoidiP17181.
KOiK05130.
OMAiVYCVKAR.
OrthoDBiEOG73FQMD.
PhylomeDBiP17181.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016669. Interferon_alpha/beta_rcpt-1.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamiPF09294. Interfer-bind. 2 hits.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
PIRSFiPIRSF016567. IFN_alpha/beta_recept-1. 1 hit.
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P17181-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN
60 70 80 90 100
RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI
110 120 130 140 150
KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT
160 170 180 190 200
KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL
210 220 230 240 250
KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY
260 270 280 290 300
TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK
310 320 330 340 350
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI
360 370 380 390 400
GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT
410 420 430 440 450
VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL
460 470 480 490 500
PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE
510 520 530 540 550
KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE

ELQQDFV
Length:557
Mass (Da):63,525
Last modified:March 7, 2006 - v3
Checksum:i24A01779DB7F356F
GO
Isoform 2 (identifier: P17181-2) [UniParc]FASTAAdd to Basket

Also known as: Sol-1, Soluble form 1

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: KTKPGNT → NISLNSH
     435-557: Missing.

Note: Incomplete sequence.

Show »
Length:434
Mass (Da):49,547
Checksum:i4744EF06968FD2EA
GO
Isoform 3 (identifier: P17181-3) [UniParc]FASTAAdd to Basket

Also known as: Sol-2, Soluble form 2

The sequence of this isoform differs from the canonical sequence as follows:
     414-421: Missing.
     428-480: Missing.

Note: Incomplete sequence.

Show »
Length:496
Mass (Da):56,718
Checksum:i16984A61FE2BF41C
GO
Isoform 4 (identifier: P17181-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Note: No experimental confirmation available.

Show »
Length:488
Mass (Da):56,046
Checksum:i29AF6E22379E2E7C
GO

Sequence cautioni

The sequence AAH02590.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171A → G in AAA52730. (PubMed:2153461)Curated
Sequence conflicti59 – 591V → M in BAD96532. 1 PublicationCurated
Sequence conflicti279 – 2791Q → R in BAD96532. 1 PublicationCurated
Sequence conflicti344 – 3441D → G in BAG35516. (PubMed:14702039)Curated
Sequence conflicti479 – 4791D → N in BAD96532. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti168 – 1681V → L.3 Publications
Corresponds to variant rs2257167 [ dbSNP | Ensembl ].
VAR_002717
Natural varianti307 – 3071V → I.1 Publication
Corresponds to variant rs17875833 [ dbSNP | Ensembl ].
VAR_020502
Natural varianti359 – 3591T → M.1 Publication
Corresponds to variant rs17875834 [ dbSNP | Ensembl ].
VAR_020503

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969Missing in isoform 4. 1 PublicationVSP_055322Add
BLAST
Alternative sequencei414 – 4218Missing in isoform 3. 1 PublicationVSP_029928
Alternative sequencei428 – 48053Missing in isoform 3. 1 PublicationVSP_029929Add
BLAST
Alternative sequencei428 – 4347KTKPGNT → NISLNSH in isoform 2. 1 PublicationVSP_029930
Alternative sequencei435 – 557123Missing in isoform 2. 1 PublicationVSP_029931Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03171 mRNA. Translation: AAA52730.1.
X60459 Genomic DNA. Translation: CAA42992.1.
AK298051 mRNA. Translation: BAG60345.1.
AK312631 mRNA. Translation: BAG35516.1.
AK222770 mRNA. Translation: BAD96490.1.
AK222812 mRNA. Translation: BAD96532.1.
AY654286 Genomic DNA. Translation: AAT49100.1.
AF039907 Genomic DNA. No translation available.
AP000296 Genomic DNA. No translation available.
AP000297 Genomic DNA. No translation available.
AP000298 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09837.1.
CH471079 Genomic DNA. Translation: EAX09839.1.
BC002590 mRNA. Translation: AAH02590.1. Sequence problems.
BC021825 mRNA. Translation: AAH21825.1.
CCDSiCCDS13624.1. [P17181-1]
PIRiA32694.
S41602.
RefSeqiNP_000620.2. NM_000629.2. [P17181-1]
XP_005261021.1. XM_005260964.1. [P17181-4]
UniGeneiHs.529400.

Genome annotation databases

EnsembliENST00000270139; ENSP00000270139; ENSG00000142166. [P17181-1]
GeneIDi3454.
KEGGihsa:3454.
UCSCiuc002yrn.3. human. [P17181-1]

Polymorphism databases

DMDMi90110827.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03171 mRNA. Translation: AAA52730.1 .
X60459 Genomic DNA. Translation: CAA42992.1 .
AK298051 mRNA. Translation: BAG60345.1 .
AK312631 mRNA. Translation: BAG35516.1 .
AK222770 mRNA. Translation: BAD96490.1 .
AK222812 mRNA. Translation: BAD96532.1 .
AY654286 Genomic DNA. Translation: AAT49100.1 .
AF039907 Genomic DNA. No translation available.
AP000296 Genomic DNA. No translation available.
AP000297 Genomic DNA. No translation available.
AP000298 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09837.1 .
CH471079 Genomic DNA. Translation: EAX09839.1 .
BC002590 mRNA. Translation: AAH02590.1 . Sequence problems.
BC021825 mRNA. Translation: AAH21825.1 .
CCDSi CCDS13624.1. [P17181-1 ]
PIRi A32694.
S41602.
RefSeqi NP_000620.2. NM_000629.2. [P17181-1 ]
XP_005261021.1. XM_005260964.1. [P17181-4 ]
UniGenei Hs.529400.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3S98 X-ray 1.90 A 30-332 [» ]
3SE3 X-ray 4.00 A 28-436 [» ]
3SE4 X-ray 3.50 A 28-436 [» ]
4PO6 X-ray 1.99 B 478-507 [» ]
ProteinModelPortali P17181.
SMRi P17181. Positions 33-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109676. 13 interactions.
DIPi DIP-57N.
IntActi P17181. 7 interactions.
MINTi MINT-107953.
STRINGi 9606.ENSP00000270139.

Chemistry

ChEMBLi CHEMBL2364170.
DrugBanki DB00034. "Interferon Alfa-2a.
DB00105. "Interferon Alfa-2b.
DB00011. Interferon alfa-n1.
DB00018. Interferon alfa-n3.
DB00069. Interferon alfacon-1.
DB00060. Interferon beta-1a.
DB00068. Interferon beta-1b.
DB05258. Natural alpha interferon.
DB00008. Peginterferon alfa-2a.
DB00022. Peginterferon alfa-2b.
GuidetoPHARMACOLOGYi 1723.

PTM databases

PhosphoSitei P17181.

Polymorphism databases

DMDMi 90110827.

Proteomic databases

MaxQBi P17181.
PaxDbi P17181.
PRIDEi P17181.

Protocols and materials databases

DNASUi 3454.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270139 ; ENSP00000270139 ; ENSG00000142166 . [P17181-1 ]
GeneIDi 3454.
KEGGi hsa:3454.
UCSCi uc002yrn.3. human. [P17181-1 ]

Organism-specific databases

CTDi 3454.
GeneCardsi GC21P034696.
HGNCi HGNC:5432. IFNAR1.
HPAi HPA018015.
MIMi 107450. gene.
neXtProti NX_P17181.
PharmGKBi PA29670.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43815.
GeneTreei ENSGT00530000063449.
HOVERGENi HBG052126.
InParanoidi P17181.
KOi K05130.
OMAi VYCVKAR.
OrthoDBi EOG73FQMD.
PhylomeDBi P17181.

Enzyme and pathway databases

Reactomei REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.
SignaLinki P17181.

Miscellaneous databases

ChiTaRSi IFNAR1. human.
EvolutionaryTracei P17181.
GeneWikii IFNAR1.
GenomeRNAii 3454.
NextBioi 13606.
PROi P17181.
SOURCEi Search...

Gene expression databases

Bgeei P17181.
CleanExi HS_IFNAR1.
ExpressionAtlasi P17181. baseline and differential.
Genevestigatori P17181.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016669. Interferon_alpha/beta_rcpt-1.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view ]
Pfami PF09294. Interfer-bind. 2 hits.
PF01108. Tissue_fac. 1 hit.
[Graphical view ]
PIRSFi PIRSF016567. IFN_alpha/beta_recept-1. 1 hit.
SMARTi SM00060. FN3. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
PROSITEi PS50853. FN3. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA."
    Uze G., Lutfalla G., Gresser I.
    Cell 60:225-234(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-168.
  2. "The structure of the human interferon alpha/beta receptor gene."
    Lutfalla G., Gardiner K., Proudhon D., Vielh E., Uze G.
    J. Biol. Chem. 267:2802-2809(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-168.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Lung.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-168.
    Tissue: Liver.
  5. SeattleSNPs variation discovery resource
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-307 AND MET-359.
  6. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Ovary.
  9. "Identification of mRNAs encoding two different soluble forms of the human interferon alpha-receptor."
    Abramovich C., Ratovitski E., Lundgren E., Revel M.
    FEBS Lett. 338:295-300(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 398-514 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 419-557 (ISOFORM 2), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Tissue: Myeloma.
  10. "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase."
    Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J.
    Mol. Cell. Biol. 14:8133-8142(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY TYK2.
  11. "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling."
    Li X., Leung S., Kerr I.M., Stark G.R.
    Mol. Cell. Biol. 17:2048-2056(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STAT1 AND STAT2.
  12. "Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation."
    Russell-Harde D., Wagner T.C., Perez H.D., Croze E.
    Biochem. Biophys. Res. Commun. 255:539-544(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFNAR2.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha."
    Claudinon J., Gonnord P., Beslard E., Marchetti M., Mitchell K., Boularan C., Johannes L., Eid P., Lamaze C.
    J. Biol. Chem. 284:24328-24340(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-463.
  15. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58; ASN-110 AND ASN-313.
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Structural linkage between ligand discrimination and receptor activation by type I interferons."
    Thomas C., Moraga I., Levin D., Krutzik P.O., Podoplelova Y., Trejo A., Lee C., Yarden G., Vleck S.E., Glenn J.S., Nolan G.P., Piehler J., Schreiber G., Garcia K.C.
    Cell 146:621-632(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 28-436 IN COMPLEX WITH IFNAR2 AND IFNW1, DISULFIDE BONDS, GLYCOSYLATION AT ASN-172.

Entry informationi

Entry nameiINAR1_HUMAN
AccessioniPrimary (citable) accession number: P17181
Secondary accession number(s): B2R6L9
, B4DNT3, D3DSF0, Q53GW9, Q53H11, Q6PKD7, Q7M4L2, Q8WTZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 7, 2006
Last modified: November 26, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3