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Reviewed, UniProtKB/Swiss-Prot P17181 (INAR1_HUMAN)

Last modified February 9, 2010. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Interferon-alpha/beta receptor 1
      Short name=IFN-alpha/beta receptor 1
      Short name=IFN-R-1
Alternative name(s):
    Type I interferon receptor 1
    Cytokine receptor family 2 member 1
      Short name=CRF2-1
    Cytokine receptor class-II member 1
Gene names
Name: IFNAR1
Synonyms: IFNAR
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.

Subcellular location

Isoform 1: Membrane; Single-pass type I membrane protein.

Tissue specificity

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. Ref.6

Post-translational modification

Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. Ref.7 Ref.8 Ref.10

Sequence similarities

Belongs to the type II cytokine receptor family.

Contains 3 fibronectin type-III domains.

Sequence caution

The sequence AAH02590.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

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Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processJAK-STAT cascade

Traceable author statement. Source: ProtInc

blood coagulation

Inferred from electronic annotation. Source: InterPro

cell surface receptor linked signal transduction

Traceable author statement. Source: ProtInc

response to virus Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentintegral to plasma membrane

Traceable author statement. Source: ProtInc

   Molecular functiontype I interferon receptor activity

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

EP300Q094721EBI-1547250,EBI-447295

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17181-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17181-2)

Also known as: Sol-1; Soluble form 1;

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: KTKPGNT → NISLNSH
     435-557: Missing.
Note: Incomplete sequence.
Isoform 3 (identifier: P17181-3)

Also known as: Sol-2; Soluble form 2;

The sequence of this isoform differs from the canonical sequence as follows:
     414-421: Missing.
     428-480: Missing.
Note: Incomplete sequence.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 557530Interferon-alpha/beta receptor 1
PRO_0000011001

Regions

Topological domain28 – 436409Extracellular Potential
Transmembrane437 – 45721 Potential
Topological domain458 – 557100Cytoplasmic Potential
Domain134 – 22491Fibronectin type-III 1
Domain230 – 32697Fibronectin type-III 2
Domain334 – 42592Fibronectin type-III 3

Amino acid modifications

Modified residue4661Phosphotyrosine; by TYK2 Probable
Modified residue4811Phosphotyrosine; by TYK2 Probable
Modified residue4941Phosphothreonine Ref.8
Modified residue4951Phosphoserine Ref.10
Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation581N-linked (GlcNAc...) Ref.9
Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Ref.9
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation2541N-linked (GlcNAc...) Potential
Glycosylation3131N-linked (GlcNAc...) Ref.9
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation3761N-linked (GlcNAc...) Potential
Glycosylation4161N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Disulfide bond79 ↔ 87 By similarity
Disulfide bond199 ↔ 220 By similarity

Natural variations

Alternative sequence414 – 4218Missing in isoform 3.
VSP_029928
Alternative sequence428 – 48053Missing in isoform 3.
VSP_029929
Alternative sequence428 – 4347KTKPGNT → NISLNSH in isoform 2.
VSP_029930
Alternative sequence435 – 557123Missing in isoform 2.
VSP_029931
Natural variant1681V → L: dbSNP rs2257167. Ref.1 Ref.2 Ref.3
VAR_002717
Natural variant3071V → I: dbSNP rs17875833. Ref.4
VAR_020502
Natural variant3591T → M: dbSNP rs17875834. Ref.4
VAR_020503

Experimental info

Sequence conflict171A → G in AAA52730. Ref.1
Sequence conflict591V → M in BAD96532. Ref.3
Sequence conflict2791Q → R in BAD96532. Ref.3
Sequence conflict4791D → N in BAD96532. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 7, 2006. Version 3.
Checksum: 24A01779DB7F356F

FASTA55763,525
        10         20         30         40         50         60 
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT 

        70         80         90        100        110        120 
FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF 

       130        140        150        160        170        180 
TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI 

       190        200        210        220        230        240 
ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ 

       250        260        270        280        290        300 
NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK 

       310        320        330        340        350        360 
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP 

       370        380        390        400        410        420 
VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV 

       430        440        450        460        470        480 
FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE 

       490        500        510        520        530        540 
YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN 

       550 
EDESESKTSE ELQQDFV

« Hide

Isoform 2 (Sol-1) (Soluble form 1).

Checksum: 4744EF06968FD2EA
Show »

FASTA43449,547
Isoform 3 (Sol-2) (Soluble form 2).

Checksum: 16984A61FE2BF41C
Show »

FASTA49656,718

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References

« Hide 'large scale' references
[1]"Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA."
Uze G., Lutfalla G., Gresser I.
Cell 60:225-234(1990) [PubMed: 2153461] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-168.
[2]"The structure of the human interferon alpha/beta receptor gene."
Lutfalla G., Gardiner K., Proudhon D., Vielh E., Uze G.
J. Biol. Chem. 267:2802-2809(1992) [PubMed: 1370833] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-168.
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-168.
Tissue: Liver.
[4]SeattleSNPs variation discovery resource
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-307 AND MET-359.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Ovary.
[6]"Identification of mRNAs encoding two different soluble forms of the human interferon alpha-receptor."
Abramovich C., Ratovitski E., Lundgren E., Revel M.
FEBS Lett. 338:295-300(1994) [PubMed: 8307198] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 398-514 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 419-557 (ISOFORM 2), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
Tissue: Myeloma.
[7]"Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase."
Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J.
Mol. Cell. Biol. 14:8133-8142(1994) [PubMed: 7526154] [Abstract]
Cited for: PHOSPHORYLATION BY TYK2.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-494, MASS SPECTROMETRY.
[9]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-58; ASN-110 AND ASN-313, MASS SPECTROMETRY.
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, MASS SPECTROMETRY.
Tissue: T-cell.
+Additional computationally mapped references.

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Web resources

SeattleSNPs

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J03171 mRNA. Translation: AAA52730.1.
X60459 Genomic DNA. Translation: CAA42992.1.
AK222770 mRNA. Translation: BAD96490.1.
AK222812 mRNA. Translation: BAD96532.1.
AY654286 Genomic DNA. Translation: AAT49100.1.
BC002590 mRNA. Translation: AAH02590.1. Sequence problems.
BC021825 mRNA. Translation: AAH21825.1.
IPIIPI00012877.
IPI00877141.
IPI00877162.
PIRA32694.
S41602.
RefSeqNP_000620.2.
UniGeneHs.529400

3D structure databases

SMRP17181. Positions 33-221.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-57N.
IntActP17181. 1 interaction.
STRINGP17181.

PTM databases

PhosphoSiteP17181.

Proteomic databases

PRIDEP17181.

Genome annotation databases

EnsemblENST00000270139; ENSP00000270139; ENSG00000142166; Homo sapiens. [Genome view]
GeneID3454.
KEGGhsa:3454.
UCSCuc002yrn.1. human.

Organism-specific databases

CTD3454.
GeneCardsGC21P033619.
H-InvDBHIX0027789.
HGNCHGNC:5432. IFNAR1.
HPAHPA018015.
MIM107450. gene.
PharmGKBPA29670.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG07702.
HOGENOMHBG125548.
HOVERGENP17181.
InParanoidP17181.
OMATSFWSEE.
OrthoDBEOG97WR76.
PhylomeDBP17181.

Enzyme and pathway databases

Pathway_Interaction_DBcd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.

Gene expression databases

ArrayExpressP17181.
BgeeP17181.
CleanExHS_IFNAR1.
GenevestigatorP17181.
GermOnlineENSG00000142166. Homo sapiens.

Family and domain databases

InterProIPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR016669. Interferon_alpha/beta_rcpt-1.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
IPR001187. Tissue_factor.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 2 hits.
PfamPF09294. Interfer-bind. 2 hits.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
PIRSFPIRSF016567. IFN_alpha/beta_recept-1. 1 hit.
SMARTSM00060. FN3. 4 hits.
[Graphical view]
PROSITEPS50853. FN3. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00034. Interferon Alfa-2a, Recombinant.
DB00105. Interferon Alfa-2b, Recombinant.
DB00011. Interferon alfa-n1.
DB00018. Interferon alfa-n3.
DB00069. Interferon alfacon-1.
DB00068. Interferon beta-1b.
DB00008. Peginterferon alfa-2a.
DB00022. Peginterferon alfa-2b.
NextBio13606.
SOURCESearch...

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Entry information

Entry nameINAR1_HUMAN
AccessionPrimary (citable) accession number: P17181
Secondary accession number(s): Q53GW9 expand/collapse secondary AC list , Q53H11, Q6PKD7, Q7M4L2, Q8WTZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 7, 2006
Last modified: February 9, 2010
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents