Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P17164 (FUCO_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tissue alpha-L-fucosidase

EC=3.2.1.51
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name=Alpha-L-fucosidase 1
Gene names
Name:Fuca1
Synonyms:Fuca
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activity

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Subunit structure

Homotetramer.

Subcellular location

Lysosome.

Sequence similarities

Belongs to the glycosyl hydrolase 29 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Ref.1
Chain29 – 462434Tissue alpha-L-fucosidase
PRO_0000010311

Sites

Site2921May be important for catalysis

Amino acid modifications

Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict31D → E in AAH81844. Ref.2
Sequence conflict3771R → K in AAH81844. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P17164 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: B9B06B62E6019C15

FASTA46253,487
        10         20         30         40         50         60 
MWDLKSEWWA VGFGLLLLLA ASAQAGGLAP HHYTPDWPSL DSRPLPRWFD EAKFGLFVHW 

        70         80         90        100        110        120 
GVYSVPAWGS EWFWWHWQGE QSSAYVRFMK ENYPPGFSYA DFAPQFTARF FHPEEWADLF 

       130        140        150        160        170        180 
QAAGAKYVVL TAKHHEGFTN WPSAVSWNWN SKDVGPHRDL VGELGAAVRK RNIRYGLYHS 

       190        200        210        220        230        240 
LFEWFHPLYL LDKKNGLKTQ HFVSTKTMPE LYDLVNRYKP DLIWSDGEWE CPDSYWNSTE 

       250        260        270        280        290        300 
FLAWLYNESP VKDQVVVNDR WGQNCSCRHG GYYNCEDKYR PHSLPDHKWE MCTSVDKASW 

       310        320        330        340        350        360 
GYRRDMSMST IVDENEIIEE LVQTISLGGN YLLNIGPNKD GVIVPIFQER LLAVGKWLQI 

       370        380        390        400        410        420 
NGEAIYASKP WRVQSERNKT VVWYTTKDSA VYATFLHWPE DGVVNLQSPK MTSATKITML 

       430        440        450        460 
GMEGELHWTQ DPLEGVLITL PQLPPGTFPV ESAWTLKLTK VN 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and sequence analysis of a cDNA encoding rat liver alpha-L-fucosidase."
Fisher K.J., Aronson N.N. Jr.
Biochem. J. 264:695-701(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-40; 90-124 AND 307-372.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16145 mRNA. Translation: CAA34268.1.
BC081844 mRNA. Translation: AAH81844.1.
PIRS10235. S07074.
RefSeqNP_036694.2. NM_012562.2.
UniGeneRn.3469.

3D structure databases

ProteinModelPortalP17164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP17164. 1 interaction.
STRING10116.ENSRNOP00000012455.

Chemistry

BindingDBP17164.
ChEMBLCHEMBL2710.

Protein family/group databases

CAZyGH29. Glycoside Hydrolase Family 29.

Proteomic databases

PaxDbP17164.
PRIDEP17164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012455; ENSRNOP00000012455; ENSRNOG00000009325.
GeneID24375.
KEGGrno:24375.
UCSCRGD:2636. rat.

Organism-specific databases

CTD2517.
RGD2636. Fuca1.

Phylogenomic databases

eggNOGCOG3669.
GeneTreeENSGT00440000035378.
HOGENOMHOG000029598.
HOVERGENHBG002155.
InParanoidP17164.
KOK01206.
OrthoDBEOG7DC249.
PhylomeDBP17164.
TreeFamTF313034.

Enzyme and pathway databases

BRENDA3.2.1.51. 5301.
SABIO-RKP17164.

Gene expression databases

GenevestigatorP17164.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProIPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
PfamPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSPR00741. GLHYDRLASE29.
SMARTSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603125.
PROP17164.

Entry information

Entry nameFUCO_RAT
AccessionPrimary (citable) accession number: P17164
Secondary accession number(s): Q642C6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries