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Protein

Tissue alpha-L-fucosidase

Gene

Fuca1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei292May be important for catalysis1

GO - Molecular functioni

  • alpha-L-fucosidase activity Source: UniProtKB
  • carbohydrate binding Source: RGD
  • fucosidase activity Source: RGD

GO - Biological processi

  • fucose metabolic process Source: UniProtKB
  • glycoside catabolic process Source: UniProtKB

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 5301.
SABIO-RKiP17164.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name:
Alpha-L-fucosidase 1
Gene namesi
Name:Fuca1
Synonyms:Fuca
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2636. Fuca1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001031129 – 462Tissue alpha-L-fucosidaseAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP17164.
PRIDEiP17164.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

IntActiP17164. 1 interactor.
STRINGi10116.ENSRNOP00000012455.

Chemistry databases

BindingDBiP17164.

Structurei

3D structure databases

ProteinModelPortaliP17164.
SMRiP17164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340. Eukaryota.
COG3669. LUCA.
HOGENOMiHOG000029598.
HOVERGENiHBG002155.
InParanoidiP17164.
KOiK01206.
PhylomeDBiP17164.
TreeFamiTF313034.

Family and domain databases

InterProiView protein in InterPro
IPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR017853. Glycoside_hydrolase_SF.
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF36. PTHR10030:SF36. 1 hit.
PfamiView protein in Pfam
PF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiView protein in SMART
SM00812. Alpha_L_fucos. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00385. ALPHA_L_FUCOSIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWDLKSEWWA VGFGLLLLLA ASAQAGGLAP HHYTPDWPSL DSRPLPRWFD
60 70 80 90 100
EAKFGLFVHW GVYSVPAWGS EWFWWHWQGE QSSAYVRFMK ENYPPGFSYA
110 120 130 140 150
DFAPQFTARF FHPEEWADLF QAAGAKYVVL TAKHHEGFTN WPSAVSWNWN
160 170 180 190 200
SKDVGPHRDL VGELGAAVRK RNIRYGLYHS LFEWFHPLYL LDKKNGLKTQ
210 220 230 240 250
HFVSTKTMPE LYDLVNRYKP DLIWSDGEWE CPDSYWNSTE FLAWLYNESP
260 270 280 290 300
VKDQVVVNDR WGQNCSCRHG GYYNCEDKYR PHSLPDHKWE MCTSVDKASW
310 320 330 340 350
GYRRDMSMST IVDENEIIEE LVQTISLGGN YLLNIGPNKD GVIVPIFQER
360 370 380 390 400
LLAVGKWLQI NGEAIYASKP WRVQSERNKT VVWYTTKDSA VYATFLHWPE
410 420 430 440 450
DGVVNLQSPK MTSATKITML GMEGELHWTQ DPLEGVLITL PQLPPGTFPV
460
ESAWTLKLTK VN
Length:462
Mass (Da):53,487
Last modified:August 1, 1990 - v1
Checksum:iB9B06B62E6019C15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3D → E in AAH81844 (PubMed:15489334).Curated1
Sequence conflicti377R → K in AAH81844 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16145 mRNA. Translation: CAA34268.1.
BC081844 mRNA. Translation: AAH81844.1.
PIRiS07074. S10235.
RefSeqiNP_036694.2. NM_012562.2.
UniGeneiRn.3469.

Genome annotation databases

GeneIDi24375.
KEGGirno:24375.
UCSCiRGD:2636. rat.

Similar proteinsi

Entry informationi

Entry nameiFUCO_RAT
AccessioniPrimary (citable) accession number: P17164
Secondary accession number(s): Q642C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: August 30, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families