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P17164

- FUCO_RAT

UniProt

P17164 - FUCO_RAT

Protein

Tissue alpha-L-fucosidase

Gene

Fuca1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

    Catalytic activityi

    An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei292 – 2921May be important for catalysis

    GO - Molecular functioni

    1. alpha-L-fucosidase activity Source: UniProtKB
    2. carbohydrate binding Source: RGD
    3. fucose binding Source: RefGenome
    4. fucosidase activity Source: RGD

    GO - Biological processi

    1. fucose metabolic process Source: UniProtKB
    2. glycoside catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.51. 5301.
    SABIO-RKP17164.

    Protein family/group databases

    CAZyiGH29. Glycoside Hydrolase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tissue alpha-L-fucosidase (EC:3.2.1.51)
    Alternative name(s):
    Alpha-L-fucosidase I
    Alpha-L-fucoside fucohydrolase 1
    Short name:
    Alpha-L-fucosidase 1
    Gene namesi
    Name:Fuca1
    Synonyms:Fuca
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi2636. Fuca1.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosome Source: RGD

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 PublicationAdd
    BLAST
    Chaini29 – 462434Tissue alpha-L-fucosidasePRO_0000010311Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP17164.
    PRIDEiP17164.

    Expressioni

    Gene expression databases

    GenevestigatoriP17164.

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    IntActiP17164. 1 interaction.
    STRINGi10116.ENSRNOP00000012455.

    Structurei

    3D structure databases

    ProteinModelPortaliP17164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 29 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3669.
    GeneTreeiENSGT00440000035378.
    HOGENOMiHOG000029598.
    HOVERGENiHBG002155.
    InParanoidiP17164.
    KOiK01206.
    OrthoDBiEOG7DC249.
    PhylomeDBiP17164.
    TreeFamiTF313034.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR016286. FUC_metazoa-typ.
    IPR028755. FUCA1.
    IPR013780. Glyco_hydro_13_b.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10030. PTHR10030. 1 hit.
    PTHR10030:SF2. PTHR10030:SF2. 1 hit.
    PfamiPF01120. Alpha_L_fucos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSiPR00741. GLHYDRLASE29.
    SMARTiSM00812. Alpha_L_fucos. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWDLKSEWWA VGFGLLLLLA ASAQAGGLAP HHYTPDWPSL DSRPLPRWFD    50
    EAKFGLFVHW GVYSVPAWGS EWFWWHWQGE QSSAYVRFMK ENYPPGFSYA 100
    DFAPQFTARF FHPEEWADLF QAAGAKYVVL TAKHHEGFTN WPSAVSWNWN 150
    SKDVGPHRDL VGELGAAVRK RNIRYGLYHS LFEWFHPLYL LDKKNGLKTQ 200
    HFVSTKTMPE LYDLVNRYKP DLIWSDGEWE CPDSYWNSTE FLAWLYNESP 250
    VKDQVVVNDR WGQNCSCRHG GYYNCEDKYR PHSLPDHKWE MCTSVDKASW 300
    GYRRDMSMST IVDENEIIEE LVQTISLGGN YLLNIGPNKD GVIVPIFQER 350
    LLAVGKWLQI NGEAIYASKP WRVQSERNKT VVWYTTKDSA VYATFLHWPE 400
    DGVVNLQSPK MTSATKITML GMEGELHWTQ DPLEGVLITL PQLPPGTFPV 450
    ESAWTLKLTK VN 462
    Length:462
    Mass (Da):53,487
    Last modified:August 1, 1990 - v1
    Checksum:iB9B06B62E6019C15
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31D → E in AAH81844. (PubMed:15489334)Curated
    Sequence conflicti377 – 3771R → K in AAH81844. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16145 mRNA. Translation: CAA34268.1.
    BC081844 mRNA. Translation: AAH81844.1.
    PIRiS07074. S10235.
    RefSeqiNP_036694.2. NM_012562.2.
    UniGeneiRn.3469.

    Genome annotation databases

    EnsembliENSRNOT00000012455; ENSRNOP00000012455; ENSRNOG00000009325.
    GeneIDi24375.
    KEGGirno:24375.
    UCSCiRGD:2636. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16145 mRNA. Translation: CAA34268.1 .
    BC081844 mRNA. Translation: AAH81844.1 .
    PIRi S07074. S10235.
    RefSeqi NP_036694.2. NM_012562.2.
    UniGenei Rn.3469.

    3D structure databases

    ProteinModelPortali P17164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P17164. 1 interaction.
    STRINGi 10116.ENSRNOP00000012455.

    Chemistry

    BindingDBi P17164.
    ChEMBLi CHEMBL2710.

    Protein family/group databases

    CAZyi GH29. Glycoside Hydrolase Family 29.

    Proteomic databases

    PaxDbi P17164.
    PRIDEi P17164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012455 ; ENSRNOP00000012455 ; ENSRNOG00000009325 .
    GeneIDi 24375.
    KEGGi rno:24375.
    UCSCi RGD:2636. rat.

    Organism-specific databases

    CTDi 2517.
    RGDi 2636. Fuca1.

    Phylogenomic databases

    eggNOGi COG3669.
    GeneTreei ENSGT00440000035378.
    HOGENOMi HOG000029598.
    HOVERGENi HBG002155.
    InParanoidi P17164.
    KOi K01206.
    OrthoDBi EOG7DC249.
    PhylomeDBi P17164.
    TreeFami TF313034.

    Enzyme and pathway databases

    BRENDAi 3.2.1.51. 5301.
    SABIO-RK P17164.

    Miscellaneous databases

    NextBioi 603125.
    PROi P17164.

    Gene expression databases

    Genevestigatori P17164.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR016286. FUC_metazoa-typ.
    IPR028755. FUCA1.
    IPR013780. Glyco_hydro_13_b.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10030. PTHR10030. 1 hit.
    PTHR10030:SF2. PTHR10030:SF2. 1 hit.
    Pfami PF01120. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSi PR00741. GLHYDRLASE29.
    SMARTi SM00812. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence analysis of a cDNA encoding rat liver alpha-L-fucosidase."
      Fisher K.J., Aronson N.N. Jr.
      Biochem. J. 264:695-701(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-40; 90-124 AND 307-372.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiFUCO_RAT
    AccessioniPrimary (citable) accession number: P17164
    Secondary accession number(s): Q642C6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3