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P17164

- FUCO_RAT

UniProt

P17164 - FUCO_RAT

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Protein
Tissue alpha-L-fucosidase
Gene
Fuca1, Fuca
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei292 – 2921May be important for catalysis

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: UniProtKB
  2. carbohydrate binding Source: RGD
  3. fucose binding Source: RefGenome
  4. fucosidase activity Source: RGD

GO - Biological processi

  1. fucose metabolic process Source: UniProtKB
  2. glycoside catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 5301.
SABIO-RKP17164.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name:
Alpha-L-fucosidase 1
Gene namesi
Name:Fuca1
Synonyms:Fuca
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi2636. Fuca1.

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 Publication
Add
BLAST
Chaini29 – 462434Tissue alpha-L-fucosidase
PRO_0000010311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi378 – 3781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP17164.
PRIDEiP17164.

Expressioni

Gene expression databases

GenevestigatoriP17164.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

IntActiP17164. 1 interaction.
STRINGi10116.ENSRNOP00000012455.

Structurei

3D structure databases

ProteinModelPortaliP17164.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3669.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
HOVERGENiHBG002155.
InParanoidiP17164.
KOiK01206.
OrthoDBiEOG7DC249.
PhylomeDBiP17164.
TreeFamiTF313034.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17164-1 [UniParc]FASTAAdd to Basket

« Hide

MWDLKSEWWA VGFGLLLLLA ASAQAGGLAP HHYTPDWPSL DSRPLPRWFD    50
EAKFGLFVHW GVYSVPAWGS EWFWWHWQGE QSSAYVRFMK ENYPPGFSYA 100
DFAPQFTARF FHPEEWADLF QAAGAKYVVL TAKHHEGFTN WPSAVSWNWN 150
SKDVGPHRDL VGELGAAVRK RNIRYGLYHS LFEWFHPLYL LDKKNGLKTQ 200
HFVSTKTMPE LYDLVNRYKP DLIWSDGEWE CPDSYWNSTE FLAWLYNESP 250
VKDQVVVNDR WGQNCSCRHG GYYNCEDKYR PHSLPDHKWE MCTSVDKASW 300
GYRRDMSMST IVDENEIIEE LVQTISLGGN YLLNIGPNKD GVIVPIFQER 350
LLAVGKWLQI NGEAIYASKP WRVQSERNKT VVWYTTKDSA VYATFLHWPE 400
DGVVNLQSPK MTSATKITML GMEGELHWTQ DPLEGVLITL PQLPPGTFPV 450
ESAWTLKLTK VN 462
Length:462
Mass (Da):53,487
Last modified:August 1, 1990 - v1
Checksum:iB9B06B62E6019C15
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31D → E in AAH81844. 1 Publication
Sequence conflicti377 – 3771R → K in AAH81844. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16145 mRNA. Translation: CAA34268.1.
BC081844 mRNA. Translation: AAH81844.1.
PIRiS07074. S10235.
RefSeqiNP_036694.2. NM_012562.2.
UniGeneiRn.3469.

Genome annotation databases

EnsembliENSRNOT00000012455; ENSRNOP00000012455; ENSRNOG00000009325.
GeneIDi24375.
KEGGirno:24375.
UCSCiRGD:2636. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16145 mRNA. Translation: CAA34268.1 .
BC081844 mRNA. Translation: AAH81844.1 .
PIRi S07074. S10235.
RefSeqi NP_036694.2. NM_012562.2.
UniGenei Rn.3469.

3D structure databases

ProteinModelPortali P17164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P17164. 1 interaction.
STRINGi 10116.ENSRNOP00000012455.

Chemistry

BindingDBi P17164.
ChEMBLi CHEMBL2710.

Protein family/group databases

CAZyi GH29. Glycoside Hydrolase Family 29.

Proteomic databases

PaxDbi P17164.
PRIDEi P17164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000012455 ; ENSRNOP00000012455 ; ENSRNOG00000009325 .
GeneIDi 24375.
KEGGi rno:24375.
UCSCi RGD:2636. rat.

Organism-specific databases

CTDi 2517.
RGDi 2636. Fuca1.

Phylogenomic databases

eggNOGi COG3669.
GeneTreei ENSGT00440000035378.
HOGENOMi HOG000029598.
HOVERGENi HBG002155.
InParanoidi P17164.
KOi K01206.
OrthoDBi EOG7DC249.
PhylomeDBi P17164.
TreeFami TF313034.

Enzyme and pathway databases

BRENDAi 3.2.1.51. 5301.
SABIO-RK P17164.

Miscellaneous databases

NextBioi 603125.
PROi P17164.

Gene expression databases

Genevestigatori P17164.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
Pfami PF01120. Alpha_L_fucos. 1 hit.
[Graphical view ]
PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSi PR00741. GLHYDRLASE29.
SMARTi SM00812. Alpha_L_fucos. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence analysis of a cDNA encoding rat liver alpha-L-fucosidase."
    Fisher K.J., Aronson N.N. Jr.
    Biochem. J. 264:695-701(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-40; 90-124 AND 307-372.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiFUCO_RAT
AccessioniPrimary (citable) accession number: P17164
Secondary accession number(s): Q642C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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