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P17156

- HSP72_MOUSE

UniProt

P17156 - HSP72_MOUSE

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Protein

Heat shock-related 70 kDa protein 2

Gene

Hspa2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164ATPBy similarity
Nucleotide bindingi205 – 2073ATPBy similarity
Nucleotide bindingi271 – 2788ATPBy similarity
Nucleotide bindingi342 – 3454ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glycolipid binding Source: MGI

GO - Biological processi

  1. male meiosis Source: MGI
  2. male meiosis I Source: MGI
  3. negative regulation of inclusion body assembly Source: Ensembl
  4. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle Source: MGI
  5. positive regulation of protein phosphorylation Source: MGI
  6. protein refolding Source: Ensembl
  7. response to stress Source: UniProtKB-KW
  8. spermatid development Source: MGI
  9. synaptonemal complex disassembly Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198626. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock-related 70 kDa protein 2
Short name:
Heat shock protein 70.2
Gene namesi
Name:Hspa2
Synonyms:Hcp70.2, Hsp70-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:96243. Hspa2.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. CatSper complex Source: UniProtKB
  3. cell surface Source: MGI
  4. cytosol Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. male germ cell nucleus Source: MGI
  7. mitochondrion Source: MGI
  8. nucleoplasm Source: Reactome
  9. synaptonemal complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Heat shock-related 70 kDa protein 2PRO_0000078259Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei403 – 4031PhosphoserineBy similarity
Modified residuei408 – 4081PhosphothreonineBy similarity
Modified residuei414 – 4141PhosphothreonineBy similarity
Modified residuei564 – 5641N6,N6,N6-trimethyllysine; by METTL21A; in vitroBy similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP17156.
PaxDbiP17156.
PRIDEiP17156.

2D gel databases

REPRODUCTION-2DPAGEIPI00331546.
P17156.
UCD-2DPAGEP17156.

PTM databases

PhosphoSiteiP17156.

Expressioni

Tissue specificityi

Expressed within the prinicipal peice and midpiece of sperm tail (at protein level).1 Publication

Developmental stagei

Specifically expressed in prophage stage of meiosis.

Gene expression databases

BgeeiP17156.
CleanExiMM_HSPA2.
GenevestigatoriP17156.

Interactioni

Subunit structurei

Interacts with FKBP6 (By similarity). Interacts with ZNF541. Component of the CatSper complex. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2.By similarity3 Publications

Protein-protein interaction databases

BioGridi200453. 14 interactions.
DIPiDIP-42071N.
IntActiP17156. 5 interactions.
MINTiMINT-1207820.
STRINGi10090.ENSMUSP00000079306.

Structurei

3D structure databases

ProteinModelPortaliP17156.
SMRiP17156. Positions 3-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiCOG0443.
GeneTreeiENSGT00750000117237.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiP17156.
KOiK03283.
OMAiEAYLGCK.
OrthoDBiEOG7PCJGF.
TreeFamiTF105042.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17156-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSARGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER
60 70 80 90 100
LIGDAAKNQV AMNPTNTIFD AKRLIGRKFE DATVQSDMKH WPFRVVSEGG
110 120 130 140 150
KPKVQVEYKG EMKTFFPEEI SSMVLTKMKE IAEAYLGGKV QSAVITVPAY
160 170 180 190 200
FNDSQRQATK DAGTITGLNV LRIINEPTAA AIAYGLDKKG CAGGEKNVLI
210 220 230 240 250
FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM VSHLAEEFKR
260 270 280 290 300
KHKKDIGPNK RAVRRLRTAC ERAKRTLSSS TQASIEIDSL YEGVDFYTSI
310 320 330 340 350
TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ
360 370 380 390 400
KLLQDFFNGK ELNKSINPDE AVAYGAAVQA AILIGDKSEN VQDLLLLDVT
410 420 430 440 450
PLSLGIETAG GVMTPLIKRN TTIPTKQTQT FTTYSDNQSS VLVQVYEGER
460 470 480 490 500
AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT FDIDANGILN VTAADKSTGK
510 520 530 540 550
ENKITITNDK GRLSKDDIDR MVQEAERYKS EDEANRDRVA AKNAVESYTY
560 570 580 590 600
NIKQTVEDEK LRGKISEQDK NKILDKCQEV INWLDRNQMA EKDEYEHKQK
610 620 630
ELERVCNPII SKLYQGGPGG GGSSGGPTIE EVD
Length:633
Mass (Da):69,642
Last modified:July 27, 2011 - v2
Checksum:i6F65773C7EFFA69F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711A → R in AAA37859. (PubMed:3405224)Curated
Sequence conflicti222 – 2221V → L in AAA37859. (PubMed:3405224)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20567 Genomic DNA. Translation: AAA37859.1.
CH466526 Genomic DNA. Translation: EDL36460.1.
BC004714 mRNA. Translation: AAH04714.1.
BC052350 mRNA. Translation: AAH52350.1.
CCDSiCCDS25993.1.
PIRiS10859.
RefSeqiNP_001002012.1. NM_001002012.1.
NP_032327.2. NM_008301.4.
XP_006515547.1. XM_006515484.1.
UniGeneiMm.296181.

Genome annotation databases

EnsembliENSMUST00000080449; ENSMUSP00000079306; ENSMUSG00000059970.
GeneIDi15512.
KEGGimmu:15512.
UCSCiuc007nyf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20567 Genomic DNA. Translation: AAA37859.1 .
CH466526 Genomic DNA. Translation: EDL36460.1 .
BC004714 mRNA. Translation: AAH04714.1 .
BC052350 mRNA. Translation: AAH52350.1 .
CCDSi CCDS25993.1.
PIRi S10859.
RefSeqi NP_001002012.1. NM_001002012.1.
NP_032327.2. NM_008301.4.
XP_006515547.1. XM_006515484.1.
UniGenei Mm.296181.

3D structure databases

ProteinModelPortali P17156.
SMRi P17156. Positions 3-616.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200453. 14 interactions.
DIPi DIP-42071N.
IntActi P17156. 5 interactions.
MINTi MINT-1207820.
STRINGi 10090.ENSMUSP00000079306.

PTM databases

PhosphoSitei P17156.

2D gel databases

REPRODUCTION-2DPAGE IPI00331546.
P17156.
UCD-2DPAGE P17156.

Proteomic databases

MaxQBi P17156.
PaxDbi P17156.
PRIDEi P17156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080449 ; ENSMUSP00000079306 ; ENSMUSG00000059970 .
GeneIDi 15512.
KEGGi mmu:15512.
UCSCi uc007nyf.1. mouse.

Organism-specific databases

CTDi 3306.
MGIi MGI:96243. Hspa2.

Phylogenomic databases

eggNOGi COG0443.
GeneTreei ENSGT00750000117237.
HOGENOMi HOG000228135.
HOVERGENi HBG051845.
InParanoidi P17156.
KOi K03283.
OMAi EAYLGCK.
OrthoDBi EOG7PCJGF.
TreeFami TF105042.

Enzyme and pathway databases

Reactomei REACT_198626. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Miscellaneous databases

NextBioi 288426.
PROi P17156.
SOURCEi Search...

Gene expression databases

Bgeei P17156.
CleanExi MM_HSPA2.
Genevestigatori P17156.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line."
    Zakeri Z.F., Wolgemuth D.J., Hunt C.R.
    Mol. Cell. Biol. 8:2925-2932(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor and Testis.
  4. "A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis."
    Choi E., Han C., Park I., Lee B., Jin S., Choi H., Kim do H., Park Z.Y., Eddy E.M., Cho C.
    J. Biol. Chem. 283:35283-35294(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF541.
  5. "A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa."
    Chung J.J., Navarro B., Krapivinsky G., Krapivinsky L., Clapham D.E.
    Nat. Commun. 2:153-153(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CATSPER COMPLEX.
    Strain: C57BL/6.
  6. "RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly."
    Lo J.C., Jamsai D., O'Connor A.E., Borg C., Clark B.J., Whisstock J.C., Field M.C., Adams V., Ishikawa T., Aitken R.J., Whittle B., Goodnow C.C., Ormandy C.J., O'Bryan M.K.
    PLoS Genet. 8:E1002969-E1002969(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RABL2, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHSP72_MOUSE
AccessioniPrimary (citable) accession number: P17156
Secondary accession number(s): Q99KD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3