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Protein

Annexin A5

Gene

ANXA5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Collagen-binding protein.

GO - Molecular functioni

  • calcium channel activity Source: AgBase
  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro

GO - Biological processi

  • calcium ion homeostasis Source: AgBase
  • negative regulation of coagulation Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name:
CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein I
Short name:
PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name:
VAC-alpha
Gene namesi
Name:ANXA5
Synonyms:ANX5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • calcium channel complex Source: AgBase
  • vesicle Source: AgBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Annexin A5PRO_0000067491Add
BLAST

Proteomic databases

PaxDbiP17153.
PRIDEiP17153.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1635947,EBI-1635766

Protein-protein interaction databases

BioGridi687731. 1 interaction.
IntActiP17153. 1 interaction.
STRINGi9031.ENSGALP00000036959.

Structurei

Secondary structure

1
321
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 2812Combined sources
Beta strandi29 – 324Combined sources
Helixi35 – 4410Combined sources
Helixi47 – 6115Combined sources
Helixi65 – 728Combined sources
Helixi75 – 8511Combined sources
Helixi88 – 10013Combined sources
Beta strandi101 – 1044Combined sources
Helixi107 – 11610Combined sources
Helixi119 – 13315Combined sources
Helixi137 – 1448Combined sources
Helixi147 – 15711Combined sources
Helixi169 – 18416Combined sources
Turni185 – 1873Combined sources
Helixi191 – 20010Combined sources
Helixi203 – 21715Combined sources
Helixi221 – 2255Combined sources
Beta strandi227 – 2293Combined sources
Helixi232 – 24514Combined sources
Helixi247 – 25913Combined sources
Beta strandi260 – 2634Combined sources
Helixi266 – 27611Combined sources
Turni277 – 2804Combined sources
Helixi281 – 29212Combined sources
Helixi296 – 3038Combined sources
Helixi306 – 31611Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ALAX-ray2.25A1-321[»]
1YIIX-ray1.42A2-321[»]
1YJ0X-ray2.95A2-321[»]
ProteinModelPortaliP17153.
SMRiP17153. Positions 3-319.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17153.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 8461Annexin 1Add
BLAST
Repeati96 – 15661Annexin 2Add
BLAST
Repeati180 – 24061Annexin 3Add
BLAST
Repeati255 – 31561Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP17153.
KOiK16646.
PhylomeDBiP17153.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view]
PANTHERiPTHR10502:SF26. PTHR10502:SF26. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYTRGTVT AFSPFDARAD AEALRKAMKG MGTDEETILK ILTSRNNAQR
60 70 80 90 100
QEIASAFKTL FGRDLVDDLK SELTGKFETL MVSLMRPARI FDAHALKHAI
110 120 130 140 150
KGAGTNEKVL TEILASRTPA EVQNIKQVYM QEYEANLEDK ITGETSGHFQ
160 170 180 190 200
RLLVVLLQAN RDPDGRVDEA LVEKDAQVLF RAGELKWGTD EETFITILGT
210 220 230 240 250
RSVSHLRRVF DKYMTISGFQ IEETIDRETS GDLEKLLLAV VKCIRSVPAY
260 270 280 290 300
FAETLYYSMK GAGTDDDTLI RVMVSRSEID LLDIRHEFRK NFAKSLYQMI
310 320
QKDTSGDYRK ALLLLCGGDD E
Length:321
Mass (Da):36,198
Last modified:February 1, 1996 - v2
Checksum:i43E2983F86797025
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681D → E AA sequence (PubMed:2833522).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30971 mRNA. Translation: AAA48591.1. Sequence problems.
U01680
, U01671, U01672, U01673, U01675, U01676, U01677, U01678, U01679 Genomic DNA. Translation: AAB39917.1.
PIRiA35381. LUCH5.
RefSeqiNP_001026709.1. NM_001031538.1.
XP_015131802.1. XM_015276316.1.
XP_015131803.1. XM_015276317.1.
UniGeneiGga.1168.

Genome annotation databases

GeneIDi428767.
KEGGigga:428767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30971 mRNA. Translation: AAA48591.1. Sequence problems.
U01680
, U01671, U01672, U01673, U01675, U01676, U01677, U01678, U01679 Genomic DNA. Translation: AAB39917.1.
PIRiA35381. LUCH5.
RefSeqiNP_001026709.1. NM_001031538.1.
XP_015131802.1. XM_015276316.1.
XP_015131803.1. XM_015276317.1.
UniGeneiGga.1168.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ALAX-ray2.25A1-321[»]
1YIIX-ray1.42A2-321[»]
1YJ0X-ray2.95A2-321[»]
ProteinModelPortaliP17153.
SMRiP17153. Positions 3-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi687731. 1 interaction.
IntActiP17153. 1 interaction.
STRINGi9031.ENSGALP00000036959.

Proteomic databases

PaxDbiP17153.
PRIDEiP17153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi428767.
KEGGigga:428767.

Organism-specific databases

CTDi308.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP17153.
KOiK16646.
PhylomeDBiP17153.
TreeFamiTF105452.

Miscellaneous databases

EvolutionaryTraceiP17153.
PROiP17153.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view]
PANTHERiPTHR10502:SF26. PTHR10502:SF26. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA5_CHICK
AccessioniPrimary (citable) accession number: P17153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.