Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin A5

Gene

ANXA5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Collagen-binding protein.

GO - Molecular functioni

  • calcium channel activity Source: AgBase
  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro

GO - Biological processi

  • calcium ion homeostasis Source: AgBase
  • negative regulation of coagulation Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name:
CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein I
Short name:
PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name:
VAC-alpha
Gene namesi
Name:ANXA5
Synonyms:ANX5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • calcium channel complex Source: AgBase
  • vesicle Source: AgBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674911 – 321Annexin A5Add BLAST321

Proteomic databases

PaxDbiP17153.
PRIDEiP17153.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1635947,EBI-1635766

Protein-protein interaction databases

BioGridi687731. 1 interactor.
IntActiP17153. 1 interactor.
STRINGi9031.ENSGALP00000036959.

Structurei

Secondary structure

1321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 28Combined sources12
Beta strandi29 – 32Combined sources4
Helixi35 – 44Combined sources10
Helixi47 – 61Combined sources15
Helixi65 – 72Combined sources8
Helixi75 – 85Combined sources11
Helixi88 – 100Combined sources13
Beta strandi101 – 104Combined sources4
Helixi107 – 116Combined sources10
Helixi119 – 133Combined sources15
Helixi137 – 144Combined sources8
Helixi147 – 157Combined sources11
Helixi169 – 184Combined sources16
Turni185 – 187Combined sources3
Helixi191 – 200Combined sources10
Helixi203 – 217Combined sources15
Helixi221 – 225Combined sources5
Beta strandi227 – 229Combined sources3
Helixi232 – 245Combined sources14
Helixi247 – 259Combined sources13
Beta strandi260 – 263Combined sources4
Helixi266 – 276Combined sources11
Turni277 – 280Combined sources4
Helixi281 – 292Combined sources12
Helixi296 – 303Combined sources8
Helixi306 – 316Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALAX-ray2.25A1-321[»]
1YIIX-ray1.42A2-321[»]
1YJ0X-ray2.95A2-321[»]
ProteinModelPortaliP17153.
SMRiP17153.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17153.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 84Annexin 1Add BLAST61
Repeati96 – 156Annexin 2Add BLAST61
Repeati180 – 240Annexin 3Add BLAST61
Repeati255 – 315Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP17153.
KOiK16646.
PhylomeDBiP17153.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view]
PANTHERiPTHR10502:SF26. PTHR10502:SF26. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYTRGTVT AFSPFDARAD AEALRKAMKG MGTDEETILK ILTSRNNAQR
60 70 80 90 100
QEIASAFKTL FGRDLVDDLK SELTGKFETL MVSLMRPARI FDAHALKHAI
110 120 130 140 150
KGAGTNEKVL TEILASRTPA EVQNIKQVYM QEYEANLEDK ITGETSGHFQ
160 170 180 190 200
RLLVVLLQAN RDPDGRVDEA LVEKDAQVLF RAGELKWGTD EETFITILGT
210 220 230 240 250
RSVSHLRRVF DKYMTISGFQ IEETIDRETS GDLEKLLLAV VKCIRSVPAY
260 270 280 290 300
FAETLYYSMK GAGTDDDTLI RVMVSRSEID LLDIRHEFRK NFAKSLYQMI
310 320
QKDTSGDYRK ALLLLCGGDD E
Length:321
Mass (Da):36,198
Last modified:February 1, 1996 - v2
Checksum:i43E2983F86797025
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168D → E AA sequence (PubMed:2833522).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30971 mRNA. Translation: AAA48591.1. Sequence problems.
U01680
, U01671, U01672, U01673, U01675, U01676, U01677, U01678, U01679 Genomic DNA. Translation: AAB39917.1.
PIRiA35381. LUCH5.
RefSeqiNP_001026709.1. NM_001031538.1.
XP_015131802.1. XM_015276316.1.
XP_015131803.1. XM_015276317.1.
UniGeneiGga.1168.

Genome annotation databases

EnsembliENSGALT00000082996; ENSGALP00000054961; ENSGALG00000011885.
GeneIDi428767.
KEGGigga:428767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30971 mRNA. Translation: AAA48591.1. Sequence problems.
U01680
, U01671, U01672, U01673, U01675, U01676, U01677, U01678, U01679 Genomic DNA. Translation: AAB39917.1.
PIRiA35381. LUCH5.
RefSeqiNP_001026709.1. NM_001031538.1.
XP_015131802.1. XM_015276316.1.
XP_015131803.1. XM_015276317.1.
UniGeneiGga.1168.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALAX-ray2.25A1-321[»]
1YIIX-ray1.42A2-321[»]
1YJ0X-ray2.95A2-321[»]
ProteinModelPortaliP17153.
SMRiP17153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi687731. 1 interactor.
IntActiP17153. 1 interactor.
STRINGi9031.ENSGALP00000036959.

Proteomic databases

PaxDbiP17153.
PRIDEiP17153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000082996; ENSGALP00000054961; ENSGALG00000011885.
GeneIDi428767.
KEGGigga:428767.

Organism-specific databases

CTDi308.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP17153.
KOiK16646.
PhylomeDBiP17153.
TreeFamiTF105452.

Miscellaneous databases

EvolutionaryTraceiP17153.
PROiP17153.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view]
PANTHERiPTHR10502:SF26. PTHR10502:SF26. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA5_CHICK
AccessioniPrimary (citable) accession number: P17153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.