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Protein

Transmembrane protein 11, mitochondrial

Gene

TMEM11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial morphogenesis.1 Publication

GO - Biological processi

  • mitochondrion organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 11, mitochondrial
Alternative name(s):
Protein PM1
Protein PMI
Gene namesi
Name:TMEM11
Synonyms:C17orf35, PM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16823. TMEM11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10017HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12418HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134893886.

Polymorphism and mutation databases

BioMutaiTMEM11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Transmembrane protein 11, mitochondrialPRO_0000072562Add
BLAST

Proteomic databases

MaxQBiP17152.
PaxDbiP17152.
PRIDEiP17152.

PTM databases

PhosphoSiteiP17152.

Expressioni

Gene expression databases

BgeeiP17152.
CleanExiHS_TMEM11.
GenevisibleiP17152. HS.

Organism-specific databases

HPAiHPA051795.

Interactioni

Subunit structurei

Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BNIP3Q129835EBI-723946,EBI-749464
BNIP3LO602384EBI-723946,EBI-849893

Protein-protein interaction databases

BioGridi114361. 19 interactions.
IntActiP17152. 8 interactions.
MINTiMINT-1422941.
STRINGi9606.ENSP00000319992.

Structurei

3D structure databases

ProteinModelPortaliP17152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG73433.
GeneTreeiENSGT00390000006617.
HOGENOMiHOG000007261.
HOVERGENiHBG002057.
InParanoidiP17152.
OMAiQVEYDSQ.
OrthoDBiEOG7ZKSCK.
PhylomeDBiP17152.
TreeFamiTF324685.

Family and domain databases

InterProiIPR026120. TMEM11.
[Graphical view]
PfamiPF14972. Mito_morph_reg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAWGRRRLG PGSSGGSARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE
60 70 80 90 100
QALEAQYKYI VIEPTRIGDE TARWITVGNC LHKTAVLAGT ACLFTPLALP
110 120 130 140 150
LDYSHYISLP AGVLSLACCT LYGISWQFDP CCKYQVEYDA YKLSRLPLHT
160 170 180 190
LTSSTPVVLV RKDDLHRKRL HNTIALAALV YCVKKIYELY AV
Length:192
Mass (Da):21,541
Last modified:August 1, 1990 - v1
Checksum:iFE46BACEBF5ACD1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51804 mRNA. Translation: CAA36102.1.
AK311965 mRNA. Translation: BAG34905.1.
BT006768 mRNA. Translation: AAP35414.1.
AC087294 Genomic DNA. No translation available.
AC087393 Genomic DNA. No translation available.
CH471210 Genomic DNA. Translation: EAX02598.1.
BC002819 mRNA. Translation: AAH02819.1.
BC005268 mRNA. Translation: AAH05268.1.
BC020815 mRNA. Translation: AAH20815.1.
CCDSiCCDS11216.1.
PIRiS15930.
RefSeqiNP_003867.1. NM_003876.2.
UniGeneiHs.592945.

Genome annotation databases

EnsembliENST00000317635; ENSP00000319992; ENSG00000178307.
GeneIDi8834.
KEGGihsa:8834.
UCSCiuc002gyp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51804 mRNA. Translation: CAA36102.1.
AK311965 mRNA. Translation: BAG34905.1.
BT006768 mRNA. Translation: AAP35414.1.
AC087294 Genomic DNA. No translation available.
AC087393 Genomic DNA. No translation available.
CH471210 Genomic DNA. Translation: EAX02598.1.
BC002819 mRNA. Translation: AAH02819.1.
BC005268 mRNA. Translation: AAH05268.1.
BC020815 mRNA. Translation: AAH20815.1.
CCDSiCCDS11216.1.
PIRiS15930.
RefSeqiNP_003867.1. NM_003876.2.
UniGeneiHs.592945.

3D structure databases

ProteinModelPortaliP17152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114361. 19 interactions.
IntActiP17152. 8 interactions.
MINTiMINT-1422941.
STRINGi9606.ENSP00000319992.

PTM databases

PhosphoSiteiP17152.

Polymorphism and mutation databases

BioMutaiTMEM11.

Proteomic databases

MaxQBiP17152.
PaxDbiP17152.
PRIDEiP17152.

Protocols and materials databases

DNASUi8834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317635; ENSP00000319992; ENSG00000178307.
GeneIDi8834.
KEGGihsa:8834.
UCSCiuc002gyp.2. human.

Organism-specific databases

CTDi8834.
GeneCardsiGC17M021042.
HGNCiHGNC:16823. TMEM11.
HPAiHPA051795.
neXtProtiNX_P17152.
PharmGKBiPA134893886.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG73433.
GeneTreeiENSGT00390000006617.
HOGENOMiHOG000007261.
HOVERGENiHBG002057.
InParanoidiP17152.
OMAiQVEYDSQ.
OrthoDBiEOG7ZKSCK.
PhylomeDBiP17152.
TreeFamiTF324685.

Miscellaneous databases

ChiTaRSiTMEM11. human.
GenomeRNAii8834.
NextBioi33156.
PROiP17152.

Gene expression databases

BgeeiP17152.
CleanExiHS_TMEM11.
GenevisibleiP17152. HS.

Family and domain databases

InterProiIPR026120. TMEM11.
[Graphical view]
PfamiPF14972. Mito_morph_reg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors."
    Murphy P.M., Malech H.L.
    Nucleic Acids Res. 18:1896-1896(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney, Placenta and Prostate.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways."
    Rival T., Macchi M., Arnaune-Pelloquin L., Poidevin M., Maillet F., Richard F., Fatmi A., Belenguer P., Royet J.
    EMBO Rep. 12:223-230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology."
    Guarani V., McNeill E.M., Paulo J.A., Huttlin E.L., Froehlich F., Gygi S.P., Van Vactor D., Harper J.W.
    Elife 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH THE MICOS COMPLEX, INTERACTION WITH IMMT.

Entry informationi

Entry nameiTMM11_HUMAN
AccessioniPrimary (citable) accession number: P17152
Secondary accession number(s): Q53YB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 22, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.