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P17152

- TMM11_HUMAN

UniProt

P17152 - TMM11_HUMAN

Protein

Transmembrane protein 11, mitochondrial

Gene

TMEM11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Plays a role in mitochondrial morphogenesis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. mitochondrion organization Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 11, mitochondrial
    Alternative name(s):
    Protein PM1
    Protein PMI
    Gene namesi
    Name:TMEM11
    Synonyms:C17orf35, PM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:16823. TMEM11.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of mitochondrial inner membrane Source: UniProtKB
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134893886.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Transmembrane protein 11, mitochondrialPRO_0000072562Add
    BLAST

    Proteomic databases

    MaxQBiP17152.
    PaxDbiP17152.
    PRIDEiP17152.

    PTM databases

    PhosphoSiteiP17152.

    Expressioni

    Gene expression databases

    BgeeiP17152.
    CleanExiHS_TMEM11.
    GenevestigatoriP17152.

    Organism-specific databases

    HPAiHPA051795.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BNIP3Q129832EBI-723946,EBI-749464

    Protein-protein interaction databases

    BioGridi114361. 6 interactions.
    IntActiP17152. 8 interactions.
    MINTiMINT-1422941.
    STRINGi9606.ENSP00000319992.

    Structurei

    3D structure databases

    ProteinModelPortaliP17152.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei84 – 10017HelicalSequence AnalysisAdd
    BLAST
    Transmembranei107 – 12418HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM11 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG73433.
    HOGENOMiHOG000007261.
    HOVERGENiHBG002057.
    InParanoidiP17152.
    OMAiTERDAMD.
    OrthoDBiEOG7ZKSCK.
    PhylomeDBiP17152.
    TreeFamiTF324685.

    Family and domain databases

    InterProiIPR026120. TMEM11.
    [Graphical view]
    PfamiPF14972. Mito_morph_reg. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17152-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAWGRRRLG PGSSGGSARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE    50
    QALEAQYKYI VIEPTRIGDE TARWITVGNC LHKTAVLAGT ACLFTPLALP 100
    LDYSHYISLP AGVLSLACCT LYGISWQFDP CCKYQVEYDA YKLSRLPLHT 150
    LTSSTPVVLV RKDDLHRKRL HNTIALAALV YCVKKIYELY AV 192
    Length:192
    Mass (Da):21,541
    Last modified:August 1, 1990 - v1
    Checksum:iFE46BACEBF5ACD1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51804 mRNA. Translation: CAA36102.1.
    AK311965 mRNA. Translation: BAG34905.1.
    BT006768 mRNA. Translation: AAP35414.1.
    AC087294 Genomic DNA. No translation available.
    AC087393 Genomic DNA. No translation available.
    CH471210 Genomic DNA. Translation: EAX02598.1.
    BC002819 mRNA. Translation: AAH02819.1.
    BC005268 mRNA. Translation: AAH05268.1.
    BC020815 mRNA. Translation: AAH20815.1.
    CCDSiCCDS11216.1.
    PIRiS15930.
    RefSeqiNP_003867.1. NM_003876.2.
    UniGeneiHs.592945.

    Genome annotation databases

    EnsembliENST00000317635; ENSP00000319992; ENSG00000178307.
    GeneIDi8834.
    KEGGihsa:8834.
    UCSCiuc002gyp.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51804 mRNA. Translation: CAA36102.1 .
    AK311965 mRNA. Translation: BAG34905.1 .
    BT006768 mRNA. Translation: AAP35414.1 .
    AC087294 Genomic DNA. No translation available.
    AC087393 Genomic DNA. No translation available.
    CH471210 Genomic DNA. Translation: EAX02598.1 .
    BC002819 mRNA. Translation: AAH02819.1 .
    BC005268 mRNA. Translation: AAH05268.1 .
    BC020815 mRNA. Translation: AAH20815.1 .
    CCDSi CCDS11216.1.
    PIRi S15930.
    RefSeqi NP_003867.1. NM_003876.2.
    UniGenei Hs.592945.

    3D structure databases

    ProteinModelPortali P17152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114361. 6 interactions.
    IntActi P17152. 8 interactions.
    MINTi MINT-1422941.
    STRINGi 9606.ENSP00000319992.

    PTM databases

    PhosphoSitei P17152.

    Proteomic databases

    MaxQBi P17152.
    PaxDbi P17152.
    PRIDEi P17152.

    Protocols and materials databases

    DNASUi 8834.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317635 ; ENSP00000319992 ; ENSG00000178307 .
    GeneIDi 8834.
    KEGGi hsa:8834.
    UCSCi uc002gyp.2. human.

    Organism-specific databases

    CTDi 8834.
    GeneCardsi GC17M021042.
    HGNCi HGNC:16823. TMEM11.
    HPAi HPA051795.
    neXtProti NX_P17152.
    PharmGKBi PA134893886.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73433.
    HOGENOMi HOG000007261.
    HOVERGENi HBG002057.
    InParanoidi P17152.
    OMAi TERDAMD.
    OrthoDBi EOG7ZKSCK.
    PhylomeDBi P17152.
    TreeFami TF324685.

    Miscellaneous databases

    ChiTaRSi TMEM11. human.
    GenomeRNAii 8834.
    NextBioi 33156.
    PROi P17152.

    Gene expression databases

    Bgeei P17152.
    CleanExi HS_TMEM11.
    Genevestigatori P17152.

    Family and domain databases

    InterProi IPR026120. TMEM11.
    [Graphical view ]
    Pfami PF14972. Mito_morph_reg. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors."
      Murphy P.M., Malech H.L.
      Nucleic Acids Res. 18:1896-1896(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney, Placenta and Prostate.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways."
      Rival T., Macchi M., Arnaune-Pelloquin L., Poidevin M., Maillet F., Richard F., Fatmi A., Belenguer P., Royet J.
      EMBO Rep. 12:223-230(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.

    Entry informationi

    Entry nameiTMM11_HUMAN
    AccessioniPrimary (citable) accession number: P17152
    Secondary accession number(s): Q53YB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3