P17152 (TMM11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 11, mitochondrial

Alternative name(s):
Protein PM1
Protein PMI

Gene names

Name:	TMEM11
Synonyms:	C17orf35, PM1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in mitochondrial morphogenesis. Ref.8
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein Ref.8.
Sequence similarities	Belongs to the TMEM11 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrion organization Inferred from mutant phenotype Ref.8. Source: UniProtKB
Cellular_component	integral to mitochondrial inner membrane Inferred from direct assay Ref.8. Source: UniProtKB integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BNIP3	Q12983	2	EBI-723946,EBI-749464

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Transmembrane protein 11, mitochondrial		PRO_0000072562
Regions
	Transmembrane	84 – 100	17	Helical; Potential
	Transmembrane	107 – 124	18	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P17152 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: FE46BACEBF5ACD1D	FASTA	192	21,541
	10 20 30 40 50 60 MAAWGRRRLG PGSSGGSARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE QALEAQYKYI 70 80 90 100 110 120 VIEPTRIGDE TARWITVGNC LHKTAVLAGT ACLFTPLALP LDYSHYISLP AGVLSLACCT 130 140 150 160 170 180 LYGISWQFDP CCKYQVEYDA YKLSRLPLHT LTSSTPVVLV RKDDLHRKRL HNTIALAALV 190 YCVKKIYELY AV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors." Murphy P.M., Malech H.L. Nucleic Acids Res. 18:1896-1896(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney, Placenta and Prostate.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways." Rival T., Macchi M., Arnaune-Pelloquin L., Poidevin M., Maillet F., Richard F., Fatmi A., Belenguer P., Royet J. EMBO Rep. 12:223-230(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X51804 mRNA. Translation: CAA36102.1. AK311965 mRNA. Translation: BAG34905.1. BT006768 mRNA. Translation: AAP35414.1. AC087294 Genomic DNA. No translation available. AC087393 Genomic DNA. No translation available. CH471210 Genomic DNA. Translation: EAX02598.1. BC002819 mRNA. Translation: AAH02819.1. BC005268 mRNA. Translation: AAH05268.1. BC020815 mRNA. Translation: AAH20815.1.
IPI	IPI00012855.
PIR	S15930.
RefSeq	NP_003867.1. NM_003876.2.
UniGene	Hs.592945.
3D structure databases
ProteinModelPortal	P17152.
ModBase	Search...
Protein-protein interaction databases
IntAct	P17152. 4 interactions.
MINT	MINT-1422941.
STRING	9606.ENSP00000319992.
PTM databases
PhosphoSite	P17152.
Proteomic databases
PaxDb	P17152.
PRIDE	P17152.
Protocols and materials databases
DNASU	8834.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317635; ENSP00000319992; ENSG00000178307.
GeneID	8834.
KEGG	hsa:8834.
UCSC	uc002gyp.2. human.
Organism-specific databases
CTD	8834.
GeneCards	GC17M021042.
HGNC	HGNC:16823. TMEM11.
HPA	HPA051795.
neXtProt	NX_P17152.
PharmGKB	PA134893886.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73433.
HOGENOM	HOG000007261.
HOVERGEN	HBG002057.
InParanoid	P17152.
OMA	HKTTVLA.
OrthoDB	EOG4KD6N4.
PhylomeDB	P17152.
Gene expression databases
Bgee	P17152.
CleanEx	HS_TMEM11.
Genevestigator	P17152.
GermOnline	ENSG00000178307. Homo sapiens.
Family and domain databases
InterPro	IPR026120. TMEM11. [Graphical view]
PANTHER	PTHR15099. PTHR15099. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	TMEM11. human.
GenomeRNAi	8834.
NextBio	33156.

Entry information

Entry name

TMM11_HUMAN

Accession

Primary (citable) accession number: P17152
Secondary accession number(s): Q53YB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.