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P17152

- TMM11_HUMAN

UniProt

P17152 - TMM11_HUMAN

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Protein
Transmembrane protein 11, mitochondrial
Gene
TMEM11, C17orf35, PM1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial morphogenesis.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. mitochondrion organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 11, mitochondrial
Alternative name(s):
Protein PM1
Protein PMI
Gene namesi
Name:TMEM11
Synonyms:C17orf35, PM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16823. TMEM11.

Subcellular locationi

Mitochondrion inner membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10017Helical; Reviewed prediction
Add
BLAST
Transmembranei107 – 12418Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of mitochondrial inner membrane Source: UniProtKB
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134893886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Transmembrane protein 11, mitochondrial
PRO_0000072562Add
BLAST

Proteomic databases

MaxQBiP17152.
PaxDbiP17152.
PRIDEiP17152.

PTM databases

PhosphoSiteiP17152.

Expressioni

Gene expression databases

BgeeiP17152.
CleanExiHS_TMEM11.
GenevestigatoriP17152.

Organism-specific databases

HPAiHPA051795.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BNIP3Q129832EBI-723946,EBI-749464

Protein-protein interaction databases

BioGridi114361. 6 interactions.
IntActiP17152. 8 interactions.
MINTiMINT-1422941.
STRINGi9606.ENSP00000319992.

Structurei

3D structure databases

ProteinModelPortaliP17152.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM11 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG73433.
HOGENOMiHOG000007261.
HOVERGENiHBG002057.
InParanoidiP17152.
OMAiTERDAMD.
OrthoDBiEOG7ZKSCK.
PhylomeDBiP17152.
TreeFamiTF324685.

Family and domain databases

InterProiIPR026120. TMEM11.
[Graphical view]
PfamiPF14972. Mito_morph_reg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17152-1 [UniParc]FASTAAdd to Basket

« Hide

MAAWGRRRLG PGSSGGSARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE    50
QALEAQYKYI VIEPTRIGDE TARWITVGNC LHKTAVLAGT ACLFTPLALP 100
LDYSHYISLP AGVLSLACCT LYGISWQFDP CCKYQVEYDA YKLSRLPLHT 150
LTSSTPVVLV RKDDLHRKRL HNTIALAALV YCVKKIYELY AV 192
Length:192
Mass (Da):21,541
Last modified:August 1, 1990 - v1
Checksum:iFE46BACEBF5ACD1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51804 mRNA. Translation: CAA36102.1.
AK311965 mRNA. Translation: BAG34905.1.
BT006768 mRNA. Translation: AAP35414.1.
AC087294 Genomic DNA. No translation available.
AC087393 Genomic DNA. No translation available.
CH471210 Genomic DNA. Translation: EAX02598.1.
BC002819 mRNA. Translation: AAH02819.1.
BC005268 mRNA. Translation: AAH05268.1.
BC020815 mRNA. Translation: AAH20815.1.
CCDSiCCDS11216.1.
PIRiS15930.
RefSeqiNP_003867.1. NM_003876.2.
UniGeneiHs.592945.

Genome annotation databases

EnsembliENST00000317635; ENSP00000319992; ENSG00000178307.
GeneIDi8834.
KEGGihsa:8834.
UCSCiuc002gyp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51804 mRNA. Translation: CAA36102.1 .
AK311965 mRNA. Translation: BAG34905.1 .
BT006768 mRNA. Translation: AAP35414.1 .
AC087294 Genomic DNA. No translation available.
AC087393 Genomic DNA. No translation available.
CH471210 Genomic DNA. Translation: EAX02598.1 .
BC002819 mRNA. Translation: AAH02819.1 .
BC005268 mRNA. Translation: AAH05268.1 .
BC020815 mRNA. Translation: AAH20815.1 .
CCDSi CCDS11216.1.
PIRi S15930.
RefSeqi NP_003867.1. NM_003876.2.
UniGenei Hs.592945.

3D structure databases

ProteinModelPortali P17152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114361. 6 interactions.
IntActi P17152. 8 interactions.
MINTi MINT-1422941.
STRINGi 9606.ENSP00000319992.

PTM databases

PhosphoSitei P17152.

Proteomic databases

MaxQBi P17152.
PaxDbi P17152.
PRIDEi P17152.

Protocols and materials databases

DNASUi 8834.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317635 ; ENSP00000319992 ; ENSG00000178307 .
GeneIDi 8834.
KEGGi hsa:8834.
UCSCi uc002gyp.2. human.

Organism-specific databases

CTDi 8834.
GeneCardsi GC17M021042.
HGNCi HGNC:16823. TMEM11.
HPAi HPA051795.
neXtProti NX_P17152.
PharmGKBi PA134893886.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73433.
HOGENOMi HOG000007261.
HOVERGENi HBG002057.
InParanoidi P17152.
OMAi TERDAMD.
OrthoDBi EOG7ZKSCK.
PhylomeDBi P17152.
TreeFami TF324685.

Miscellaneous databases

ChiTaRSi TMEM11. human.
GenomeRNAii 8834.
NextBioi 33156.
PROi P17152.

Gene expression databases

Bgeei P17152.
CleanExi HS_TMEM11.
Genevestigatori P17152.

Family and domain databases

InterProi IPR026120. TMEM11.
[Graphical view ]
Pfami PF14972. Mito_morph_reg. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors."
    Murphy P.M., Malech H.L.
    Nucleic Acids Res. 18:1896-1896(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney, Placenta and Prostate.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways."
    Rival T., Macchi M., Arnaune-Pelloquin L., Poidevin M., Maillet F., Richard F., Fatmi A., Belenguer P., Royet J.
    EMBO Rep. 12:223-230(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.

Entry informationi

Entry nameiTMM11_HUMAN
AccessioniPrimary (citable) accession number: P17152
Secondary accession number(s): Q53YB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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