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P17125

- TGFB3_MOUSE

UniProt

P17125 - TGFB3_MOUSE

Protein

Transforming growth factor beta-3

Gene

Tgfb3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Involved in embryogenesis and cell differentiation.

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. aging Source: Ensembl
    3. cell-cell junction organization Source: Ensembl
    4. cell growth Source: InterPro
    5. cellular response to growth factor stimulus Source: MGI
    6. detection of hypoxia Source: Ensembl
    7. digestive tract development Source: Ensembl
    8. embryonic neurocranium morphogenesis Source: Ensembl
    9. face morphogenesis Source: UniProtKB
    10. female pregnancy Source: Ensembl
    11. frontal suture morphogenesis Source: Ensembl
    12. inner ear development Source: Ensembl
    13. in utero embryonic development Source: MGI
    14. lung alveolus development Source: BHF-UCL
    15. mammary gland development Source: MGI
    16. menstrual cycle phase Source: Ensembl
    17. negative regulation of cell proliferation Source: MGI
    18. negative regulation of DNA replication Source: Ensembl
    19. negative regulation of macrophage cytokine production Source: Ensembl
    20. negative regulation of neuron apoptotic process Source: MGI
    21. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    22. organ morphogenesis Source: MGI
    23. ossification involved in bone remodeling Source: Ensembl
    24. palate development Source: BHF-UCL
    25. positive regulation of apoptotic process Source: MGI
    26. positive regulation of bone mineralization Source: Ensembl
    27. positive regulation of cell division Source: UniProtKB-KW
    28. positive regulation of collagen biosynthetic process Source: Ensembl
    29. positive regulation of DNA replication Source: Ensembl
    30. positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
    31. positive regulation of filopodium assembly Source: MGI
    32. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    33. positive regulation of protein secretion Source: Ensembl
    34. positive regulation of SMAD protein import into nucleus Source: BHF-UCL
    35. positive regulation of transcription, DNA-templated Source: BHF-UCL
    36. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    37. response to estrogen Source: Ensembl
    38. response to laminar fluid shear stress Source: Ensembl
    39. response to progesterone Source: Ensembl
    40. salivary gland morphogenesis Source: Ensembl
    41. SMAD protein import into nucleus Source: Ensembl
    42. transforming growth factor beta receptor signaling pathway Source: Ensembl
    43. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_198998. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming growth factor beta-3
    Short name:
    TGF-beta-3
    Cleaved into the following chain:
    Gene namesi
    Name:Tgfb3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:98727. Tgfb3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular matrix Source: MGI
    3. extracellular space Source: Ensembl
    4. neuronal cell body Source: Ensembl
    5. nucleus Source: Ensembl
    6. secretory granule Source: Ensembl
    7. T-tubule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 298275Latency-associated peptideBy similarityPRO_0000033798Add
    BLAST
    Chaini299 – 410112Transforming growth factor beta-3PRO_0000033799Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi305 ↔ 314By similarity
    Disulfide bondi313 ↔ 376By similarity
    Disulfide bondi342 ↔ 407By similarity
    Disulfide bondi346 ↔ 409By similarity
    Disulfide bondi375 – 375InterchainBy similarity

    Post-translational modificationi

    The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP17125.

    PTM databases

    PhosphoSiteiP17125.

    Expressioni

    Tissue specificityi

    Expressed in both testis and ovary.

    Gene expression databases

    ArrayExpressiP17125.
    BgeeiP17125.
    CleanExiMM_TGFB3.
    GenevestigatoriP17125.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with ASPN By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP17125.
    SMRiP17125. Positions 22-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi259 – 2613Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG269146.
    HOVERGENiHBG074115.
    InParanoidiP17125.
    PhylomeDBiP17125.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    IPR015618. Transform_grow_fac_b3.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001787. TGF-beta. 1 hit.
    PRINTSiPR01423. TGFBETA.
    PR01426. TGFBETA3.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17125-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLQRALVVL ALLNLATISL SLSTCTTLDF GHIKKKRVEA IRGQILSKLR    50
    LTSPPEPSVM THVPYQVLAL YNSTRELLEE MHGEREEGCT QETSESEYYA 100
    KEIHKFDMIQ GLAEHNELAV CPKGITSKVF RFNVSSVEKN GTNLFRAEFR 150
    VLRVPNPSSK RTEQRIELFQ ILRPDEHIAK QRYIGGKNLP TRGTAEWLSF 200
    DVTDTVREWL LRRESNLGLE ISIHCPCHTF QPNGDILENV HEVMEIKFKG 250
    VDNEDDHGRG DLGRLKKQKD HHNPHLILMM IPPHRLDSPG QGSQRKKRAL 300
    DTNYCFRNLE ENCCVRPLYI DFRQDLGWKW VHEPKGYYAN FCSGPCPYLR 350
    SADTTHSTVL GLYNTLNPEA SASPCCVPQD LEPLTILYYV GRTPKVEQLS 400
    NMVVKSCKCS 410
    Length:410
    Mass (Da):46,885
    Last modified:August 1, 1990 - v1
    Checksum:i250F7048CA432BD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32745 mRNA. Translation: AAA40422.1.
    PIRiA41397.
    UniGeneiMm.3992.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32745 mRNA. Translation: AAA40422.1 .
    PIRi A41397.
    UniGenei Mm.3992.

    3D structure databases

    ProteinModelPortali P17125.
    SMRi P17125. Positions 22-410.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P17125.

    Proteomic databases

    PRIDEi P17125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98727. Tgfb3.

    Phylogenomic databases

    eggNOGi NOG269146.
    HOVERGENi HBG074115.
    InParanoidi P17125.
    PhylomeDBi P17125.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_198998. Molecules associated with elastic fibres.

    Miscellaneous databases

    PROi P17125.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17125.
    Bgeei P17125.
    CleanExi MM_TGFB3.
    Genevestigatori P17125.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    IPR015618. Transform_grow_fac_b3.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001787. TGF-beta. 1 hit.
    PRINTSi PR01423. TGFBETA.
    PR01426. TGFBETA3.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues."
      Miller D.A., Lee A., Matsui Y., Chen E.Y., Moses H.L., Derynck R.
      Mol. Endocrinol. 3:1926-1934(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning by polymerase chain reaction of a new mouse TGF-beta, mTGF-beta 3."
      Denhez F., Lafyatis R., Kondaiah P., Roberts A.B., Sporn M.B.
      Growth Factors 3:139-146(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cell lineage specificity of expression of the murine transforming growth factor beta 3 and transforming growth factor beta 1 genes."
      Watrin F., Scotto L., Assoian R.K., Wolgemuth D.J.
      Cell Growth Differ. 2:77-83(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 285-410.
      Tissue: Testis.

    Entry informationi

    Entry nameiTGFB3_MOUSE
    AccessioniPrimary (citable) accession number: P17125
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3