P17123 (SPO12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sporulation-specific protein 12

Gene names

Name:	SPO12
Ordered Locus Names:	YHR152W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	It is required for meiosis I chromosome division during sporulation. A component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Ref.4
Miscellaneous	Its negative tail is functionally important. Present with 937 molecules/cell in log phase SD medium. Ref.5

Ontologies

Keywords
Biological process	Meiosis Sporulation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	meiosis I Inferred from mutant phenotype. Source: SGD mitotic cell cycle Inferred from genetic interaction. Source: SGD regulation of exit from mitosis Inferred from genetic interaction Ref.4. Source: SGD sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Sporulation-specific protein 12		PRO_0000072133
Regions
	Region	159 – 173	15	Negative-charged tail

Sequences

	Sequence		Length	Mass (Da)
	P17123 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: E114394516451F60	FASTA	173	19,912
	10 20 30 40 50 60 MSNKASDQSA RTASILKTDI TRENTITRSS SSNNDNYHHH NNINNYNESA KTGEDANKEN 70 80 90 100 110 120 IPNLEEEIAA FRIFRKKSTS NLKSSHTTSN LVKKTMFKRD LLKQDPKRKL QLQQRFASPT 130 140 150 160 170 DRLVSPCSLK LNEHKVKMFG KKKKVNPMKL NFKGNLAADS EDVEIDEDEE YFY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complementary transcripts from two genes necessary for normal meiosis in the yeast Saccharomyces cerevisiae." Malavasic M.J., Elder R.T. Mol. Cell. Biol. 10:2809-2819(1990) [PubMed: 2188099] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase." Stegmeier F., Visintin R., Amon A. Cell 108:207-220(2002) [PubMed: 11832211] [Abstract] Cited for: FUNCTION AS A COMPONENT OF THE FEAR NETWORK.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M32653 Genomic DNA. Translation: AAA35076.1. U10397 Genomic DNA. Translation: AAB68979.1. BK006934 Genomic DNA. Translation: DAA06845.1.
PIR	B36321.
RefSeq	NP_012022.1. NM_001179283.1.
3D structure databases
ProteinModelPortal	P17123.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1654N.
IntAct	P17123. 35 interactions.
MINT	MINT-377178.
STRING	P17123.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR152W; YHR152W; YHR152W.
GeneID	856557.
KEGG	sce:YHR152W.
NMPDR	fig|4932.3.peg.3186.
Organism-specific databases
CYGD	YHR152w.
SGD	S000001195. SPO12.
Phylogenomic databases
eggNOG	fuNOG12891.
GeneTree	EFGT00050000008632.
OrthoDB	EOG41G6F0.
Gene expression databases
ArrayExpress	P17123.
Genevestigator	P17123.
GermOnline	YHR152W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007727. Spo12. [Graphical view]
KO	K12576.
Pfam	PF05032. Spo12. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982375.

Entry information

Entry name

SPO12_YEAST

Accession

Primary (citable) accession number: P17123
Secondary accession number(s): D3DLA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program