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Protein

Thermopsin

Gene

thpS

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May represent a new class of acid proteases. It digests proteins and peptides in acidic solution.

Catalytic activityi

Specificity similar to pepsin A, prefers bulky hydrophobic side-chains on either side of the scissible bond.

pH dependencei

Optimum pH is 2.

Temperature dependencei

Optimum temperature is 90 degrees Celsius. Thermostable.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.42. 6160.

Protein family/group databases

MEROPSiA05.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermopsin (EC:3.4.23.42)
Gene namesi
Name:thpS
Ordered Locus Names:Saci_1714
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

  • Secreted

  • Note: May be linked to cells by covalent linkages through some side chains.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000002849929 – 411 PublicationAdd BLAST13
ChainiPRO_000002850042 – 340ThermopsinAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Glycosylationi65N-linked (GlcNAc...)Curated1
Glycosylationi69N-linked (GlcNAc...)Curated1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi327N-linked (GlcNAc...)Sequence analysis1
Glycosylationi334N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Miscellaneous databases

PMAP-CutDBP17118.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiarCOG03670. Archaea.
ENOG4111JH3. LUCA.
HOGENOMiHOG000270793.
KOiK01385.

Family and domain databases

InterProiIPR007981. Peptidase_A5.
[Graphical view]
PfamiPF05317. Thermopsin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFKSICLII LLSALIIPYI PQNIYFFPHR NTTGATISSG LYVNPYLYYT
60 70 80 90 100
SPPAPAGIAS FGLYNYSGNV TPYVITTNEM LGYVNITSLL AYNREALRYG
110 120 130 140 150
VDPYSATLQF NIVLSVNTSN GVYAYWLQDV GQFQTNKNSL TFIDNVWNLT
160 170 180 190 200
GSLSTLSSSA ITGNGQVASA GGGQTFYYDV GPSYTYSFPL SYIYIINMSY
210 220 230 240 250
TSNAVYVWIG YEIIQIGQTE YGTVNYYDKI TIYQPNIISA SLMINGNNYT
260 270 280 290 300
PNGLYYDAEL VWGGGGNGAP TSFNSLNCTL GLYYISNGSI TPVPSLYTFG
310 320 330 340
ADTAEAAYNV YTTMNNGVPI AYNGIENLTI LTNNFSVILI
Length:340
Mass (Da):37,262
Last modified:August 1, 1990 - v1
Checksum:iE2758C0BC287FCE1
GO

Sequence cautioni

The sequence AAY81020 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05184 Genomic DNA. Translation: AAA72221.1.
CP000077 Genomic DNA. Translation: AAY81020.1. Different initiation.
PIRiA35009.
RefSeqiWP_015385662.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY81020; AAY81020; Saci_1714.
GeneIDi3474479.
KEGGisai:Saci_1714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05184 Genomic DNA. Translation: AAA72221.1.
CP000077 Genomic DNA. Translation: AAY81020.1. Different initiation.
PIRiA35009.
RefSeqiWP_015385662.1. NC_007181.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA05.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY81020; AAY81020; Saci_1714.
GeneIDi3474479.
KEGGisai:Saci_1714.

Phylogenomic databases

eggNOGiarCOG03670. Archaea.
ENOG4111JH3. LUCA.
HOGENOMiHOG000270793.
KOiK01385.

Enzyme and pathway databases

BRENDAi3.4.23.42. 6160.

Miscellaneous databases

PMAP-CutDBP17118.

Family and domain databases

InterProiIPR007981. Peptidase_A5.
[Graphical view]
PfamiPF05317. Thermopsin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHPS_SULAC
AccessioniPrimary (citable) accession number: P17118
Secondary accession number(s): Q4J861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.