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Protein

Interleukin-2

Gene

Il2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

  • carbohydrate binding Source: RGD
  • cytokine activity Source: RGD
  • glycosphingolipid binding Source: RGD
  • growth factor activity Source: UniProtKB-KW
  • interleukin-2 receptor binding Source: RGD
  • kappa-type opioid receptor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-392451. G beta:gamma signalling through PI3Kgamma.
R-RNO-451927. Interleukin-2 family signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:Il2
Synonyms:Il-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620047. Il2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001550021 – 155Interleukin-2Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi78 ↔ 126By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17108.
PRIDEiP17108.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017348.
GenevisibleiP17108. RN.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: RGD
  • growth factor activity Source: UniProtKB-KW
  • interleukin-2 receptor binding Source: RGD
  • kappa-type opioid receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023327.

Structurei

3D structure databases

ProteinModelPortaliP17108.
SMRiP17108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiP17108.
KOiK05429.
OMAiKWITFCQ.
OrthoDBiEOG091G0VTZ.
PhylomeDBiP17108.
TreeFamiTF338200.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
PANTHERiPTHR45426. PTHR45426. 1 hit.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00424. INTERLEUKIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSMQLASCV ALTLVLLVNS APTSSPAKET QQHLEQLLLD LQVLLRGIDN
60 70 80 90 100
YKNLKLPMML TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL
110 120 130 140 150
EDAGNFISNI RVTVVKLKGS ENKFECQFDD EPATVVEFLR RWIAICQSII

STMTQ
Length:155
Mass (Da):17,633
Last modified:August 1, 1990 - v1
Checksum:i67A8554A73BF30A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22899 mRNA. Translation: AAA41427.1.
PIRiA45882. A31278.
RefSeqiNP_446288.1. NM_053836.1.
UniGeneiRn.9871.

Genome annotation databases

EnsembliENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348.
GeneIDi116562.
KEGGirno:116562.
UCSCiRGD:620047. rat.

Similar proteinsi

Entry informationi

Entry nameiIL2_RAT
AccessioniPrimary (citable) accession number: P17108
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 22, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families