P17108 (IL2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-2
Short name=IL-2

Alternative name(s):
T-cell growth factor
Short name=TCGF

Gene names

Name:	Il2
Synonyms:	Il-2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-2 family.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway Inferred from mutant phenotype. Source: RGD elevation of cytosolic calcium ion concentration Inferred from direct assay. Source: RGD immune response Inferred from electronic annotation. Source: InterPro negative regulation of heart contraction Inferred from direct assay. Source: RGD negative regulation of protein phosphorylation Inferred from direct assay. Source: RGD positive regulation of dendritic spine development Inferred from direct assay. Source: RGD positive regulation of regulatory T cell differentiation Inferred from direct assay. Source: RGD
Cellular component	extracellular space Inferred from direct assay. Source: RGD
Molecular function	carbohydrate binding Inferred from direct assay. Source: RGD cytokine activity Inferred from direct assay. Source: RGD glycosphingolipid binding Inferred from direct assay. Source: RGD growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW interleukin-2 receptor binding Inferred from mutant phenotype. Source: RGD kappa-type opioid receptor binding Inferred from mutant phenotype. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 155	135	Interleukin-2		PRO_0000015500
Amino acid modifications
	Glycosylation	23	1	O-linked (GalNAc...) By similarity
	Disulfide bond	78 ↔ 126		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P17108 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 67A8554A73BF30A0	FASTA	155	17,633
	10 20 30 40 50 60 MYSMQLASCV ALTLVLLVNS APTSSPAKET QQHLEQLLLD LQVLLRGIDN YKNLKLPMML 70 80 90 100 110 120 TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL EDAGNFISNI RVTVVKLKGS 130 140 150 ENKFECQFDD EPATVVEFLR RWIAICQSII STMTQ

References

[1]	"Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin 2 cDNA probe to rat MHC class II-associated invariant chain mRNA." McKnight A.J., Mason D.W., Barclay A.N. Immunogenetics 30:145-147(1989) [PubMed: 2788130] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M22899 mRNA. Translation: AAA41427.1.
IPI	IPI00213555.
PIR	A31278. A45882.
RefSeq	NP_446288.1. NM_053836.1.
UniGene	Rn.9871.
3D structure databases
ProteinModelPortal	P17108.
SMR	P17108. Positions 21-154.
ModBase	Search...
Protein-protein interaction databases
STRING	P17108.
Proteomic databases
PRIDE	P17108.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348.
GeneID	116562.
KEGG	rno:116562.
UCSC	NM_053836. rat.
Organism-specific databases
CTD	3558.
RGD	620047. Il2.
Phylogenomic databases
eggNOG	roNOG17466.
GeneTree	ENSGT00390000003555.
HOVERGEN	HBG007496.
InParanoid	P17108.
OMA	KWITFCQ.
OrthoDB	EOG46Q6V2.
PhylomeDB	P17108.
Gene expression databases
ArrayExpress	P17108.
Genevestigator	P17108.
GermOnline	ENSRNOG00000017348. Rattus norvegicus.
Family and domain databases
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000779. Interleukin-2. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
KO	K05429.
PANTHER	PTHR11443. Interleukin-2. 1 hit.
Pfam	PF00715. IL2. 1 hit. [Graphical view]
PRINTS	PR00265. INTERLEUKIN2.
ProDom	PD003649. Interleukin-2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00189. IL2. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00424. INTERLEUKIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	619233.

Entry information

Entry name

IL2_RAT

Accession

Primary (citable) accession number: P17108

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	November 16, 2011
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program