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Protein

Interleukin-2

Gene

Il2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

  • carbohydrate binding Source: RGD
  • cytokine activity Source: RGD
  • glycosphingolipid binding Source: RGD
  • interleukin-2 receptor binding Source: RGD
  • kappa-type opioid receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-392451. G beta:gamma signalling through PI3Kgamma.
R-RNO-451927. Interleukin-2 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:Il2
Synonyms:Il-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620047. Il2.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 155135Interleukin-2PRO_0000015500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231O-linked (GalNAc...)By similarity
Disulfide bondi78 ↔ 126By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17108.
PRIDEiP17108.

Expressioni

Gene expression databases

GenevisibleiP17108. RN.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: RGD
  • interleukin-2 receptor binding Source: RGD
  • kappa-type opioid receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023327.

Structurei

3D structure databases

ProteinModelPortaliP17108.
SMRiP17108. Positions 21-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiP17108.
KOiK05429.
OMAiLMSNINV.
OrthoDBiEOG72RN13.
PhylomeDBiP17108.
TreeFamiTF338200.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSMQLASCV ALTLVLLVNS APTSSPAKET QQHLEQLLLD LQVLLRGIDN
60 70 80 90 100
YKNLKLPMML TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL
110 120 130 140 150
EDAGNFISNI RVTVVKLKGS ENKFECQFDD EPATVVEFLR RWIAICQSII

STMTQ
Length:155
Mass (Da):17,633
Last modified:August 1, 1990 - v1
Checksum:i67A8554A73BF30A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22899 mRNA. Translation: AAA41427.1.
PIRiA45882. A31278.
RefSeqiNP_446288.1. NM_053836.1.
UniGeneiRn.9871.

Genome annotation databases

EnsembliENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348.
GeneIDi116562.
KEGGirno:116562.
UCSCiRGD:620047. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22899 mRNA. Translation: AAA41427.1.
PIRiA45882. A31278.
RefSeqiNP_446288.1. NM_053836.1.
UniGeneiRn.9871.

3D structure databases

ProteinModelPortaliP17108.
SMRiP17108. Positions 21-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023327.

Proteomic databases

PaxDbiP17108.
PRIDEiP17108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348.
GeneIDi116562.
KEGGirno:116562.
UCSCiRGD:620047. rat.

Organism-specific databases

CTDi3558.
RGDi620047. Il2.

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiP17108.
KOiK05429.
OMAiLMSNINV.
OrthoDBiEOG72RN13.
PhylomeDBiP17108.
TreeFamiTF338200.

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-392451. G beta:gamma signalling through PI3Kgamma.
R-RNO-451927. Interleukin-2 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-912526. Interleukin receptor SHC signaling.

Miscellaneous databases

PROiP17108.

Gene expression databases

GenevisibleiP17108. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin 2 cDNA probe to rat MHC class II-associated invariant chain mRNA."
    McKnight A.J., Mason D.W., Barclay A.N.
    Immunogenetics 30:145-147(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL2_RAT
AccessioniPrimary (citable) accession number: P17108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.