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Protein

Zinc finger protein 8

Gene

ZNF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 8
Alternative name(s):
Zinc finger protein HF.18
Gene namesi
Name:ZNF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13154. ZNF8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37728.

Polymorphism and mutation databases

BioMutaiZNF8.
DMDMi55977777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Zinc finger protein 8PRO_0000047331Add
BLAST

Proteomic databases

EPDiP17098.
MaxQBiP17098.
PaxDbiP17098.
PeptideAtlasiP17098.
PRIDEiP17098.

PTM databases

iPTMnetiP17098.
PhosphoSiteiP17098.

Expressioni

Tissue specificityi

Ubiquitously present in many human cell lines of different embryological derivation.1 Publication

Gene expression databases

BgeeiP17098.
CleanExiHS_ZNF8.
GenevisibleiP17098. HS.

Organism-specific databases

HPAiHPA034797.
HPA034798.

Interactioni

Protein-protein interaction databases

BioGridi113386. 8 interactions.
IntActiP17098. 3 interactions.
STRINGi9606.ENSP00000196548.

Structurei

3D structure databases

ProteinModelPortaliP17098.
SMRiP17098. Positions 25-65, 219-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9672KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17098.
KOiK09228.
OMAiGENCVLS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17098.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEDEGVAG VMSVGPPAAR LQEPVTFRDV AVDFTQEEWG QLDPTQRILY
60 70 80 90 100
RDVMLETFGH LLSIGPELPK PEVISQLEQG TELWVAERGT TQGCHPAWEP
110 120 130 140 150
RSESQASRKE EGLPEEEPSH VTGREGFPTD APYPTTLGKD RECQSQSLAL
160 170 180 190 200
KEQNNLKQLE FGLKEAPVQD QGYKTLRLRE NCVLSSSPNP FPEISRGEYL
210 220 230 240 250
YTYDSQITDS EHNSSLVSQQ TGSPGKQPGE NSDCHRDSSQ AIPITELTKS
260 270 280 290 300
QVQDKPYKCT DCGKSFNHNA HLTVHKRIHT GERPYMCKEC GKAFSQNSSL
310 320 330 340 350
VQHERIHTGD KPYKCAECGK SFCHSTHLTV HRRIHTGEKP YECQDCGRAF
360 370 380 390 400
NQNSSLGRHK RTHTGEKPYT CSVCGKSFSR TTCLFLHLRT HTEERPYECN
410 420 430 440 450
HCGKGFRHSS SLAQHQRKHA GEKPFECRQR LIFEQTPALT KHEWTEALGC
460 470 480 490 500
DPPLSQDERT HRSDRPFKCN QCGKCFIQSS HLIRHQITHT REEQPHGRSR
510 520 530 540 550
RREQSSSRNS HLVQHQHPNS RKSSAGGAKA GQPESRALAL FDIQKIMQEK
560 570
NPVHVIGVEE PSVGASMLFD IREST
Length:575
Mass (Da):64,970
Last modified:November 23, 2004 - v2
Checksum:iE8F5B9C2FBED92C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601H → Y in AAA61314 (PubMed:2106481).Curated
Sequence conflicti172 – 1721G → A in AAA61314 (PubMed:2106481).Curated
Sequence conflicti528 – 5281A → R in AAA61314 (PubMed:2106481).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039323 mRNA. Translation: AAH39323.1.
M29581 mRNA. Translation: AAA61314.1.
CCDSiCCDS12974.1.
PIRiB34612.
RefSeqiNP_066575.2. NM_021089.2.
UniGeneiHs.590941.
Hs.713519.

Genome annotation databases

EnsembliENST00000621650; ENSP00000477716; ENSG00000278129.
GeneIDi7554.
KEGGihsa:7554.
UCSCiuc002qry.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039323 mRNA. Translation: AAH39323.1.
M29581 mRNA. Translation: AAA61314.1.
CCDSiCCDS12974.1.
PIRiB34612.
RefSeqiNP_066575.2. NM_021089.2.
UniGeneiHs.590941.
Hs.713519.

3D structure databases

ProteinModelPortaliP17098.
SMRiP17098. Positions 25-65, 219-531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113386. 8 interactions.
IntActiP17098. 3 interactions.
STRINGi9606.ENSP00000196548.

PTM databases

iPTMnetiP17098.
PhosphoSiteiP17098.

Polymorphism and mutation databases

BioMutaiZNF8.
DMDMi55977777.

Proteomic databases

EPDiP17098.
MaxQBiP17098.
PaxDbiP17098.
PeptideAtlasiP17098.
PRIDEiP17098.

Protocols and materials databases

DNASUi7554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621650; ENSP00000477716; ENSG00000278129.
GeneIDi7554.
KEGGihsa:7554.
UCSCiuc002qry.2. human.

Organism-specific databases

CTDi7554.
GeneCardsiZNF8.
HGNCiHGNC:13154. ZNF8.
HPAiHPA034797.
HPA034798.
MIMi194532. gene.
neXtProtiNX_P17098.
PharmGKBiPA37728.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17098.
KOiK09228.
OMAiGENCVLS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17098.
TreeFamiTF337055.

Miscellaneous databases

GeneWikiiZNF8.
GenomeRNAii7554.
PROiP17098.
SOURCEiSearch...

Gene expression databases

BgeeiP17098.
CleanExiHS_ZNF8.
GenevisibleiP17098. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes."
    Lania L., Donti E., Pannuti A., Pascucci A., Pengue G., Feliciello I., la Mantia G., Lanfrancone L., Pelicci P.-G.
    Genomics 6:333-340(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-575, TISSUE SPECIFICITY.
    Tissue: Placenta.

Entry informationi

Entry nameiZNF8_HUMAN
AccessioniPrimary (citable) accession number: P17098
Secondary accession number(s): Q6PI99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.