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Protein

Zinc finger protein 8

Gene

ZNF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083842-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 8
Alternative name(s):
Zinc finger protein HF.18
Gene namesi
Name:ZNF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13154. ZNF8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000278129.
PharmGKBiPA37728.

Polymorphism and mutation databases

BioMutaiZNF8.
DMDMi55977777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473311 – 575Zinc finger protein 8Add BLAST575

Proteomic databases

EPDiP17098.
MaxQBiP17098.
PaxDbiP17098.
PeptideAtlasiP17098.
PRIDEiP17098.

PTM databases

iPTMnetiP17098.
PhosphoSitePlusiP17098.

Expressioni

Tissue specificityi

Ubiquitously present in many human cell lines of different embryological derivation.1 Publication

Gene expression databases

CleanExiHS_ZNF8.
GenevisibleiP17098. HS.

Organism-specific databases

HPAiHPA034797.
HPA034798.

Interactioni

Subunit structurei

Interacts with SMAD1 (via MH1 and MH2 domains) (By similarity). Interacts with SMAD5 (PubMed:12370310). Interacts weakly with SMAD2 (By similarity). Interacts weakly with SMAD3 and SMAD4 (PubMed:12370310).By similarity1 Publication

Protein-protein interaction databases

BioGridi113386. 8 interactors.
IntActiP17098. 3 interactors.
STRINGi9606.ENSP00000196548.

Structurei

3D structure databases

ProteinModelPortaliP17098.
SMRiP17098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 96KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17098.
KOiK09228.
OMAiPYPTTLG.
OrthoDBiEOG091G02KC.
PhylomeDBiP17098.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEDEGVAG VMSVGPPAAR LQEPVTFRDV AVDFTQEEWG QLDPTQRILY
60 70 80 90 100
RDVMLETFGH LLSIGPELPK PEVISQLEQG TELWVAERGT TQGCHPAWEP
110 120 130 140 150
RSESQASRKE EGLPEEEPSH VTGREGFPTD APYPTTLGKD RECQSQSLAL
160 170 180 190 200
KEQNNLKQLE FGLKEAPVQD QGYKTLRLRE NCVLSSSPNP FPEISRGEYL
210 220 230 240 250
YTYDSQITDS EHNSSLVSQQ TGSPGKQPGE NSDCHRDSSQ AIPITELTKS
260 270 280 290 300
QVQDKPYKCT DCGKSFNHNA HLTVHKRIHT GERPYMCKEC GKAFSQNSSL
310 320 330 340 350
VQHERIHTGD KPYKCAECGK SFCHSTHLTV HRRIHTGEKP YECQDCGRAF
360 370 380 390 400
NQNSSLGRHK RTHTGEKPYT CSVCGKSFSR TTCLFLHLRT HTEERPYECN
410 420 430 440 450
HCGKGFRHSS SLAQHQRKHA GEKPFECRQR LIFEQTPALT KHEWTEALGC
460 470 480 490 500
DPPLSQDERT HRSDRPFKCN QCGKCFIQSS HLIRHQITHT REEQPHGRSR
510 520 530 540 550
RREQSSSRNS HLVQHQHPNS RKSSAGGAKA GQPESRALAL FDIQKIMQEK
560 570
NPVHVIGVEE PSVGASMLFD IREST
Length:575
Mass (Da):64,970
Last modified:November 23, 2004 - v2
Checksum:iE8F5B9C2FBED92C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60H → Y in AAA61314 (PubMed:2106481).Curated1
Sequence conflicti172G → A in AAA61314 (PubMed:2106481).Curated1
Sequence conflicti528A → R in AAA61314 (PubMed:2106481).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039323 mRNA. Translation: AAH39323.1.
M29581 mRNA. Translation: AAA61314.1.
CCDSiCCDS12974.1.
PIRiB34612.
RefSeqiNP_066575.2. NM_021089.2.
UniGeneiHs.590941.
Hs.713519.

Genome annotation databases

EnsembliENST00000621650; ENSP00000477716; ENSG00000278129.
GeneIDi7554.
KEGGihsa:7554.
UCSCiuc002qry.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039323 mRNA. Translation: AAH39323.1.
M29581 mRNA. Translation: AAA61314.1.
CCDSiCCDS12974.1.
PIRiB34612.
RefSeqiNP_066575.2. NM_021089.2.
UniGeneiHs.590941.
Hs.713519.

3D structure databases

ProteinModelPortaliP17098.
SMRiP17098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113386. 8 interactors.
IntActiP17098. 3 interactors.
STRINGi9606.ENSP00000196548.

PTM databases

iPTMnetiP17098.
PhosphoSitePlusiP17098.

Polymorphism and mutation databases

BioMutaiZNF8.
DMDMi55977777.

Proteomic databases

EPDiP17098.
MaxQBiP17098.
PaxDbiP17098.
PeptideAtlasiP17098.
PRIDEiP17098.

Protocols and materials databases

DNASUi7554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621650; ENSP00000477716; ENSG00000278129.
GeneIDi7554.
KEGGihsa:7554.
UCSCiuc002qry.2. human.

Organism-specific databases

CTDi7554.
GeneCardsiZNF8.
HGNCiHGNC:13154. ZNF8.
HPAiHPA034797.
HPA034798.
MIMi194532. gene.
neXtProtiNX_P17098.
OpenTargetsiENSG00000278129.
PharmGKBiPA37728.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17098.
KOiK09228.
OMAiPYPTTLG.
OrthoDBiEOG091G02KC.
PhylomeDBiP17098.
TreeFamiTF337055.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083842-MONOMER.

Miscellaneous databases

GeneWikiiZNF8.
GenomeRNAii7554.
PROiP17098.
SOURCEiSearch...

Gene expression databases

CleanExiHS_ZNF8.
GenevisibleiP17098. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF8_HUMAN
AccessioniPrimary (citable) accession number: P17098
Secondary accession number(s): Q6PI99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 172 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.