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Protein

Zinc finger protein 7

Gene

ZNF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri223 – 245C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147789-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 7
Alternative name(s):
Zinc finger protein HF.16
Zinc finger protein KOX4
Gene namesi
Name:ZNF7
Synonyms:KOX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:13139. ZNF7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7553.
OpenTargetsiENSG00000147789.
PharmGKBiPA37713.

Polymorphism and mutation databases

BioMutaiZNF7.
DMDMi141685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473301 – 686Zinc finger protein 7Add BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17097.
MaxQBiP17097.
PaxDbiP17097.
PeptideAtlasiP17097.
PRIDEiP17097.

PTM databases

iPTMnetiP17097.
PhosphoSitePlusiP17097.

Expressioni

Tissue specificityi

Ubiquitously present in many human cell lines of different embryological derivation.

Gene expression databases

BgeeiENSG00000147789.
CleanExiHS_ZNF7.
ExpressionAtlasiP17097. baseline and differential.
GenevisibleiP17097. HS.

Organism-specific databases

HPAiHPA030296.
HPA059090.

Interactioni

Protein-protein interaction databases

BioGridi113385. 8 interactors.
IntActiP17097. 4 interactors.
MINTiMINT-4657474.
STRINGi9606.ENSP00000320627.

Structurei

3D structure databases

ProteinModelPortaliP17097.
SMRiP17097.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 76KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri223 – 245C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133771.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17097.
KOiK09228.
OMAiNALEGST.
OrthoDBiEOG091G02KC.
PhylomeDBiP17097.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17097-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVVTFGDVA VHFSREEWQC LDPGQRALYR EVMLENHSSV AGLAGFLVFK
60 70 80 90 100
PELISRLEQG EEPWVLDLQG AEGTEAPRTS KTDSTIRTEN EQACEDMDIL
110 120 130 140 150
KSESYGTVVR ISPQDFPQNP GFGDVSDSEV WLDSHLGSPG LKVTGFTFQN
160 170 180 190 200
NCLNEETVVP KTFTKDAPQG CKELGSSGLD CQPLESQGES AEGMSQRCEE
210 220 230 240 250
CGKGIRATSD IALHWEINTQ KISRCQECQK KLSDCLQGKH TNNCHGEKPY
260 270 280 290 300
ECAECGKVFR LCSQLNQHQR IHTGEKPFKC TECGKAFRLS SKLIQHQRIH
310 320 330 340 350
TGEKPYRCEE CGKAFGQSSS LIHHQRIHTG ERPYGCRECG KAFSQQSQLV
360 370 380 390 400
RHQRTHTGER PYPCKECGKA FSQSSTLAQH QRMHTGEKAQ ILKASDSPSL
410 420 430 440 450
VAHQRIHAVE KPFKCDECGK AFRWISRLSQ HQLIHTGEKP YKCNKCTKAF
460 470 480 490 500
GCSSRLIRHQ RTHTGEKPFK CDECGKGFVQ GSHLIQHQRI HTGEKPYVCN
510 520 530 540 550
DCGKAFSQSS SLIYHQRIHK GEKPYECLQC GKAFSMSTQL TIHQRVHTGE
560 570 580 590 600
RPYKCNECGK AFSQNSTLFQ HQIIHAGVKP YECSECGKAF SRSSYLIEHQ
610 620 630 640 650
RIHTRAQWFY EYGNALEGST FVSRKKVNTI KKLHQCEDCE KIFRWRSHLI
660 670 680
IHQRIHTGEK PYKCNDCGKA FNRSSRLTQH QKIHMG
Length:686
Mass (Da):77,887
Last modified:August 1, 1990 - v1
Checksum:i0397ADDABEFD4FBF
GO
Isoform 2 (identifier: P17097-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGFLGCWCVSFQ

Show »
Length:697
Mass (Da):79,115
Checksum:iC9C248D00B217CE6
GO
Isoform 3 (identifier: P17097-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-148: DSTIRTENEQ...PGLKVTGFTF → GFLGRPTMGQ...RRGTSAIWMV
     149-686: Missing.

Show »
Length:148
Mass (Da):16,352
Checksum:iC5E94630F86C1300
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024191188G → R.1 PublicationCorresponds to variant rs1735169dbSNPEnsembl.1
Natural variantiVAR_052744347S → L.Corresponds to variant rs2228180dbSNPEnsembl.1
Natural variantiVAR_052745596L → F.Corresponds to variant rs1735170dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0548221M → MGFLGCWCVSFQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_05482383 – 148DSTIR…TGFTF → GFLGRPTMGQEPRHPHAPPA TPVPGLPKHCSQRLTLPPPG LSSSPLGHFLVHDQDRRRGT SAIWMV in isoform 3. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_054824149 – 686Missing in isoform 3. 1 PublicationAdd BLAST538

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29580 mRNA. Translation: AAA61313.1.
AK096025 mRNA. Translation: BAC04677.1.
AK300001 mRNA. Translation: BAG61820.1.
AF235103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82039.1.
CH471162 Genomic DNA. Translation: EAW82040.1.
CH471162 Genomic DNA. Translation: EAW82041.1.
BC058923 mRNA. Translation: AAH58923.1.
X52335 mRNA. Translation: CAA36561.1.
CCDSiCCDS6435.1. [P17097-1]
CCDS64996.1. [P17097-2]
CCDS64998.1. [P17097-3]
PIRiA34612.
RefSeqiNP_001269724.1. NM_001282795.1. [P17097-2]
NP_001269725.1. NM_001282796.1. [P17097-3]
NP_001269726.1. NM_001282797.1.
NP_001317552.1. NM_001330623.1.
NP_003407.1. NM_003416.3. [P17097-1]
XP_011515594.1. XM_011517292.2. [P17097-2]
XP_011515595.1. XM_011517293.2. [P17097-1]
XP_011515596.1. XM_011517294.2. [P17097-1]
UniGeneiHs.493218.

Genome annotation databases

EnsembliENST00000446747; ENSP00000393260; ENSG00000147789. [P17097-2]
ENST00000525266; ENSP00000435252; ENSG00000147789. [P17097-3]
ENST00000528372; ENSP00000432724; ENSG00000147789. [P17097-1]
GeneIDi7553.
KEGGihsa:7553.
UCSCiuc003zeh.4. human. [P17097-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29580 mRNA. Translation: AAA61313.1.
AK096025 mRNA. Translation: BAC04677.1.
AK300001 mRNA. Translation: BAG61820.1.
AF235103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82039.1.
CH471162 Genomic DNA. Translation: EAW82040.1.
CH471162 Genomic DNA. Translation: EAW82041.1.
BC058923 mRNA. Translation: AAH58923.1.
X52335 mRNA. Translation: CAA36561.1.
CCDSiCCDS6435.1. [P17097-1]
CCDS64996.1. [P17097-2]
CCDS64998.1. [P17097-3]
PIRiA34612.
RefSeqiNP_001269724.1. NM_001282795.1. [P17097-2]
NP_001269725.1. NM_001282796.1. [P17097-3]
NP_001269726.1. NM_001282797.1.
NP_001317552.1. NM_001330623.1.
NP_003407.1. NM_003416.3. [P17097-1]
XP_011515594.1. XM_011517292.2. [P17097-2]
XP_011515595.1. XM_011517293.2. [P17097-1]
XP_011515596.1. XM_011517294.2. [P17097-1]
UniGeneiHs.493218.

3D structure databases

ProteinModelPortaliP17097.
SMRiP17097.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113385. 8 interactors.
IntActiP17097. 4 interactors.
MINTiMINT-4657474.
STRINGi9606.ENSP00000320627.

PTM databases

iPTMnetiP17097.
PhosphoSitePlusiP17097.

Polymorphism and mutation databases

BioMutaiZNF7.
DMDMi141685.

Proteomic databases

EPDiP17097.
MaxQBiP17097.
PaxDbiP17097.
PeptideAtlasiP17097.
PRIDEiP17097.

Protocols and materials databases

DNASUi7553.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446747; ENSP00000393260; ENSG00000147789. [P17097-2]
ENST00000525266; ENSP00000435252; ENSG00000147789. [P17097-3]
ENST00000528372; ENSP00000432724; ENSG00000147789. [P17097-1]
GeneIDi7553.
KEGGihsa:7553.
UCSCiuc003zeh.4. human. [P17097-1]

Organism-specific databases

CTDi7553.
DisGeNETi7553.
GeneCardsiZNF7.
HGNCiHGNC:13139. ZNF7.
HPAiHPA030296.
HPA059090.
MIMi194531. gene.
neXtProtiNX_P17097.
OpenTargetsiENSG00000147789.
PharmGKBiPA37713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133771.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17097.
KOiK09228.
OMAiNALEGST.
OrthoDBiEOG091G02KC.
PhylomeDBiP17097.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147789-MONOMER.

Miscellaneous databases

ChiTaRSiZNF7. human.
GeneWikiiZNF7.
GenomeRNAii7553.
PROiP17097.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147789.
CleanExiHS_ZNF7.
ExpressionAtlasiP17097. baseline and differential.
GenevisibleiP17097. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF7_HUMAN
AccessioniPrimary (citable) accession number: P17097
Secondary accession number(s): B4DT08
, D3DWN6, P17015, Q8N8Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.