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P17097 (ZNF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 7
Alternative name(s):
Zinc finger protein HF.16
Zinc finger protein KOX4
Gene names
Name:ZNF7
Synonyms:KOX4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

Ubiquitously present in many human cell lines of different embryological derivation.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 15 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17097-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17097-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGFLGCWCVSFQ
Isoform 3 (identifier: P17097-3)

The sequence of this isoform differs from the canonical sequence as follows:
     83-148: DSTIRTENEQ...PGLKVTGFTF → GFLGRPTMGQ...RRGTSAIWMV
     149-686: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 686686Zinc finger protein 7
PRO_0000047330

Regions

Domain4 – 7673KRAB
Zinc finger223 – 24523C2H2-type 1
Zinc finger250 – 27223C2H2-type 2
Zinc finger278 – 30023C2H2-type 3
Zinc finger306 – 32823C2H2-type 4
Zinc finger334 – 35623C2H2-type 5
Zinc finger362 – 38423C2H2-type 6
Zinc finger413 – 43523C2H2-type 7
Zinc finger441 – 46323C2H2-type 8
Zinc finger469 – 49123C2H2-type 9
Zinc finger497 – 51923C2H2-type 10
Zinc finger525 – 54723C2H2-type 11
Zinc finger553 – 57523C2H2-type 12
Zinc finger581 – 60323C2H2-type 13
Zinc finger634 – 65623C2H2-type 14
Zinc finger662 – 68423C2H2-type 15

Amino acid modifications

Modified residue1261Phosphoserine Ref.8
Modified residue1381Phosphoserine Ref.8

Natural variations

Alternative sequence11M → MGFLGCWCVSFQ in isoform 2.
VSP_054822
Alternative sequence83 – 14866DSTIR…TGFTF → GFLGRPTMGQEPRHPHAPPA TPVPGLPKHCSQRLTLPPPG LSSSPLGHFLVHDQDRRRGT SAIWMV in isoform 3.
VSP_054823
Alternative sequence149 – 686538Missing in isoform 3.
VSP_054824
Natural variant1881G → R. Ref.4
Corresponds to variant rs1735169 [ dbSNP | Ensembl ].
VAR_024191
Natural variant3471S → L.
Corresponds to variant rs2228180 [ dbSNP | Ensembl ].
VAR_052744
Natural variant5961L → F.
Corresponds to variant rs1735170 [ dbSNP | Ensembl ].
VAR_052745

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 0397ADDABEFD4FBF

FASTA68677,887
        10         20         30         40         50         60 
MEVVTFGDVA VHFSREEWQC LDPGQRALYR EVMLENHSSV AGLAGFLVFK PELISRLEQG 

        70         80         90        100        110        120 
EEPWVLDLQG AEGTEAPRTS KTDSTIRTEN EQACEDMDIL KSESYGTVVR ISPQDFPQNP 

       130        140        150        160        170        180 
GFGDVSDSEV WLDSHLGSPG LKVTGFTFQN NCLNEETVVP KTFTKDAPQG CKELGSSGLD 

       190        200        210        220        230        240 
CQPLESQGES AEGMSQRCEE CGKGIRATSD IALHWEINTQ KISRCQECQK KLSDCLQGKH 

       250        260        270        280        290        300 
TNNCHGEKPY ECAECGKVFR LCSQLNQHQR IHTGEKPFKC TECGKAFRLS SKLIQHQRIH 

       310        320        330        340        350        360 
TGEKPYRCEE CGKAFGQSSS LIHHQRIHTG ERPYGCRECG KAFSQQSQLV RHQRTHTGER 

       370        380        390        400        410        420 
PYPCKECGKA FSQSSTLAQH QRMHTGEKAQ ILKASDSPSL VAHQRIHAVE KPFKCDECGK 

       430        440        450        460        470        480 
AFRWISRLSQ HQLIHTGEKP YKCNKCTKAF GCSSRLIRHQ RTHTGEKPFK CDECGKGFVQ 

       490        500        510        520        530        540 
GSHLIQHQRI HTGEKPYVCN DCGKAFSQSS SLIYHQRIHK GEKPYECLQC GKAFSMSTQL 

       550        560        570        580        590        600 
TIHQRVHTGE RPYKCNECGK AFSQNSTLFQ HQIIHAGVKP YECSECGKAF SRSSYLIEHQ 

       610        620        630        640        650        660 
RIHTRAQWFY EYGNALEGST FVSRKKVNTI KKLHQCEDCE KIFRWRSHLI IHQRIHTGEK 

       670        680 
PYKCNDCGKA FNRSSRLTQH QKIHMG 

« Hide

Isoform 2 [UniParc].

Checksum: C9C248D00B217CE6
Show »

FASTA69779,115
Isoform 3 [UniParc].

Checksum: C5E94630F86C1300
Show »

FASTA14816,352

References

« Hide 'large scale' references
[1]"cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes."
Lania L., Donti E., Pannuti A., Pascucci A., Pengue G., Feliciello I., la Mantia G., Lanfrancone L., Pelicci P.-G.
Genomics 6:333-340(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
[3]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-188.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Urinary bladder.
[6]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 413-468.
Tissue: Lymphoid tissue.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29580 mRNA. Translation: AAA61313.1.
AK096025 mRNA. Translation: BAC04677.1.
AK300001 mRNA. Translation: BAG61820.1.
AF235103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82039.1.
CH471162 Genomic DNA. Translation: EAW82040.1.
CH471162 Genomic DNA. Translation: EAW82041.1.
BC058923 mRNA. Translation: AAH58923.1.
X52335 mRNA. Translation: CAA36561.1.
CCDSCCDS6435.1.
PIRA34612.
RefSeqNP_001269724.1. NM_001282795.1. [P17097-2]
NP_001269725.1. NM_001282796.1. [P17097-3]
NP_001269726.1. NM_001282797.1.
NP_003407.1. NM_003416.3. [P17097-1]
XP_006716716.1. XM_006716653.1. [P17097-2]
UniGeneHs.493218.

3D structure databases

ProteinModelPortalP17097.
SMRP17097. Positions 168-684.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113385. 3 interactions.
IntActP17097. 2 interactions.
MINTMINT-4657474.
STRING9606.ENSP00000320627.

PTM databases

PhosphoSiteP17097.

Polymorphism databases

DMDM141685.

Proteomic databases

MaxQBP17097.
PaxDbP17097.
PRIDEP17097.

Protocols and materials databases

DNASU7553.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000325241; ENSP00000320627; ENSG00000147789.
ENST00000446747; ENSP00000393260; ENSG00000147789.
ENST00000525266; ENSP00000435252; ENSG00000147789.
ENST00000528372; ENSP00000432724; ENSG00000147789.
GeneID7553.
KEGGhsa:7553.
UCSCuc003zeg.4. human. [P17097-1]

Organism-specific databases

CTD7553.
GeneCardsGC08P146052.
HGNCHGNC:13139. ZNF7.
HPAHPA030296.
MIM194531. gene.
neXtProtNX_P17097.
PharmGKBPA37713.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP17097.
KOK09228.
OrthoDBEOG7KSX7Q.
PhylomeDBP17097.
TreeFamTF341817.

Gene expression databases

ArrayExpressP17097.
BgeeP17097.
CleanExHS_ZNF7.
GenevestigatorP17097.

Family and domain databases

Gene3D3.30.160.60. 15 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF7. human.
GeneWikiZNF7.
GenomeRNAi7553.
NextBio29551.
PROP17097.
SOURCESearch...

Entry information

Entry nameZNF7_HUMAN
AccessionPrimary (citable) accession number: P17097
Secondary accession number(s): B4DT08 expand/collapse secondary AC list , D3DWN6, P17015, Q8N8Y4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM