SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17097

- ZNF7_HUMAN

UniProt

P17097 - ZNF7_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein 7

Gene
ZNF7, KOX4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri223 – 24523C2H2-type 1Add
BLAST
Zinc fingeri250 – 27223C2H2-type 2Add
BLAST
Zinc fingeri278 – 30023C2H2-type 3Add
BLAST
Zinc fingeri306 – 32823C2H2-type 4Add
BLAST
Zinc fingeri334 – 35623C2H2-type 5Add
BLAST
Zinc fingeri362 – 38423C2H2-type 6Add
BLAST
Zinc fingeri413 – 43523C2H2-type 7Add
BLAST
Zinc fingeri441 – 46323C2H2-type 8Add
BLAST
Zinc fingeri469 – 49123C2H2-type 9Add
BLAST
Zinc fingeri497 – 51923C2H2-type 10Add
BLAST
Zinc fingeri525 – 54723C2H2-type 11Add
BLAST
Zinc fingeri553 – 57523C2H2-type 12Add
BLAST
Zinc fingeri581 – 60323C2H2-type 13Add
BLAST
Zinc fingeri634 – 65623C2H2-type 14Add
BLAST
Zinc fingeri662 – 68423C2H2-type 15Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. regulation of transcription, DNA-templated Source: RefGenome
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 7
Alternative name(s):
Zinc finger protein HF.16
Zinc finger protein KOX4
Gene namesi
Name:ZNF7
Synonyms:KOX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:13139. ZNF7.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Zinc finger protein 7PRO_0000047330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261Phosphoserine1 Publication
Modified residuei138 – 1381Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP17097.
PaxDbiP17097.
PRIDEiP17097.

PTM databases

PhosphoSiteiP17097.

Expressioni

Tissue specificityi

Ubiquitously present in many human cell lines of different embryological derivation.

Gene expression databases

ArrayExpressiP17097.
BgeeiP17097.
CleanExiHS_ZNF7.
GenevestigatoriP17097.

Organism-specific databases

HPAiHPA030296.

Interactioni

Protein-protein interaction databases

BioGridi113385. 3 interactions.
IntActiP17097. 2 interactions.
MINTiMINT-4657474.
STRINGi9606.ENSP00000320627.

Structurei

3D structure databases

ProteinModelPortaliP17097.
SMRiP17097. Positions 168-684.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7673KRABAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri223 – 24523C2H2-type 1Add
BLAST
Zinc fingeri250 – 27223C2H2-type 2Add
BLAST
Zinc fingeri278 – 30023C2H2-type 3Add
BLAST
Zinc fingeri306 – 32823C2H2-type 4Add
BLAST
Zinc fingeri334 – 35623C2H2-type 5Add
BLAST
Zinc fingeri362 – 38423C2H2-type 6Add
BLAST
Zinc fingeri413 – 43523C2H2-type 7Add
BLAST
Zinc fingeri441 – 46323C2H2-type 8Add
BLAST
Zinc fingeri469 – 49123C2H2-type 9Add
BLAST
Zinc fingeri497 – 51923C2H2-type 10Add
BLAST
Zinc fingeri525 – 54723C2H2-type 11Add
BLAST
Zinc fingeri553 – 57523C2H2-type 12Add
BLAST
Zinc fingeri581 – 60323C2H2-type 13Add
BLAST
Zinc fingeri634 – 65623C2H2-type 14Add
BLAST
Zinc fingeri662 – 68423C2H2-type 15Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17097.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17097.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P17097-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEVVTFGDVA VHFSREEWQC LDPGQRALYR EVMLENHSSV AGLAGFLVFK    50
PELISRLEQG EEPWVLDLQG AEGTEAPRTS KTDSTIRTEN EQACEDMDIL 100
KSESYGTVVR ISPQDFPQNP GFGDVSDSEV WLDSHLGSPG LKVTGFTFQN 150
NCLNEETVVP KTFTKDAPQG CKELGSSGLD CQPLESQGES AEGMSQRCEE 200
CGKGIRATSD IALHWEINTQ KISRCQECQK KLSDCLQGKH TNNCHGEKPY 250
ECAECGKVFR LCSQLNQHQR IHTGEKPFKC TECGKAFRLS SKLIQHQRIH 300
TGEKPYRCEE CGKAFGQSSS LIHHQRIHTG ERPYGCRECG KAFSQQSQLV 350
RHQRTHTGER PYPCKECGKA FSQSSTLAQH QRMHTGEKAQ ILKASDSPSL 400
VAHQRIHAVE KPFKCDECGK AFRWISRLSQ HQLIHTGEKP YKCNKCTKAF 450
GCSSRLIRHQ RTHTGEKPFK CDECGKGFVQ GSHLIQHQRI HTGEKPYVCN 500
DCGKAFSQSS SLIYHQRIHK GEKPYECLQC GKAFSMSTQL TIHQRVHTGE 550
RPYKCNECGK AFSQNSTLFQ HQIIHAGVKP YECSECGKAF SRSSYLIEHQ 600
RIHTRAQWFY EYGNALEGST FVSRKKVNTI KKLHQCEDCE KIFRWRSHLI 650
IHQRIHTGEK PYKCNDCGKA FNRSSRLTQH QKIHMG 686
Length:686
Mass (Da):77,887
Last modified:August 1, 1990 - v1
Checksum:i0397ADDABEFD4FBF
GO
Isoform 2 (identifier: P17097-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGFLGCWCVSFQ

Show »
Length:697
Mass (Da):79,115
Checksum:iC9C248D00B217CE6
GO
Isoform 3 (identifier: P17097-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-148: DSTIRTENEQ...PGLKVTGFTF → GFLGRPTMGQ...RRGTSAIWMV
     149-686: Missing.

Show »
Length:148
Mass (Da):16,352
Checksum:iC5E94630F86C1300
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti188 – 1881G → R.1 Publication
Corresponds to variant rs1735169 [ dbSNP | Ensembl ].
VAR_024191
Natural varianti347 – 3471S → L.
Corresponds to variant rs2228180 [ dbSNP | Ensembl ].
VAR_052744
Natural varianti596 – 5961L → F.
Corresponds to variant rs1735170 [ dbSNP | Ensembl ].
VAR_052745

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MGFLGCWCVSFQ in isoform 2. VSP_054822
Alternative sequencei83 – 14866DSTIR…TGFTF → GFLGRPTMGQEPRHPHAPPA TPVPGLPKHCSQRLTLPPPG LSSSPLGHFLVHDQDRRRGT SAIWMV in isoform 3. VSP_054823Add
BLAST
Alternative sequencei149 – 686538Missing in isoform 3. VSP_054824Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29580 mRNA. Translation: AAA61313.1.
AK096025 mRNA. Translation: BAC04677.1.
AK300001 mRNA. Translation: BAG61820.1.
AF235103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82039.1.
CH471162 Genomic DNA. Translation: EAW82040.1.
CH471162 Genomic DNA. Translation: EAW82041.1.
BC058923 mRNA. Translation: AAH58923.1.
X52335 mRNA. Translation: CAA36561.1.
CCDSiCCDS6435.1. [P17097-1]
CCDS64996.1. [P17097-2]
CCDS64998.1. [P17097-3]
PIRiA34612.
RefSeqiNP_001269724.1. NM_001282795.1. [P17097-2]
NP_001269725.1. NM_001282796.1. [P17097-3]
NP_001269726.1. NM_001282797.1.
NP_003407.1. NM_003416.3. [P17097-1]
XP_006716716.1. XM_006716653.1. [P17097-2]
UniGeneiHs.493218.

Genome annotation databases

EnsembliENST00000325241; ENSP00000320627; ENSG00000147789.
ENST00000446747; ENSP00000393260; ENSG00000147789.
ENST00000525266; ENSP00000435252; ENSG00000147789.
ENST00000528372; ENSP00000432724; ENSG00000147789.
GeneIDi7553.
KEGGihsa:7553.
UCSCiuc003zeg.4. human. [P17097-1]
uc003zeh.2. human.

Polymorphism databases

DMDMi141685.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29580 mRNA. Translation: AAA61313.1 .
AK096025 mRNA. Translation: BAC04677.1 .
AK300001 mRNA. Translation: BAG61820.1 .
AF235103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82039.1 .
CH471162 Genomic DNA. Translation: EAW82040.1 .
CH471162 Genomic DNA. Translation: EAW82041.1 .
BC058923 mRNA. Translation: AAH58923.1 .
X52335 mRNA. Translation: CAA36561.1 .
CCDSi CCDS6435.1. [P17097-1 ]
CCDS64996.1. [P17097-2 ]
CCDS64998.1. [P17097-3 ]
PIRi A34612.
RefSeqi NP_001269724.1. NM_001282795.1. [P17097-2 ]
NP_001269725.1. NM_001282796.1. [P17097-3 ]
NP_001269726.1. NM_001282797.1.
NP_003407.1. NM_003416.3. [P17097-1 ]
XP_006716716.1. XM_006716653.1. [P17097-2 ]
UniGenei Hs.493218.

3D structure databases

ProteinModelPortali P17097.
SMRi P17097. Positions 168-684.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113385. 3 interactions.
IntActi P17097. 2 interactions.
MINTi MINT-4657474.
STRINGi 9606.ENSP00000320627.

PTM databases

PhosphoSitei P17097.

Polymorphism databases

DMDMi 141685.

Proteomic databases

MaxQBi P17097.
PaxDbi P17097.
PRIDEi P17097.

Protocols and materials databases

DNASUi 7553.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325241 ; ENSP00000320627 ; ENSG00000147789 .
ENST00000446747 ; ENSP00000393260 ; ENSG00000147789 .
ENST00000525266 ; ENSP00000435252 ; ENSG00000147789 .
ENST00000528372 ; ENSP00000432724 ; ENSG00000147789 .
GeneIDi 7553.
KEGGi hsa:7553.
UCSCi uc003zeg.4. human. [P17097-1 ]
uc003zeh.2. human.

Organism-specific databases

CTDi 7553.
GeneCardsi GC08P146052.
HGNCi HGNC:13139. ZNF7.
HPAi HPA030296.
MIMi 194531. gene.
neXtProti NX_P17097.
PharmGKBi PA37713.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P17097.
KOi K09228.
OrthoDBi EOG7KSX7Q.
PhylomeDBi P17097.
TreeFami TF341817.

Miscellaneous databases

ChiTaRSi ZNF7. human.
GeneWikii ZNF7.
GenomeRNAii 7553.
NextBioi 29551.
PROi P17097.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17097.
Bgeei P17097.
CleanExi HS_ZNF7.
Genevestigatori P17097.

Family and domain databases

Gene3Di 3.30.160.60. 15 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes."
    Lania L., Donti E., Pannuti A., Pascucci A., Pengue G., Feliciello I., la Mantia G., Lanfrancone L., Pelicci P.-G.
    Genomics 6:333-340(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-188.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Urinary bladder.
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 413-468.
    Tissue: Lymphoid tissue.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126 AND SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiZNF7_HUMAN
AccessioniPrimary (citable) accession number: P17097
Secondary accession number(s): B4DT08
, D3DWN6, P17015, Q8N8Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 3, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi