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Protein

High mobility group protein HMG-I/HMG-Y

Gene

HMGA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 31A.T hook 1Add BLAST11
DNA bindingi53 – 63A.T hook 2Add BLAST11
DNA bindingi78 – 89A.T hook 3Add BLAST12

GO - Molecular functioni

  • 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
  • AT DNA binding Source: UniProtKB
  • chromatin binding Source: BHF-UCL
  • DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB
  • DNA binding Source: ProtInc
  • enzyme binding Source: UniProtKB
  • ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  • peroxisome proliferator activated receptor binding Source: UniProtKB
  • retinoic acid receptor binding Source: UniProtKB
  • retinoid X receptor binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding Source: BHF-UCL
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • base-excision repair Source: UniProtKB
  • DNA unwinding involved in DNA replication Source: UniProtKB
  • establishment of integrated proviral latency Source: Reactome
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of chromatin silencing Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nuclear transport Source: Reactome
  • nucleosome disassembly Source: UniProtKB
  • oncogene-induced cell senescence Source: UniProtKB
  • positive regulation of cellular senescence Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • protein complex assembly Source: UniProtKB
  • regulation of transcription, DNA-templated Source: ProtInc
  • response to virus Source: UniProtKB
  • senescence-associated heterochromatin focus assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137309-MONOMER.
ReactomeiR-HSA-162592. Integration of provirus.
R-HSA-164843. 2-LTR circle formation.
R-HSA-175567. Integration of viral DNA into host genomic DNA.
R-HSA-177539. Autointegration results in viral DNA circles.
R-HSA-180689. APOBEC3G mediated resistance to HIV-1 infection.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-2559584. Formation of Senescence-Associated Heterochromatin Foci (SAHF).
SignaLinkiP17096.
SIGNORiP17096.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein HMG-I/HMG-Y
Short name:
HMG-I(Y)
Alternative name(s):
High mobility group AT-hook protein 1
Short name:
High mobility group protein A1
High mobility group protein R
Gene namesi
Name:HMGA1
Synonyms:HMGIY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:5010. HMGA1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • focal adhesion Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • RNA polymerase II transcription factor complex Source: BHF-UCL
  • senescence-associated heterochromatin focus Source: UniProtKB
  • transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26R → A: Does not affect methylation by PRMT6. 1 Publication1
Mutagenesisi58R → A: Decreases methylation by PRMT6. Abolishes methylation by PRMT6; when associated with A-60. 1 Publication1
Mutagenesisi60R → A: Decreases methylation by PRMT6. Abolishes methylation by PRMT6; when associated with A-58. 1 Publication1

Organism-specific databases

DisGeNETi3159.
MalaCardsiHMGA1.
OpenTargetsiENSG00000137309.
PharmGKBiPA35094.

Polymorphism and mutation databases

BioMutaiHMGA1.
DMDMi123377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002067082 – 107High mobility group protein HMG-I/HMG-YAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei7N6-acetyllysineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei26Asymmetric dimethylarginine; alternate2 Publications1
Modified residuei26Omega-N-methylarginine; alternate2 Publications1
Modified residuei26Symmetric dimethylarginine; alternate2 Publications1
Modified residuei36Phosphoserine; by HIPK2 and CDC2Combined sources1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei53Phosphothreonine; by HIPK2 and CDC2Combined sources1
Modified residuei58Asymmetric dimethylarginine; by PRMT6; alternate1 Publication1
Modified residuei58Omega-N-methylarginine; by PRMT6; alternate1 Publication1
Modified residuei60Asymmetric dimethylarginine; by PRMT6; alternate1 Publication1
Modified residuei60Omega-N-methylarginine; by PRMT6; alternate1 Publication1
Modified residuei78Phosphothreonine; by HIPK2 and CDC21 Publication1
Modified residuei99PhosphoserineCombined sources1 Publication1
Modified residuei102Phosphoserine; by CKCombined sources1 Publication1
Modified residuei103Phosphoserine; by CKCombined sources1 Publication1
Isoform HMG-Y (identifier: P17096-2)
Modified residuei42PhosphothreonineCombined sources1
Modified residuei67PhosphothreonineCombined sources1

Post-translational modificationi

Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.2 Publications
HMG-Y is not methylated.
Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP17096.
MaxQBiP17096.
PaxDbiP17096.
PeptideAtlasiP17096.
PRIDEiP17096.
TopDownProteomicsiP17096-1. [P17096-1]
P17096-2. [P17096-2]
P17096-3. [P17096-3]

PTM databases

iPTMnetiP17096.
PhosphoSitePlusiP17096.

Expressioni

Gene expression databases

BgeeiENSG00000137309.
CleanExiHS_HMGA1.
ExpressionAtlasiP17096. baseline and differential.
GenevisibleiP17096. HS.

Organism-specific databases

HPAiCAB032200.

Interactioni

Subunit structurei

Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complex.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT6Q96LA84EBI-746854,EBI-912440

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • peroxisome proliferator activated receptor binding Source: UniProtKB
  • retinoic acid receptor binding Source: UniProtKB
  • retinoid X receptor binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109402. 93 interactors.
DIPiDIP-29687N.
IntActiP17096. 52 interactors.
MINTiMINT-262941.
STRINGi9606.ENSP00000308227.

Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi53 – 55Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EZDNMR-A51-71[»]
2EZENMR-A51-75[»]
2EZFNMR-A80-89[»]
2EZGNMR-A80-89[»]
DisProtiDP00040.
ProteinModelPortaliP17096.
SMRiP17096.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 77Interaction with HIPK2By similarityAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi91 – 106Glu-rich (acidic)Add BLAST16

Sequence similaritiesi

Belongs to the HMGA family.Curated
Contains 3 A.T hook DNA-binding domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J4ZT. Eukaryota.
ENOG410Z566. LUCA.
GeneTreeiENSGT00730000111329.
HOGENOMiHOG000076308.
HOVERGENiHBG063451.
InParanoidiP17096.
KOiK09282.
OMAiKPQVSAN.
TreeFamiTF351623.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGA.
IPR031079. HMGA1_mammal.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view]
PANTHERiPTHR23341:SF1. PTHR23341:SF1. 1 hit.
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiSM00384. AT_hook. 3 hits.
[Graphical view]
PROSITEiPS00354. HMGI_Y. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform HMG-I (identifier: P17096-1) [UniParc]FASTAAdd to basket
Also known as: HMGA1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE
60 70 80 90 100
VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ

ESSEEEQ
Length:107
Mass (Da):11,676
Last modified:January 23, 2007 - v3
Checksum:iE9C4E3F2200914B8
GO
Isoform HMG-Y (identifier: P17096-2) [UniParc]FASTAAdd to basket
Also known as: HMGA1b

The sequence of this isoform differs from the canonical sequence as follows:
     35-45: Missing.

Show »
Length:96
Mass (Da):10,679
Checksum:iB82DCAA29E6D18FD
GO
Isoform HMG-R (identifier: P17096-3) [UniParc]FASTAAdd to basket
Also known as: HMGA1c

The sequence of this isoform differs from the canonical sequence as follows:
     66-107: NKGAAKTRKT...ISQESSEEEQ → KNWRRRKRRA...RIHTCPPGQG

Show »
Length:179
Mass (Da):19,694
Checksum:i91E56E235C504AAA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107Q → QQQ AA sequence (PubMed:2920035).Curated1

Mass spectrometryi

Isoform HMG-I : Molecular mass is 11750±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl and 2 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11828±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl and 3 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11765±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl, 1 methyl and 2 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11844±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl, 1 methyl and 3 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11780±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl, 2 methyl and 2 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11858±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl, 2 methyl and 3 phosphate groups.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00218235 – 45Missing in isoform HMG-Y. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_01808466 – 107NKGAA…SEEEQ → KNWRRRKRRASRRSPRRRSS DPCVPPAPHWRSSFLLGLDS FAPLPPPPPLPQAHHHHRLW PPPPSSTCALTTTLHSTPAA AGLPWAEWGAVFPWPQFPAP PAHPRIHTCPPGQG in isoform HMG-R. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14957 mRNA. Translation: CAA33080.1.
X14958 mRNA. Translation: CAA33081.1.
M23614 mRNA. Translation: AAA88072.1.
M23615 mRNA. Translation: AAA88073.1.
M23616 mRNA. Translation: AAA88074.1.
M23617 mRNA. Translation: AAA88075.1.
M23618 mRNA. Translation: AAA88076.1.
M23619 mRNA. Translation: AAA35998.1.
L17131 Genomic DNA. Translation: AAB00145.1.
AF176039 mRNA. Translation: AAD53889.1.
AL354740 Genomic DNA. Translation: CAI14991.1.
BC004924 mRNA. Translation: AAH04924.1.
BC008832 mRNA. Translation: AAH08832.1.
BC063434 mRNA. Translation: AAH63434.1.
BC067083 mRNA. Translation: AAH67083.1.
BC071864 mRNA. Translation: AAH71864.1.
CCDSiCCDS4788.1. [P17096-2]
CCDS4789.1. [P17096-1]
PIRiA32794.
RefSeqiNP_001306006.1. NM_001319077.1. [P17096-2]
NP_001306007.1. NM_001319078.1. [P17096-1]
NP_001306008.1. NM_001319079.1. [P17096-1]
NP_001306009.1. NM_001319080.1.
NP_001306010.1. NM_001319081.1. [P17096-1]
NP_001306011.1. NM_001319082.1. [P17096-1]
NP_002122.1. NM_002131.3. [P17096-2]
NP_665906.1. NM_145899.2. [P17096-1]
NP_665908.1. NM_145901.2. [P17096-1]
NP_665909.1. NM_145902.2. [P17096-2]
NP_665910.1. NM_145903.2. [P17096-2]
NP_665912.1. NM_145905.2. [P17096-2]
UniGeneiHs.518805.
Hs.696527.
Hs.703764.

Genome annotation databases

EnsembliENST00000311487; ENSP00000308227; ENSG00000137309. [P17096-1]
ENST00000347617; ENSP00000288245; ENSG00000137309. [P17096-2]
ENST00000374116; ENSP00000363230; ENSG00000137309. [P17096-2]
ENST00000401473; ENSP00000385693; ENSG00000137309. [P17096-2]
ENST00000447654; ENSP00000399888; ENSG00000137309. [P17096-1]
GeneIDi3159.
KEGGihsa:3159.
UCSCiuc003oit.4. human. [P17096-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14957 mRNA. Translation: CAA33080.1.
X14958 mRNA. Translation: CAA33081.1.
M23614 mRNA. Translation: AAA88072.1.
M23615 mRNA. Translation: AAA88073.1.
M23616 mRNA. Translation: AAA88074.1.
M23617 mRNA. Translation: AAA88075.1.
M23618 mRNA. Translation: AAA88076.1.
M23619 mRNA. Translation: AAA35998.1.
L17131 Genomic DNA. Translation: AAB00145.1.
AF176039 mRNA. Translation: AAD53889.1.
AL354740 Genomic DNA. Translation: CAI14991.1.
BC004924 mRNA. Translation: AAH04924.1.
BC008832 mRNA. Translation: AAH08832.1.
BC063434 mRNA. Translation: AAH63434.1.
BC067083 mRNA. Translation: AAH67083.1.
BC071864 mRNA. Translation: AAH71864.1.
CCDSiCCDS4788.1. [P17096-2]
CCDS4789.1. [P17096-1]
PIRiA32794.
RefSeqiNP_001306006.1. NM_001319077.1. [P17096-2]
NP_001306007.1. NM_001319078.1. [P17096-1]
NP_001306008.1. NM_001319079.1. [P17096-1]
NP_001306009.1. NM_001319080.1.
NP_001306010.1. NM_001319081.1. [P17096-1]
NP_001306011.1. NM_001319082.1. [P17096-1]
NP_002122.1. NM_002131.3. [P17096-2]
NP_665906.1. NM_145899.2. [P17096-1]
NP_665908.1. NM_145901.2. [P17096-1]
NP_665909.1. NM_145902.2. [P17096-2]
NP_665910.1. NM_145903.2. [P17096-2]
NP_665912.1. NM_145905.2. [P17096-2]
UniGeneiHs.518805.
Hs.696527.
Hs.703764.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EZDNMR-A51-71[»]
2EZENMR-A51-75[»]
2EZFNMR-A80-89[»]
2EZGNMR-A80-89[»]
DisProtiDP00040.
ProteinModelPortaliP17096.
SMRiP17096.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109402. 93 interactors.
DIPiDIP-29687N.
IntActiP17096. 52 interactors.
MINTiMINT-262941.
STRINGi9606.ENSP00000308227.

PTM databases

iPTMnetiP17096.
PhosphoSitePlusiP17096.

Polymorphism and mutation databases

BioMutaiHMGA1.
DMDMi123377.

Proteomic databases

EPDiP17096.
MaxQBiP17096.
PaxDbiP17096.
PeptideAtlasiP17096.
PRIDEiP17096.
TopDownProteomicsiP17096-1. [P17096-1]
P17096-2. [P17096-2]
P17096-3. [P17096-3]

Protocols and materials databases

DNASUi3159.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311487; ENSP00000308227; ENSG00000137309. [P17096-1]
ENST00000347617; ENSP00000288245; ENSG00000137309. [P17096-2]
ENST00000374116; ENSP00000363230; ENSG00000137309. [P17096-2]
ENST00000401473; ENSP00000385693; ENSG00000137309. [P17096-2]
ENST00000447654; ENSP00000399888; ENSG00000137309. [P17096-1]
GeneIDi3159.
KEGGihsa:3159.
UCSCiuc003oit.4. human. [P17096-1]

Organism-specific databases

CTDi3159.
DisGeNETi3159.
GeneCardsiHMGA1.
HGNCiHGNC:5010. HMGA1.
HPAiCAB032200.
MalaCardsiHMGA1.
MIMi600701. gene.
neXtProtiNX_P17096.
OpenTargetsiENSG00000137309.
PharmGKBiPA35094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4ZT. Eukaryota.
ENOG410Z566. LUCA.
GeneTreeiENSGT00730000111329.
HOGENOMiHOG000076308.
HOVERGENiHBG063451.
InParanoidiP17096.
KOiK09282.
OMAiKPQVSAN.
TreeFamiTF351623.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137309-MONOMER.
ReactomeiR-HSA-162592. Integration of provirus.
R-HSA-164843. 2-LTR circle formation.
R-HSA-175567. Integration of viral DNA into host genomic DNA.
R-HSA-177539. Autointegration results in viral DNA circles.
R-HSA-180689. APOBEC3G mediated resistance to HIV-1 infection.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-2559584. Formation of Senescence-Associated Heterochromatin Foci (SAHF).
SignaLinkiP17096.
SIGNORiP17096.

Miscellaneous databases

ChiTaRSiHMGA1. human.
GeneWikiiHMGA1.
GenomeRNAii3159.
PROiP17096.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137309.
CleanExiHS_HMGA1.
ExpressionAtlasiP17096. baseline and differential.
GenevisibleiP17096. HS.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGA.
IPR031079. HMGA1_mammal.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view]
PANTHERiPTHR23341:SF1. PTHR23341:SF1. 1 hit.
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiSM00384. AT_hook. 3 hits.
[Graphical view]
PROSITEiPS00354. HMGI_Y. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGA1_HUMAN
AccessioniPrimary (citable) accession number: P17096
Secondary accession number(s): P10910, Q5T6U9, Q9UKB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 196 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.