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Protein

High mobility group protein HMG-I/HMG-Y

Gene

Hmga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 31A.T hook 1Add BLAST11
DNA bindingi53 – 63A.T hook 2Add BLAST11
DNA bindingi78 – 89A.T hook 3Add BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-2559584. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein HMG-I/HMG-Y
Short name:
HMG-I(Y)
Alternative name(s):
High mobility group AT-hook protein 1
Short name:
High mobility group protein A1
Gene namesi
Name:Hmga1
Synonyms:Hmgi, Hmgiy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 11, Chromosome 17

Organism-specific databases

MGIiMGI:96160. Hmga1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002067092 – 107High mobility group protein HMG-I/HMG-YAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei9PhosphoserineBy similarity1
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei26Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei26Omega-N-methylarginine; alternateBy similarity1
Modified residuei26Symmetric dimethylarginine; alternateBy similarity1
Modified residuei36Phosphoserine; by HIPK2 and CDC2By similarity1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei44Phosphoserine1 Publication1
Modified residuei49Phosphoserine1 Publication1
Modified residuei53Phosphothreonine; by HIPK2 and CDC2Combined sources1
Modified residuei58Asymmetric dimethylarginine; by PRMT6; alternateBy similarity1
Modified residuei58Omega-N-methylarginine; by PRMT6; alternateBy similarity1
Modified residuei60Asymmetric dimethylarginine; by PRMT6; alternateBy similarity1
Modified residuei60Omega-N-methylarginine; by PRMT6; alternateBy similarity1
Modified residuei99PhosphoserineCombined sources1 Publication1
Modified residuei102PhosphoserineCombined sources1 Publication1
Modified residuei103PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation may modulate DNA-binding affinity (By similarity).By similarity
Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP17095.
PaxDbiP17095.
PeptideAtlasiP17095.
PRIDEiP17095.
TopDownProteomicsiP17095-1. [P17095-1]
P17095-2. [P17095-2]

PTM databases

iPTMnetiP17095.
PhosphoSitePlusiP17095.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046711.
CleanExiMM_HMGA1.
ExpressionAtlasiP17095. baseline and differential.
GenevisibleiP17095. MM.

Interactioni

Subunit structurei

Interacts with HIPK2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200340. 8 interactors.
DIPiDIP-53N.
IntActiP17095. 4 interactors.
MINTiMINT-1848156.
STRINGi10090.ENSMUSP00000113011.

Structurei

3D structure databases

ProteinModelPortaliP17095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 77Interaction with HIPK21 PublicationAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi91 – 106Glu-rich (acidic)Add BLAST16

Sequence similaritiesi

Belongs to the HMGA family.Curated
Contains 3 A.T hook DNA-binding domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J4ZT. Eukaryota.
ENOG410Z566. LUCA.
GeneTreeiENSGT00730000111329.
HOGENOMiHOG000076308.
HOVERGENiHBG063451.
InParanoidiP17095.
KOiK09282.
OMAiKPQVSAN.
PhylomeDBiP17095.
TreeFamiTF351623.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGA.
IPR031079. HMGA1_mammal.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view]
PANTHERiPTHR23341:SF1. PTHR23341:SF1. 1 hit.
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiSM00384. AT_hook. 3 hits.
[Graphical view]
PROSITEiPS00354. HMGI_Y. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform HMG-I (identifier: P17095-2) [UniParc]FASTAAdd to basket
Also known as: HMGA1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESGSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE
60 70 80 90 100
VPTPKRPRGR PKGSKNKGAA KTRKVTTAPG RKPRGRPKKL EKEEEEGISQ

ESSEEEQ
Length:107
Mass (Da):11,614
Last modified:January 23, 2007 - v4
Checksum:i4EC39386611959FC
GO
Isoform HMG-Y (identifier: P17095-1) [UniParc]FASTAAdd to basket
Also known as: HMGA1b, HMGI-E

The sequence of this isoform differs from the canonical sequence as follows:
     35-45: Missing.

Show »
Length:96
Mass (Da):10,617
Checksum:iA77A3FD7CA6C08EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106E → G in AAK66158 (PubMed:11410365).Curated1
Sequence conflicti106E → G in AAK66159 (PubMed:11410365).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01240635 – 45Missing in isoform HMG-Y. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04179 mRNA. Translation: AAA37820.1.
AF285780 Genomic DNA. Translation: AAK66158.1.
AF285780 Genomic DNA. Translation: AAK66159.1.
AK010617 mRNA. Translation: BAB27065.1.
BC013455 mRNA. Translation: AAH13455.1.
CCDSiCCDS28564.1. [P17095-2]
CCDS49010.1. [P17095-2]
CCDS50044.1. [P17095-1]
PIRiA31895.
RefSeqiNP_001020598.1. NM_001025427.3. [P17095-2]
NP_001034445.1. NM_001039356.2. [P17095-2]
NP_001159948.1. NM_001166476.1. [P17095-2]
NP_001159949.1. NM_001166477.1. [P17095-1]
NP_001160007.1. NM_001166535.1. [P17095-2]
NP_001160008.1. NM_001166536.1. [P17095-2]
NP_001160009.1. NM_001166537.1. [P17095-1]
NP_001160011.1. NM_001166539.1. [P17095-1]
NP_001160012.1. NM_001166540.1. [P17095-1]
NP_001160013.1. NM_001166541.1. [P17095-1]
NP_001160014.1. NM_001166542.1. [P17095-1]
NP_057869.2. NM_016660.3. [P17095-2]
UniGeneiMm.426212.
Mm.440289.
Mm.4438.

Genome annotation databases

EnsembliENSMUST00000105046; ENSMUSP00000100667; ENSMUSG00000078249. [P17095-2]
ENSMUST00000114888; ENSMUSP00000110538; ENSMUSG00000046711. [P17095-1]
ENSMUST00000117254; ENSMUSP00000113011; ENSMUSG00000046711. [P17095-2]
ENSMUST00000117600; ENSMUSP00000113068; ENSMUSG00000046711. [P17095-2]
ENSMUST00000118570; ENSMUSP00000114101; ENSMUSG00000046711. [P17095-1]
ENSMUST00000118599; ENSMUSP00000113015; ENSMUSG00000046711. [P17095-2]
ENSMUST00000119486; ENSMUSP00000113916; ENSMUSG00000046711. [P17095-2]
GeneIDi111241.
15361.
KEGGimmu:111241.
mmu:15361.
UCSCiuc008boz.2. mouse. [P17095-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04179 mRNA. Translation: AAA37820.1.
AF285780 Genomic DNA. Translation: AAK66158.1.
AF285780 Genomic DNA. Translation: AAK66159.1.
AK010617 mRNA. Translation: BAB27065.1.
BC013455 mRNA. Translation: AAH13455.1.
CCDSiCCDS28564.1. [P17095-2]
CCDS49010.1. [P17095-2]
CCDS50044.1. [P17095-1]
PIRiA31895.
RefSeqiNP_001020598.1. NM_001025427.3. [P17095-2]
NP_001034445.1. NM_001039356.2. [P17095-2]
NP_001159948.1. NM_001166476.1. [P17095-2]
NP_001159949.1. NM_001166477.1. [P17095-1]
NP_001160007.1. NM_001166535.1. [P17095-2]
NP_001160008.1. NM_001166536.1. [P17095-2]
NP_001160009.1. NM_001166537.1. [P17095-1]
NP_001160011.1. NM_001166539.1. [P17095-1]
NP_001160012.1. NM_001166540.1. [P17095-1]
NP_001160013.1. NM_001166541.1. [P17095-1]
NP_001160014.1. NM_001166542.1. [P17095-1]
NP_057869.2. NM_016660.3. [P17095-2]
UniGeneiMm.426212.
Mm.440289.
Mm.4438.

3D structure databases

ProteinModelPortaliP17095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200340. 8 interactors.
DIPiDIP-53N.
IntActiP17095. 4 interactors.
MINTiMINT-1848156.
STRINGi10090.ENSMUSP00000113011.

PTM databases

iPTMnetiP17095.
PhosphoSitePlusiP17095.

Proteomic databases

EPDiP17095.
PaxDbiP17095.
PeptideAtlasiP17095.
PRIDEiP17095.
TopDownProteomicsiP17095-1. [P17095-1]
P17095-2. [P17095-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105046; ENSMUSP00000100667; ENSMUSG00000078249. [P17095-2]
ENSMUST00000114888; ENSMUSP00000110538; ENSMUSG00000046711. [P17095-1]
ENSMUST00000117254; ENSMUSP00000113011; ENSMUSG00000046711. [P17095-2]
ENSMUST00000117600; ENSMUSP00000113068; ENSMUSG00000046711. [P17095-2]
ENSMUST00000118570; ENSMUSP00000114101; ENSMUSG00000046711. [P17095-1]
ENSMUST00000118599; ENSMUSP00000113015; ENSMUSG00000046711. [P17095-2]
ENSMUST00000119486; ENSMUSP00000113916; ENSMUSG00000046711. [P17095-2]
GeneIDi111241.
15361.
KEGGimmu:111241.
mmu:15361.
UCSCiuc008boz.2. mouse. [P17095-2]

Organism-specific databases

CTDi111241.
3159.
MGIiMGI:96160. Hmga1.

Phylogenomic databases

eggNOGiENOG410J4ZT. Eukaryota.
ENOG410Z566. LUCA.
GeneTreeiENSGT00730000111329.
HOGENOMiHOG000076308.
HOVERGENiHBG063451.
InParanoidiP17095.
KOiK09282.
OMAiKPQVSAN.
PhylomeDBiP17095.
TreeFamiTF351623.

Enzyme and pathway databases

ReactomeiR-MMU-2559584. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Miscellaneous databases

PROiP17095.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046711.
CleanExiMM_HMGA1.
ExpressionAtlasiP17095. baseline and differential.
GenevisibleiP17095. MM.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGA.
IPR031079. HMGA1_mammal.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view]
PANTHERiPTHR23341:SF1. PTHR23341:SF1. 1 hit.
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiSM00384. AT_hook. 3 hits.
[Graphical view]
PROSITEiPS00354. HMGI_Y. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGA1_MOUSE
AccessioniPrimary (citable) accession number: P17095
Secondary accession number(s): Q91WV2, Q924L7, Q924L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 167 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.