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Protein

High mobility group protein HMG-I/HMG-Y

Gene

Hmga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 31A.T hook 1Add BLAST11
DNA bindingi53 – 63A.T hook 2Add BLAST11
DNA bindingi78 – 89A.T hook 3Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2559584. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein HMG-I/HMG-Y
Short name:
HMG-I(Y)
Alternative name(s):
High mobility group AT-hook protein 1
Short name:
High mobility group protein A1
Gene namesi
Name:Hmga1
Synonyms:Hmgi, Hmgiy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 11, Chromosome 17

Organism-specific databases

MGIiMGI:96160. Hmga1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002067092 – 107High mobility group protein HMG-I/HMG-YAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei8ADP-ribosylserineBy similarity1
Modified residuei9ADP-ribosylserine; alternateBy similarity1
Modified residuei9Phosphoserine; alternateBy similarity1
Modified residuei15N6-acetyllysine; alternateCombined sources1
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei26Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei26Omega-N-methylarginine; alternateBy similarity1
Modified residuei26Symmetric dimethylarginine; alternateBy similarity1
Modified residuei36Phosphoserine; by HIPK2 and CDC2By similarity1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei44Phosphoserine1 Publication1
Modified residuei49Phosphoserine1 Publication1
Modified residuei53Phosphothreonine; by HIPK2 and CDC2Combined sources1
Modified residuei58Asymmetric dimethylarginine; by PRMT6; alternateBy similarity1
Modified residuei58Omega-N-methylarginine; by PRMT6; alternateBy similarity1
Modified residuei60Asymmetric dimethylarginine; by PRMT6; alternateBy similarity1
Modified residuei60Omega-N-methylarginine; by PRMT6; alternateBy similarity1
Modified residuei99PhosphoserineCombined sources1 Publication1
Modified residuei102PhosphoserineCombined sources1 Publication1
Modified residuei103PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation may modulate DNA-binding affinity (By similarity).By similarity
Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17095.
PaxDbiP17095.
PeptideAtlasiP17095.
PRIDEiP17095.
TopDownProteomicsiP17095-1. [P17095-1]
P17095-2. [P17095-2]

PTM databases

iPTMnetiP17095.
PhosphoSitePlusiP17095.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046711.
CleanExiMM_HMGA1.
ExpressionAtlasiP17095. baseline and differential.
GenevisibleiP17095. MM.

Interactioni

Subunit structurei

Interacts with HIPK2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200340. 8 interactors.
DIPiDIP-53N.
IntActiP17095. 4 interactors.
MINTiMINT-1848156.
STRINGi10090.ENSMUSP00000113011.

Structurei

3D structure databases

ProteinModelPortaliP17095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 77Interaction with HIPK21 PublicationAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi91 – 106Glu-rich (acidic)Add BLAST16

Sequence similaritiesi

Belongs to the HMGA family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J4ZT. Eukaryota.
ENOG410Z566. LUCA.
GeneTreeiENSGT00730000111329.
HOGENOMiHOG000076308.
HOVERGENiHBG063451.
InParanoidiP17095.
KOiK09282.
OMAiNMSDKGT.
PhylomeDBiP17095.
TreeFamiTF351623.

Family and domain databases

InterProiView protein in InterPro
IPR017956. AT_hook_DNA-bd_motif.
IPR000116. HMGA.
IPR031079. HMGA1_mammal.
IPR000637. HMGI/Y_DNA-bd_CS.
PANTHERiPTHR23341:SF6. PTHR23341:SF6. 1 hit.
PRINTSiPR00929. ATHOOK.
PR00930. HIGHMOBLTYIY.
SMARTiView protein in SMART
SM00384. AT_hook. 3 hits.
PROSITEiView protein in PROSITE
PS00354. HMGI_Y. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform HMG-I (identifier: P17095-2) [UniParc]FASTAAdd to basket
Also known as: HMGA1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESGSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE
60 70 80 90 100
VPTPKRPRGR PKGSKNKGAA KTRKVTTAPG RKPRGRPKKL EKEEEEGISQ

ESSEEEQ
Length:107
Mass (Da):11,614
Last modified:January 23, 2007 - v4
Checksum:i4EC39386611959FC
GO
Isoform HMG-Y (identifier: P17095-1) [UniParc]FASTAAdd to basket
Also known as: HMGA1b, HMGI-E

The sequence of this isoform differs from the canonical sequence as follows:
     35-45: Missing.

Show »
Length:96
Mass (Da):10,617
Checksum:iA77A3FD7CA6C08EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106E → G in AAK66158 (PubMed:11410365).Curated1
Sequence conflicti106E → G in AAK66159 (PubMed:11410365).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01240635 – 45Missing in isoform HMG-Y. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04179 mRNA. Translation: AAA37820.1.
AF285780 Genomic DNA. Translation: AAK66158.1.
AF285780 Genomic DNA. Translation: AAK66159.1.
AK010617 mRNA. Translation: BAB27065.1.
BC013455 mRNA. Translation: AAH13455.1.
CCDSiCCDS28564.1. [P17095-2]
CCDS49010.1. [P17095-2]
CCDS50044.1. [P17095-1]
PIRiA31895.
RefSeqiNP_001020598.1. NM_001025427.3. [P17095-2]
NP_001034445.1. NM_001039356.2. [P17095-2]
NP_001159948.1. NM_001166476.1. [P17095-2]
NP_001159949.1. NM_001166477.1. [P17095-1]
NP_001160007.1. NM_001166535.1. [P17095-2]
NP_001160008.1. NM_001166536.1. [P17095-2]
NP_001160009.1. NM_001166537.1. [P17095-1]
NP_001160011.1. NM_001166539.1. [P17095-1]
NP_001160012.1. NM_001166540.1. [P17095-1]
NP_001160013.1. NM_001166541.1. [P17095-1]
NP_001160014.1. NM_001166542.1. [P17095-1]
NP_057869.2. NM_016660.3. [P17095-2]
UniGeneiMm.426212.
Mm.440289.
Mm.4438.

Genome annotation databases

EnsembliENSMUST00000105046; ENSMUSP00000100667; ENSMUSG00000078249. [P17095-2]
ENSMUST00000114888; ENSMUSP00000110538; ENSMUSG00000046711. [P17095-1]
ENSMUST00000117254; ENSMUSP00000113011; ENSMUSG00000046711. [P17095-2]
ENSMUST00000117600; ENSMUSP00000113068; ENSMUSG00000046711. [P17095-2]
ENSMUST00000118570; ENSMUSP00000114101; ENSMUSG00000046711. [P17095-1]
ENSMUST00000118599; ENSMUSP00000113015; ENSMUSG00000046711. [P17095-2]
ENSMUST00000119486; ENSMUSP00000113916; ENSMUSG00000046711. [P17095-2]
GeneIDi111241.
15361.
KEGGimmu:111241.
mmu:15361.
UCSCiuc008boz.2. mouse. [P17095-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHMGA1_MOUSE
AccessioniPrimary (citable) accession number: P17095
Secondary accession number(s): Q91WV2, Q924L7, Q924L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 172 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families