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Protein

Colipase

Gene

Clps

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.By similarity

GO - Molecular functioni

  • enzyme activator activity Source: RGD

GO - Biological processi

  • digestion Source: UniProtKB-KW
  • lipid catabolic process Source: UniProtKB-KW
  • positive regulation of catalytic activity Source: RGD
  • post-embryonic development Source: RGD
  • response to food Source: RGD
Complete GO annotation...

Keywords - Biological processi

Digestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:Clps
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2363. Clps.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Add
BLAST
Propeptidei18 – 225Enterostatin, activation peptideSequence analysisPRO_0000005706
Chaini23 – 11290ColipasePRO_0000005707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP17084.

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000611.

Structurei

3D structure databases

ProteinModelPortaliP17084.
SMRiP17084. Positions 19-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiP17084.
KOiK14460.
PhylomeDBiP17084.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiPF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
[Graphical view]
PRINTSiPR00128. COLIPASE.
SMARTiSM00023. COLIPASE. 1 hit.
[Graphical view]
PROSITEiPS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLVVLLVT LVAVAYAAPG PRGLFINLED GEICVNSMQC KSRCCQHDTI
60 70 80 90 100
LGIARCTHKA MENSECSPKT LYGIYYRCPC ERGLTCEGDR SIIGAITNTN
110
YGVCLDSTRS KQ
Length:112
Mass (Da):12,252
Last modified:October 25, 2002 - v2
Checksum:iE5B6B7D4A7C05BFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181A → V in AAA40943 (PubMed:2129524).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33333 mRNA. Translation: AAA40943.1.
M58370 mRNA. Translation: AAA20505.1.
PIRiI51909.
RefSeqiNP_037271.1. NM_013139.1.
UniGeneiRn.6714.

Genome annotation databases

GeneIDi25680.
KEGGirno:25680.
UCSCiRGD:2363. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33333 mRNA. Translation: AAA40943.1.
M58370 mRNA. Translation: AAA20505.1.
PIRiI51909.
RefSeqiNP_037271.1. NM_013139.1.
UniGeneiRn.6714.

3D structure databases

ProteinModelPortaliP17084.
SMRiP17084. Positions 19-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000611.

Proteomic databases

PaxDbiP17084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25680.
KEGGirno:25680.
UCSCiRGD:2363. rat.

Organism-specific databases

CTDi1208.
RGDi2363. Clps.

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiP17084.
KOiK14460.
PhylomeDBiP17084.

Miscellaneous databases

NextBioi607643.
PROiP17084.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiPF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
[Graphical view]
PRINTSiPR00128. COLIPASE.
SMARTiSM00023. COLIPASE. 1 hit.
[Graphical view]
PROSITEiPS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat pancreatic colipase mRNA: nucleotide sequence of a cDNA clone and nutritional regulation by a lipidic diet."
    Wicker C., Puigserver A.
    Biochem. Biophys. Res. Commun. 167:130-136(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development."
    Payne R.M., Sims H.F., Jennens M.L., Lowe M.E.
    Am. J. Physiol. 266:G914-G921(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCOL_RAT
AccessioniPrimary (citable) accession number: P17084
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 25, 2002
Last modified: November 11, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.