Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho-related GTP-binding protein RhoQ

Gene

RHOQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.1 Publication

Enzyme regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

  • GBD domain binding Source: BHF-UCL
  • GTPase activity Source: BHF-UCL
  • GTP binding Source: UniProtKB-KW
  • profilin binding Source: BHF-UCL

GO - Biological processi

  • cellular response to insulin stimulus Source: BHF-UCL
  • cortical actin cytoskeleton organization Source: BHF-UCL
  • GTP metabolic process Source: BHF-UCL
  • insulin receptor signaling pathway Source: BHF-UCL
  • negative regulation of establishment of protein localization to plasma membrane Source: BHF-UCL
  • positive regulation of filopodium assembly Source: BHF-UCL
  • positive regulation of glucose import Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • regulation of actin cytoskeleton organization Source: BHF-UCL
  • regulation of cell shape Source: Ensembl
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119729-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-194840. Rho GTPase cycle.
R-HSA-5627083. RHO GTPases regulate CFTR trafficking.
SignaLinkiP17081.
SIGNORiP17081.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoQ
Alternative name(s):
Ras-like protein TC10
Ras-like protein family member 7A
Gene namesi
Name:RHOQ
Synonyms:ARHQ, RASL7A, TC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:17736. RHOQ.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell membrane 1 Publication; Lipid-anchor 1 Publication

GO - Cellular componenti

  • actin filament Source: BHF-UCL
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • Golgi-associated vesicle membrane Source: Reactome
  • membrane raft Source: Ensembl
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23T → N: Loss of interaction with GOPC. 1 Publication1
Mutagenesisi44D → A: Loss of interaction with GOPC. 1 Publication1
Mutagenesisi67Q → L: Constitutively active. Interacts with PARD6 proteins and GOPC. 1 Publication1

Organism-specific databases

DisGeNETi23433.
OpenTargetsiENSG00000119729.
PharmGKBiPA134904280.

Polymorphism and mutation databases

BioMutaiRHOQ.
DMDMi62906861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988711 – 202Rho-related GTP-binding protein RhoQAdd BLAST202
PropeptideiPRO_0000281222203 – 205Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202Cysteine methyl esterBy similarity1
Lipidationi202S-farnesyl cysteineBy similarity1

Post-translational modificationi

May be post-translationally modified by both palmitoylation and polyisoprenylation.

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP17081.
PaxDbiP17081.
PeptideAtlasiP17081.
PRIDEiP17081.

PTM databases

iPTMnetiP17081.
PhosphoSitePlusiP17081.
SwissPalmiP17081.

Expressioni

Gene expression databases

BgeeiENSG00000119729.
CleanExiHS_RHOQ.
ExpressionAtlasiP17081. baseline and differential.
GenevisibleiP17081. HS.

Interactioni

Subunit structurei

Interacts with CDC42EP4 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ). Interacts with EXO70 in a GTP-dependent manner. Interacts with GOPC.By similarity4 Publications

GO - Molecular functioni

  • GBD domain binding Source: BHF-UCL
  • profilin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi117001. 13 interactors.
IntActiP17081. 4 interactors.
STRINGi9606.ENSP00000238738.

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 16Combined sources11
Helixi22 – 31Combined sources10
Beta strandi46 – 54Combined sources9
Beta strandi56 – 62Combined sources7
Beta strandi67 – 70Combined sources4
Turni71 – 73Combined sources3
Helixi74 – 77Combined sources4
Beta strandi82 – 89Combined sources8
Helixi93 – 101Combined sources9
Helixi103 – 110Combined sources8
Beta strandi116 – 121Combined sources6
Helixi129 – 135Combined sources7
Turni136 – 139Combined sources4
Helixi145 – 155Combined sources11
Beta strandi160 – 162Combined sources3
Turni165 – 167Combined sources3
Helixi171 – 183Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ATXX-ray2.65A/B1-185[»]
ProteinModelPortaliP17081.
SMRiP17081.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17081.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOVERGENiHBG009351.
InParanoidiP17081.
KOiK07194.
PhylomeDBiP17081.
TreeFamiTF101109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHGPGALML KCVVVGDGAV GKTCLLMSYA NDAFPEEYVP TVFDHYAVSV
60 70 80 90 100
TVGGKQYLLG LYDTAGQEDY DRLRPLSYPM TDVFLICFSV VNPASFQNVK
110 120 130 140 150
EEWVPELKEY APNVPFLLIG TQIDLRDDPK TLARLNDMKE KPICVEQGQK
160 170 180 190 200
LAKEIGACCY VECSALTQKG LKTVFDEAII AILTPKKHTV KKRIGSRCIN

CCLIT
Length:205
Mass (Da):22,659
Last modified:April 26, 2005 - v2
Checksum:i82695B4F8FBF0B75
GO

Sequence cautioni

The sequence AAA36547 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM21123 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31470 mRNA. Translation: AAA36547.1. Different initiation.
AF498976 mRNA. Translation: AAM21123.1. Different initiation.
AC018682 Genomic DNA. Translation: AAY14834.1.
CH471053 Genomic DNA. Translation: EAX00251.1.
BC056154 mRNA. Translation: AAH56154.3.
BC065291 mRNA. Translation: AAH65291.2.
BC070485 mRNA. Translation: AAH70485.2.
BC093805 mRNA. Translation: AAH93805.2.
BC101806 mRNA. Translation: AAI01807.1.
CCDSiCCDS33191.1.
PIRiD34788. TVHUC4.
RefSeqiNP_036381.2. NM_012249.3.
UniGeneiHs.709193.

Genome annotation databases

EnsembliENST00000238738; ENSP00000238738; ENSG00000119729.
GeneIDi23433.
KEGGihsa:23433.
UCSCiuc061ivt.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31470 mRNA. Translation: AAA36547.1. Different initiation.
AF498976 mRNA. Translation: AAM21123.1. Different initiation.
AC018682 Genomic DNA. Translation: AAY14834.1.
CH471053 Genomic DNA. Translation: EAX00251.1.
BC056154 mRNA. Translation: AAH56154.3.
BC065291 mRNA. Translation: AAH65291.2.
BC070485 mRNA. Translation: AAH70485.2.
BC093805 mRNA. Translation: AAH93805.2.
BC101806 mRNA. Translation: AAI01807.1.
CCDSiCCDS33191.1.
PIRiD34788. TVHUC4.
RefSeqiNP_036381.2. NM_012249.3.
UniGeneiHs.709193.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ATXX-ray2.65A/B1-185[»]
ProteinModelPortaliP17081.
SMRiP17081.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117001. 13 interactors.
IntActiP17081. 4 interactors.
STRINGi9606.ENSP00000238738.

PTM databases

iPTMnetiP17081.
PhosphoSitePlusiP17081.
SwissPalmiP17081.

Polymorphism and mutation databases

BioMutaiRHOQ.
DMDMi62906861.

Proteomic databases

EPDiP17081.
PaxDbiP17081.
PeptideAtlasiP17081.
PRIDEiP17081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238738; ENSP00000238738; ENSG00000119729.
GeneIDi23433.
KEGGihsa:23433.
UCSCiuc061ivt.1. human.

Organism-specific databases

CTDi23433.
DisGeNETi23433.
GeneCardsiRHOQ.
HGNCiHGNC:17736. RHOQ.
MIMi605857. gene.
neXtProtiNX_P17081.
OpenTargetsiENSG00000119729.
PharmGKBiPA134904280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOVERGENiHBG009351.
InParanoidiP17081.
KOiK07194.
PhylomeDBiP17081.
TreeFamiTF101109.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119729-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-194840. Rho GTPase cycle.
R-HSA-5627083. RHO GTPases regulate CFTR trafficking.
SignaLinkiP17081.
SIGNORiP17081.

Miscellaneous databases

ChiTaRSiRHOQ. human.
EvolutionaryTraceiP17081.
GeneWikiiRHOQ.
GenomeRNAii23433.
PROiP17081.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119729.
CleanExiHS_RHOQ.
ExpressionAtlasiP17081. baseline and differential.
GenevisibleiP17081. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHOQ_HUMAN
AccessioniPrimary (citable) accession number: P17081
Secondary accession number(s): D6W5A6
, Q0VGN1, Q52LS8, Q53SJ1, Q6NS39, Q6P146, Q7Z480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.