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P17081

- RHOQ_HUMAN

UniProt

P17081 - RHOQ_HUMAN

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Protein
Rho-related GTP-binding protein RhoQ
Gene
RHOQ, ARHQ, RASL7A, TC10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.1 Publication

Enzyme regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTP By similarity
Nucleotide bindingi63 – 675GTP By similarity
Nucleotide bindingi121 – 1244GTP By similarity

GO - Molecular functioni

  1. GBD domain binding Source: BHF-UCL
  2. GTP binding Source: UniProtKB-KW
  3. GTPase activity Source: BHF-UCL
  4. profilin binding Source: BHF-UCL

GO - Biological processi

  1. GTP catabolic process Source: BHF-UCL
  2. cellular response to insulin stimulus Source: BHF-UCL
  3. cortical actin cytoskeleton organization Source: BHF-UCL
  4. insulin receptor signaling pathway Source: BHF-UCL
  5. negative regulation of establishment of protein localization to plasma membrane Source: BHF-UCL
  6. positive regulation of filopodium assembly Source: BHF-UCL
  7. positive regulation of glucose import Source: BHF-UCL
  8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  9. regulation of actin cytoskeleton organization Source: BHF-UCL
  10. regulation of cell shape Source: Ensembl
  11. regulation of small GTPase mediated signal transduction Source: Reactome
  12. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_147867. Translocation of GLUT4 to the plasma membrane.
SignaLinkiP17081.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoQ
Alternative name(s):
Ras-like protein TC10
Ras-like protein family member 7A
Gene namesi
Name:RHOQ
Synonyms:ARHQ, RASL7A, TC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17736. RHOQ.

Subcellular locationi

Cytoplasm. Cell membrane; Lipid-anchor 1 Publication

GO - Cellular componenti

  1. actin filament Source: BHF-UCL
  2. cytosol Source: Reactome
  3. membrane raft Source: Ensembl
  4. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 231T → N: Loss of interaction with GOPC. 1 Publication
Mutagenesisi44 – 441D → A: Loss of interaction with GOPC. 1 Publication
Mutagenesisi67 – 671Q → L: Constitutively active. Interacts with PARD6 proteins and GOPC. 1 Publication

Organism-specific databases

PharmGKBiPA134904280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Rho-related GTP-binding protein RhoQ
PRO_0000198871Add
BLAST
Propeptidei203 – 2053Removed in mature form By similarity
PRO_0000281222

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021Cysteine methyl ester By similarity
Lipidationi202 – 2021S-farnesyl cysteine By similarity

Post-translational modificationi

May be post-translationally modified by both palmitoylation and polyisoprenylation.

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP17081.
PaxDbiP17081.
PRIDEiP17081.

PTM databases

PhosphoSiteiP17081.

Expressioni

Gene expression databases

ArrayExpressiP17081.
BgeeiP17081.
CleanExiHS_RHOQ.
GenevestigatoriP17081.

Interactioni

Subunit structurei

Interacts with CDC42EP4 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP By similarity. Interacts with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ). Interacts with EXO70 in a GTP-dependent manner. Interacts with GOPC.4 Publications

Protein-protein interaction databases

BioGridi117001. 13 interactions.
IntActiP17081. 4 interactions.
STRINGi9606.ENSP00000238738.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 1611
Helixi22 – 3110
Beta strandi46 – 549
Beta strandi56 – 627
Beta strandi67 – 704
Turni71 – 733
Helixi74 – 774
Beta strandi82 – 898
Helixi93 – 1019
Helixi103 – 1108
Beta strandi116 – 1216
Helixi129 – 1357
Turni136 – 1394
Helixi145 – 15511
Beta strandi160 – 1623
Turni165 – 1673
Helixi171 – 18313

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ATXX-ray2.65A/B1-185[»]
ProteinModelPortaliP17081.
SMRiP17081. Positions 1-185.

Miscellaneous databases

EvolutionaryTraceiP17081.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 469Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOVERGENiHBG009351.
InParanoidiP17081.
KOiK07194.
OMAiLAPRCIN.
OrthoDBiEOG764747.
PhylomeDBiP17081.
TreeFamiTF101109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17081-1 [UniParc]FASTAAdd to Basket

« Hide

MAHGPGALML KCVVVGDGAV GKTCLLMSYA NDAFPEEYVP TVFDHYAVSV    50
TVGGKQYLLG LYDTAGQEDY DRLRPLSYPM TDVFLICFSV VNPASFQNVK 100
EEWVPELKEY APNVPFLLIG TQIDLRDDPK TLARLNDMKE KPICVEQGQK 150
LAKEIGACCY VECSALTQKG LKTVFDEAII AILTPKKHTV KKRIGSRCIN 200
CCLIT 205
Length:205
Mass (Da):22,659
Last modified:April 26, 2005 - v2
Checksum:i82695B4F8FBF0B75
GO

Sequence cautioni

The sequence AAA36547.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAM21123.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31470 mRNA. Translation: AAA36547.1. Different initiation.
AF498976 mRNA. Translation: AAM21123.1. Different initiation.
AC018682 Genomic DNA. Translation: AAY14834.1.
CH471053 Genomic DNA. Translation: EAX00251.1.
BC056154 mRNA. Translation: AAH56154.3.
BC065291 mRNA. Translation: AAH65291.2.
BC070485 mRNA. Translation: AAH70485.2.
BC093805 mRNA. Translation: AAH93805.2.
BC101806 mRNA. Translation: AAI01807.1.
CCDSiCCDS33191.1.
PIRiD34788. TVHUC4.
RefSeqiNP_036381.2. NM_012249.3.
UniGeneiHs.709193.

Genome annotation databases

EnsembliENST00000238738; ENSP00000238738; ENSG00000119729.
GeneIDi23433.
KEGGihsa:23433.
UCSCiuc002rva.3. human.

Polymorphism databases

DMDMi62906861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31470 mRNA. Translation: AAA36547.1 . Different initiation.
AF498976 mRNA. Translation: AAM21123.1 . Different initiation.
AC018682 Genomic DNA. Translation: AAY14834.1 .
CH471053 Genomic DNA. Translation: EAX00251.1 .
BC056154 mRNA. Translation: AAH56154.3 .
BC065291 mRNA. Translation: AAH65291.2 .
BC070485 mRNA. Translation: AAH70485.2 .
BC093805 mRNA. Translation: AAH93805.2 .
BC101806 mRNA. Translation: AAI01807.1 .
CCDSi CCDS33191.1.
PIRi D34788. TVHUC4.
RefSeqi NP_036381.2. NM_012249.3.
UniGenei Hs.709193.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ATX X-ray 2.65 A/B 1-185 [» ]
ProteinModelPortali P17081.
SMRi P17081. Positions 1-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117001. 13 interactions.
IntActi P17081. 4 interactions.
STRINGi 9606.ENSP00000238738.

PTM databases

PhosphoSitei P17081.

Polymorphism databases

DMDMi 62906861.

Proteomic databases

MaxQBi P17081.
PaxDbi P17081.
PRIDEi P17081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000238738 ; ENSP00000238738 ; ENSG00000119729 .
GeneIDi 23433.
KEGGi hsa:23433.
UCSCi uc002rva.3. human.

Organism-specific databases

CTDi 23433.
GeneCardsi GC02P046768.
HGNCi HGNC:17736. RHOQ.
MIMi 605857. gene.
neXtProti NX_P17081.
PharmGKBi PA134904280.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOVERGENi HBG009351.
InParanoidi P17081.
KOi K07194.
OMAi LAPRCIN.
OrthoDBi EOG764747.
PhylomeDBi P17081.
TreeFami TF101109.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_147867. Translocation of GLUT4 to the plasma membrane.
SignaLinki P17081.

Miscellaneous databases

ChiTaRSi RHOQ. human.
EvolutionaryTracei P17081.
GeneWikii RHOQ.
GenomeRNAii 23433.
NextBioi 45687.
PROi P17081.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17081.
Bgeei P17081.
CleanExi HS_RHOQ.
Genevestigatori P17081.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line."
    Drivas G.T., Shih A., Coutavas E., Rush M.G., D'Eustachio P.
    Mol. Cell. Biol. 10:1793-1798(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  6. "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins."
    Joberty G., Perlungher R.R., Macara I.G.
    Mol. Cell. Biol. 19:6585-6597(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC42EP1; CDC42EP2 AND CDC42EP3.
    Tissue: Embryo.
  7. "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42."
    Joberty G., Petersen C., Gao L., Macara I.G.
    Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARD6A AND PARD6G, MUTAGENESIS OF GLN-67.
  8. "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10."
    Neudauer C.L., Joberty G., Macara I.G.
    Biochem. Biophys. Res. Commun. 280:541-547(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOPC, MUTAGENESIS OF THR-23 AND ASP-44.
  9. "Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10."
    Cheng J., Wang H., Guggino W.B.
    J. Biol. Chem. 280:3731-3739(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOPC, SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiRHOQ_HUMAN
AccessioniPrimary (citable) accession number: P17081
Secondary accession number(s): D6W5A6
, Q0VGN1, Q52LS8, Q53SJ1, Q6NS39, Q6P146, Q7Z480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 26, 2005
Last modified: September 3, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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