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Protein

40S ribosomal protein S19

Gene

Rps19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for pre-rRNA processing and maturation of 40S ribosomal subunits.By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • structural constituent of ribosome Source: HGNC
  • translation initiation factor binding Source: UniProtKB

GO - Biological processi

  • erythrocyte differentiation Source: HGNC
  • ribosomal small subunit assembly Source: GO_Central
  • translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S19
Gene namesi
Name:Rps19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi68440. Rps19.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: HGNC
  • nucleolus Source: HGNC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 14514440S ribosomal protein S19PRO_0000153814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysineBy similarity
Modified residuei111 – 1111N6-acetyllysineBy similarity
Modified residuei115 – 1151N6-acetyllysineBy similarity
Modified residuei143 – 1431N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP17074.
PRIDEiP17074.

PTM databases

iPTMnetiP17074.
PhosphoSiteiP17074.

Expressioni

Gene expression databases

BgeeiENSRNOG00000037897.
GenevisibleiP17074. RN.

Interactioni

Subunit structurei

Interacts with RPS19BP1.By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • translation initiation factor binding Source: UniProtKB

Protein-protein interaction databases

IntActiP17074. 3 interactions.
MINTiMINT-4580819.
STRINGi10116.ENSRNOP00000066808.

Structurei

3D structure databases

ProteinModelPortaliP17074.
SMRiP17074. Positions 2-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S19e family.Curated

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
HOGENOMiHOG000230649.
HOVERGENiHBG000240.
InParanoidiP17074.
KOiK02966.
OrthoDBiEOG091G0QM7.
PhylomeDBiP17074.
TreeFamiTF315008.

Family and domain databases

InterProiIPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiPF01090. Ribosomal_S19e. 1 hit.
[Graphical view]
ProDomiPD003854. Ribosomal_S19e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01413. Ribosomal_S19e. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00628. RIBOSOMAL_S19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE
60 70 80 90 100
NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVRPS HFSRGSKSVA
110 120 130 140
RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKKH
Length:145
Mass (Da):16,085
Last modified:January 23, 2007 - v3
Checksum:i180032B887FA6E41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51707 mRNA. Translation: CAA36003.1.
BC087641 mRNA. Translation: AAH87641.1.
PIRiA43770. R3RT19.
RefSeqiNP_001032423.1. NM_001037346.2.
XP_003750695.1. XM_003750647.3.
XP_006228473.1. XM_006228411.1.
XP_008765123.1. XM_008766901.1.
UniGeneiRn.115882.
Rn.127775.

Genome annotation databases

EnsembliENSRNOT00000027246; ENSRNOP00000027246; ENSRNOG00000037897.
GeneIDi100910336.
29287.
KEGGirno:100910336.
rno:29287.
UCSCiRGD:68440. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51707 mRNA. Translation: CAA36003.1.
BC087641 mRNA. Translation: AAH87641.1.
PIRiA43770. R3RT19.
RefSeqiNP_001032423.1. NM_001037346.2.
XP_003750695.1. XM_003750647.3.
XP_006228473.1. XM_006228411.1.
XP_008765123.1. XM_008766901.1.
UniGeneiRn.115882.
Rn.127775.

3D structure databases

ProteinModelPortaliP17074.
SMRiP17074. Positions 2-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17074. 3 interactions.
MINTiMINT-4580819.
STRINGi10116.ENSRNOP00000066808.

PTM databases

iPTMnetiP17074.
PhosphoSiteiP17074.

Proteomic databases

PaxDbiP17074.
PRIDEiP17074.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027246; ENSRNOP00000027246; ENSRNOG00000037897.
GeneIDi100910336.
29287.
KEGGirno:100910336.
rno:29287.
UCSCiRGD:68440. rat.

Organism-specific databases

CTDi6223.
RGDi68440. Rps19.

Phylogenomic databases

eggNOGiKOG3411. Eukaryota.
COG2238. LUCA.
GeneTreeiENSGT00390000013102.
HOGENOMiHOG000230649.
HOVERGENiHBG000240.
InParanoidiP17074.
KOiK02966.
OrthoDBiEOG091G0QM7.
PhylomeDBiP17074.
TreeFamiTF315008.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP17074.

Gene expression databases

BgeeiENSRNOG00000037897.
GenevisibleiP17074. RN.

Family and domain databases

InterProiIPR001266. Ribosomal_S19e.
IPR018277. Ribosomal_S19e_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11710. PTHR11710. 1 hit.
PfamiPF01090. Ribosomal_S19e. 1 hit.
[Graphical view]
ProDomiPD003854. Ribosomal_S19e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01413. Ribosomal_S19e. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00628. RIBOSOMAL_S19E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS19_RAT
AccessioniPrimary (citable) accession number: P17074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.