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Protein

Isocitrate lyase

Gene
N/A
Organism
Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in storage lipid mobilization during the growth of higher plant seedling.By similarity

Catalytic activityi

Isocitrate = succinate + glyoxylate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: glyoxylate cycle

This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from isocitrate.By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Isocitrate lyase
  2. Malate synthase, glyoxysomal
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi175MagnesiumBy similarity1
Active sitei213Proton acceptorBy similarity1
Binding sitei250SubstrateBy similarity1
Binding sitei472SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi4.1.3.1. 2499.
UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyaseBy similarity (EC:4.1.3.1By similarity)
Short name:
ICLBy similarity
Alternative name(s):
IsocitraseBy similarity
IsocitratsysaseBy similarity
OrganismiGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Taxonomic identifieri3635 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMalvalesMalvaceaeMalvoideaeGossypium
Proteomesi
  • UP000189702 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688061 – 576Isocitrate lyaseAdd BLAST576

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP17069.
SMRiP17069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 106Substrate bindingBy similarity3
Regioni214 – 215Substrate bindingBy similarity2
Regioni437 – 441Substrate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi574 – 576Microbody targeting signalSequence analysis3

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
PANTHERiPTHR21631. PTHR21631. 1 hit.
PfamiView protein in Pfam
PF00463. ICL. 1 hit.
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiView protein in PROSITE
PS00161. ISOCITRATE_LYASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P17069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASFSVPSM IMEEEGRFET EVAEVQAWWN SERFKLTRRP YSARDVVALR
60 70 80 90 100
GSLKQSYGSN EMAKKLWTTL KTHQANGTAS RTFGALDPVQ VTMMAKHLDS
110 120 130 140 150
IYVSGWQCSS THTTTNEPGP DLADYPYDTV PNKVEHLFFA QQYHDRKQRE
160 170 180 190 200
ARMSMSREER ARTPYVDYLK PIIADGDTGF GGTTATVKLC KLFVERGAAG
210 220 230 240 250
VHIEDQSSVT KKCGHMAGKV LVAVSEHINR LVAARLQFDV MGVETVLVAR
260 270 280 290 300
TDAVAATLIQ TNVDTRDHQF ILGATNPNLR GKSLANMLAE GMAAGKNGPQ
310 320 330 340 350
LQAIEDNWLA IAQLKTFSEC VMDAIKSMNI TEDEKRRRMN EWMNHSSYDK
360 370 380 390 400
CLSNEQAREI AERLGLQNLF WDWDLPRTRE GFYRFRGSVM AAIVRGWAFA
410 420 430 440 450
PHADLIWMET SSPDMVECTR FAEGVKSMHP EIMLAYNLSP SFNWDASGMT
460 470 480 490 500
DEHMRDFIPR IAKLGFCWQF ITLAGFHADA LVTDTFARDF ARRGMLAYVE
510 520 530 540 550
KIQREERNNG VDTLAHQKWS GANFYDRYLK TVQGGISSTA AMGKGVTEEQ
560 570
FKETWTRPGA GNIGSEGNLV VAKARM
Length:576
Mass (Da):64,733
Last modified:August 1, 1990 - v1
Checksum:i84D211AA3DCE8700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52136 mRNA. Translation: CAA36381.1.
PIRiS10771. WZCNIU.
RefSeqiNP_001314103.1. NM_001327174.1.
UniGeneiGhi.16500.

Genome annotation databases

GeneIDi107920350.

Similar proteinsi

Entry informationi

Entry nameiACEA_GOSHI
AccessioniPrimary (citable) accession number: P17069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families