P17066 (HSP76_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock 70 kDa protein 6

Alternative name(s):
Heat shock 70 kDa protein B'

Gene names

Name:	HSPA6
Synonyms:	HSP70B'

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	643 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage By similarity.
Induction	Only at higher temperatures, and no basal expression.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to unfolded protein Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 643

643

Heat shock 70 kDa protein 6

PRO_0000078264

Natural variations

Natural variant

65

1

P → T. Ref.2

VAR_060718

Natural variant

95

1

R → Q. Ref.2

VAR_060719

Natural variant

150

1

A → T. Ref.2
Corresponds to variant rs10919224 [ dbSNP | Ensembl ].

VAR_049605

Natural variant

153

1

N → S. Ref.2
Corresponds to variant rs10919225 [ dbSNP | Ensembl ].

VAR_049606

Natural variant

154

1

D → N. Ref.2
Corresponds to variant rs10919226 [ dbSNP | Ensembl ].

VAR_049607

Natural variant

159

1

A → V. Ref.2

VAR_060720

Natural variant

170

1

N → K. Ref.2
Corresponds to variant rs41297704 [ dbSNP | Ensembl ].

VAR_049608

Natural variant

173

1

R → P. Ref.2
Corresponds to variant rs41297708 [ dbSNP | Ensembl ].

VAR_049609

Natural variant

178

1

P → A. Ref.2
Corresponds to variant rs41297710 [ dbSNP | Ensembl ].

VAR_049610

Natural variant

194

1

E → K. Ref.2
Corresponds to variant rs41297714 [ dbSNP | Ensembl ].

VAR_049611

Natural variant

198

1

L → F. Ref.2
Corresponds to variant rs1079109 [ dbSNP | Ensembl ].

VAR_024182

Natural variant

260

1

R → H.
Corresponds to variant rs41299256 [ dbSNP | Ensembl ].

VAR_049612

Natural variant

297

1

T → K. Ref.2

VAR_060721

Natural variant

336

1

V → F.
Corresponds to variant rs417707 [ dbSNP | Ensembl ].

VAR_059360

Natural variant

464

1

S → I. Ref.2
Corresponds to variant rs388218 [ dbSNP | Ensembl ].

VAR_049613

Natural variant

471

1

R → H. Ref.2
Corresponds to variant rs41299256 [ dbSNP | Ensembl ].

VAR_049614

Natural variant

528

1

K → E. Ref.2
Corresponds to variant rs570189 [ dbSNP | Ensembl ].

VAR_049615

Natural variant

528

1

K → R.
Corresponds to variant rs570167 [ dbSNP | Ensembl ].

VAR_059361

Natural variant

562

1

D → E. Ref.2
Corresponds to variant rs753856 [ dbSNP | Ensembl ].

VAR_024183

Natural variant

572

1

M → V.
Corresponds to variant rs452004 [ dbSNP | Ensembl ].

VAR_049616

Natural variant

577

1

R → Q. Ref.2
Corresponds to variant rs368844 [ dbSNP | Ensembl ].

VAR_049617

Natural variant

626

1

T → A. Ref.2
Corresponds to variant rs41299260 [ dbSNP | Ensembl ].

VAR_049618

Experimental info

Sequence conflict

106 – 108

3

RVC → PVS Ref.1

Sequence conflict

106 – 108

3

RVC → PVS Ref.3

Sequence conflict

263

1

R → G in CAA36061. Ref.1

Secondary structure

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643

Helix Strand Turn

Details...

Beta strand

9 – 12

4

Beta strand

15 – 24

10

Beta strand

27 – 30

4

Beta strand

38 – 41

4

Beta strand

44 – 46

3

Beta strand

51 – 53

3

Helix

55 – 59

5

Turn

60 – 63

4

Helix

65 – 67

3

Helix

72 – 74

3

Turn

75 – 77

3

Helix

83 – 90

8

Beta strand

93 – 99

7

Beta strand

102 – 109

8

Beta strand

112 – 116

5

Helix

118 – 137

20

Beta strand

143 – 148

6

Helix

154 – 166

13

Beta strand

170 – 176

7

Helix

177 – 184

8

Turn

185 – 188

4

Beta strand

195 – 202

8

Beta strand

207 – 215

9

Beta strand

218 – 227

10

Helix

232 – 251

20

Helix

259 – 275

17

Turn

276 – 278

3

Beta strand

280 – 290

11

Beta strand

293 – 300

8

Helix

301 – 314

14

Helix

316 – 326

11

Helix

330 – 332

3

Beta strand

334 – 340

7

Helix

341 – 344

4

Helix

346 – 355

10

Turn

356 – 358

3

Turn

367 – 369

3

Helix

370 – 383

14

Sequences

	Sequence		Length	Mass (Da)
	P17066 [UniParc]. Last modified September 19, 2003. Version 2. Checksum: BCE348F0226DB70B	FASTA	643	71,028
	10 20 30 40 50 60 MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ 70 80 90 100 110 120 AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG GKPKVRVCYR GEDKTFYPEE 130 140 150 160 170 180 ISSMVLSKMK ETAEAYLGQP VKHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA 190 200 210 220 230 240 AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV 250 260 270 280 290 300 NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT 310 320 330 340 350 360 RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK LLQDFFNGKE 370 380 390 400 410 420 LNKSINPDEA VAYGAAVQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA 430 440 450 460 470 480 TIPTKQTQTF TTYSDNQPGV FIQVYEGERA MTKDNNLLGR FELSGIPPAP RGVPQIEVTF 490 500 510 520 530 540 DIDANGILSV TATDRSTGKA NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA 550 560 570 580 590 600 KNSLEAHVFH VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE 610 620 630 640 LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA." Leung T.K.C., Rajendran M.Y., Monfries C., Hall C., Lim L. Biochem. J. 267:125-132(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Lung.
[2]	NIEHS SNPs program Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-65; GLN-95; THR-150; SER-153; ASN-154; VAL-159; LYS-170; PRO-173; ALA-178; LYS-194; PHE-198; LYS-297; ILE-464; HIS-471; GLU-528; GLU-562; GLN-577 AND ALA-626.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Skin.
[5]	"The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1." Leung T.K.C., Hall C., Rajendran M., Spurr N.K., Lim L. Genomics 12:74-79(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-250.
[6]	"Cis-acting elements involved in the regulated expression of a human HSP70 gene." Schiller P., Amin J., Ananthan J., Brown M.E., Scott W.A., Voellmy R. J. Mol. Biol. 203:97-105(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X51757 Genomic DNA. Translation: CAA36061.1.
X51758 mRNA. Translation: CAA36062.1.
DQ521571 Genomic DNA. Translation: ABF47108.1.
AL590385 Genomic DNA. Translation: CAI16120.1.
BC004279 mRNA. Translation: AAH04279.1.
BC035665 mRNA. Translation: AAH35665.1.
S78631 Genomic DNA. No translation available.

IPI

IPI00339269.

PIR

S09036.

RefSeq

NP_002146.2. NM_002155.3.

UniGene

Hs.654614.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3FE1	X-ray	2.20	A/B/C	6-385	[»]

ProteinModelPortal

P17066.

ModBase

Search...

Protein-protein interaction databases

IntAct

P17066. 19 interactions.

MINT

MINT-1139180.

STRING

9606.ENSP00000310219.

PTM databases

PhosphoSite

P17066.

Polymorphism databases

DMDM

34978357.

2D gel databases

UCD-2DPAGE

P17066.

Proteomic databases

PaxDb

P17066.

PRIDE

P17066.

Protocols and materials databases

DNASU

3310.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000309758; ENSP00000310219; ENSG00000173110.

GeneID

3310.

KEGG

hsa:3310.

UCSC

uc001gaq.3. human.

Organism-specific databases

CTD

3310.

GeneCards

GC01P161495.

HGNC

HGNC:5239. HSPA6.

HPA

CAB017452.
HPA028549.

MIM

140555. gene.

neXtProt

NX_P17066.

PharmGKB

PA29505.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0443.

HOGENOM

HOG000228135.

HOVERGEN

HBG051845.

InParanoid

P17066.

KO

K03283.

OMA

LEAYVFH.

OrthoDB

EOG4Q58P1.

PhylomeDB

P17066.

Gene expression databases

Bgee

P17066.

CleanEx

HS_HSPA6.

Genevestigator

P17066.

GermOnline

ENSG00000173110. Homo sapiens.

Family and domain databases

InterPro

IPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]

Pfam

PF00012. HSP70. 1 hit.
[Graphical view]

PRINTS

PR00301. HEATSHOCK70.

PROSITE

PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P17066.

GenomeRNAi

3310.

NextBio

13127.

SOURCE

Search...

Entry information

Entry name

HSP76_HUMAN

Accession

Primary (citable) accession number: P17066
Secondary accession number(s): Q1HBA8, Q8IYK7, Q9BT95

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	September 19, 2003
Last modified:	May 1, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.