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Protein

Purine-cytosine permease FCY2

Gene

FCY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This permease has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine.

Miscellaneous

Present with 23600 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cytidine transmembrane transporter activity Source: SGD
  • nucleobase transmembrane transporter activity Source: SGD

GO - Biological processi

  • cytidine transport Source: SGD
  • cytosine transport Source: SGD
  • purine-containing compound transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-30233-MONOMER

Protein family/group databases

TCDBi2.A.39.2.1 the nucleobase:cation symporter-1 (ncs1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Purine-cytosine permease FCY2
Short name:
PCP FCY2
Alternative name(s):
Cytosine/purine transport protein FCY2
Fluorocytosine resistance protein 2
Gene namesi
Name:FCY2
Ordered Locus Names:YER056C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER056C
SGDiS000000858 FCY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 121ExtracellularSequence analysis2
Transmembranei122 – 141HelicalSequence analysisAdd BLAST20
Topological domaini142 – 198CytoplasmicSequence analysisAdd BLAST57
Transmembranei199 – 218HelicalSequence analysisAdd BLAST20
Topological domaini219 – 256ExtracellularSequence analysisAdd BLAST38
Transmembranei257 – 276HelicalSequence analysisAdd BLAST20
Topological domaini277 – 300CytoplasmicSequence analysisAdd BLAST24
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Topological domaini321 – 347ExtracellularSequence analysisAdd BLAST27
Transmembranei348 – 367HelicalSequence analysisAdd BLAST20
Topological domaini368 – 398CytoplasmicSequence analysisAdd BLAST31
Transmembranei399 – 418HelicalSequence analysisAdd BLAST20
Topological domaini419 – 465ExtracellularSequence analysisAdd BLAST47
Transmembranei466 – 485HelicalSequence analysisAdd BLAST20
Topological domaini486 – 533CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979201 – 533Purine-cytosine permease FCY2Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki16Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei18PhosphoserineCombined sources1

Post-translational modificationi

Not N-glycosylated.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP17064
PaxDbiP17064
PRIDEiP17064

PTM databases

iPTMnetiP17064

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PHO88P382643EBI-2047850,EBI-13350

Protein-protein interaction databases

BioGridi36796, 105 interactors
DIPiDIP-7593N
IntActiP17064, 6 interactors
MINTiP17064
STRINGi4932.YER056C

Structurei

3D structure databases

ProteinModelPortaliP17064
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 184Surface seekingSequence analysisAdd BLAST20

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000162981
InParanoidiP17064
OMAiVEPINEN
OrthoDBiEOG092C1MEG

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681 NCS1
IPR001248 Pur-cyt_permease
IPR026030 Pur-cyt_permease_Fcy2/21/22
IPR038271 Pur-cyt_permease_sf
PANTHERiPTHR31806 PTHR31806, 1 hit
PfamiView protein in Pfam
PF02133 Transp_cyt_pur, 1 hit
PIRSFiPIRSF002744 Pur-cyt_permease, 1 hit
TIGRFAMsiTIGR00800 ncs1, 1 hit

Sequencei

Sequence statusi: Complete.

P17064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEGNNVYE IQDLEKRSPV IGSSLENEKK VAASETFTAT SEDDQQYIVE
60 70 80 90 100
SSEATKLSWF HKFFASLNAE TKGVEPVTED EKTDDSILNA ASMWFSANMV
110 120 130 140 150
IASYALGALG PMVFGLNFGQ SVLVIIFFNI MGLIFVAFFS VFGAELGLRQ
160 170 180 190 200
MILSRYLVGN VTARIFSLIN VIACVGWGIV NTSVSAQLLN MVNEGSGHVC
210 220 230 240 250
PIWAGCLIII GGTVLVTFFG YSVIHAYEKW SWVPNFAVFL VIIAQLSRSG
260 270 280 290 300
KFKGGEWVGG ATTAGSVLSF GSSIFGFAAG WTTYAADYTV YMPKSTNKYK
310 320 330 340 350
IFFSLVAGLA FPLFFTMILG AASAMAALND PTWKAYYDKN AMGGVIYAIL
360 370 380 390 400
VPNSLNGFGQ FCCVLLALST IANNIPNMYT VALSAQALWA PLAKIPRVVW
410 420 430 440 450
TMAGNAATLG ISIPATYYFD GFMENFMDSI GYYLAIYIAI SCSEHFFYRR
460 470 480 490 500
SFSAYNIDDW DNWEHLPIGI AGTAALIVGA FGVALGMCQT YWVGEIGRLI
510 520 530
GKYGGDIGFE LGASWAFIIY NILRPLELKY FGR
Length:533
Mass (Da):58,201
Last modified:February 1, 1995 - v2
Checksum:i762DDB9483A546AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192V → M in CAA36040 (PubMed:2191181).Curated1
Sequence conflicti261A → G in CAA36040 (PubMed:2191181).Curated1
Sequence conflicti459D → Y in V01306 (PubMed:6300123).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51751 Genomic DNA Translation: CAA36040.1
U18813 Genomic DNA Translation: AAB64592.1
V01306 Genomic DNA No translation available.
BK006939 Genomic DNA Translation: DAA07713.1
PIRiS50559 GRBYCP
RefSeqiNP_010976.1, NM_001178947.1

Genome annotation databases

EnsemblFungiiYER056C; YER056C; YER056C
GeneIDi856783
KEGGisce:YER056C

Similar proteinsi

Entry informationi

Entry nameiFCY2_YEAST
AccessioniPrimary (citable) accession number: P17064
Secondary accession number(s): D3DLV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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