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P17063

- GIA1_GIAIN

UniProt

P17063 - GIA1_GIAIN

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Protein

Giardin subunit alpha-1

Gene
N/A
Organism
Giardia intestinalis (Giardia lamblia)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: InterPro
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. cytoskeleton organization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Giardin subunit alpha-1
OrganismiGiardia intestinalis (Giardia lamblia)
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

Subcellular locationi

Cytoplasmcytoskeleton
Note: Most likely in the edges of the ventral disk microribbons.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Giardin subunit alpha-1PRO_0000067522Add
BLAST

Structurei

Secondary structure

1
295
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1613Combined sources
Helixi20 – 289Combined sources
Helixi32 – 4615Combined sources
Helixi50 – 578Combined sources
Helixi62 – 709Combined sources
Helixi74 – 8714Combined sources
Helixi92 – 998Combined sources
Helixi104 – 11815Combined sources
Helixi122 – 1309Combined sources
Beta strandi132 – 1343Combined sources
Helixi135 – 14511Combined sources
Helixi155 – 16713Combined sources
Helixi171 – 18010Combined sources
Helixi183 – 19614Combined sources
Beta strandi197 – 1993Combined sources
Helixi201 – 2088Combined sources
Helixi211 – 22515Combined sources
Helixi227 – 24014Combined sources
Helixi245 – 25511Combined sources
Helixi256 – 2583Combined sources
Helixi262 – 2654Combined sources
Helixi266 – 2683Combined sources
Helixi272 – 2798Combined sources
Helixi284 – 2929Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EVFX-ray1.90A1-295[»]
4EVHX-ray2.60A1-295[»]
ProteinModelPortaliP17063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 6966AnnexinAdd
BLAST

Sequence similaritiesi

Belongs to the giardin subunit alpha family.Curated
Contains 1 annexin repeat.Curated

Keywords - Domaini

Annexin

Family and domain databases

Gene3Di1.10.220.10. 1 hit.
InterProiIPR008088. Alpha_giardin.
IPR018502. Annexin_repeat.
[Graphical view]
PfamiPF00191. Annexin. 1 hit.
[Graphical view]
PRINTSiPR01712. ALPHAGIARDIN.
SMARTiSM00335. ANX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17063-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKVTDIANE LKQAIDAKDE VQIAFIASEY SAESREKIAK AYVASYGKEL
60 70 80 90 100
PDDIKKALKG GSEESLLMDL FSDRHEVRAQ HIRDALSGRN DHMAFFDTVI
110 120 130 140 150
LCTPEDWHET VAAYTRMFKK PLVEDFMKDV GRKEDWCLLM EKWMAHERVS
160 170 180 190 200
RPGSPEDEAQ RLDQAFDQKN TAYLIDFFGT VPSAEYRPIA EAFKAQNGKS
210 220 230 240 250
IEQAIATIYT KTDYYTFYCA HFALLGMHRL AAYLINCACN DKGDEKRMRR
260 270 280 290
ITGMMVDKCL GAKHAYKIYG DMGTDIERCF DKRMAPILRT LWRVK
Length:295
Mass (Da):33,890
Last modified:August 1, 1990 - v1
Checksum:i9DA8F7318E7E4C50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52485 Genomic DNA. Translation: CAA36727.1.
PIRiA33735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52485 Genomic DNA. Translation: CAA36727.1 .
PIRi A33735.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EVF X-ray 1.90 A 1-295 [» ]
4EVH X-ray 2.60 A 1-295 [» ]
ProteinModelPortali P17063.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.220.10. 1 hit.
InterProi IPR008088. Alpha_giardin.
IPR018502. Annexin_repeat.
[Graphical view ]
Pfami PF00191. Annexin. 1 hit.
[Graphical view ]
PRINTSi PR01712. ALPHAGIARDIN.
SMARTi SM00335. ANX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ultrastructural localization of giardins to the edges of disk microribbons of Giarida lamblia and the nucleotide and deduced protein sequence of alpha giardin."
    Peattie D.A., Alonso R.A., Hein A., Caulfield J.P.
    J. Cell Biol. 109:2323-2335(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 3-31.
    Strain: Portland-1.
  2. "Nucleotide sequence of a second alpha giardin gene and molecular analysis of the alpha giardin genes and transcripts in Giardia lamblia."
    Alonso R.A., Peattie D.A.
    Mol. Biochem. Parasitol. 50:95-104(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Portland-1.

Entry informationi

Entry nameiGIA1_GIAIN
AccessioniPrimary (citable) accession number: P17063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3