Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Giardin subunit alpha-1

Gene
N/A
Organism
Giardia intestinalis (Giardia lamblia)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Giardin subunit alpha-1
OrganismiGiardia intestinalis (Giardia lamblia)
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

Subcellular locationi

  • cytoskeleton
  • Note: Most likely in the edges of the ventral disk microribbons.

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675221 – 295Giardin subunit alpha-1Add BLAST295

Proteomic databases

PRIDEiP17063

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Helixi20 – 28Combined sources9
Helixi32 – 46Combined sources15
Helixi50 – 57Combined sources8
Helixi62 – 70Combined sources9
Helixi74 – 87Combined sources14
Helixi92 – 99Combined sources8
Helixi104 – 118Combined sources15
Helixi122 – 130Combined sources9
Beta strandi132 – 134Combined sources3
Helixi135 – 145Combined sources11
Helixi155 – 167Combined sources13
Helixi171 – 180Combined sources10
Helixi183 – 196Combined sources14
Beta strandi197 – 199Combined sources3
Helixi201 – 208Combined sources8
Helixi211 – 225Combined sources15
Helixi227 – 240Combined sources14
Helixi245 – 255Combined sources11
Helixi256 – 258Combined sources3
Helixi262 – 265Combined sources4
Helixi266 – 268Combined sources3
Helixi272 – 279Combined sources8
Helixi284 – 292Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EVFX-ray1.90A1-295[»]
4EVHX-ray2.60A1-295[»]
ProteinModelPortaliP17063
SMRiP17063
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 69AnnexinAdd BLAST66

Sequence similaritiesi

Belongs to the giardin subunit alpha family.Curated

Keywords - Domaini

Annexin

Family and domain databases

Gene3Di1.10.220.104 hits
InterProiView protein in InterPro
IPR008088 Alpha_giardin
IPR018502 Annexin_repeat
IPR037104 Annexin_sf
PfamiView protein in Pfam
PF00191 Annexin, 1 hit
PRINTSiPR01712 ALPHAGIARDIN
SMARTiView protein in SMART
SM00335 ANX, 1 hit

Sequencei

Sequence statusi: Complete.

P17063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKVTDIANE LKQAIDAKDE VQIAFIASEY SAESREKIAK AYVASYGKEL
60 70 80 90 100
PDDIKKALKG GSEESLLMDL FSDRHEVRAQ HIRDALSGRN DHMAFFDTVI
110 120 130 140 150
LCTPEDWHET VAAYTRMFKK PLVEDFMKDV GRKEDWCLLM EKWMAHERVS
160 170 180 190 200
RPGSPEDEAQ RLDQAFDQKN TAYLIDFFGT VPSAEYRPIA EAFKAQNGKS
210 220 230 240 250
IEQAIATIYT KTDYYTFYCA HFALLGMHRL AAYLINCACN DKGDEKRMRR
260 270 280 290
ITGMMVDKCL GAKHAYKIYG DMGTDIERCF DKRMAPILRT LWRVK
Length:295
Mass (Da):33,890
Last modified:August 1, 1990 - v1
Checksum:i9DA8F7318E7E4C50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52485 Genomic DNA Translation: CAA36727.1
PIRiA33735

Similar proteinsi

Entry informationi

Entry nameiGIA1_GIAIN
AccessioniPrimary (citable) accession number: P17063
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing