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P17063

- GIA1_GIAIN

UniProt

P17063 - GIA1_GIAIN

Protein

Giardin subunit alpha-1

Gene
N/A
Organism
Giardia intestinalis (Giardia lamblia)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: InterPro
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. cytoskeleton organization Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Giardin subunit alpha-1
    OrganismiGiardia intestinalis (Giardia lamblia)
    Taxonomic identifieri5741 [NCBI]
    Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

    Subcellular locationi

    Cytoplasmcytoskeleton
    Note: Most likely in the edges of the ventral disk microribbons.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Giardin subunit alpha-1PRO_0000067522Add
    BLAST

    Structurei

    Secondary structure

    1
    295
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 1613
    Helixi20 – 289
    Helixi32 – 4615
    Helixi50 – 578
    Helixi62 – 709
    Helixi74 – 8714
    Helixi92 – 998
    Helixi104 – 11815
    Helixi122 – 1309
    Beta strandi132 – 1343
    Helixi135 – 14511
    Helixi155 – 16713
    Helixi171 – 18010
    Helixi183 – 19614
    Beta strandi197 – 1993
    Helixi201 – 2088
    Helixi211 – 22515
    Helixi227 – 24014
    Helixi245 – 25511
    Helixi256 – 2583
    Helixi262 – 2654
    Helixi266 – 2683
    Helixi272 – 2798
    Helixi284 – 2929

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4EVFX-ray1.90A1-295[»]
    4EVHX-ray2.60A1-295[»]
    ProteinModelPortaliP17063.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati4 – 6966AnnexinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the giardin subunit alpha family.Curated
    Contains 1 annexin repeat.Curated

    Keywords - Domaini

    Annexin

    Family and domain databases

    Gene3Di1.10.220.10. 1 hit.
    InterProiIPR008088. Alpha_giardin.
    IPR018502. Annexin_repeat.
    [Graphical view]
    PfamiPF00191. Annexin. 1 hit.
    [Graphical view]
    PRINTSiPR01712. ALPHAGIARDIN.
    SMARTiSM00335. ANX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17063-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKVTDIANE LKQAIDAKDE VQIAFIASEY SAESREKIAK AYVASYGKEL    50
    PDDIKKALKG GSEESLLMDL FSDRHEVRAQ HIRDALSGRN DHMAFFDTVI 100
    LCTPEDWHET VAAYTRMFKK PLVEDFMKDV GRKEDWCLLM EKWMAHERVS 150
    RPGSPEDEAQ RLDQAFDQKN TAYLIDFFGT VPSAEYRPIA EAFKAQNGKS 200
    IEQAIATIYT KTDYYTFYCA HFALLGMHRL AAYLINCACN DKGDEKRMRR 250
    ITGMMVDKCL GAKHAYKIYG DMGTDIERCF DKRMAPILRT LWRVK 295
    Length:295
    Mass (Da):33,890
    Last modified:August 1, 1990 - v1
    Checksum:i9DA8F7318E7E4C50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52485 Genomic DNA. Translation: CAA36727.1.
    PIRiA33735.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52485 Genomic DNA. Translation: CAA36727.1 .
    PIRi A33735.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4EVF X-ray 1.90 A 1-295 [» ]
    4EVH X-ray 2.60 A 1-295 [» ]
    ProteinModelPortali P17063.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.220.10. 1 hit.
    InterProi IPR008088. Alpha_giardin.
    IPR018502. Annexin_repeat.
    [Graphical view ]
    Pfami PF00191. Annexin. 1 hit.
    [Graphical view ]
    PRINTSi PR01712. ALPHAGIARDIN.
    SMARTi SM00335. ANX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ultrastructural localization of giardins to the edges of disk microribbons of Giarida lamblia and the nucleotide and deduced protein sequence of alpha giardin."
      Peattie D.A., Alonso R.A., Hein A., Caulfield J.P.
      J. Cell Biol. 109:2323-2335(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 3-31.
      Strain: Portland-1.
    2. "Nucleotide sequence of a second alpha giardin gene and molecular analysis of the alpha giardin genes and transcripts in Giardia lamblia."
      Alonso R.A., Peattie D.A.
      Mol. Biochem. Parasitol. 50:95-104(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Portland-1.

    Entry informationi

    Entry nameiGIA1_GIAIN
    AccessioniPrimary (citable) accession number: P17063
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3