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Protein

Giardin subunit alpha-1

Gene
N/A
Organism
Giardia intestinalis (Giardia lamblia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Giardin subunit alpha-1
OrganismiGiardia intestinalis (Giardia lamblia)
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675221 – 295Giardin subunit alpha-1Add BLAST295

Proteomic databases

PRIDEiP17063.

Interactioni

Protein-protein interaction databases

STRINGi184922.XP_001704310.1.

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Helixi20 – 28Combined sources9
Helixi32 – 46Combined sources15
Helixi50 – 57Combined sources8
Helixi62 – 70Combined sources9
Helixi74 – 87Combined sources14
Helixi92 – 99Combined sources8
Helixi104 – 118Combined sources15
Helixi122 – 130Combined sources9
Beta strandi132 – 134Combined sources3
Helixi135 – 145Combined sources11
Helixi155 – 167Combined sources13
Helixi171 – 180Combined sources10
Helixi183 – 196Combined sources14
Beta strandi197 – 199Combined sources3
Helixi201 – 208Combined sources8
Helixi211 – 225Combined sources15
Helixi227 – 240Combined sources14
Helixi245 – 255Combined sources11
Helixi256 – 258Combined sources3
Helixi262 – 265Combined sources4
Helixi266 – 268Combined sources3
Helixi272 – 279Combined sources8
Helixi284 – 292Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EVFX-ray1.90A1-295[»]
4EVHX-ray2.60A1-295[»]
ProteinModelPortaliP17063.
SMRiP17063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 69AnnexinAdd BLAST66

Sequence similaritiesi

Belongs to the giardin subunit alpha family.Curated
Contains 1 annexin repeat.Curated

Keywords - Domaini

Annexin

Family and domain databases

Gene3Di1.10.220.10. 1 hit.
InterProiIPR008088. Alpha_giardin.
IPR018502. Annexin_repeat.
[Graphical view]
PfamiPF00191. Annexin. 1 hit.
[Graphical view]
PRINTSiPR01712. ALPHAGIARDIN.
SMARTiSM00335. ANX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKVTDIANE LKQAIDAKDE VQIAFIASEY SAESREKIAK AYVASYGKEL
60 70 80 90 100
PDDIKKALKG GSEESLLMDL FSDRHEVRAQ HIRDALSGRN DHMAFFDTVI
110 120 130 140 150
LCTPEDWHET VAAYTRMFKK PLVEDFMKDV GRKEDWCLLM EKWMAHERVS
160 170 180 190 200
RPGSPEDEAQ RLDQAFDQKN TAYLIDFFGT VPSAEYRPIA EAFKAQNGKS
210 220 230 240 250
IEQAIATIYT KTDYYTFYCA HFALLGMHRL AAYLINCACN DKGDEKRMRR
260 270 280 290
ITGMMVDKCL GAKHAYKIYG DMGTDIERCF DKRMAPILRT LWRVK
Length:295
Mass (Da):33,890
Last modified:August 1, 1990 - v1
Checksum:i9DA8F7318E7E4C50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52485 Genomic DNA. Translation: CAA36727.1.
PIRiA33735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52485 Genomic DNA. Translation: CAA36727.1.
PIRiA33735.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EVFX-ray1.90A1-295[»]
4EVHX-ray2.60A1-295[»]
ProteinModelPortaliP17063.
SMRiP17063.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi184922.XP_001704310.1.

Proteomic databases

PRIDEiP17063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.220.10. 1 hit.
InterProiIPR008088. Alpha_giardin.
IPR018502. Annexin_repeat.
[Graphical view]
PfamiPF00191. Annexin. 1 hit.
[Graphical view]
PRINTSiPR01712. ALPHAGIARDIN.
SMARTiSM00335. ANX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIA1_GIAIN
AccessioniPrimary (citable) accession number: P17063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.