SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17063

- GIA1_GIAIN

UniProt

P17063 - GIA1_GIAIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Giardin subunit alpha-1
Gene
N/A
Organism
Giardia intestinalis (Giardia lamblia)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. calcium-dependent phospholipid binding Source: InterPro

GO - Biological processi

  1. cytoskeleton organization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Giardin subunit alpha-1
OrganismiGiardia intestinalis (Giardia lamblia)
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

Subcellular locationi

Cytoplasmcytoskeleton
Note: Most likely in the edges of the ventral disk microribbons.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Giardin subunit alpha-1
PRO_0000067522Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1613
Helixi20 – 289
Helixi32 – 4615
Helixi50 – 578
Helixi62 – 709
Helixi74 – 8714
Helixi92 – 998
Helixi104 – 11815
Helixi122 – 1309
Beta strandi132 – 1343
Helixi135 – 14511
Helixi155 – 16713
Helixi171 – 18010
Helixi183 – 19614
Beta strandi197 – 1993
Helixi201 – 2088
Helixi211 – 22515
Helixi227 – 24014
Helixi245 – 25511
Helixi256 – 2583
Helixi262 – 2654
Helixi266 – 2683
Helixi272 – 2798
Helixi284 – 2929

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EVFX-ray1.90A1-295[»]
4EVHX-ray2.60A1-295[»]
ProteinModelPortaliP17063.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 6966Annexin
Add
BLAST

Sequence similaritiesi

Contains 1 annexin repeat.

Keywords - Domaini

Annexin

Family and domain databases

Gene3Di1.10.220.10. 1 hit.
InterProiIPR008088. Alpha_giardin.
IPR018502. Annexin_repeat.
[Graphical view]
PfamiPF00191. Annexin. 1 hit.
[Graphical view]
PRINTSiPR01712. ALPHAGIARDIN.
SMARTiSM00335. ANX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17063-1 [UniParc]FASTAAdd to Basket

« Hide

MPKVTDIANE LKQAIDAKDE VQIAFIASEY SAESREKIAK AYVASYGKEL    50
PDDIKKALKG GSEESLLMDL FSDRHEVRAQ HIRDALSGRN DHMAFFDTVI 100
LCTPEDWHET VAAYTRMFKK PLVEDFMKDV GRKEDWCLLM EKWMAHERVS 150
RPGSPEDEAQ RLDQAFDQKN TAYLIDFFGT VPSAEYRPIA EAFKAQNGKS 200
IEQAIATIYT KTDYYTFYCA HFALLGMHRL AAYLINCACN DKGDEKRMRR 250
ITGMMVDKCL GAKHAYKIYG DMGTDIERCF DKRMAPILRT LWRVK 295
Length:295
Mass (Da):33,890
Last modified:August 1, 1990 - v1
Checksum:i9DA8F7318E7E4C50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52485 Genomic DNA. Translation: CAA36727.1.
PIRiA33735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52485 Genomic DNA. Translation: CAA36727.1 .
PIRi A33735.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EVF X-ray 1.90 A 1-295 [» ]
4EVH X-ray 2.60 A 1-295 [» ]
ProteinModelPortali P17063.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.220.10. 1 hit.
InterProi IPR008088. Alpha_giardin.
IPR018502. Annexin_repeat.
[Graphical view ]
Pfami PF00191. Annexin. 1 hit.
[Graphical view ]
PRINTSi PR01712. ALPHAGIARDIN.
SMARTi SM00335. ANX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ultrastructural localization of giardins to the edges of disk microribbons of Giarida lamblia and the nucleotide and deduced protein sequence of alpha giardin."
    Peattie D.A., Alonso R.A., Hein A., Caulfield J.P.
    J. Cell Biol. 109:2323-2335(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 3-31.
    Strain: Portland-1.
  2. "Nucleotide sequence of a second alpha giardin gene and molecular analysis of the alpha giardin genes and transcripts in Giardia lamblia."
    Alonso R.A., Peattie D.A.
    Mol. Biochem. Parasitol. 50:95-104(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Portland-1.

Entry informationi

Entry nameiGIA1_GIAIN
AccessioniPrimary (citable) accession number: P17063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi