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P17063 (GIA1_GIAIN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Giardin subunit alpha-1
OrganismGiardia intestinalis (Giardia lamblia)
Taxonomic identifier5741 [NCBI]
Taxonomic lineageEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst. They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk.

Subcellular location

Cytoplasmcytoskeleton. Note: Most likely in the edges of the ventral disk microribbons.

Sequence similarities

Belongs to the giardin subunit alpha family.

Contains 1 annexin repeat.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   DomainAnnexin
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processcytoskeleton organization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

calcium-dependent phospholipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Giardin subunit alpha-1
PRO_0000067522

Regions

Repeat4 – 6966Annexin

Secondary structure

............................................. 295
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P17063 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 9DA8F7318E7E4C50

FASTA29533,890
        10         20         30         40         50         60 
MPKVTDIANE LKQAIDAKDE VQIAFIASEY SAESREKIAK AYVASYGKEL PDDIKKALKG 

        70         80         90        100        110        120 
GSEESLLMDL FSDRHEVRAQ HIRDALSGRN DHMAFFDTVI LCTPEDWHET VAAYTRMFKK 

       130        140        150        160        170        180 
PLVEDFMKDV GRKEDWCLLM EKWMAHERVS RPGSPEDEAQ RLDQAFDQKN TAYLIDFFGT 

       190        200        210        220        230        240 
VPSAEYRPIA EAFKAQNGKS IEQAIATIYT KTDYYTFYCA HFALLGMHRL AAYLINCACN 

       250        260        270        280        290 
DKGDEKRMRR ITGMMVDKCL GAKHAYKIYG DMGTDIERCF DKRMAPILRT LWRVK 

« Hide

References

[1]"Ultrastructural localization of giardins to the edges of disk microribbons of Giarida lamblia and the nucleotide and deduced protein sequence of alpha giardin."
Peattie D.A., Alonso R.A., Hein A., Caulfield J.P.
J. Cell Biol. 109:2323-2335(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 3-31.
Strain: Portland-1.
[2]"Nucleotide sequence of a second alpha giardin gene and molecular analysis of the alpha giardin genes and transcripts in Giardia lamblia."
Alonso R.A., Peattie D.A.
Mol. Biochem. Parasitol. 50:95-104(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Portland-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52485 Genomic DNA. Translation: CAA36727.1.
PIRA33735.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4EVFX-ray1.90A1-295[»]
4EVHX-ray2.60A1-295[»]
ProteinModelPortalP17063.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.220.10. 1 hit.
InterProIPR008088. Alpha_giardin.
IPR018502. Annexin_repeat.
[Graphical view]
PfamPF00191. Annexin. 1 hit.
[Graphical view]
PRINTSPR01712. ALPHAGIARDIN.
SMARTSM00335. ANX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGIA1_GIAIN
AccessionPrimary (citable) accession number: P17063
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references