ID CRTE_RHOCB Reviewed; 289 AA. AC P17060; D5AP77; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1990, sequence version 1. DT 27-MAR-2024, entry version 121. DE RecName: Full=Geranylgeranyl diphosphate synthase; DE Short=GGPP synthase; DE EC=2.5.1.29; DE AltName: Full=Farnesyltranstransferase; GN Name=crtE; OrderedLocusNames=RCAP_rcc00684; OS Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales; OC Paracoccaceae; Rhodobacter. OX NCBI_TaxID=272942; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003; RX PubMed=2747617; DOI=10.1007/bf00334364; RA Armstrong G.A., Alberti M., Leach F., Hearst J.E.; RT "Nucleotide sequence, organization, and nature of the protein products of RT the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus."; RL Mol. Gen. Genet. 216:254-268(1989). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003; RX PubMed=20418398; DOI=10.1128/jb.00366-10; RA Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., RA Haselkorn R.; RT "Complete genome sequence of the photosynthetic purple nonsulfur bacterium RT Rhodobacter capsulatus SB 1003."; RL J. Bacteriol. 192:3545-3546(2010). CC -!- FUNCTION: Catalyzes the condensation of farnesyl diphosphate (FPP) and CC isopentenyl diphosphate (IPP) to yield geranylgeranyl diphosphate CC (GGPP) needed for biosynthesis of carotenoids and diterpenes. CC {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = CC (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate; CC Xref=Rhea:RHEA:17653, ChEBI:CHEBI:33019, ChEBI:CHEBI:58756, CC ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; EC=2.5.1.29; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; CC Note=Binds 2 Mg(2+) ions per subunit. {ECO:0000250}; CC -!- PATHWAY: Isoprenoid biosynthesis; geranylgeranyl diphosphate CC biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and CC isopentenyl diphosphate: step 1/1. CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X52291; CAA36538.1; -; Genomic_DNA. DR EMBL; Z11165; CAA77545.1; -; Genomic_DNA. DR EMBL; CP001312; ADE84449.1; -; Genomic_DNA. DR PIR; S04407; S04407. DR RefSeq; WP_013066428.1; NC_014034.1. DR AlphaFoldDB; P17060; -. DR SMR; P17060; -. DR STRING; 272942.RCAP_rcc00684; -. DR GeneID; 31489630; -. DR KEGG; rcp:RCAP_rcc00684; -. DR eggNOG; COG0142; Bacteria. DR HOGENOM; CLU_014015_0_1_5; -. DR OrthoDB; 9805316at2; -. DR BioCyc; MetaCyc:MONOMER-14935; -. DR UniPathway; UPA00389; UER00564. DR Proteomes; UP000002361; Chromosome. DR GO; GO:0004311; F:farnesyltranstransferase activity; ISS:UniProtKB. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0033386; P:geranylgeranyl diphosphate biosynthetic process; ISS:UniProtKB. DR GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW. DR CDD; cd00685; Trans_IPPS_HT; 1. DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1. DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf. DR InterPro; IPR000092; Polyprenyl_synt. DR InterPro; IPR033749; Polyprenyl_synt_CS. DR PANTHER; PTHR43281; FARNESYL DIPHOSPHATE SYNTHASE; 1. DR PANTHER; PTHR43281:SF1; FARNESYL DIPHOSPHATE SYNTHASE; 1. DR Pfam; PF00348; polyprenyl_synt; 1. DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1. DR SUPFAM; SSF48576; Terpenoid synthases; 1. DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1. DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1. PE 3: Inferred from homology; KW Carotenoid biosynthesis; Chlorophyll biosynthesis; Isoprene biosynthesis; KW Magnesium; Metal-binding; Photosynthesis; Reference proteome; Transferase. FT CHAIN 1..289 FT /note="Geranylgeranyl diphosphate synthase" FT /id="PRO_0000123994" FT BINDING 43 FT /ligand="isopentenyl diphosphate" FT /ligand_id="ChEBI:CHEBI:128769" FT /evidence="ECO:0000250|UniProtKB:P14324" FT BINDING 73 FT /ligand="isopentenyl diphosphate" FT /ligand_id="ChEBI:CHEBI:128769" FT /evidence="ECO:0000250|UniProtKB:Q12051" FT BINDING 80 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000250|UniProtKB:P14324" FT BINDING 80 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000250|UniProtKB:P14324" FT BINDING 86 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000250|UniProtKB:P14324" FT BINDING 86 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000250|UniProtKB:P14324" FT BINDING 91 FT /ligand="(2E,6E)-farnesyl diphosphate" FT /ligand_id="ChEBI:CHEBI:175763" FT /evidence="ECO:0000250" FT BINDING 92 FT /ligand="isopentenyl diphosphate" FT /ligand_id="ChEBI:CHEBI:128769" FT /evidence="ECO:0000250|UniProtKB:P14324" FT BINDING 170 FT /ligand="(2E,6E)-farnesyl diphosphate" FT /ligand_id="ChEBI:CHEBI:175763" FT /evidence="ECO:0000250" FT BINDING 171 FT /ligand="(2E,6E)-farnesyl diphosphate" FT /ligand_id="ChEBI:CHEBI:175763" FT /evidence="ECO:0000250" FT BINDING 205 FT /ligand="(2E,6E)-farnesyl diphosphate" FT /ligand_id="ChEBI:CHEBI:175763" FT /evidence="ECO:0000250" SQ SEQUENCE 289 AA; 30044 MW; CF483A26ECA9C859 CRC64; MSLDKRIESA LVKALSPEAL GESPPLLAAA LPYGVFPGGA RIRPTILVSV ALACGDDCPA VTDAAAVALE LMHCASLVHD DLPAFDNADI RRGKPSLHKA YNEPLAVLAG DSLLIRGFEV LADVGAVNPD RALKLISKLG QLSGARGGIC AGQAWESESK VDLAAYHQAK TGALFIAATQ MGAIAAGYEA EPWFDLGMRI GSAFQIADDL KDALMSAEAM GKPAGQDIAN ERPNAVKTMG IEGARKHLQD VLAGAIASIP SCPGEAKLAQ MVQLYAHKIM DIPASAERG //