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Protein

Geranylgeranyl diphosphate synthase

Gene

crtE

Organism
Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) to yield geranylgeranyl diphosphate (GGPP) needed for biosynthesis of carotenoids and diterpenes.By similarity

Catalytic activityi

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathway:igeranylgeranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Geranylgeranyl diphosphate synthase (crtE)
This subpathway is part of the pathway geranylgeranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate, the pathway geranylgeranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Isopentenyl diphosphateBy similarity
Binding sitei73 – 731Isopentenyl diphosphateBy similarity
Metal bindingi80 – 801Magnesium 1By similarity
Metal bindingi80 – 801Magnesium 2By similarity
Metal bindingi86 – 861Magnesium 1By similarity
Metal bindingi86 – 861Magnesium 2By similarity
Binding sitei91 – 911Farnesyl diphosphateBy similarity
Binding sitei92 – 921Isopentenyl diphosphateBy similarity
Binding sitei170 – 1701Farnesyl diphosphateBy similarity
Binding sitei171 – 1711Farnesyl diphosphateBy similarity
Binding sitei205 – 2051Farnesyl diphosphateBy similarity
Metal bindingi208 – 2081Magnesium 3By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carotenoid biosynthesis, Chlorophyll biosynthesis, Isoprene biosynthesis, Photosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14935.
RCAP272942:GJIY-697-MONOMER.
UniPathwayiUPA00389; UER00564.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl diphosphate synthase (EC:2.5.1.29)
Short name:
GGPP synthase
Alternative name(s):
Farnesyltranstransferase
Gene namesi
Name:crtE
Ordered Locus Names:RCAP_rcc00684
OrganismiRhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Taxonomic identifieri272942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002361 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Geranylgeranyl diphosphate synthasePRO_0000123994Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272942.RCAP_rcc00684.

Structurei

3D structure databases

ProteinModelPortaliP17060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000009101.
KOiK13789.
OMAiICAGQGW.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDKRIESA LVKALSPEAL GESPPLLAAA LPYGVFPGGA RIRPTILVSV
60 70 80 90 100
ALACGDDCPA VTDAAAVALE LMHCASLVHD DLPAFDNADI RRGKPSLHKA
110 120 130 140 150
YNEPLAVLAG DSLLIRGFEV LADVGAVNPD RALKLISKLG QLSGARGGIC
160 170 180 190 200
AGQAWESESK VDLAAYHQAK TGALFIAATQ MGAIAAGYEA EPWFDLGMRI
210 220 230 240 250
GSAFQIADDL KDALMSAEAM GKPAGQDIAN ERPNAVKTMG IEGARKHLQD
260 270 280
VLAGAIASIP SCPGEAKLAQ MVQLYAHKIM DIPASAERG
Length:289
Mass (Da):30,044
Last modified:August 1, 1990 - v1
Checksum:iCF483A26ECA9C859
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52291 Genomic DNA. Translation: CAA36538.1.
Z11165 Genomic DNA. Translation: CAA77545.1.
CP001312 Genomic DNA. Translation: ADE84449.1.
PIRiS04407.
RefSeqiWP_013066428.1. NC_014034.1.

Genome annotation databases

EnsemblBacteriaiADE84449; ADE84449; RCAP_rcc00684.
KEGGircp:RCAP_rcc00684.
PATRICi35501436. VBIRhoCap134200_0695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52291 Genomic DNA. Translation: CAA36538.1.
Z11165 Genomic DNA. Translation: CAA77545.1.
CP001312 Genomic DNA. Translation: ADE84449.1.
PIRiS04407.
RefSeqiWP_013066428.1. NC_014034.1.

3D structure databases

ProteinModelPortaliP17060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272942.RCAP_rcc00684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE84449; ADE84449; RCAP_rcc00684.
KEGGircp:RCAP_rcc00684.
PATRICi35501436. VBIRhoCap134200_0695.

Phylogenomic databases

HOGENOMiHOG000009101.
KOiK13789.
OMAiICAGQGW.

Enzyme and pathway databases

UniPathwayiUPA00389; UER00564.
BioCyciMetaCyc:MONOMER-14935.
RCAP272942:GJIY-697-MONOMER.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus."
    Armstrong G.A., Alberti M., Leach F., Hearst J.E.
    Mol. Gen. Genet. 216:254-268(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
  2. "Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003."
    Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R.
    J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Entry informationi

Entry nameiCRTE_RHOCB
AccessioniPrimary (citable) accession number: P17060
Secondary accession number(s): D5AP77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.