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P17060

- CRTE_RHOCB

UniProt

P17060 - CRTE_RHOCB

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Protein

Geranylgeranyl diphosphate synthase

Gene

crtE

Organism
Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) to yield geranylgeranyl diphosphate (GGPP) needed for biosynthesis of carotenoids and diterpenes.By similarity

Catalytic activityi

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg(2+) ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Isopentenyl diphosphateBy similarity
Binding sitei73 – 731Isopentenyl diphosphateBy similarity
Metal bindingi80 – 801Magnesium 1By similarity
Metal bindingi80 – 801Magnesium 2By similarity
Metal bindingi86 – 861Magnesium 1By similarity
Metal bindingi86 – 861Magnesium 2By similarity
Binding sitei91 – 911Farnesyl diphosphateBy similarity
Binding sitei92 – 921Isopentenyl diphosphateBy similarity
Binding sitei170 – 1701Farnesyl diphosphateBy similarity
Binding sitei171 – 1711Farnesyl diphosphateBy similarity
Binding sitei205 – 2051Farnesyl diphosphateBy similarity
Metal bindingi208 – 2081Magnesium 3By similarity

GO - Molecular functioni

  1. farnesyltranstransferase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
  2. chlorophyll biosynthetic process Source: UniProtKB-KW
  3. geranylgeranyl diphosphate biosynthetic process Source: UniProtKB
  4. photosynthesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carotenoid biosynthesis, Chlorophyll biosynthesis, Isoprene biosynthesis, Photosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14935.
RCAP272942:GJIY-697-MONOMER.
UniPathwayiUPA00389; UER00564.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl diphosphate synthase (EC:2.5.1.29)
Short name:
GGPP synthase
Alternative name(s):
Farnesyltranstransferase
Gene namesi
Name:crtE
Ordered Locus Names:RCAP_rcc00684
OrganismiRhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Taxonomic identifieri272942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002361: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Geranylgeranyl diphosphate synthasePRO_0000123994Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP17060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000009101.
KOiK13789.
OMAiIVAGQAW.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17060-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLDKRIESA LVKALSPEAL GESPPLLAAA LPYGVFPGGA RIRPTILVSV
60 70 80 90 100
ALACGDDCPA VTDAAAVALE LMHCASLVHD DLPAFDNADI RRGKPSLHKA
110 120 130 140 150
YNEPLAVLAG DSLLIRGFEV LADVGAVNPD RALKLISKLG QLSGARGGIC
160 170 180 190 200
AGQAWESESK VDLAAYHQAK TGALFIAATQ MGAIAAGYEA EPWFDLGMRI
210 220 230 240 250
GSAFQIADDL KDALMSAEAM GKPAGQDIAN ERPNAVKTMG IEGARKHLQD
260 270 280
VLAGAIASIP SCPGEAKLAQ MVQLYAHKIM DIPASAERG
Length:289
Mass (Da):30,044
Last modified:August 1, 1990 - v1
Checksum:iCF483A26ECA9C859
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52291 Genomic DNA. Translation: CAA36538.1.
Z11165 Genomic DNA. Translation: CAA77545.1.
CP001312 Genomic DNA. Translation: ADE84449.1.
PIRiS04407.
RefSeqiWP_013066428.1. NC_014034.1.
YP_003576856.1. NC_014034.1.

Genome annotation databases

EnsemblBacteriaiADE84449; ADE84449; RCAP_rcc00684.
GeneIDi9003513.
KEGGircp:RCAP_rcc00684.
PATRICi35501436. VBIRhoCap134200_0695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52291 Genomic DNA. Translation: CAA36538.1 .
Z11165 Genomic DNA. Translation: CAA77545.1 .
CP001312 Genomic DNA. Translation: ADE84449.1 .
PIRi S04407.
RefSeqi WP_013066428.1. NC_014034.1.
YP_003576856.1. NC_014034.1.

3D structure databases

ProteinModelPortali P17060.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE84449 ; ADE84449 ; RCAP_rcc00684 .
GeneIDi 9003513.
KEGGi rcp:RCAP_rcc00684.
PATRICi 35501436. VBIRhoCap134200_0695.

Phylogenomic databases

HOGENOMi HOG000009101.
KOi K13789.
OMAi IVAGQAW.

Enzyme and pathway databases

UniPathwayi UPA00389 ; UER00564 .
BioCyci MetaCyc:MONOMER-14935.
RCAP272942:GJIY-697-MONOMER.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view ]
PANTHERi PTHR12001. PTHR12001. 1 hit.
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus."
    Armstrong G.A., Alberti M., Leach F., Hearst J.E.
    Mol. Gen. Genet. 216:254-268(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
  2. "Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003."
    Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R.
    J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Entry informationi

Entry nameiCRTE_RHOCB
AccessioniPrimary (citable) accession number: P17060
Secondary accession number(s): D5AP77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3