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P17060 (CRTE_RHOCB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl diphosphate synthase

Short name=GGPP synthase
EC=2.5.1.29
Alternative name(s):
Farnesyltranstransferase
Gene names
Name:crtE
Ordered Locus Names:RCAP_rcc00684
OrganismRhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) [Complete proteome] [HAMAP]
Taxonomic identifier272942 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) to yield geranylgeranyl diphosphate (GGPP) needed for biosynthesis of carotenoids and diterpenes By similarity.

Catalytic activity

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Geranylgeranyl diphosphate synthase
PRO_0000123994

Sites

Metal binding801Magnesium 1 By similarity
Metal binding801Magnesium 2 By similarity
Metal binding861Magnesium 1 By similarity
Metal binding861Magnesium 2 By similarity
Metal binding2081Magnesium 3 By similarity
Binding site431Isopentenyl diphosphate By similarity
Binding site731Isopentenyl diphosphate By similarity
Binding site911Farnesyl diphosphate By similarity
Binding site921Isopentenyl diphosphate By similarity
Binding site1701Farnesyl diphosphate By similarity
Binding site1711Farnesyl diphosphate By similarity
Binding site2051Farnesyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P17060 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: CF483A26ECA9C859

FASTA28930,044
        10         20         30         40         50         60 
MSLDKRIESA LVKALSPEAL GESPPLLAAA LPYGVFPGGA RIRPTILVSV ALACGDDCPA 

        70         80         90        100        110        120 
VTDAAAVALE LMHCASLVHD DLPAFDNADI RRGKPSLHKA YNEPLAVLAG DSLLIRGFEV 

       130        140        150        160        170        180 
LADVGAVNPD RALKLISKLG QLSGARGGIC AGQAWESESK VDLAAYHQAK TGALFIAATQ 

       190        200        210        220        230        240 
MGAIAAGYEA EPWFDLGMRI GSAFQIADDL KDALMSAEAM GKPAGQDIAN ERPNAVKTMG 

       250        260        270        280 
IEGARKHLQD VLAGAIASIP SCPGEAKLAQ MVQLYAHKIM DIPASAERG 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus."
Armstrong G.A., Alberti M., Leach F., Hearst J.E.
Mol. Gen. Genet. 216:254-268(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
[2]"Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003."
Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R.
J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52291 Genomic DNA. Translation: CAA36538.1.
Z11165 Genomic DNA. Translation: CAA77545.1.
CP001312 Genomic DNA. Translation: ADE84449.1.
PIRS04407.
RefSeqYP_003576856.1. NC_014034.1.

3D structure databases

ProteinModelPortalP17060.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADE84449; ADE84449; RCAP_rcc00684.
GeneID9003513.
KEGGrcp:RCAP_rcc00684.
PATRIC35501436. VBIRhoCap134200_0695.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000009101.
KOK13789.
OMAIVAGQAW.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-14935.
RCAP272942:GJIY-697-MONOMER.
UniPathwayUPA00389; UER00564.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERPTHR12001. PTHR12001. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRTE_RHOCB
AccessionPrimary (citable) accession number: P17060
Secondary accession number(s): D5AP77
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways