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P17060

- CRTE_RHOCB

UniProt

P17060 - CRTE_RHOCB

Protein

Geranylgeranyl diphosphate synthase

Gene

crtE

Organism
Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) to yield geranylgeranyl diphosphate (GGPP) needed for biosynthesis of carotenoids and diterpenes.By similarity

    Catalytic activityi

    (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

    Cofactori

    Binds 3 magnesium ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431Isopentenyl diphosphateBy similarity
    Binding sitei73 – 731Isopentenyl diphosphateBy similarity
    Metal bindingi80 – 801Magnesium 1By similarity
    Metal bindingi80 – 801Magnesium 2By similarity
    Metal bindingi86 – 861Magnesium 1By similarity
    Metal bindingi86 – 861Magnesium 2By similarity
    Binding sitei91 – 911Farnesyl diphosphateBy similarity
    Binding sitei92 – 921Isopentenyl diphosphateBy similarity
    Binding sitei170 – 1701Farnesyl diphosphateBy similarity
    Binding sitei171 – 1711Farnesyl diphosphateBy similarity
    Binding sitei205 – 2051Farnesyl diphosphateBy similarity
    Metal bindingi208 – 2081Magnesium 3By similarity

    GO - Molecular functioni

    1. farnesyltranstransferase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB-KW
    2. chlorophyll biosynthetic process Source: UniProtKB-KW
    3. geranylgeranyl diphosphate biosynthetic process Source: UniProtKB
    4. photosynthesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis, Chlorophyll biosynthesis, Isoprene biosynthesis, Photosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14935.
    RCAP272942:GJIY-697-MONOMER.
    UniPathwayiUPA00389; UER00564.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geranylgeranyl diphosphate synthase (EC:2.5.1.29)
    Short name:
    GGPP synthase
    Alternative name(s):
    Farnesyltranstransferase
    Gene namesi
    Name:crtE
    Ordered Locus Names:RCAP_rcc00684
    OrganismiRhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
    Taxonomic identifieri272942 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002361: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Geranylgeranyl diphosphate synthasePRO_0000123994Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP17060.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000009101.
    KOiK13789.
    OMAiIVAGQAW.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PANTHERiPTHR12001. PTHR12001. 1 hit.
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17060-1 [UniParc]FASTAAdd to Basket

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    MSLDKRIESA LVKALSPEAL GESPPLLAAA LPYGVFPGGA RIRPTILVSV    50
    ALACGDDCPA VTDAAAVALE LMHCASLVHD DLPAFDNADI RRGKPSLHKA 100
    YNEPLAVLAG DSLLIRGFEV LADVGAVNPD RALKLISKLG QLSGARGGIC 150
    AGQAWESESK VDLAAYHQAK TGALFIAATQ MGAIAAGYEA EPWFDLGMRI 200
    GSAFQIADDL KDALMSAEAM GKPAGQDIAN ERPNAVKTMG IEGARKHLQD 250
    VLAGAIASIP SCPGEAKLAQ MVQLYAHKIM DIPASAERG 289
    Length:289
    Mass (Da):30,044
    Last modified:August 1, 1990 - v1
    Checksum:iCF483A26ECA9C859
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52291 Genomic DNA. Translation: CAA36538.1.
    Z11165 Genomic DNA. Translation: CAA77545.1.
    CP001312 Genomic DNA. Translation: ADE84449.1.
    PIRiS04407.
    RefSeqiWP_013066428.1. NC_014034.1.
    YP_003576856.1. NC_014034.1.

    Genome annotation databases

    EnsemblBacteriaiADE84449; ADE84449; RCAP_rcc00684.
    GeneIDi9003513.
    KEGGircp:RCAP_rcc00684.
    PATRICi35501436. VBIRhoCap134200_0695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52291 Genomic DNA. Translation: CAA36538.1 .
    Z11165 Genomic DNA. Translation: CAA77545.1 .
    CP001312 Genomic DNA. Translation: ADE84449.1 .
    PIRi S04407.
    RefSeqi WP_013066428.1. NC_014034.1.
    YP_003576856.1. NC_014034.1.

    3D structure databases

    ProteinModelPortali P17060.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE84449 ; ADE84449 ; RCAP_rcc00684 .
    GeneIDi 9003513.
    KEGGi rcp:RCAP_rcc00684.
    PATRICi 35501436. VBIRhoCap134200_0695.

    Phylogenomic databases

    HOGENOMi HOG000009101.
    KOi K13789.
    OMAi IVAGQAW.

    Enzyme and pathway databases

    UniPathwayi UPA00389 ; UER00564 .
    BioCyci MetaCyc:MONOMER-14935.
    RCAP272942:GJIY-697-MONOMER.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    PANTHERi PTHR12001. PTHR12001. 1 hit.
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus."
      Armstrong G.A., Alberti M., Leach F., Hearst J.E.
      Mol. Gen. Genet. 216:254-268(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
    2. "Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003."
      Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R.
      J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

    Entry informationi

    Entry nameiCRTE_RHOCB
    AccessioniPrimary (citable) accession number: P17060
    Secondary accession number(s): D5AP77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3