P17060 (CRTE_RHOCB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Geranylgeranyl pyrophosphate synthase
Short name=GGPP synthase
EC=2.5.1.29

Alternative name(s):
Farnesyltranstransferase

Gene names

Name:	crtE
Ordered Locus Names:	RCAP_rcc00684

Organism

Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) [Complete proteome] [HAMAP]

Taxonomic identifier

272942 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › Rhodobacter capsulatus

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Cofactor	Binds 3 magnesium ions per subunit By similarity.
Pathway	Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
Sequence similarities	Belongs to the FPP/GGPP synthase family.

Ontologies

Keywords
Biological process	Carotenoid biosynthesis Chlorophyll biosynthesis Isoprene biosynthesis Photosynthesis
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW geranylgeranyl diphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	farnesyltranstransferase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Geranylgeranyl pyrophosphate synthase		PRO_0000123994
Sites
	Metal binding	80	1	Magnesium 1 By similarity
	Metal binding	80	1	Magnesium 2 By similarity
	Metal binding	86	1	Magnesium 1 By similarity
	Metal binding	86	1	Magnesium 2 By similarity
	Metal binding	208	1	Magnesium 3 By similarity
	Binding site	43	1	Isopentenyl diphosphate By similarity
	Binding site	73	1	Isopentenyl diphosphate By similarity
	Binding site	91	1	Farnesyl diphosphate By similarity
	Binding site	92	1	Isopentenyl diphosphate By similarity
	Binding site	170	1	Farnesyl diphosphate By similarity
	Binding site	171	1	Farnesyl diphosphate By similarity
	Binding site	205	1	Farnesyl diphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P17060 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: CF483A26ECA9C859	FASTA	289	30,044
	10 20 30 40 50 60 MSLDKRIESA LVKALSPEAL GESPPLLAAA LPYGVFPGGA RIRPTILVSV ALACGDDCPA 70 80 90 100 110 120 VTDAAAVALE LMHCASLVHD DLPAFDNADI RRGKPSLHKA YNEPLAVLAG DSLLIRGFEV 130 140 150 160 170 180 LADVGAVNPD RALKLISKLG QLSGARGGIC AGQAWESESK VDLAAYHQAK TGALFIAATQ 190 200 210 220 230 240 MGAIAAGYEA EPWFDLGMRI GSAFQIADDL KDALMSAEAM GKPAGQDIAN ERPNAVKTMG 250 260 270 280 IEGARKHLQD VLAGAIASIP SCPGEAKLAQ MVQLYAHKIM DIPASAERG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus." Armstrong G.A., Alberti M., Leach F., Hearst J.E. Mol. Gen. Genet. 216:254-268(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
[2]	"Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003." Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R. J. Bacteriol. 192:3545-3546(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52291 Genomic DNA. Translation: CAA36538.1. Z11165 Genomic DNA. Translation: CAA77545.1. CP001312 Genomic DNA. Translation: ADE84449.1.
PIR	S04407.
RefSeq	YP_003576856.1. NC_014034.1.
3D structure databases
ProteinModelPortal	P17060.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADE84449; ADE84449; RCAP_rcc00684.
GeneID	9003513.
KEGG	rcp:RCAP_rcc00684.
PATRIC	35501436. VBIRhoCap134200_0695.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000009101.
KO	K13789.
OMA	RIRPTIC.
ProtClustDB	CLSK903955.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-14935. RCAP272942:GJIY-697-MONOMER.
UniPathway	UPA00389; UER00564.
Family and domain databases
Gene3D	1.10.600.10. 1 hit.
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
PANTHER	PTHR12001. PTHR12001. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
SUPFAM	SSF48576. Terpenoid_synth. 1 hit.
PROSITE	PS00723. POLYPRENYL_SYNTHASE_1. 1 hit. PS00444. POLYPRENYL_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRTE_RHOCB

Accession

Primary (citable) accession number: P17060
Secondary accession number(s): D5AP77

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program