Reviewed, UniProtKB/Swiss-Prot P17060 (CRTE_RHOCA)

Names and origin

Protein names

Recommended name:
    Geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
    EC=2.5.1.29
Alternative name(s):
    Farnesyltranstransferase

Gene names

Name:

crtE

Organism

Rhodobacter capsulatus (Rhodopseudomonas capsulata)

Taxonomic identifier

1061 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Cofactor	Binds 3 magnesium ions per subunit By similarity.
Pathway	Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Carotenoid biosynthesis Chlorophyll biosynthesis Isoprene biosynthesis Photosynthesis
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Gene Ontology (GO)
Biological process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	farnesyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Geranylgeranyl pyrophosphate synthetase		PRO_0000123994
Sites
	Metal binding	80	1	Magnesium 1 By similarity
	Metal binding	80	1	Magnesium 2 By similarity
	Metal binding	86	1	Magnesium 1 By similarity
	Metal binding	86	1	Magnesium 2 By similarity
	Metal binding	208	1	Magnesium 3 By similarity
	Binding site	43	1	Isopentenyl diphosphate By similarity
	Binding site	73	1	Isopentenyl diphosphate By similarity
	Binding site	91	1	Farnesyl diphosphate By similarity
	Binding site	92	1	Isopentenyl diphosphate By similarity
	Binding site	170	1	Farnesyl diphosphate By similarity
	Binding site	171	1	Farnesyl diphosphate By similarity
	Binding site	205	1	Farnesyl diphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P17060-1 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: CF483A26ECA9C859	FASTA	289	30,044
	10 20 30 40 50 60 MSLDKRIESA LVKALSPEAL GESPPLLAAA LPYGVFPGGA RIRPTILVSV ALACGDDCPA 70 80 90 100 110 120 VTDAAAVALE LMHCASLVHD DLPAFDNADI RRGKPSLHKA YNEPLAVLAG DSLLIRGFEV 130 140 150 160 170 180 LADVGAVNPD RALKLISKLG QLSGARGGIC AGQAWESESK VDLAAYHQAK TGALFIAATQ 190 200 210 220 230 240 MGAIAAGYEA EPWFDLGMRI GSAFQIADDL KDALMSAEAM GKPAGQDIAN ERPNAVKTMG 250 260 270 280 IEGARKHLQD VLAGAIASIP SCPGEAKLAQ MVQLYAHKIM DIPASAERG

References

[1]

"Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus." Armstrong G.A., Alberti M., Leach F., Hearst J.E. Mol. Gen. Genet. 216:254-268(1989) [PubMed: 2747617] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 23782 / LMG 2373 / NCIB 11773 / SB1003 / St. Louis and BEC404.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X52291 Genomic DNA. Translation: CAA36538.1. Z11165 Genomic DNA. Translation: CAA77545.1.
PIR	S04407.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.29. 567.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRTE_RHOCA

Accession

Primary (citable) accession number: P17060

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)