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P17047 (LAMP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 2

Short name=LAMP-2
Short name=Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
Lysosomal membrane glycoprotein type B
Short name=LGP-B
CD_antigen=CD107b
Gene names
Name:Lamp2
Synonyms:Lamp-2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Post-translational modification

O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans By similarity.

Sequence similarities

Belongs to the LAMP family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform LAMP-2A (identifier: P17047-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform LAMP-2B (identifier: P17047-2)

The sequence of this isoform differs from the canonical sequence as follows:
     371-415: QDCSADEDNF...KRHHTGYEQF → EECAADSDLN...RKSRTGYQSV
Isoform LAMP-2C (identifier: P17047-3)

The sequence of this isoform differs from the canonical sequence as follows:
     372-415: DCSADEDNFL...KRHHTGYEQF → ECSLDDDTIL...RKTYAGYQTL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525
Chain26 – 415390Lysosome-associated membrane glycoprotein 2
PRO_0000017111

Regions

Topological domain26 – 379354Lumenal Potential
Transmembrane380 – 40425Helical; Potential
Topological domain405 – 41511Cytoplasmic Potential
Region26 – 188163First lumenal domain
Region189 – 23345Hinge
Region234 – 379146Second lumenal domain

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation2341N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation2801N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Glycosylation3611N-linked (GlcNAc...) Potential
Disulfide bond37 ↔ 75 By similarity
Disulfide bond149 ↔ 185 By similarity
Disulfide bond237 ↔ 270 By similarity
Disulfide bond336 ↔ 373 By similarity

Natural variations

Alternative sequence371 – 41545QDCSA…GYEQF → EECAADSDLNFLIPVAVGVA LGFLIIAVFISYMIGRRKSR TGYQSV in isoform LAMP-2B.
VSP_003045
Alternative sequence372 – 41544DCSAD…GYEQF → ECSLDDDTILIPIIVGAGLS GLIIVIVIAYLIGRRKTYAG YQTL in isoform LAMP-2C.
VSP_003046

Experimental info

Sequence conflict2721P → H in BAE34951. Ref.2
Sequence conflict2891F → L in AAA39412. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform LAMP-2A [UniParc].

Last modified May 31, 2011. Version 2.
Checksum: 053A874B4DF67C88

FASTA41545,681
        10         20         30         40         50         60 
MCLSPVKGAK LILIFLFLGA VQSNALIVNL TDSKGTCLYA EWEMNFTITY ETTNQTNKTI 

        70         80         90        100        110        120 
TIAVPDKATH DGSSCGDDRN SAKIMIQFGF AVSWAVNFTK EASHYSIHDI VLSYNTSDST 

       130        140        150        160        170        180 
VFPGAVAKGV HTVKNPENFK VPLDVIFKCN SVLTYNLTPV VQKYWGIHLQ AFVQNGTVSK 

       190        200        210        220        230        240 
NEQVCEEDQT PTTVAPIIHT TAPSTTTTLT PTSTPTPTPT PTPTVGNYSI RNGNTTCLLA 

       250        260        270        280        290        300 
TMGLQLNITE EKVPFIFNIN PATTNFTGSC QPQSAQLRLN NSQIKYLDFI FAVKNEKRFY 

       310        320        330        340        350        360 
LKEVNVYMYL ANGSAFNISN KNLSFWDAPL GSSYMCNKEQ VLSVSRAFQI NTFNLKVQPF 

       370        380        390        400        410 
NVTKGQYSTA QDCSADEDNF LVPIAVGAAL GGVLILVLLA YFIGLKRHHT GYEQF 

« Hide

Isoform LAMP-2B [UniParc].

Checksum: F6FE0E2F2B5689E2
Show »

FASTA41645,797
Isoform LAMP-2C [UniParc].

Checksum: FF0021CBFDEED589
Show »

FASTA41545,655

References

« Hide 'large scale' references
[1]"The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins."
Cha Y., Holland S.M., August J.T.
J. Biol. Chem. 265:5008-5013(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2A).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LAMP-2A AND LAMP-2B).
Strain: C57BL/6J.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LAMP-2B).
[6]"Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells."
Granger B.L., Green S.A., Gabel C.A., Howe C.L., Mellman I., Helenius A.
J. Biol. Chem. 265:12036-12043(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 58-128 AND 186-415.
[7]"The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c."
Gough N.R., Hatem C.L., Fambrough D.M.
DNA Cell Biol. 14:863-867(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05287 mRNA. Translation: AAA39412.1.
AK159272 mRNA. Translation: BAE34951.1.
AK032974 mRNA. Translation: BAC28106.1.
AK163933 mRNA. Translation: BAE37543.1.
AL513356 Genomic DNA. Translation: CAM17143.1.
AL513356 Genomic DNA. Translation: CAM17144.1.
CH466570 Genomic DNA. Translation: EDL29016.1.
CH466570 Genomic DNA. Translation: EDL29018.1.
BC138718 mRNA. Translation: AAI38719.1.
BC138723 mRNA. Translation: AAI38724.1.
M32017 mRNA. Translation: AAA39429.1.
M32018 Genomic DNA. Translation: AAA39430.1.
CCDSCCDS30092.1. [P17047-1]
CCDS30093.1. [P17047-3]
PIRA35560.
RefSeqNP_001017959.1. NM_001017959.2. [P17047-1]
NP_001277414.1. NM_001290485.1. [P17047-2]
NP_034815.2. NM_010685.4. [P17047-3]
UniGeneMm.414016.
Mm.486.

3D structure databases

ProteinModelPortalP17047.
SMRP17047. Positions 226-375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201106. 2 interactions.
IntActP17047. 3 interactions.
MINTMINT-1857994.
STRING10090.ENSMUSP00000074448.

PTM databases

PhosphoSiteP17047.

Proteomic databases

MaxQBP17047.
PaxDbP17047.
PRIDEP17047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000016678; ENSMUSP00000016678; ENSMUSG00000016534. [P17047-1]
ENSMUST00000061755; ENSMUSP00000052283; ENSMUSG00000016534. [P17047-3]
ENSMUST00000074913; ENSMUSP00000074448; ENSMUSG00000016534. [P17047-2]
GeneID16784.
KEGGmmu:16784.
UCSCuc009szw.1. mouse. [P17047-1]
uc009szx.1. mouse. [P17047-3]

Organism-specific databases

CTD3920.
MGIMGI:96748. Lamp2.

Phylogenomic databases

eggNOGNOG301998.
GeneTreeENSGT00530000063068.
HOGENOMHOG000230942.
HOVERGENHBG052303.
KOK06528.
OMAAPNESEQ.
OrthoDBEOG7ZD1VH.
TreeFamTF316339.

Gene expression databases

ArrayExpressP17047.
BgeeP17047.
CleanExMM_LAMP2.
GenevestigatorP17047.

Family and domain databases

InterProIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLAMP2. mouse.
NextBio290644.
PROP17047.
SOURCESearch...

Entry information

Entry nameLAMP2_MOUSE
AccessionPrimary (citable) accession number: P17047
Secondary accession number(s): A2A430, Q3TXG5, Q8BSG8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 31, 2011
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot