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P17046 (LAMP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 2

Short name=LAMP-2
Short name=Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
LGP-110
LGP-96
Lysosomal membrane glycoprotein type B
Short name=LGP-B
CD_antigen=CD107b
Gene names
Name:Lamp2
Synonyms:Lamp-2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Post-translational modification

O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans By similarity.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.3
Chain26 – 411386Lysosome-associated membrane glycoprotein 2
PRO_0000017112

Regions

Topological domain26 – 376351Lumenal Potential
Transmembrane377 – 40024Helical; Potential
Topological domain401 – 41111Cytoplasmic Potential
Region27 – 188162First lumenal domain
Region189 – 22941Hinge
Region230 – 376147Second lumenal domain

Amino acid modifications

Glycosylation301N-linked (GlcNAc...) Probable
Glycosylation461N-linked (GlcNAc...) Potential
Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential
Glycosylation3081N-linked (GlcNAc...) Potential
Glycosylation3181N-linked (GlcNAc...) Potential
Glycosylation3571N-linked (GlcNAc...) Potential
Disulfide bond38 ↔ 75 By similarity
Disulfide bond149 ↔ 185 By similarity
Disulfide bond233 ↔ 266 By similarity
Disulfide bond332 ↔ 369 By similarity

Sequences

Sequence LengthMass (Da)Tools
P17046 [UniParc].

Last modified March 1, 1992. Version 2.
Checksum: 3E197B786A174DE8

FASTA41145,164
        10         20         30         40         50         60 
MRLPLSGYGS KLVLLFLFLG AVRSDALKLN LTDSKGTCLY AEWEMNFTIT YEALKVNETV 

        70         80         90        100        110        120 
TITVPDKVTY NGSSCGDDKN GAKIMIQYGS TLSWAVNFTK EASQYFINNI TLSYNTNDTK 

       130        140        150        160        170        180 
TFPGAVPKGI LTVIIPVGSQ LPLGVIFKCS SVLTFNLSPV VQHYWGIHLQ AFVQNGTVSK 

       190        200        210        220        230        240 
HEQVCKEDKT ATTVAPIIHT TVPSPTTTLT PTSIPVPTPT VGNYTISNGN ATCLLATMGL 

       250        260        270        280        290        300 
QLNITEEKVP FIFNINPATT NFTGSCQPQT AQLRLNNSQI KYLDFIFAVK NEKRFYLKEV 

       310        320        330        340        350        360 
NVNMYLANGS AFHVSNNNLS FWDAPLGSSY MCNKEQVVSV SRTFQINTFN LKVQPFNVTK 

       370        380        390        400        410 
GEYSTAQDCS ADEDNFLVPI AVGAALGGVL ILVLLAYFIG LKRHHTGYEQ F 

« Hide

References

[1]"Isolation and sequencing of a cDNA clone encoding 96 kDa sialoglycoprotein in rat liver lysosomal membranes."
Noguchi Y., Himeno M., Sasaki H., Tanaka Y., Kono A., Sakaki Y., Kato K.
Biochem. Biophys. Res. Commun. 164:1113-1120(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells."
Granger B.L., Green S.A., Gabel C.A., Howe C.L., Mellman I., Helenius A.
J. Biol. Chem. 265:12036-12043(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-411.
[3]"Purification, some properties, and tissue distribution of a major lysosome-associated membrane glycoprotein (r-lamp-2) of rat liver."
Akasaki K., Yamaguchi Y., Furuno K., Tsuji H.
J. Biochem. 110:922-927(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-36.
Tissue: Liver.
[4]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 121-148; 282-290 AND 404-411, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D90211 mRNA. Translation: BAA14236.1.
M32016 mRNA. Translation: AAA41526.1.
PIRA33664.
UniGeneRn.1722.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP17046. 3 interactions.
MINTMINT-2982158.
STRING10116.ENSRNOP00000000177.

Proteomic databases

PaxDbP17046.
PRIDEP17046.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2990. rat.

Organism-specific databases

RGD2990. Lamp2.

Phylogenomic databases

eggNOGNOG301998.
HOGENOMHOG000230942.
HOVERGENHBG052303.
InParanoidP17046.
PhylomeDBP17046.

Gene expression databases

GenevestigatorP17046.

Family and domain databases

InterProIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP17046.

Entry information

Entry nameLAMP2_RAT
AccessionPrimary (citable) accession number: P17046
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families