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P17046

- LAMP2_RAT

UniProt

P17046 - LAMP2_RAT

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Protein

Lysosome-associated membrane glycoprotein 2

Gene
Lamp2, Lamp-2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

GO - Biological processi

  1. protein stabilization Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
LGP-110
LGP-96
Lysosomal membrane glycoprotein type B
Short name:
LGP-B
CD_antigen: CD107b
Gene namesi
Name:Lamp2
Synonyms:Lamp-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2990. Lamp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 376351Lumenal Reviewed predictionAdd
BLAST
Transmembranei377 – 40024Helical; Reviewed predictionAdd
BLAST
Topological domaini401 – 41111Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endosome Source: RGD
  2. endosome membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosomal membrane Source: UniProtKB-SubCell
  5. lysosome Source: RGD
  6. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 411386Lysosome-associated membrane glycoprotein 2PRO_0000017112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...) Inferred
Disulfide bondi38 ↔ 75 By similarity
Glycosylationi46 – 461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi149 ↔ 185 By similarity
Glycosylationi175 – 1751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi230 – 2301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi233 ↔ 266 By similarity
Glycosylationi243 – 2431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi332 ↔ 369 By similarity
Glycosylationi357 – 3571N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17046.
PRIDEiP17046.

Expressioni

Gene expression databases

GenevestigatoriP17046.

Interactioni

Protein-protein interaction databases

IntActiP17046. 3 interactions.
MINTiMINT-2982158.
STRINGi10116.ENSRNOP00000000177.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 188162First lumenal domainAdd
BLAST
Regioni189 – 22941HingeAdd
BLAST
Regioni230 – 376147Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP17046.
PhylomeDBiP17046.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17046-1 [UniParc]FASTAAdd to Basket

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MRLPLSGYGS KLVLLFLFLG AVRSDALKLN LTDSKGTCLY AEWEMNFTIT    50
YEALKVNETV TITVPDKVTY NGSSCGDDKN GAKIMIQYGS TLSWAVNFTK 100
EASQYFINNI TLSYNTNDTK TFPGAVPKGI LTVIIPVGSQ LPLGVIFKCS 150
SVLTFNLSPV VQHYWGIHLQ AFVQNGTVSK HEQVCKEDKT ATTVAPIIHT 200
TVPSPTTTLT PTSIPVPTPT VGNYTISNGN ATCLLATMGL QLNITEEKVP 250
FIFNINPATT NFTGSCQPQT AQLRLNNSQI KYLDFIFAVK NEKRFYLKEV 300
NVNMYLANGS AFHVSNNNLS FWDAPLGSSY MCNKEQVVSV SRTFQINTFN 350
LKVQPFNVTK GEYSTAQDCS ADEDNFLVPI AVGAALGGVL ILVLLAYFIG 400
LKRHHTGYEQ F 411
Length:411
Mass (Da):45,164
Last modified:March 1, 1992 - v2
Checksum:i3E197B786A174DE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90211 mRNA. Translation: BAA14236.1.
M32016 mRNA. Translation: AAA41526.1.
PIRiA33664.
UniGeneiRn.1722.

Genome annotation databases

UCSCiRGD:2990. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90211 mRNA. Translation: BAA14236.1 .
M32016 mRNA. Translation: AAA41526.1 .
PIRi A33664.
UniGenei Rn.1722.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P17046. 3 interactions.
MINTi MINT-2982158.
STRINGi 10116.ENSRNOP00000000177.

Proteomic databases

PaxDbi P17046.
PRIDEi P17046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2990. rat.

Organism-specific databases

RGDi 2990. Lamp2.

Phylogenomic databases

eggNOGi NOG301998.
HOGENOMi HOG000230942.
HOVERGENi HBG052303.
InParanoidi P17046.
PhylomeDBi P17046.

Miscellaneous databases

PROi P17046.

Gene expression databases

Genevestigatori P17046.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequencing of a cDNA clone encoding 96 kDa sialoglycoprotein in rat liver lysosomal membranes."
    Noguchi Y., Himeno M., Sasaki H., Tanaka Y., Kono A., Sakaki Y., Kato K.
    Biochem. Biophys. Res. Commun. 164:1113-1120(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells."
    Granger B.L., Green S.A., Gabel C.A., Howe C.L., Mellman I., Helenius A.
    J. Biol. Chem. 265:12036-12043(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-411.
  3. "Purification, some properties, and tissue distribution of a major lysosome-associated membrane glycoprotein (r-lamp-2) of rat liver."
    Akasaki K., Yamaguchi Y., Furuno K., Tsuji H.
    J. Biochem. 110:922-927(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-36.
    Tissue: Liver.
  4. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 121-148; 282-290 AND 404-411, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiLAMP2_RAT
AccessioniPrimary (citable) accession number: P17046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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