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P17046

- LAMP2_RAT

UniProt

P17046 - LAMP2_RAT

Protein

Lysosome-associated membrane glycoprotein 2

Gene

Lamp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

    GO - Biological processi

    1. protein stabilization Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 2
    Short name:
    LAMP-2
    Short name:
    Lysosome-associated membrane protein 2
    Alternative name(s):
    CD107 antigen-like family member B
    LGP-110
    LGP-96
    Lysosomal membrane glycoprotein type B
    Short name:
    LGP-B
    CD_antigen: CD107b
    Gene namesi
    Name:Lamp2
    Synonyms:Lamp-2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2990. Lamp2.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: RGD
    2. endosome membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. lysosomal membrane Source: UniProtKB-SubCell
    5. lysosome Source: RGD
    6. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25251 PublicationAdd
    BLAST
    Chaini26 – 411386Lysosome-associated membrane glycoprotein 2PRO_0000017112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi30 – 301N-linked (GlcNAc...)Curated
    Disulfide bondi38 ↔ 75PROSITE-ProRule annotation
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 185PROSITE-ProRule annotation
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi233 ↔ 266PROSITE-ProRule annotation
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi332 ↔ 369PROSITE-ProRule annotation
    Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP17046.
    PRIDEiP17046.

    Expressioni

    Gene expression databases

    GenevestigatoriP17046.

    Interactioni

    Protein-protein interaction databases

    IntActiP17046. 6 interactions.
    MINTiMINT-2982158.
    STRINGi10116.ENSRNOP00000000177.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 376351LumenalSequence AnalysisAdd
    BLAST
    Topological domaini401 – 41111CytoplasmicPROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei377 – 40024HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni27 – 188162First lumenal domainAdd
    BLAST
    Regioni189 – 22941HingeAdd
    BLAST
    Regioni230 – 376147Second lumenal domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301998.
    HOGENOMiHOG000230942.
    HOVERGENiHBG052303.
    InParanoidiP17046.
    PhylomeDBiP17046.

    Family and domain databases

    InterProiIPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS00310. LAMP_1. 1 hit.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17046-1 [UniParc]FASTAAdd to Basket

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    MRLPLSGYGS KLVLLFLFLG AVRSDALKLN LTDSKGTCLY AEWEMNFTIT    50
    YEALKVNETV TITVPDKVTY NGSSCGDDKN GAKIMIQYGS TLSWAVNFTK 100
    EASQYFINNI TLSYNTNDTK TFPGAVPKGI LTVIIPVGSQ LPLGVIFKCS 150
    SVLTFNLSPV VQHYWGIHLQ AFVQNGTVSK HEQVCKEDKT ATTVAPIIHT 200
    TVPSPTTTLT PTSIPVPTPT VGNYTISNGN ATCLLATMGL QLNITEEKVP 250
    FIFNINPATT NFTGSCQPQT AQLRLNNSQI KYLDFIFAVK NEKRFYLKEV 300
    NVNMYLANGS AFHVSNNNLS FWDAPLGSSY MCNKEQVVSV SRTFQINTFN 350
    LKVQPFNVTK GEYSTAQDCS ADEDNFLVPI AVGAALGGVL ILVLLAYFIG 400
    LKRHHTGYEQ F 411
    Length:411
    Mass (Da):45,164
    Last modified:March 1, 1992 - v2
    Checksum:i3E197B786A174DE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90211 mRNA. Translation: BAA14236.1.
    M32016 mRNA. Translation: AAA41526.1.
    PIRiA33664.
    UniGeneiRn.1722.

    Genome annotation databases

    UCSCiRGD:2990. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90211 mRNA. Translation: BAA14236.1 .
    M32016 mRNA. Translation: AAA41526.1 .
    PIRi A33664.
    UniGenei Rn.1722.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P17046. 6 interactions.
    MINTi MINT-2982158.
    STRINGi 10116.ENSRNOP00000000177.

    Proteomic databases

    PaxDbi P17046.
    PRIDEi P17046.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2990. rat.

    Organism-specific databases

    RGDi 2990. Lamp2.

    Phylogenomic databases

    eggNOGi NOG301998.
    HOGENOMi HOG000230942.
    HOVERGENi HBG052303.
    InParanoidi P17046.
    PhylomeDBi P17046.

    Miscellaneous databases

    PROi P17046.

    Gene expression databases

    Genevestigatori P17046.

    Family and domain databases

    InterProi IPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS00310. LAMP_1. 1 hit.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequencing of a cDNA clone encoding 96 kDa sialoglycoprotein in rat liver lysosomal membranes."
      Noguchi Y., Himeno M., Sasaki H., Tanaka Y., Kono A., Sakaki Y., Kato K.
      Biochem. Biophys. Res. Commun. 164:1113-1120(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells."
      Granger B.L., Green S.A., Gabel C.A., Howe C.L., Mellman I., Helenius A.
      J. Biol. Chem. 265:12036-12043(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-411.
    3. "Purification, some properties, and tissue distribution of a major lysosome-associated membrane glycoprotein (r-lamp-2) of rat liver."
      Akasaki K., Yamaguchi Y., Furuno K., Tsuji H.
      J. Biochem. 110:922-927(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-36.
      Tissue: Liver.
    4. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 121-148; 282-290 AND 404-411, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiLAMP2_RAT
    AccessioniPrimary (citable) accession number: P17046
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3