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Protein

Lysosome-associated membrane glycoprotein 2

Gene

Lamp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

GO - Biological processi

  1. protein stabilization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
LGP-110
LGP-96
Lysosomal membrane glycoprotein type B
Short name:
LGP-B
CD_antigen: CD107b
Gene namesi
Name:Lamp2
Synonyms:Lamp-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2990. Lamp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 376351LumenalSequence AnalysisAdd
BLAST
Transmembranei377 – 40024HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini401 – 41111CytoplasmicPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  1. endosome Source: RGD
  2. endosome membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosomal membrane Source: UniProtKB-SubCell
  5. lysosome Source: RGD
  6. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 411386Lysosome-associated membrane glycoprotein 2PRO_0000017112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Curated
Disulfide bondi38 ↔ 75PROSITE-ProRule annotation
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi149 ↔ 185PROSITE-ProRule annotation
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi233 ↔ 266PROSITE-ProRule annotation
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi332 ↔ 369PROSITE-ProRule annotation
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17046.
PRIDEiP17046.

Expressioni

Gene expression databases

GenevestigatoriP17046.

Interactioni

Protein-protein interaction databases

IntActiP17046. 6 interactions.
MINTiMINT-2982158.
STRINGi10116.ENSRNOP00000000177.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 188162First lumenal domainAdd
BLAST
Regioni189 – 22941HingeAdd
BLAST
Regioni230 – 376147Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP17046.
PhylomeDBiP17046.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPLSGYGS KLVLLFLFLG AVRSDALKLN LTDSKGTCLY AEWEMNFTIT
60 70 80 90 100
YEALKVNETV TITVPDKVTY NGSSCGDDKN GAKIMIQYGS TLSWAVNFTK
110 120 130 140 150
EASQYFINNI TLSYNTNDTK TFPGAVPKGI LTVIIPVGSQ LPLGVIFKCS
160 170 180 190 200
SVLTFNLSPV VQHYWGIHLQ AFVQNGTVSK HEQVCKEDKT ATTVAPIIHT
210 220 230 240 250
TVPSPTTTLT PTSIPVPTPT VGNYTISNGN ATCLLATMGL QLNITEEKVP
260 270 280 290 300
FIFNINPATT NFTGSCQPQT AQLRLNNSQI KYLDFIFAVK NEKRFYLKEV
310 320 330 340 350
NVNMYLANGS AFHVSNNNLS FWDAPLGSSY MCNKEQVVSV SRTFQINTFN
360 370 380 390 400
LKVQPFNVTK GEYSTAQDCS ADEDNFLVPI AVGAALGGVL ILVLLAYFIG
410
LKRHHTGYEQ F
Length:411
Mass (Da):45,164
Last modified:February 29, 1992 - v2
Checksum:i3E197B786A174DE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90211 mRNA. Translation: BAA14236.1.
M32016 mRNA. Translation: AAA41526.1.
PIRiA33664.
UniGeneiRn.1722.

Genome annotation databases

UCSCiRGD:2990. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90211 mRNA. Translation: BAA14236.1.
M32016 mRNA. Translation: AAA41526.1.
PIRiA33664.
UniGeneiRn.1722.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17046. 6 interactions.
MINTiMINT-2982158.
STRINGi10116.ENSRNOP00000000177.

Proteomic databases

PaxDbiP17046.
PRIDEiP17046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2990. rat.

Organism-specific databases

RGDi2990. Lamp2.

Phylogenomic databases

eggNOGiNOG301998.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP17046.
PhylomeDBiP17046.

Miscellaneous databases

PROiP17046.

Gene expression databases

GenevestigatoriP17046.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and sequencing of a cDNA clone encoding 96 kDa sialoglycoprotein in rat liver lysosomal membranes."
    Noguchi Y., Himeno M., Sasaki H., Tanaka Y., Kono A., Sakaki Y., Kato K.
    Biochem. Biophys. Res. Commun. 164:1113-1120(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells."
    Granger B.L., Green S.A., Gabel C.A., Howe C.L., Mellman I., Helenius A.
    J. Biol. Chem. 265:12036-12043(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-411.
  3. "Purification, some properties, and tissue distribution of a major lysosome-associated membrane glycoprotein (r-lamp-2) of rat liver."
    Akasaki K., Yamaguchi Y., Furuno K., Tsuji H.
    J. Biochem. 110:922-927(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-36.
    Tissue: Liver.
  4. Lubec G., Kang S.U., Lubec S.
    Submitted (AUG-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 121-148; 282-290 AND 404-411, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiLAMP2_RAT
AccessioniPrimary (citable) accession number: P17046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1990
Last sequence update: February 29, 1992
Last modified: January 6, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.