Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 32

Gene

ZNF32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri77 – 99C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri105 – 127C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri133 – 155C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri161 – 183C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 266C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 32
Alternative name(s):
C2H2-546
Zinc finger protein KOX30
Gene namesi
Name:ZNF32
Synonyms:KOX30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13095. ZNF32.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7580.
OpenTargetsiENSG00000169740.
PharmGKBiPA37670.

Polymorphism and mutation databases

BioMutaiZNF32.
DMDMi85681868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473611 – 273Zinc finger protein 32Add BLAST273

Proteomic databases

EPDiP17041.
MaxQBiP17041.
PaxDbiP17041.
PeptideAtlasiP17041.
PRIDEiP17041.

PTM databases

iPTMnetiP17041.
PhosphoSitePlusiP17041.

Expressioni

Gene expression databases

BgeeiENSG00000169740.
CleanExiHS_ZNF32.
ExpressionAtlasiP17041. baseline and differential.
GenevisibleiP17041. HS.

Organism-specific databases

HPAiHPA059640.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-4P603723EBI-1965483,EBI-10178153
KRTAP10-5P603703EBI-1965483,EBI-10172150
KRTAP10-7P604093EBI-1965483,EBI-10172290
KRTAP10-8P604103EBI-1965483,EBI-10171774
NOTCH2NLQ7Z3S93EBI-1965483,EBI-945833

Protein-protein interaction databases

BioGridi113409. 9 interactors.
IntActiP17041. 11 interactors.
STRINGi9606.ENSP00000363556.

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi80 – 82Combined sources3
Beta strandi85 – 88Combined sources4
Helixi89 – 95Combined sources7
Helixi96 – 98Combined sources3
Beta strandi104 – 106Combined sources3
Turni108 – 110Combined sources3
Beta strandi113 – 116Combined sources4
Helixi117 – 124Combined sources8
Turni125 – 127Combined sources3
Beta strandi136 – 138Combined sources3
Helixi145 – 153Combined sources9
Turni192 – 195Combined sources4
Beta strandi198 – 200Combined sources3
Helixi201 – 205Combined sources5
Helixi208 – 210Combined sources3
Beta strandi248 – 250Combined sources3
Beta strandi253 – 256Combined sources4
Helixi257 – 266Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EPCNMR-A241-269[»]
2EPTNMR-A74-101[»]
2EPUNMR-A100-131[»]
2YTANMR-A130-157[»]
2YTBNMR-A185-213[»]
ProteinModelPortaliP17041.
SMRiP17041.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17041.

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri77 – 99C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri105 – 127C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri133 – 155C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri161 – 183C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 266C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132351.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17041.
OMAiDFQSSFR.
OrthoDBiEOG091G02KC.
PhylomeDBiP17041.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGFPTATLL DCHGRYAQNV AFFNVMTEAH HKYDHSEATG SSSWDIQNSF
60 70 80 90 100
RREKLEQKSP DSKTLQEDSP GVRQRVYECQ ECGKSFRQKG SLTLHERIHT
110 120 130 140 150
GQKPFECTHC GKSFRAKGNL VTHQRIHTGE KPYQCKECGK SFSQRGSLAV
160 170 180 190 200
HERLHTGQKP YECAICQRSF RNQSNLAVHR RVHSGEKPYR CDQCGKAFSQ
210 220 230 240 250
KGSLIVHIRV HTGLKPYACT QCRKSFHTRG NCILHGKIHT GETPYLCGQC
260 270
GKSFTQRGSL AVHQRSCSQR LTL
Length:273
Mass (Da):31,029
Last modified:January 10, 2006 - v2
Checksum:i91E7148C665C4734
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118G → A in CAA36587 (PubMed:2288909).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69645 mRNA. Translation: AAB09561.1.
AL645634 Genomic DNA. Translation: CAH73489.1.
BC022842 mRNA. Translation: AAH22842.1.
X52361 mRNA. Translation: CAA36587.1.
CCDSiCCDS7206.1.
PIRiI37971.
RefSeqiNP_001005368.1. NM_001005368.2.
NP_001311094.1. NM_001324165.1.
NP_001311097.1. NM_001324168.1.
NP_008904.1. NM_006973.2.
XP_016872105.1. XM_017016616.1.
UniGeneiHs.522885.
Hs.608956.

Genome annotation databases

EnsembliENST00000374433; ENSP00000363556; ENSG00000169740.
ENST00000395797; ENSP00000379143; ENSG00000169740.
GeneIDi7580.
KEGGihsa:7580.
UCSCiuc001jbb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69645 mRNA. Translation: AAB09561.1.
AL645634 Genomic DNA. Translation: CAH73489.1.
BC022842 mRNA. Translation: AAH22842.1.
X52361 mRNA. Translation: CAA36587.1.
CCDSiCCDS7206.1.
PIRiI37971.
RefSeqiNP_001005368.1. NM_001005368.2.
NP_001311094.1. NM_001324165.1.
NP_001311097.1. NM_001324168.1.
NP_008904.1. NM_006973.2.
XP_016872105.1. XM_017016616.1.
UniGeneiHs.522885.
Hs.608956.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EPCNMR-A241-269[»]
2EPTNMR-A74-101[»]
2EPUNMR-A100-131[»]
2YTANMR-A130-157[»]
2YTBNMR-A185-213[»]
ProteinModelPortaliP17041.
SMRiP17041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113409. 9 interactors.
IntActiP17041. 11 interactors.
STRINGi9606.ENSP00000363556.

PTM databases

iPTMnetiP17041.
PhosphoSitePlusiP17041.

Polymorphism and mutation databases

BioMutaiZNF32.
DMDMi85681868.

Proteomic databases

EPDiP17041.
MaxQBiP17041.
PaxDbiP17041.
PeptideAtlasiP17041.
PRIDEiP17041.

Protocols and materials databases

DNASUi7580.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374433; ENSP00000363556; ENSG00000169740.
ENST00000395797; ENSP00000379143; ENSG00000169740.
GeneIDi7580.
KEGGihsa:7580.
UCSCiuc001jbb.4. human.

Organism-specific databases

CTDi7580.
DisGeNETi7580.
GeneCardsiZNF32.
HGNCiHGNC:13095. ZNF32.
HPAiHPA059640.
MIMi194539. gene.
neXtProtiNX_P17041.
OpenTargetsiENSG00000169740.
PharmGKBiPA37670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132351.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17041.
OMAiDFQSSFR.
OrthoDBiEOG091G02KC.
PhylomeDBiP17041.
TreeFamiTF337055.

Miscellaneous databases

EvolutionaryTraceiP17041.
GenomeRNAii7580.
PROiP17041.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169740.
CleanExiHS_ZNF32.
ExpressionAtlasiP17041. baseline and differential.
GenevisibleiP17041. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF32_HUMAN
AccessioniPrimary (citable) accession number: P17041
Secondary accession number(s): Q92951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.