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Protein

Zinc finger protein 32

Gene

ZNF32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 9923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri105 – 12723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri133 – 15523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri161 – 18323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26622C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 32
Alternative name(s):
C2H2-546
Zinc finger protein KOX30
Gene namesi
Name:ZNF32
Synonyms:KOX30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13095. ZNF32.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37670.

Polymorphism and mutation databases

BioMutaiZNF32.
DMDMi85681868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Zinc finger protein 32PRO_0000047361Add
BLAST

Proteomic databases

MaxQBiP17041.
PaxDbiP17041.
PRIDEiP17041.

PTM databases

iPTMnetiP17041.
PhosphoSiteiP17041.

Expressioni

Gene expression databases

BgeeiP17041.
CleanExiHS_ZNF32.
ExpressionAtlasiP17041. baseline and differential.
GenevisibleiP17041. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-4P603723EBI-1965483,EBI-10178153
KRTAP10-5P603703EBI-1965483,EBI-10172150
KRTAP10-7P604093EBI-1965483,EBI-10172290
KRTAP10-8P604103EBI-1965483,EBI-10171774
NOTCH2NLQ7Z3S93EBI-1965483,EBI-945833

Protein-protein interaction databases

BioGridi113409. 9 interactions.
IntActiP17041. 8 interactions.
STRINGi9606.ENSP00000363556.

Structurei

Secondary structure

1
273
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi80 – 823Combined sources
Beta strandi85 – 884Combined sources
Helixi89 – 957Combined sources
Helixi96 – 983Combined sources
Beta strandi104 – 1063Combined sources
Turni108 – 1103Combined sources
Beta strandi113 – 1164Combined sources
Helixi117 – 1248Combined sources
Turni125 – 1273Combined sources
Beta strandi136 – 1383Combined sources
Helixi145 – 1539Combined sources
Turni192 – 1954Combined sources
Beta strandi198 – 2003Combined sources
Helixi201 – 2055Combined sources
Helixi208 – 2103Combined sources
Beta strandi248 – 2503Combined sources
Beta strandi253 – 2564Combined sources
Helixi257 – 26610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EPCNMR-A241-269[»]
2EPTNMR-A74-101[»]
2EPUNMR-A100-131[»]
2YTANMR-A130-157[»]
2YTBNMR-A185-213[»]
ProteinModelPortaliP17041.
SMRiP17041. Positions 74-269.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17041.

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 9923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri105 – 12723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri133 – 15523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri161 – 18323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26622C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17041.
OMAiDFQSSFR.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17041.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGFPTATLL DCHGRYAQNV AFFNVMTEAH HKYDHSEATG SSSWDIQNSF
60 70 80 90 100
RREKLEQKSP DSKTLQEDSP GVRQRVYECQ ECGKSFRQKG SLTLHERIHT
110 120 130 140 150
GQKPFECTHC GKSFRAKGNL VTHQRIHTGE KPYQCKECGK SFSQRGSLAV
160 170 180 190 200
HERLHTGQKP YECAICQRSF RNQSNLAVHR RVHSGEKPYR CDQCGKAFSQ
210 220 230 240 250
KGSLIVHIRV HTGLKPYACT QCRKSFHTRG NCILHGKIHT GETPYLCGQC
260 270
GKSFTQRGSL AVHQRSCSQR LTL
Length:273
Mass (Da):31,029
Last modified:January 10, 2006 - v2
Checksum:i91E7148C665C4734
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181G → A in CAA36587 (PubMed:2288909).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69645 mRNA. Translation: AAB09561.1.
AL645634 Genomic DNA. Translation: CAH73489.1.
BC022842 mRNA. Translation: AAH22842.1.
X52361 mRNA. Translation: CAA36587.1.
CCDSiCCDS7206.1.
PIRiI37971.
RefSeqiNP_001005368.1. NM_001005368.1.
NP_008904.1. NM_006973.2.
UniGeneiHs.522885.
Hs.608956.

Genome annotation databases

EnsembliENST00000374433; ENSP00000363556; ENSG00000169740.
ENST00000395797; ENSP00000379143; ENSG00000169740.
GeneIDi7580.
KEGGihsa:7580.
UCSCiuc001jbb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69645 mRNA. Translation: AAB09561.1.
AL645634 Genomic DNA. Translation: CAH73489.1.
BC022842 mRNA. Translation: AAH22842.1.
X52361 mRNA. Translation: CAA36587.1.
CCDSiCCDS7206.1.
PIRiI37971.
RefSeqiNP_001005368.1. NM_001005368.1.
NP_008904.1. NM_006973.2.
UniGeneiHs.522885.
Hs.608956.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EPCNMR-A241-269[»]
2EPTNMR-A74-101[»]
2EPUNMR-A100-131[»]
2YTANMR-A130-157[»]
2YTBNMR-A185-213[»]
ProteinModelPortaliP17041.
SMRiP17041. Positions 74-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113409. 9 interactions.
IntActiP17041. 8 interactions.
STRINGi9606.ENSP00000363556.

PTM databases

iPTMnetiP17041.
PhosphoSiteiP17041.

Polymorphism and mutation databases

BioMutaiZNF32.
DMDMi85681868.

Proteomic databases

MaxQBiP17041.
PaxDbiP17041.
PRIDEiP17041.

Protocols and materials databases

DNASUi7580.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374433; ENSP00000363556; ENSG00000169740.
ENST00000395797; ENSP00000379143; ENSG00000169740.
GeneIDi7580.
KEGGihsa:7580.
UCSCiuc001jbb.4. human.

Organism-specific databases

CTDi7580.
GeneCardsiZNF32.
HGNCiHGNC:13095. ZNF32.
MIMi194539. gene.
neXtProtiNX_P17041.
PharmGKBiPA37670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17041.
OMAiDFQSSFR.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17041.
TreeFamiTF337055.

Miscellaneous databases

EvolutionaryTraceiP17041.
GenomeRNAii7580.
NextBioi29633.
PROiP17041.
SOURCEiSearch...

Gene expression databases

BgeeiP17041.
CleanExiHS_ZNF32.
ExpressionAtlasiP17041. baseline and differential.
GenevisibleiP17041. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells."
    Drew P.D., Gado A.M., Canning R.D., Nagle J.W., Dehejia A.M., Polymeropoulos M.H., Biddison W.E., Jacobson S., Becker K.G.
    J. Neurovirol. 3:455-459(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-128.
    Tissue: Lymphoid tissue.
  5. "Solution structure of zinc finger domain 7 in zinc finger protein 32."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 74-269.

Entry informationi

Entry nameiZNF32_HUMAN
AccessioniPrimary (citable) accession number: P17041
Secondary accession number(s): Q92951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: May 11, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.