ID   ZSC20_HUMAN             Reviewed;        1043 AA.
AC   P17040; A8K2D0; B1ALI4; B1ALI5; B1ALI6; Q6ZN23; Q96FA9; Q96H84;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 3.
DT   27-MAR-2024, entry version 212.
DE   RecName: Full=Zinc finger and SCAN domain-containing protein 20;
DE   AltName: Full=Zinc finger protein 31;
DE   AltName: Full=Zinc finger protein 360;
DE   AltName: Full=Zinc finger protein KOX29;
GN   Name=ZSCAN20; Synonyms=KOX29, ZNF31, ZNF360;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP   ASP-432.
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASP-432.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND VARIANT
RP   ASP-432.
RC   TISSUE=Eye, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 875-930 (ISOFORMS 1/2/3).
RC   TISSUE=Lymphoid tissue;
RX   PubMed=2288909;
RA   Thiesen H.-J.;
RT   "Multiple genes encoding zinc finger domains are expressed in human T
RT   cells.";
RL   New Biol. 2:363-374(1990).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       P17040-4; A0A0S2Z6X0: ZKSCAN4; NbExp=3; IntAct=EBI-16440054, EBI-16431094;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=P17040-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P17040-2; Sequence=VSP_036735;
CC       Name=3;
CC         IsoId=P17040-3; Sequence=VSP_036738;
CC       Name=4;
CC         IsoId=P17040-4; Sequence=VSP_036736, VSP_036737, VSP_036739;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK131405; BAD18552.1; -; mRNA.
DR   EMBL; AK290195; BAF82884.1; -; mRNA.
DR   EMBL; AC115285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL138837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471059; EAX07454.1; -; Genomic_DNA.
DR   EMBL; BC008827; AAH08827.1; -; mRNA.
DR   EMBL; BC011404; AAH11404.1; -; mRNA.
DR   EMBL; X52360; CAA36586.1; -; mRNA.
DR   CCDS; CCDS41300.1; -. [P17040-1]
DR   PIR; I37969; I37969.
DR   RefSeq; NP_660281.2; NM_145238.3. [P17040-1]
DR   RefSeq; XP_005271228.1; XM_005271171.3.
DR   RefSeq; XP_006710937.1; XM_006710874.3.
DR   RefSeq; XP_016857726.1; XM_017002237.1. [P17040-1]
DR   RefSeq; XP_016857727.1; XM_017002238.1. [P17040-3]
DR   AlphaFoldDB; P17040; -.
DR   SMR; P17040; -.
DR   BioGRID; 113408; 65.
DR   IntAct; P17040; 57.
DR   STRING; 9606.ENSP00000355053; -.
DR   GlyGen; P17040; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P17040; -.
DR   PhosphoSitePlus; P17040; -.
DR   BioMuta; ZSCAN20; -.
DR   DMDM; 229485383; -.
DR   EPD; P17040; -.
DR   jPOST; P17040; -.
DR   MassIVE; P17040; -.
DR   MaxQB; P17040; -.
DR   PaxDb; 9606-ENSP00000355053; -.
DR   PeptideAtlas; P17040; -.
DR   ProteomicsDB; 53445; -. [P17040-1]
DR   ProteomicsDB; 53446; -. [P17040-2]
DR   ProteomicsDB; 53447; -. [P17040-3]
DR   ProteomicsDB; 53448; -. [P17040-4]
DR   ABCD; P17040; 4 sequenced antibodies.
DR   Antibodypedia; 8548; 155 antibodies from 27 providers.
DR   DNASU; 7579; -.
DR   Ensembl; ENST00000361328.7; ENSP00000355053.3; ENSG00000121903.15. [P17040-1]
DR   Ensembl; ENST00000373413.2; ENSP00000362512.1; ENSG00000121903.15. [P17040-4]
DR   Ensembl; ENST00000684572.1; ENSP00000507139.1; ENSG00000121903.15. [P17040-1]
DR   GeneID; 7579; -.
DR   KEGG; hsa:7579; -.
DR   MANE-Select; ENST00000684572.1; ENSP00000507139.1; NM_001377376.1; NP_001364305.1.
DR   UCSC; uc001bxj.5; human. [P17040-1]
DR   AGR; HGNC:13093; -.
DR   CTD; 7579; -.
DR   DisGeNET; 7579; -.
DR   GeneCards; ZSCAN20; -.
DR   HGNC; HGNC:13093; ZSCAN20.
DR   HPA; ENSG00000121903; Low tissue specificity.
DR   MIM; 611315; gene.
DR   neXtProt; NX_P17040; -.
DR   OpenTargets; ENSG00000121903; -.
DR   PharmGKB; PA37668; -.
DR   VEuPathDB; HostDB:ENSG00000121903; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000161580; -.
DR   HOGENOM; CLU_002678_88_0_1; -.
DR   InParanoid; P17040; -.
DR   OMA; KLQTCHQ; -.
DR   OrthoDB; 4627582at2759; -.
DR   PhylomeDB; P17040; -.
DR   TreeFam; TF337082; -.
DR   PathwayCommons; P17040; -.
DR   SignaLink; P17040; -.
DR   BioGRID-ORCS; 7579; 229 hits in 1180 CRISPR screens.
DR   GenomeRNAi; 7579; -.
DR   Pharos; P17040; Tdark.
DR   PRO; PR:P17040; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; P17040; Protein.
DR   Bgee; ENSG00000121903; Expressed in sperm and 115 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 10.
DR   Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR   InterPro; IPR044822; Myb_DNA-bind_4.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24393:SF162; ZINC FINGER PROTEIN 879; 1.
DR   Pfam; PF13837; Myb_DNA-bind_4; 2.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   SMART; SM00717; SANT; 2.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR   SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
DR   Genevisible; P17040; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..1043
FT                   /note="Zinc finger and SCAN domain-containing protein 20"
FT                   /id="PRO_0000047360"
FT   DOMAIN          51..133
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT   ZN_FING         710..732
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         738..760
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         766..788
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         794..816
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         875..897
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         903..925
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         931..953
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         959..981
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         987..1009
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1015..1037
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          30..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          835..873
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         25..90
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_036735"
FT   VAR_SEQ         202..255
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_036736"
FT   VAR_SEQ         482..487
FT                   /note="AGVHWG -> GKNMGV (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_036737"
FT   VAR_SEQ         482
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_036738"
FT   VAR_SEQ         488..1043
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_036739"
FT   VARIANT         248
FT                   /note="D -> N (in dbSNP:rs34446695)"
FT                   /id="VAR_054799"
FT   VARIANT         432
FT                   /note="Y -> D (in dbSNP:rs4403594)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT                   /id="VAR_054800"
FT   CONFLICT        100
FT                   /note="L -> P (in Ref. 1; BAF82884)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        126
FT                   /note="V -> M (in Ref. 1; BAF82884)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        740
FT                   /note="C -> R (in Ref. 1; BAD18552)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1043 AA;  117541 MW;  1598FB5F243773FE CRC64;
     MAMALELQAQ ASPQPEPEEL LIVKLEEDSW GSESKLWEKD RGSVSGPEAS RQRFRQFQYR
     DAAGPHEAFS QLWALCCRWL RPEIRLKEQI LELLVLEQFL TILPREVQTW VQARHPESGE
     EAVALVEDWH RETRTAGQSG LELHTEETRP LKTGEEAQSF QLQPVDPWPE GQSQKKGVKN
     TCPDLPNHLN AEVAPQPLKE SAVLTPRVPT LPKMGSVGDW EVTAESQEAL GPGKHAEKEL
     CKDPPGDDCG NSVCLGVPVS KPSNTSEKEQ GPEFWGLSLI NSGKRSTADY SLDNEPAQAL
     TWRDSRAWEE QYQWDVEDMK VSGVHWGYEE TKTFLAILSE SPFSEKLRTC HQNRQVYRAI
     AEQLRARGFL RTLEQCRYRV KNLLRNYRKA KSSHPPGTCP FYEELEALVR ARTAIRATDG
     PGEAVALPRL GYSDAEMDEQ EEGGWDPEEM AEDCNGAGLV NVESTQGPRI AGAPALFQSR
     IAGVHWGYEE TKAFLAILSE SPFSEKLRTC HQNSQVYRAI AERLCALGFL RTLEQCRYRF
     KNLLRSYRKA KSSHPPGTCP FYEELDSLMR ARAAVRAMGT VREAAGLPRC GQSSAETDAQ
     EAWGEVANED AVKPSTLCPK APDMGFEMRH EDEDQISEQD IFEGLPGALS KCPTEAVCQP
     LDWGEDSENE NEDEGQWGNP SQEQWQESSS EEDLEKLIDH QGLYLAEKPY KCDTCMKSFS
     RSSHFIAHQR IHTGEKPYKC LECGKNFSDR SNLNTHQRIH TGEKPYKCLE CGKSFSDHSN
     LITHQRIHTG EKPYKCGECW KSFNQSSNLL KHQRIHLGGN PDQCSEPGGN FAQSPSFSAH
     WRNSTEETAP EQPQSISKDL NSPGPHSTNS GEKLYECSEC GRSFSKSSAL ISHQRIHTGE
     KPYECAECGK SFSKSSTLAN HQRTHTGEKP YKCVDCGKCF SERSKLITHQ RVHTGEKPYK
     CLECGKFFRD RSNLITHQRI HTGEKPYKCR ECGKCFNQSS SLIIHQRIHT GEKPYKCTEC
     GKDFNNSSHF SAHRRTHAGG KAS
//