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Protein

Zinc finger and SCAN domain-containing protein 20

Gene

ZSCAN20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri710 – 732C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri766 – 788C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri794 – 816C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri875 – 897C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri903 – 925C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri931 – 953C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri959 – 981C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri987 – 1009C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1015 – 1037C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 20
Alternative name(s):
Zinc finger protein 31
Zinc finger protein 360
Zinc finger protein KOX29
Gene namesi
Name:ZSCAN20
Synonyms:KOX29, ZNF31, ZNF360
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121903.14
HGNCiHGNC:13093 ZSCAN20
MIMi611315 gene
neXtProtiNX_P17040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7579
OpenTargetsiENSG00000121903
PharmGKBiPA37668

Polymorphism and mutation databases

BioMutaiZSCAN20
DMDMi229485383

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473601 – 1043Zinc finger and SCAN domain-containing protein 20Add BLAST1043

Proteomic databases

MaxQBiP17040
PaxDbiP17040
PeptideAtlasiP17040
PRIDEiP17040

PTM databases

iPTMnetiP17040
PhosphoSitePlusiP17040

Expressioni

Gene expression databases

BgeeiENSG00000121903
CleanExiHS_ZSCAN20
GenevisibleiP17040 HS

Organism-specific databases

HPAiHPA017933

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZKSCAN4A0A0S2Z6X03EBI-16440054,EBI-16431094

Protein-protein interaction databases

BioGridi113408, 58 interactors
IntActiP17040, 2 interactors
STRINGi9606.ENSP00000324450

Structurei

3D structure databases

ProteinModelPortaliP17040
SMRiP17040
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 133SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri710 – 732C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri766 – 788C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri794 – 816C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri875 – 897C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri903 – 925C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri931 – 953C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri959 – 981C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri987 – 1009C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1015 – 1037C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063287
HOVERGENiHBG018163
InParanoidiP17040
KOiK09230
OMAiIDHQGLY
OrthoDBiEOG091G02KC
PhylomeDBiP17040
TreeFamiTF337082

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001005 SANT/Myb
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17040-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMALELQAQ ASPQPEPEEL LIVKLEEDSW GSESKLWEKD RGSVSGPEAS
60 70 80 90 100
RQRFRQFQYR DAAGPHEAFS QLWALCCRWL RPEIRLKEQI LELLVLEQFL
110 120 130 140 150
TILPREVQTW VQARHPESGE EAVALVEDWH RETRTAGQSG LELHTEETRP
160 170 180 190 200
LKTGEEAQSF QLQPVDPWPE GQSQKKGVKN TCPDLPNHLN AEVAPQPLKE
210 220 230 240 250
SAVLTPRVPT LPKMGSVGDW EVTAESQEAL GPGKHAEKEL CKDPPGDDCG
260 270 280 290 300
NSVCLGVPVS KPSNTSEKEQ GPEFWGLSLI NSGKRSTADY SLDNEPAQAL
310 320 330 340 350
TWRDSRAWEE QYQWDVEDMK VSGVHWGYEE TKTFLAILSE SPFSEKLRTC
360 370 380 390 400
HQNRQVYRAI AEQLRARGFL RTLEQCRYRV KNLLRNYRKA KSSHPPGTCP
410 420 430 440 450
FYEELEALVR ARTAIRATDG PGEAVALPRL GYSDAEMDEQ EEGGWDPEEM
460 470 480 490 500
AEDCNGAGLV NVESTQGPRI AGAPALFQSR IAGVHWGYEE TKAFLAILSE
510 520 530 540 550
SPFSEKLRTC HQNSQVYRAI AERLCALGFL RTLEQCRYRF KNLLRSYRKA
560 570 580 590 600
KSSHPPGTCP FYEELDSLMR ARAAVRAMGT VREAAGLPRC GQSSAETDAQ
610 620 630 640 650
EAWGEVANED AVKPSTLCPK APDMGFEMRH EDEDQISEQD IFEGLPGALS
660 670 680 690 700
KCPTEAVCQP LDWGEDSENE NEDEGQWGNP SQEQWQESSS EEDLEKLIDH
710 720 730 740 750
QGLYLAEKPY KCDTCMKSFS RSSHFIAHQR IHTGEKPYKC LECGKNFSDR
760 770 780 790 800
SNLNTHQRIH TGEKPYKCLE CGKSFSDHSN LITHQRIHTG EKPYKCGECW
810 820 830 840 850
KSFNQSSNLL KHQRIHLGGN PDQCSEPGGN FAQSPSFSAH WRNSTEETAP
860 870 880 890 900
EQPQSISKDL NSPGPHSTNS GEKLYECSEC GRSFSKSSAL ISHQRIHTGE
910 920 930 940 950
KPYECAECGK SFSKSSTLAN HQRTHTGEKP YKCVDCGKCF SERSKLITHQ
960 970 980 990 1000
RVHTGEKPYK CLECGKFFRD RSNLITHQRI HTGEKPYKCR ECGKCFNQSS
1010 1020 1030 1040
SLIIHQRIHT GEKPYKCTEC GKDFNNSSHF SAHRRTHAGG KAS
Length:1,043
Mass (Da):117,541
Last modified:March 24, 2009 - v3
Checksum:i1598FB5F243773FE
GO
Isoform 2 (identifier: P17040-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-90: Missing.

Show »
Length:977
Mass (Da):109,706
Checksum:i5E283FEE045D4525
GO
Isoform 3 (identifier: P17040-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-482: Missing.

Note: No experimental confirmation available.
Show »
Length:1,042
Mass (Da):117,470
Checksum:i68BCA6E9110E3EB0
GO
Isoform 4 (identifier: P17040-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-255: Missing.
     482-487: AGVHWG → GKNMGV
     488-1043: Missing.

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):49,035
Checksum:i63C40A82025DB27B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100L → P in BAF82884 (PubMed:14702039).Curated1
Sequence conflicti126V → M in BAF82884 (PubMed:14702039).Curated1
Sequence conflicti740C → R in BAD18552 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054799248D → N. Corresponds to variant dbSNP:rs34446695Ensembl.1
Natural variantiVAR_054800432Y → D3 PublicationsCorresponds to variant dbSNP:rs4403594Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03673525 – 90Missing in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_036736202 – 255Missing in isoform 4. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_036737482 – 487AGVHWG → GKNMGV in isoform 4. 1 Publication6
Alternative sequenceiVSP_036738482Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_036739488 – 1043Missing in isoform 4. 1 PublicationAdd BLAST556

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131405 mRNA Translation: BAD18552.1
AK290195 mRNA Translation: BAF82884.1
AC115285 Genomic DNA No translation available.
AL138837 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07454.1
BC008827 mRNA Translation: AAH08827.1
BC011404 mRNA Translation: AAH11404.1
X52360 mRNA Translation: CAA36586.1
CCDSiCCDS41300.1 [P17040-1]
PIRiI37969
RefSeqiNP_660281.2, NM_145238.3
XP_005271228.1, XM_005271171.3 [P17040-3]
XP_006710937.1, XM_006710874.3 [P17040-1]
XP_016857726.1, XM_017002237.1 [P17040-1]
XP_016857727.1, XM_017002238.1 [P17040-3]
UniGeneiHs.442705

Genome annotation databases

EnsembliENST00000361328; ENSP00000355053; ENSG00000121903 [P17040-1]
ENST00000373413; ENSP00000362512; ENSG00000121903 [P17040-4]
GeneIDi7579
KEGGihsa:7579
UCSCiuc001bxj.5 human [P17040-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZSC20_HUMAN
AccessioniPrimary (citable) accession number: P17040
Secondary accession number(s): A8K2D0
, B1ALI4, B1ALI5, B1ALI6, Q6ZN23, Q96FA9, Q96H84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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