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UniProtKB - P17040 (ZSC20_HUMAN)

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Protein

Zinc finger and SCAN domain-containing protein 20

Gene

ZSCAN20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri710 – 732C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri766 – 788C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri794 – 816C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri875 – 897C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri903 – 925C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri931 – 953C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri959 – 981C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri987 – 1009C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1015 – 1037C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 20
Alternative name(s):
Zinc finger protein 31
Zinc finger protein 360
Zinc finger protein KOX29
Gene namesi
Name:ZSCAN20
Synonyms:KOX29, ZNF31, ZNF360
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13093. ZSCAN20.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7579.
OpenTargetsiENSG00000121903.
PharmGKBiPA37668.

Polymorphism and mutation databases

BioMutaiZSCAN20.
DMDMi229485383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473601 – 1043Zinc finger and SCAN domain-containing protein 20Add BLAST1043

Proteomic databases

MaxQBiP17040.
PaxDbiP17040.
PeptideAtlasiP17040.
PRIDEiP17040.

PTM databases

iPTMnetiP17040.
PhosphoSitePlusiP17040.

Expressioni

Gene expression databases

BgeeiENSG00000121903.
CleanExiHS_ZSCAN20.
GenevisibleiP17040. HS.

Organism-specific databases

HPAiHPA017933.

Interactioni

Protein-protein interaction databases

BioGridi113408. 57 interactors.
IntActiP17040. 1 interactor.
MINTiMINT-1456758.
STRINGi9606.ENSP00000324450.

Structurei

3D structure databases

ProteinModelPortaliP17040.
SMRiP17040.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 133SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri710 – 732C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri766 – 788C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri794 – 816C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri875 – 897C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri903 – 925C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri931 – 953C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri959 – 981C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri987 – 1009C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1015 – 1037C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOVERGENiHBG018163.
InParanoidiP17040.
KOiK09230.
OMAiIDHQGLY.
OrthoDBiEOG091G02KC.
PhylomeDBiP17040.
TreeFamiTF337082.

Family and domain databases

InterProiView protein in InterPro
IPR008916. Retrov_capsid_C.
IPR001005. SANT/Myb.
IPR003309. SCAN_dom.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00717. SANT. 2 hits.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17040-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMALELQAQ ASPQPEPEEL LIVKLEEDSW GSESKLWEKD RGSVSGPEAS 
        60         70         80         90        100
RQRFRQFQYR DAAGPHEAFS QLWALCCRWL RPEIRLKEQI LELLVLEQFL 
       110        120        130        140        150
TILPREVQTW VQARHPESGE EAVALVEDWH RETRTAGQSG LELHTEETRP 
       160        170        180        190        200
LKTGEEAQSF QLQPVDPWPE GQSQKKGVKN TCPDLPNHLN AEVAPQPLKE 
       210        220        230        240        250
SAVLTPRVPT LPKMGSVGDW EVTAESQEAL GPGKHAEKEL CKDPPGDDCG 
       260        270        280        290        300
NSVCLGVPVS KPSNTSEKEQ GPEFWGLSLI NSGKRSTADY SLDNEPAQAL 
       310        320        330        340        350
TWRDSRAWEE QYQWDVEDMK VSGVHWGYEE TKTFLAILSE SPFSEKLRTC 
       360        370        380        390        400
HQNRQVYRAI AEQLRARGFL RTLEQCRYRV KNLLRNYRKA KSSHPPGTCP 
       410        420        430        440        450
FYEELEALVR ARTAIRATDG PGEAVALPRL GYSDAEMDEQ EEGGWDPEEM 
       460        470        480        490        500
AEDCNGAGLV NVESTQGPRI AGAPALFQSR IAGVHWGYEE TKAFLAILSE 
       510        520        530        540        550
SPFSEKLRTC HQNSQVYRAI AERLCALGFL RTLEQCRYRF KNLLRSYRKA 
       560        570        580        590        600
KSSHPPGTCP FYEELDSLMR ARAAVRAMGT VREAAGLPRC GQSSAETDAQ 
       610        620        630        640        650
EAWGEVANED AVKPSTLCPK APDMGFEMRH EDEDQISEQD IFEGLPGALS 
       660        670        680        690        700
KCPTEAVCQP LDWGEDSENE NEDEGQWGNP SQEQWQESSS EEDLEKLIDH 
       710        720        730        740        750
QGLYLAEKPY KCDTCMKSFS RSSHFIAHQR IHTGEKPYKC LECGKNFSDR 
       760        770        780        790        800
SNLNTHQRIH TGEKPYKCLE CGKSFSDHSN LITHQRIHTG EKPYKCGECW 
       810        820        830        840        850
KSFNQSSNLL KHQRIHLGGN PDQCSEPGGN FAQSPSFSAH WRNSTEETAP 
       860        870        880        890        900
EQPQSISKDL NSPGPHSTNS GEKLYECSEC GRSFSKSSAL ISHQRIHTGE 
       910        920        930        940        950
KPYECAECGK SFSKSSTLAN HQRTHTGEKP YKCVDCGKCF SERSKLITHQ 
       960        970        980        990       1000
RVHTGEKPYK CLECGKFFRD RSNLITHQRI HTGEKPYKCR ECGKCFNQSS 
      1010       1020       1030       1040 
SLIIHQRIHT GEKPYKCTEC GKDFNNSSHF SAHRRTHAGG KAS
Length:1,043
Mass (Da):117,541
Last modified:March 24, 2009 - v3
Checksum:i1598FB5F243773FE
GO
Isoform 2 (identifier: P17040-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-90: Missing.

Show »
Length:977
Mass (Da):109,706
Checksum:i5E283FEE045D4525
GO
Isoform 3 (identifier: P17040-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-482: Missing.

Note: No experimental confirmation available.
Show »
Length:1,042
Mass (Da):117,470
Checksum:i68BCA6E9110E3EB0
GO
Isoform 4 (identifier: P17040-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-255: Missing.
     482-487: AGVHWG → GKNMGV
     488-1043: Missing.

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):49,035
Checksum:i63C40A82025DB27B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100L → P in BAF82884 (PubMed:14702039).Curated1
Sequence conflicti126V → M in BAF82884 (PubMed:14702039).Curated1
Sequence conflicti740C → R in BAD18552 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054799248D → N. Corresponds to variant dbSNP:rs34446695Ensembl.1
Natural variantiVAR_054800432Y → D3 PublicationsCorresponds to variant dbSNP:rs4403594Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03673525 – 90Missing in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_036736202 – 255Missing in isoform 4. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_036737482 – 487AGVHWG → GKNMGV in isoform 4. 1 Publication6
Alternative sequenceiVSP_036738482Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_036739488 – 1043Missing in isoform 4. 1 PublicationAdd BLAST556

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131405 mRNA. Translation: BAD18552.1.
AK290195 mRNA. Translation: BAF82884.1.
AL138837, AC115285 Genomic DNA. Translation: CAI19593.1.
AL138837, AC115285 Genomic DNA. Translation: CAI19594.1.
AL138837, AC115285 Genomic DNA. Translation: CAM12881.1.
CH471059 Genomic DNA. Translation: EAX07454.1.
BC008827 mRNA. Translation: AAH08827.1.
BC011404 mRNA. Translation: AAH11404.1.
X52360 mRNA. Translation: CAA36586.1.
CCDSiCCDS41300.1. [P17040-1]
PIRiI37969.
RefSeqiNP_660281.2. NM_145238.3.
XP_005271228.1. XM_005271171.3. [P17040-3]
XP_006710937.1. XM_006710874.3. [P17040-1]
XP_016857726.1. XM_017002237.1. [P17040-1]
XP_016857727.1. XM_017002238.1. [P17040-3]
UniGeneiHs.442705.

Genome annotation databases

EnsembliENST00000361328; ENSP00000355053; ENSG00000121903. [P17040-1]
ENST00000373413; ENSP00000362512; ENSG00000121903. [P17040-4]
GeneIDi7579.
KEGGihsa:7579.
UCSCiuc001bxj.5. human. [P17040-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZSC20_HUMAN
AccessioniPrimary (citable) accession number: P17040
Secondary accession number(s): A8K2D0
, B1ALI4, B1ALI5, B1ALI6, Q6ZN23, Q96FA9, Q96H84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: June 7, 2017
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families