UniProtKB - P17040 (ZSC20_HUMAN)
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Protein
Zinc finger and SCAN domain-containing protein 20
Gene
ZSCAN20
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 710 – 732 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 738 – 760 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 766 – 788 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 794 – 816 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 875 – 897 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 903 – 925 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 931 – 953 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 959 – 981 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 987 – 1009 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1015 – 1037 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 20Alternative name(s): Zinc finger protein 31 Zinc finger protein 360 Zinc finger protein KOX29 |
Gene namesi | Name:ZSCAN20 Synonyms:KOX29, ZNF31, ZNF360 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000121903.14. |
HGNCi | HGNC:13093. ZSCAN20. |
MIMi | 611315. gene. |
neXtProti | NX_P17040. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7579. |
OpenTargetsi | ENSG00000121903. |
PharmGKBi | PA37668. |
Polymorphism and mutation databases
BioMutai | ZSCAN20. |
DMDMi | 229485383. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047360 | 1 – 1043 | Zinc finger and SCAN domain-containing protein 20Add BLAST | 1043 |
Proteomic databases
MaxQBi | P17040. |
PaxDbi | P17040. |
PeptideAtlasi | P17040. |
PRIDEi | P17040. |
PTM databases
iPTMneti | P17040. |
PhosphoSitePlusi | P17040. |
Expressioni
Gene expression databases
Bgeei | ENSG00000121903. |
CleanExi | HS_ZSCAN20. |
Genevisiblei | P17040. HS. |
Organism-specific databases
HPAi | HPA017933. |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
ZKSCAN4 | A0A0S2Z6X0 | 3 | EBI-16440054,EBI-16431094 |
Protein-protein interaction databases
BioGridi | 113408. 58 interactors. |
IntActi | P17040. 2 interactors. |
STRINGi | 9606.ENSP00000324450. |
Structurei
3D structure databases
ProteinModelPortali | P17040. |
SMRi | P17040. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 133 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 710 – 732 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 738 – 760 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 766 – 788 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 794 – 816 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 875 – 897 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 903 – 925 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 931 – 953 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 959 – 981 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 987 – 1009 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1015 – 1037 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721. Eukaryota. COG5048. LUCA. |
GeneTreei | ENSGT00530000063287. |
HOVERGENi | HBG018163. |
InParanoidi | P17040. |
KOi | K09230. |
OMAi | IDHQGLY. |
OrthoDBi | EOG091G02KC. |
PhylomeDBi | P17040. |
TreeFami | TF337082. |
Family and domain databases
CDDi | cd07936. SCAN. 1 hit. |
Gene3Di | 1.10.4020.10. 1 hit. |
InterProi | View protein in InterPro IPR001005. SANT/Myb. IPR003309. SCAN_dom. IPR038269. SCAN_sf. IPR036236. Znf_C2H2_sf. IPR013087. Znf_C2H2_type. |
Pfami | View protein in Pfam PF02023. SCAN. 1 hit. |
SMARTi | View protein in SMART SM00717. SANT. 2 hits. SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 10 hits. |
SUPFAMi | SSF57667. SSF57667. 6 hits. |
PROSITEi | View protein in PROSITE PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P17040-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAMALELQAQ ASPQPEPEEL LIVKLEEDSW GSESKLWEKD RGSVSGPEAS
60 70 80 90 100
RQRFRQFQYR DAAGPHEAFS QLWALCCRWL RPEIRLKEQI LELLVLEQFL
110 120 130 140 150
TILPREVQTW VQARHPESGE EAVALVEDWH RETRTAGQSG LELHTEETRP
160 170 180 190 200
LKTGEEAQSF QLQPVDPWPE GQSQKKGVKN TCPDLPNHLN AEVAPQPLKE
210 220 230 240 250
SAVLTPRVPT LPKMGSVGDW EVTAESQEAL GPGKHAEKEL CKDPPGDDCG
260 270 280 290 300
NSVCLGVPVS KPSNTSEKEQ GPEFWGLSLI NSGKRSTADY SLDNEPAQAL
310 320 330 340 350
TWRDSRAWEE QYQWDVEDMK VSGVHWGYEE TKTFLAILSE SPFSEKLRTC
360 370 380 390 400
HQNRQVYRAI AEQLRARGFL RTLEQCRYRV KNLLRNYRKA KSSHPPGTCP
410 420 430 440 450
FYEELEALVR ARTAIRATDG PGEAVALPRL GYSDAEMDEQ EEGGWDPEEM
460 470 480 490 500
AEDCNGAGLV NVESTQGPRI AGAPALFQSR IAGVHWGYEE TKAFLAILSE
510 520 530 540 550
SPFSEKLRTC HQNSQVYRAI AERLCALGFL RTLEQCRYRF KNLLRSYRKA
560 570 580 590 600
KSSHPPGTCP FYEELDSLMR ARAAVRAMGT VREAAGLPRC GQSSAETDAQ
610 620 630 640 650
EAWGEVANED AVKPSTLCPK APDMGFEMRH EDEDQISEQD IFEGLPGALS
660 670 680 690 700
KCPTEAVCQP LDWGEDSENE NEDEGQWGNP SQEQWQESSS EEDLEKLIDH
710 720 730 740 750
QGLYLAEKPY KCDTCMKSFS RSSHFIAHQR IHTGEKPYKC LECGKNFSDR
760 770 780 790 800
SNLNTHQRIH TGEKPYKCLE CGKSFSDHSN LITHQRIHTG EKPYKCGECW
810 820 830 840 850
KSFNQSSNLL KHQRIHLGGN PDQCSEPGGN FAQSPSFSAH WRNSTEETAP
860 870 880 890 900
EQPQSISKDL NSPGPHSTNS GEKLYECSEC GRSFSKSSAL ISHQRIHTGE
910 920 930 940 950
KPYECAECGK SFSKSSTLAN HQRTHTGEKP YKCVDCGKCF SERSKLITHQ
960 970 980 990 1000
RVHTGEKPYK CLECGKFFRD RSNLITHQRI HTGEKPYKCR ECGKCFNQSS
1010 1020 1030 1040
SLIIHQRIHT GEKPYKCTEC GKDFNNSSHF SAHRRTHAGG KAS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 100 | L → P in BAF82884 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 126 | V → M in BAF82884 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 740 | C → R in BAD18552 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054799 | 248 | D → N. Corresponds to variant dbSNP:rs34446695Ensembl. | 1 | |
Natural variantiVAR_054800 | 432 | Y → D3 PublicationsCorresponds to variant dbSNP:rs4403594Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036735 | 25 – 90 | Missing in isoform 2. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_036736 | 202 – 255 | Missing in isoform 4. 1 PublicationAdd BLAST | 54 | |
Alternative sequenceiVSP_036737 | 482 – 487 | AGVHWG → GKNMGV in isoform 4. 1 Publication | 6 | |
Alternative sequenceiVSP_036738 | 482 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_036739 | 488 – 1043 | Missing in isoform 4. 1 PublicationAdd BLAST | 556 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131405 mRNA. Translation: BAD18552.1. AK290195 mRNA. Translation: BAF82884.1. AL138837, AC115285 Genomic DNA. Translation: CAI19593.1. AL138837, AC115285 Genomic DNA. Translation: CAI19594.1. AL138837, AC115285 Genomic DNA. Translation: CAM12881.1. CH471059 Genomic DNA. Translation: EAX07454.1. BC008827 mRNA. Translation: AAH08827.1. BC011404 mRNA. Translation: AAH11404.1. X52360 mRNA. Translation: CAA36586.1. |
CCDSi | CCDS41300.1. [P17040-1] |
PIRi | I37969. |
RefSeqi | NP_660281.2. NM_145238.3. XP_005271228.1. XM_005271171.3. [P17040-3] XP_006710937.1. XM_006710874.3. [P17040-1] XP_016857726.1. XM_017002237.1. [P17040-1] XP_016857727.1. XM_017002238.1. [P17040-3] |
UniGenei | Hs.442705. |
Genome annotation databases
Ensembli | ENST00000361328; ENSP00000355053; ENSG00000121903. [P17040-1] ENST00000373413; ENSP00000362512; ENSG00000121903. [P17040-4] |
GeneIDi | 7579. |
KEGGi | hsa:7579. |
UCSCi | uc001bxj.5. human. [P17040-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | ZSC20_HUMAN | |
Accessioni | P17040Primary (citable) accession number: P17040 Secondary accession number(s): A8K2D0 Q96H84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | March 24, 2009 | |
Last modified: | March 28, 2018 | |
This is version 176 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |