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P17040 (ZSC20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and SCAN domain-containing protein 20
Alternative name(s):
Zinc finger protein 31
Zinc finger protein 360
Zinc finger protein KOX29
Gene names
Name:ZSCAN20
Synonyms:KOX29, ZNF31, ZNF360
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1043 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17040-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17040-2)

The sequence of this isoform differs from the canonical sequence as follows:
     25-90: Missing.
Isoform 3 (identifier: P17040-3)

The sequence of this isoform differs from the canonical sequence as follows:
     482-482: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: P17040-4)

The sequence of this isoform differs from the canonical sequence as follows:
     202-255: Missing.
     482-487: AGVHWG → GKNMGV
     488-1043: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10431043Zinc finger and SCAN domain-containing protein 20
PRO_0000047360

Regions

Domain51 – 13383SCAN box
Zinc finger710 – 73223C2H2-type 1
Zinc finger738 – 76023C2H2-type 2
Zinc finger766 – 78823C2H2-type 3
Zinc finger794 – 81623C2H2-type 4
Zinc finger875 – 89723C2H2-type 5
Zinc finger903 – 92523C2H2-type 6
Zinc finger931 – 95323C2H2-type 7
Zinc finger959 – 98123C2H2-type 8
Zinc finger987 – 100923C2H2-type 9
Zinc finger1015 – 103723C2H2-type 10

Natural variations

Alternative sequence25 – 9066Missing in isoform 2.
VSP_036735
Alternative sequence202 – 25554Missing in isoform 4.
VSP_036736
Alternative sequence482 – 4876AGVHWG → GKNMGV in isoform 4.
VSP_036737
Alternative sequence4821Missing in isoform 3.
VSP_036738
Alternative sequence488 – 1043556Missing in isoform 4.
VSP_036739
Natural variant2481D → N.
Corresponds to variant rs34446695 [ dbSNP | Ensembl ].
VAR_054799
Natural variant4321Y → D. Ref.1 Ref.3 Ref.4
Corresponds to variant rs4403594 [ dbSNP | Ensembl ].
VAR_054800

Experimental info

Sequence conflict1001L → P in BAF82884. Ref.1
Sequence conflict1261V → M in BAF82884. Ref.1
Sequence conflict7401C → R in BAD18552. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 24, 2009. Version 3.
Checksum: 1598FB5F243773FE

FASTA1,043117,541
        10         20         30         40         50         60 
MAMALELQAQ ASPQPEPEEL LIVKLEEDSW GSESKLWEKD RGSVSGPEAS RQRFRQFQYR 

        70         80         90        100        110        120 
DAAGPHEAFS QLWALCCRWL RPEIRLKEQI LELLVLEQFL TILPREVQTW VQARHPESGE 

       130        140        150        160        170        180 
EAVALVEDWH RETRTAGQSG LELHTEETRP LKTGEEAQSF QLQPVDPWPE GQSQKKGVKN 

       190        200        210        220        230        240 
TCPDLPNHLN AEVAPQPLKE SAVLTPRVPT LPKMGSVGDW EVTAESQEAL GPGKHAEKEL 

       250        260        270        280        290        300 
CKDPPGDDCG NSVCLGVPVS KPSNTSEKEQ GPEFWGLSLI NSGKRSTADY SLDNEPAQAL 

       310        320        330        340        350        360 
TWRDSRAWEE QYQWDVEDMK VSGVHWGYEE TKTFLAILSE SPFSEKLRTC HQNRQVYRAI 

       370        380        390        400        410        420 
AEQLRARGFL RTLEQCRYRV KNLLRNYRKA KSSHPPGTCP FYEELEALVR ARTAIRATDG 

       430        440        450        460        470        480 
PGEAVALPRL GYSDAEMDEQ EEGGWDPEEM AEDCNGAGLV NVESTQGPRI AGAPALFQSR 

       490        500        510        520        530        540 
IAGVHWGYEE TKAFLAILSE SPFSEKLRTC HQNSQVYRAI AERLCALGFL RTLEQCRYRF 

       550        560        570        580        590        600 
KNLLRSYRKA KSSHPPGTCP FYEELDSLMR ARAAVRAMGT VREAAGLPRC GQSSAETDAQ 

       610        620        630        640        650        660 
EAWGEVANED AVKPSTLCPK APDMGFEMRH EDEDQISEQD IFEGLPGALS KCPTEAVCQP 

       670        680        690        700        710        720 
LDWGEDSENE NEDEGQWGNP SQEQWQESSS EEDLEKLIDH QGLYLAEKPY KCDTCMKSFS 

       730        740        750        760        770        780 
RSSHFIAHQR IHTGEKPYKC LECGKNFSDR SNLNTHQRIH TGEKPYKCLE CGKSFSDHSN 

       790        800        810        820        830        840 
LITHQRIHTG EKPYKCGECW KSFNQSSNLL KHQRIHLGGN PDQCSEPGGN FAQSPSFSAH 

       850        860        870        880        890        900 
WRNSTEETAP EQPQSISKDL NSPGPHSTNS GEKLYECSEC GRSFSKSSAL ISHQRIHTGE 

       910        920        930        940        950        960 
KPYECAECGK SFSKSSTLAN HQRTHTGEKP YKCVDCGKCF SERSKLITHQ RVHTGEKPYK 

       970        980        990       1000       1010       1020 
CLECGKFFRD RSNLITHQRI HTGEKPYKCR ECGKCFNQSS SLIIHQRIHT GEKPYKCTEC 

      1030       1040 
GKDFNNSSHF SAHRRTHAGG KAS 

« Hide

Isoform 2 [UniParc].

Checksum: 5E283FEE045D4525
Show »

FASTA977109,706
Isoform 3 [UniParc].

Checksum: 68BCA6E9110E3EB0
Show »

FASTA1,042117,470
Isoform 4 [UniParc].

Checksum: 63C40A82025DB27B
Show »

FASTA43349,035

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ASP-432.
Tissue: Thalamus.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-432.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT ASP-432.
Tissue: Eye and Muscle.
[5]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 875-930 (ISOFORMS 1/2/3).
Tissue: Lymphoid tissue.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK131405 mRNA. Translation: BAD18552.1.
AK290195 mRNA. Translation: BAF82884.1.
AL138837, AC115285 Genomic DNA. Translation: CAI19593.1.
AL138837, AC115285 Genomic DNA. Translation: CAI19594.1.
AL138837, AC115285 Genomic DNA. Translation: CAM12881.1.
CH471059 Genomic DNA. Translation: EAX07454.1.
BC008827 mRNA. Translation: AAH08827.1.
BC011404 mRNA. Translation: AAH11404.1.
X52360 mRNA. Translation: CAA36586.1.
PIRI37969.
RefSeqNP_660281.2. NM_145238.3.
XP_005271228.1. XM_005271171.1.
UniGeneHs.442705.

3D structure databases

ProteinModelPortalP17040.
SMRP17040. Positions 47-132, 695-1037.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113408. 3 interactions.
IntActP17040. 1 interaction.
MINTMINT-1456758.
STRING9606.ENSP00000324450.

PTM databases

PhosphoSiteP17040.

Polymorphism databases

DMDM229485383.

Proteomic databases

PaxDbP17040.
PRIDEP17040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361328; ENSP00000355053; ENSG00000121903. [P17040-1]
ENST00000373413; ENSP00000362512; ENSG00000121903. [P17040-4]
GeneID7579.
KEGGhsa:7579.
UCSCuc001bxj.4. human. [P17040-1]
uc001bxk.2. human. [P17040-4]
uc009vui.3. human. [P17040-3]

Organism-specific databases

CTD7579.
GeneCardsGC01P033938.
HGNCHGNC:13093. ZSCAN20.
HPAHPA017933.
MIM611315. gene.
neXtProtNX_P17040.
PharmGKBPA37668.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
KOK09230.
OMAPGALSKC.
OrthoDBEOG7KSX7Q.
PhylomeDBP17040.
TreeFamTF337082.

Gene expression databases

BgeeP17040.
CleanExHS_ZSCAN20.
GenevestigatorP17040.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR001005. SANT/Myb.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00717. SANT. 2 hits.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7579.
NextBio29629.
PROP17040.
SOURCESearch...

Entry information

Entry nameZSC20_HUMAN
AccessionPrimary (citable) accession number: P17040
Secondary accession number(s): A8K2D0 expand/collapse secondary AC list , B1ALI4, B1ALI5, B1ALI6, Q6ZN23, Q96FA9, Q96H84
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM