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Protein

Zinc finger protein 30

Gene

ZNF30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri120 – 142C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri148 – 170C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 30
Alternative name(s):
Zinc finger protein KOX28
Gene namesi
Name:ZNF30
Synonyms:KOX28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000168661.14.
HGNCiHGNC:13090. ZNF30.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168661.
PharmGKBiPA37665.

Polymorphism and mutation databases

BioMutaiZNF30.
DMDMi332278252.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473591 – 623Zinc finger protein 30Add BLAST623

Proteomic databases

EPDiP17039.
MaxQBiP17039.
PaxDbiP17039.
PeptideAtlasiP17039.
PRIDEiP17039.

PTM databases

iPTMnetiP17039.
PhosphoSitePlusiP17039.

Expressioni

Gene expression databases

BgeeiENSG00000168661.
CleanExiHS_ZNF30.
ExpressionAtlasiP17039. baseline and differential.
GenevisibleiP17039. HS.

Organism-specific databases

HPAiHPA030400.

Interactioni

Protein-protein interaction databases

BioGridi124660. 2 interactors.
IntActiP17039. 1 interactor.
STRINGi9606.ENSP00000303889.

Structurei

3D structure databases

ProteinModelPortaliP17039.
SMRiP17039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri120 – 142C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri148 – 170C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000140787.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17039.
KOiK09228.
OMAiFVKHGRI.
OrthoDBiEOG091G02KC.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 10 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17039-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHKYVGLQY HGSVTFEDVA IAFSQQEWES LDSSQRGLYR DVMLENYRNL
60 70 80 90 100
VSMGHSRSKP HVIALLEQWK EPEVTVRKDG RRWCTDLQLE DDTIGCKEMP
110 120 130 140 150
TSENCPSFAL HQKISRQKPR ECQEYGKTLC QDSKPVQHER IHSSEKPNRC
160 170 180 190 200
KECGKNFSNG HQLTIHQRLH VGEKPYKYEK CGKAFISGSA FVKHGRIHTG
210 220 230 240 250
EKPLKCKQCG KTISGSYQLT VHKSIHTGKK PYECGECGKA FLVYGKLTRH
260 270 280 290 300
QSTHTGEKPF GCEECGKAFS TFSYLVQHQR IHTSEKPYEC KECGKAFSTS
310 320 330 340 350
SPLAKHQRIH TGEKPYECKE CGKSFTVYGQ LTRHQSIHTG EKPFECKECG
360 370 380 390 400
KAFRLSSFLH AHQRIHAEIK PYGCKECGRT FSRASYLVQH GRLHTGEKPY
410 420 430 440 450
ECKECGKAFS TGSYLVQHQR IHTGEKPYEC KECGKAFISR HQLTVHQRVH
460 470 480 490 500
TGEKPYECKE CGKAFRVHVH LTQHRKIHTD VKPYECKECG KTFSRASYLV
510 520 530 540 550
QHSRIHTGKK PYECKECGKA FSSGSYLVQH QRIHTGEKPY ECNKCGKAFT
560 570 580 590 600
VYGQLIGHQS VHTGEKPFEC KECGKAFRLN SFLTEHQRVH TGEKPFKCKK
610 620
CGKTFRYSSA LKVHLRKHMS VIP
Length:623
Mass (Da):71,417
Last modified:May 3, 2011 - v5
Checksum:i50F63EFB2027C717
GO
Isoform 2 (identifier: P17039-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: M → MA

Show »
Length:624
Mass (Da):71,489
Checksum:i2B02E220567934F5
GO
Isoform 3 (identifier: P17039-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: D → G
     87-623: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:86
Mass (Da):10,040
Checksum:iD2FB1AA24ACFDC1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14V → M in BAG58432 (PubMed:14702039).Curated1
Sequence conflicti24S → F in BAG58432 (PubMed:14702039).Curated1
Sequence conflicti193K → R in CAE45802 (PubMed:17974005).Curated1
Sequence conflicti238G → W in CAE45802 (PubMed:17974005).Curated1
Sequence conflicti304A → V in CAE45802 (PubMed:17974005).Curated1
Sequence conflicti492T → A in AAI42997 (PubMed:15489334).Curated1
Sequence conflicti493F → L in CAE45802 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047736123Q → R3 PublicationsCorresponds to variant dbSNP:rs1811Ensembl.1
Natural variantiVAR_047737190A → T. Corresponds to variant dbSNP:rs8100497Ensembl.1
Natural variantiVAR_047738379R → K2 PublicationsCorresponds to variant dbSNP:rs1345658Ensembl.1
Natural variantiVAR_047739400Y → C1 PublicationCorresponds to variant dbSNP:rs765746Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04094253M → MA in isoform 2. 1 Publication1
Alternative sequenceiVSP_04094386D → G in isoform 3. 2 Publications1
Alternative sequenceiVSP_04094487 – 623Missing in isoform 3. 2 PublicationsAdd BLAST537

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295515 mRNA. Translation: BAG58432.1.
AK290435 mRNA. Translation: BAF83124.1.
BX640666 mRNA. Translation: CAE45802.1.
AC008555 Genomic DNA. No translation available.
BC142996 mRNA. Translation: AAI42997.1.
X52359 mRNA. Translation: CAA36585.1.
CCDSiCCDS46044.1. [P17039-2]
CCDS46045.1. [P17039-1]
PIRiI37968.
RefSeqiNP_001092907.1. NM_001099437.1. [P17039-2]
NP_001092908.1. NM_001099438.1. [P17039-2]
NP_919306.2. NM_194325.2. [P17039-1]
XP_011525745.1. XM_011527443.2. [P17039-2]
XP_011525746.1. XM_011527444.1. [P17039-2]
XP_016882912.1. XM_017027423.1. [P17039-2]
XP_016882913.1. XM_017027424.1. [P17039-2]
XP_016882914.1. XM_017027425.1. [P17039-1]
XP_016882915.1. XM_017027426.1. [P17039-1]
XP_016882916.1. XM_017027427.1.
XP_016882917.1. XM_017027428.1.
XP_016882918.1. XM_017027429.1.
UniGeneiHs.657402.

Genome annotation databases

EnsembliENST00000303586; ENSP00000303889; ENSG00000168661. [P17039-2]
ENST00000439785; ENSP00000403441; ENSG00000168661. [P17039-2]
ENST00000601142; ENSP00000469954; ENSG00000168661. [P17039-1]
ENST00000601957; ENSP00000470094; ENSG00000168661. [P17039-3]
GeneIDi90075.
KEGGihsa:90075.
UCSCiuc010edp.2. human. [P17039-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF30_HUMAN
AccessioniPrimary (citable) accession number: P17039
Secondary accession number(s): A5PLP1
, A8K320, B4DIC0, Q6N068
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 3, 2011
Last modified: November 22, 2017
This is version 169 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families