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P17038 (ZNF43_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 43
Alternative name(s):
Zinc finger protein 39
Zinc finger protein HTF6
Zinc finger protein KOX27
Gene names
Name:ZNF43
Synonyms:KOX27, ZNF39, ZNF39L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length809 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

T- and B-cell lines.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 22 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17038-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17038-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MGPLTFM → M

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 809809Zinc finger protein 43
PRO_0000047376

Regions

Domain7 – 7569KRAB
Zinc finger174 – 19623C2H2-type 1
Zinc finger202 – 22423C2H2-type 2; degenerate
Zinc finger230 – 25223C2H2-type 3; degenerate
Zinc finger258 – 28023C2H2-type 4; degenerate
Zinc finger286 – 30823C2H2-type 5
Zinc finger314 – 33623C2H2-type 6
Zinc finger342 – 36423C2H2-type 7
Zinc finger370 – 39223C2H2-type 8
Zinc finger398 – 42023C2H2-type 9
Zinc finger426 – 44823C2H2-type 10
Zinc finger454 – 47623C2H2-type 11
Zinc finger482 – 50423C2H2-type 12
Zinc finger510 – 53223C2H2-type 13
Zinc finger538 – 56023C2H2-type 14
Zinc finger566 – 58823C2H2-type 15
Zinc finger594 – 61623C2H2-type 16
Zinc finger622 – 64423C2H2-type 17
Zinc finger650 – 67223C2H2-type 18
Zinc finger678 – 70023C2H2-type 19
Zinc finger706 – 72823C2H2-type 20
Zinc finger734 – 75623C2H2-type 21
Zinc finger762 – 78423C2H2-type 22

Natural variations

Alternative sequence1 – 77MGPLTFM → M in isoform 2.
VSP_036734
Natural variant2441R → C in a colorectal cancer sample; somatic mutation. Ref.10
VAR_035569
Natural variant7181S → P. Ref.1
Corresponds to variant rs1063327 [ dbSNP | Ensembl ].
VAR_054794

Experimental info

Sequence conflict431L → M in AAA58674. Ref.8
Sequence conflict1871P → S in AAA58674. Ref.8
Sequence conflict5731K → R in BAF84042. Ref.3
Sequence conflict6221Y → H in CAI45941. Ref.4
Sequence conflict7381E → G in CAI45941. Ref.4
Sequence conflict7971V → M in BAF84042. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 24, 2009. Version 4.
Checksum: 03386F299D6794C4

FASTA80994,124
        10         20         30         40         50         60 
MGPLTFMDVA IEFCLEEWQC LDIAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEQEK 

        70         80         90        100        110        120 
EPWEPMRRHE MVAKPPVMCS HFTQDFWPEQ HIKDPFQKAT LRRYKNCEHK NVHLKKDHKS 

       130        140        150        160        170        180 
VDECKVHRGG YNGFNQCLPA TQSKIFLFDK CVKAFHKFSN SNRHKISHTE KKLFKCKECG 

       190        200        210        220        230        240 
KSFCMLPHLA QHKIIHTRVN FCKCEKCGKA FNCPSIITKH KRINTGEKPY TCEECGKVFN 

       250        260        270        280        290        300 
WSSRLTTHKK NYTRYKLYKC EECGKAFNKS SILTTHKIIR TGEKFYKCKE CAKAFNQSSN 

       310        320        330        340        350        360 
LTEHKKIHPG EKPYKCEECG KAFNWPSTLT KHKRIHTGEK PYTCEECGKA FNQFSNLTTH 

       370        380        390        400        410        420 
KRIHTAEKFY KCTECGEAFS RSSNLTKHKK IHTEKKPYKC EECGKAFKWS SKLTEHKLTH 

       430        440        450        460        470        480 
TGEKPYKCEE CGKAFNWPST LTKHNRIHTG EKPYKCEVCG KAFNQFSNLT THKRIHTAEK 

       490        500        510        520        530        540 
PYKCEECGKA FSRSSNLTKH KKIHIEKKPY KCEECGKAFK WSSKLTEHKI THTGEKPYKC 

       550        560        570        580        590        600 
EECGKAFNHF SILTKHKRIH TGEKPYKCEE CGKAFTQSSN LTTHKKIHTG EKFYKCEECG 

       610        620        630        640        650        660 
KAFTQSSNLT THKKIHTGGK PYKCEECGKA FNQFSTLTKH KIIHTEEKPY KCEECGKAFK 

       670        680        690        700        710        720 
WSSTLTKHKI IHTGEKPYKC EECGKAFKLS STLSTHKIIH TGEKPYKCEK CGKAFNRSSN 

       730        740        750        760        770        780 
LIEHKKIHTG EQPYKCEECG KAFNYSSHLN THKRIHTKEQ PYKCKECGKA FNQYSNLTTH 

       790        800 
NKIHTGEKLY KPEDVTVILT TPQTFSNIK 

« Hide

Isoform 2 [UniParc].

Checksum: 8A3BCB47ECDD1500
Show »

FASTA80393,478

References

« Hide 'large scale' references
[1]"A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines."
Lovering R., Trowsdale J.
Nucleic Acids Res. 19:2921-2927(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PRO-718.
Tissue: T-cell.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Endometrium.
[5]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph.
[8]"The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-196 (ISOFORMS 1/2).
[9]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 482-537 (ISOFORMS 1/2).
Tissue: Lymphoid tissue.
[10]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-244.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59244 mRNA. Translation: CAA41932.1.
BT009756 mRNA. Translation: AAP88758.1.
AK291353 mRNA. Translation: BAF84042.1.
CR933640 mRNA. Translation: CAI45941.1.
AC010617 Genomic DNA. No translation available.
AC092364 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84908.1.
BC006528 mRNA. Translation: AAH06528.2.
M61869 mRNA. Translation: AAA58674.1.
X52358 mRNA. Translation: CAA36584.1.
CCDSCCDS12413.2. [P17038-1]
CCDS59367.1. [P17038-2]
PIRD39384.
S26823.
RefSeqNP_001243577.1. NM_001256648.1. [P17038-2]
NP_001243578.1. NM_001256649.1. [P17038-2]
NP_001243579.1. NM_001256650.1. [P17038-2]
NP_003414.2. NM_003423.3. [P17038-1]
UniGeneHs.534365.

3D structure databases

ProteinModelPortalP17038.
SMRP17038. Positions 158-792.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113420. 1 interaction.
MINTMINT-2801356.
STRING9606.ENSP00000347045.

PTM databases

PhosphoSiteP17038.

Polymorphism databases

DMDM229485311.

Proteomic databases

PaxDbP17038.
PRIDEP17038.

Protocols and materials databases

DNASU7594.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354959; ENSP00000347045; ENSG00000198521. [P17038-1]
ENST00000573408; ENSP00000465732; ENSG00000262928. [P17038-1]
ENST00000594012; ENSP00000469578; ENSG00000198521. [P17038-2]
ENST00000594923; ENSP00000470376; ENSG00000262928. [P17038-2]
ENST00000595461; ENSP00000469645; ENSG00000198521. [P17038-2]
ENST00000596906; ENSP00000470003; ENSG00000262928. [P17038-2]
ENST00000598381; ENSP00000470275; ENSG00000198521. [P17038-2]
ENST00000599986; ENSP00000471644; ENSG00000262928. [P17038-2]
GeneID7594.
KEGGhsa:7594.
UCSCuc002nqj.4. human. [P17038-1]

Organism-specific databases

CTD7594.
GeneCardsGC19M021987.
HGNCHGNC:13109. ZNF43.
HPAHPA050271.
MIM603972. gene.
neXtProtNX_P17038.
PharmGKBPA37684.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP17038.
KOK09228.
OMAFYKCTEC.
PhylomeDBP17038.
TreeFamTF343410.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressP17038.
BgeeP17038.
CleanExHS_ZNF43.
GenevestigatorP17038.

Family and domain databases

Gene3D3.30.160.60. 23 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 22 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF43.
GenomeRNAi7594.
NextBio29679.
PROP17038.
SOURCESearch...

Entry information

Entry nameZNF43_HUMAN
AccessionPrimary (citable) accession number: P17038
Secondary accession number(s): A8K5N8 expand/collapse secondary AC list , P28160, Q53XQ2, Q5H9T3, Q96DG1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: July 9, 2014
This is version 150 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM