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Protein

Zinc finger protein 3

Gene

ZNF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri200 – 22223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. identical protein binding Source: IntAct
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. leukocyte activation Source: UniProtKB
  3. multicellular organismal development Source: UniProtKB-KW
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 3
Alternative name(s):
Zinc finger protein HF.12
Zinc finger protein HZF3.1
Zinc finger protein KOX25
Gene namesi
Name:ZNF3
Synonyms:KOX25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13089. ZNF3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Zinc finger protein 3PRO_0000047368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP17036.
PaxDbiP17036.
PRIDEiP17036.

PTM databases

PhosphoSiteiP17036.

Expressioni

Gene expression databases

BgeeiP17036.
CleanExiHS_ZNF3.
ExpressionAtlasiP17036. baseline and differential.
GenevestigatoriP17036.

Organism-specific databases

HPAiHPA003719.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1640965,EBI-1640965
ZNF212Q9UDV64EBI-1640965,EBI-1640204

Protein-protein interaction databases

BioGridi113383. 9 interactions.
IntActiP17036. 4 interactions.
STRINGi9606.ENSP00000299667.

Structurei

3D structure databases

ProteinModelPortaliP17036.
SMRiP17036. Positions 167-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 12373KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri200 – 22223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121886.
HOVERGENiHBG018163.
InParanoidiP17036.
KOiK09228.
OMAiECMECGG.
OrthoDBiEOG73JKWC.
PhylomeDBiP17036.
TreeFamiTF337732.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17036-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL
60 70 80 90 100
VTFEDVAVYF IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ
110 120 130 140 150
EISEDTRSHG VLLGRFQKDI SQGLKFKEAY EREVSLKRPL GNSPGERLNR
160 170 180 190 200
KMPDFGQVTV EEKLTPRGER SEKYNDFGNS FTVNSNLISH QRLPVGDRPH
210 220 230 240 250
KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS SHLIQHQRIH
260 270 280 290 300
TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT
310 320 330 340 350
HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS
360 370 380 390 400
QSSHLYQHQR IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE
410 420 430 440
CGKAFRYSSA LVRHQRIHTG EKPLNGIGMS KSSLRVTTEL NIREST
Length:446
Mass (Da):50,916
Last modified:April 26, 2004 - v3
Checksum:iEEF50906695779A6
GO
Isoform 2 (identifier: P17036-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-446: RETRTENDQE...TTELNIREST → WIHVCLTTQK...LASVEPPDTF

Show »
Length:131
Mass (Da):14,627
Checksum:iEB7B1403D9614BAB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211P → L in BAA91019 (PubMed:14702039).Curated
Sequence conflicti252 – 2565GEKPY → IRDSG in CAA30269 (PubMed:3380682).Curated
Sequence conflicti336 – 38752GEKPY…LIQHQ → EALPTFVTLIRLLPSVDPIV TNEAAFPAESLATIFALIWR LFCVHSLMFKKV in BAA91019 (PubMed:14702039).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021I → T.
Corresponds to variant rs11550034 [ dbSNP | Ensembl ].
VAR_052743

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei92 – 446355RETRT…IREST → WIHVCLTTQKVMLAWLTGTL SVAKGLCSSELASVEPPDTF in isoform 2. 2 PublicationsVSP_041156Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217988 mRNA. Translation: AAG17231.1.
AF193057 mRNA. Translation: AAG22485.1.
AK000223 mRNA. Translation: BAA91019.1.
AK297625 mRNA. Translation: BAH12633.1.
CH471091 Genomic DNA. Translation: EAW76605.1.
CH471091 Genomic DNA. Translation: EAW76606.1.
CH471091 Genomic DNA. Translation: EAW76608.1.
BC011887 mRNA. Translation: AAH11887.2.
BC013603 mRNA. Translation: AAH13603.2.
X60153 mRNA. Translation: CAB94195.1.
X52356 mRNA. Translation: CAA36582.1.
X07290 mRNA. Translation: CAA30269.1.
CCDSiCCDS43618.1. [P17036-2]
CCDS43619.1. [P17036-1]
PIRiS00754.
RefSeqiNP_001265213.1. NM_001278284.1. [P17036-1]
NP_001265216.1. NM_001278287.1. [P17036-1]
NP_001265219.1. NM_001278290.1. [P17036-1]
NP_060185.2. NM_017715.3. [P17036-2]
NP_116313.3. NM_032924.4. [P17036-1]
UniGeneiHs.435302.

Genome annotation databases

EnsembliENST00000299667; ENSP00000299667; ENSG00000166526. [P17036-1]
ENST00000303915; ENSP00000306372; ENSG00000166526. [P17036-1]
ENST00000413658; ENSP00000399951; ENSG00000166526. [P17036-2]
ENST00000424697; ENSP00000415358; ENSG00000166526. [P17036-1]
GeneIDi7551.
KEGGihsa:7551.
UCSCiuc003usp.4. human. [P17036-2]
uc003usq.4. human. [P17036-1]

Polymorphism databases

DMDMi46577682.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217988 mRNA. Translation: AAG17231.1.
AF193057 mRNA. Translation: AAG22485.1.
AK000223 mRNA. Translation: BAA91019.1.
AK297625 mRNA. Translation: BAH12633.1.
CH471091 Genomic DNA. Translation: EAW76605.1.
CH471091 Genomic DNA. Translation: EAW76606.1.
CH471091 Genomic DNA. Translation: EAW76608.1.
BC011887 mRNA. Translation: AAH11887.2.
BC013603 mRNA. Translation: AAH13603.2.
X60153 mRNA. Translation: CAB94195.1.
X52356 mRNA. Translation: CAA36582.1.
X07290 mRNA. Translation: CAA30269.1.
CCDSiCCDS43618.1. [P17036-2]
CCDS43619.1. [P17036-1]
PIRiS00754.
RefSeqiNP_001265213.1. NM_001278284.1. [P17036-1]
NP_001265216.1. NM_001278287.1. [P17036-1]
NP_001265219.1. NM_001278290.1. [P17036-1]
NP_060185.2. NM_017715.3. [P17036-2]
NP_116313.3. NM_032924.4. [P17036-1]
UniGeneiHs.435302.

3D structure databases

ProteinModelPortaliP17036.
SMRiP17036. Positions 167-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113383. 9 interactions.
IntActiP17036. 4 interactions.
STRINGi9606.ENSP00000299667.

PTM databases

PhosphoSiteiP17036.

Polymorphism databases

DMDMi46577682.

Proteomic databases

MaxQBiP17036.
PaxDbiP17036.
PRIDEiP17036.

Protocols and materials databases

DNASUi7551.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299667; ENSP00000299667; ENSG00000166526. [P17036-1]
ENST00000303915; ENSP00000306372; ENSG00000166526. [P17036-1]
ENST00000413658; ENSP00000399951; ENSG00000166526. [P17036-2]
ENST00000424697; ENSP00000415358; ENSG00000166526. [P17036-1]
GeneIDi7551.
KEGGihsa:7551.
UCSCiuc003usp.4. human. [P17036-2]
uc003usq.4. human. [P17036-1]

Organism-specific databases

CTDi7551.
GeneCardsiGC07M099661.
HGNCiHGNC:13089. ZNF3.
HPAiHPA003719.
MIMi194510. gene.
601261. gene.
neXtProtiNX_P17036.
PharmGKBiPA37664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121886.
HOVERGENiHBG018163.
InParanoidiP17036.
KOiK09228.
OMAiECMECGG.
OrthoDBiEOG73JKWC.
PhylomeDBiP17036.
TreeFamiTF337732.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF3. human.
GeneWikiiZNF3.
GenomeRNAii7551.
NextBioi29541.
PROiP17036.
SOURCEiSearch...

Gene expression databases

BgeeiP17036.
CleanExiHS_ZNF3.
ExpressionAtlasiP17036. baseline and differential.
GenevestigatoriP17036.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel Human cDNA clones with function of inhibiting cancer cell growth."
    Gu J.R., Wan D.F., Zhao X.T., Zhou X.M., Jiang H.Q., Zhang P.P., Qin W.X., Huang Y., Qiu X.K., Qian L.F., He L.P., Li H.N., Yu Y., Yu J., Han L.H.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-387 (ISOFORM 1).
    Tissue: Colon mucosa.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary and Skin.
  5. "Members of the zinc finger protein gene family sharing a conserved N-terminal module."
    Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G.
    Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-250 (ISOFORM 1).
    Tissue: Teratocarcinoma.
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 340-395.
    Tissue: Lymphoid tissue.
  7. "Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation."
    Pannuti A., Lanfrancone L., Pascucci A., Pelicci P.-G., la Mantia G., Lania L.
    Nucleic Acids Res. 16:4227-4237(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 252-446.
    Tissue: Placenta.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZNF3_HUMAN
AccessioniPrimary (citable) accession number: P17036
Secondary accession number(s): D6W5U0
, P13683, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 26, 2004
Last modified: February 4, 2015
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.