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P17036

- ZNF3_HUMAN

UniProt

P17036 - ZNF3_HUMAN

Protein

Zinc finger protein 3

Gene

ZNF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 158 (01 Oct 2014)
      Sequence version 3 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Involved in cell differentiation and/or proliferation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri200 – 22223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. identical protein binding Source: IntAct
    3. protein binding Source: IntAct
    4. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. leukocyte activation Source: UniProtKB
    3. multicellular organismal development Source: UniProtKB-KW
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 3
    Alternative name(s):
    Zinc finger protein HF.12
    Zinc finger protein HZF3.1
    Zinc finger protein KOX25
    Gene namesi
    Name:ZNF3
    Synonyms:KOX25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:13089. ZNF3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37664.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Zinc finger protein 3PRO_0000047368Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei143 – 1431Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP17036.
    PaxDbiP17036.
    PRIDEiP17036.

    PTM databases

    PhosphoSiteiP17036.

    Expressioni

    Gene expression databases

    ArrayExpressiP17036.
    BgeeiP17036.
    CleanExiHS_ZNF3.
    GenevestigatoriP17036.

    Organism-specific databases

    HPAiHPA003719.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-1640965,EBI-1640965
    ZNF212Q9UDV64EBI-1640965,EBI-1640204

    Protein-protein interaction databases

    BioGridi113383. 6 interactions.
    IntActiP17036. 4 interactions.
    STRINGi9606.ENSP00000299667.

    Structurei

    3D structure databases

    ProteinModelPortaliP17036.
    SMRiP17036. Positions 167-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 12373KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri200 – 22223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG018163.
    InParanoidiP17036.
    KOiK09228.
    OMAiMGDRPHK.
    OrthoDBiEOG73JKWC.
    PhylomeDBiP17036.
    TreeFamiTF337732.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P17036-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL    50
    VTFEDVAVYF IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ 100
    EISEDTRSHG VLLGRFQKDI SQGLKFKEAY EREVSLKRPL GNSPGERLNR 150
    KMPDFGQVTV EEKLTPRGER SEKYNDFGNS FTVNSNLISH QRLPVGDRPH 200
    KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS SHLIQHQRIH 250
    TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT 300
    HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS 350
    QSSHLYQHQR IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE 400
    CGKAFRYSSA LVRHQRIHTG EKPLNGIGMS KSSLRVTTEL NIREST 446
    Length:446
    Mass (Da):50,916
    Last modified:April 26, 2004 - v3
    Checksum:iEEF50906695779A6
    GO
    Isoform 2 (identifier: P17036-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         92-446: RETRTENDQE...TTELNIREST → WIHVCLTTQK...LASVEPPDTF

    Show »
    Length:131
    Mass (Da):14,627
    Checksum:iEB7B1403D9614BAB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211P → L in BAA91019. (PubMed:14702039)Curated
    Sequence conflicti252 – 2565GEKPY → IRDSG in CAA30269. (PubMed:3380682)Curated
    Sequence conflicti336 – 38752GEKPY…LIQHQ → EALPTFVTLIRLLPSVDPIV TNEAAFPAESLATIFALIWR LFCVHSLMFKKV in BAA91019. (PubMed:14702039)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti102 – 1021I → T.
    Corresponds to variant rs11550034 [ dbSNP | Ensembl ].
    VAR_052743

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei92 – 446355RETRT…IREST → WIHVCLTTQKVMLAWLTGTL SVAKGLCSSELASVEPPDTF in isoform 2. 2 PublicationsVSP_041156Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217988 mRNA. Translation: AAG17231.1.
    AF193057 mRNA. Translation: AAG22485.1.
    AK000223 mRNA. Translation: BAA91019.1.
    AK297625 mRNA. Translation: BAH12633.1.
    CH471091 Genomic DNA. Translation: EAW76605.1.
    CH471091 Genomic DNA. Translation: EAW76606.1.
    CH471091 Genomic DNA. Translation: EAW76608.1.
    BC011887 mRNA. Translation: AAH11887.2.
    BC013603 mRNA. Translation: AAH13603.2.
    X60153 mRNA. Translation: CAB94195.1.
    X52356 mRNA. Translation: CAA36582.1.
    X07290 mRNA. Translation: CAA30269.1.
    CCDSiCCDS43618.1. [P17036-2]
    CCDS43619.1. [P17036-1]
    PIRiS00754.
    RefSeqiNP_001265213.1. NM_001278284.1. [P17036-1]
    NP_001265216.1. NM_001278287.1. [P17036-1]
    NP_001265219.1. NM_001278290.1. [P17036-1]
    NP_060185.2. NM_017715.3. [P17036-2]
    NP_116313.3. NM_032924.4. [P17036-1]
    UniGeneiHs.435302.

    Genome annotation databases

    GeneIDi7551.
    KEGGihsa:7551.
    UCSCiuc003usp.4. human. [P17036-2]
    uc003usq.4. human. [P17036-1]

    Polymorphism databases

    DMDMi46577682.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217988 mRNA. Translation: AAG17231.1 .
    AF193057 mRNA. Translation: AAG22485.1 .
    AK000223 mRNA. Translation: BAA91019.1 .
    AK297625 mRNA. Translation: BAH12633.1 .
    CH471091 Genomic DNA. Translation: EAW76605.1 .
    CH471091 Genomic DNA. Translation: EAW76606.1 .
    CH471091 Genomic DNA. Translation: EAW76608.1 .
    BC011887 mRNA. Translation: AAH11887.2 .
    BC013603 mRNA. Translation: AAH13603.2 .
    X60153 mRNA. Translation: CAB94195.1 .
    X52356 mRNA. Translation: CAA36582.1 .
    X07290 mRNA. Translation: CAA30269.1 .
    CCDSi CCDS43618.1. [P17036-2 ]
    CCDS43619.1. [P17036-1 ]
    PIRi S00754.
    RefSeqi NP_001265213.1. NM_001278284.1. [P17036-1 ]
    NP_001265216.1. NM_001278287.1. [P17036-1 ]
    NP_001265219.1. NM_001278290.1. [P17036-1 ]
    NP_060185.2. NM_017715.3. [P17036-2 ]
    NP_116313.3. NM_032924.4. [P17036-1 ]
    UniGenei Hs.435302.

    3D structure databases

    ProteinModelPortali P17036.
    SMRi P17036. Positions 167-425.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113383. 6 interactions.
    IntActi P17036. 4 interactions.
    STRINGi 9606.ENSP00000299667.

    PTM databases

    PhosphoSitei P17036.

    Polymorphism databases

    DMDMi 46577682.

    Proteomic databases

    MaxQBi P17036.
    PaxDbi P17036.
    PRIDEi P17036.

    Protocols and materials databases

    DNASUi 7551.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7551.
    KEGGi hsa:7551.
    UCSCi uc003usp.4. human. [P17036-2 ]
    uc003usq.4. human. [P17036-1 ]

    Organism-specific databases

    CTDi 7551.
    GeneCardsi GC07M099661.
    HGNCi HGNC:13089. ZNF3.
    HPAi HPA003719.
    MIMi 194510. gene.
    601261. gene.
    neXtProti NX_P17036.
    PharmGKBi PA37664.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG018163.
    InParanoidi P17036.
    KOi K09228.
    OMAi MGDRPHK.
    OrthoDBi EOG73JKWC.
    PhylomeDBi P17036.
    TreeFami TF337732.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF3. human.
    GeneWikii ZNF3.
    GenomeRNAii 7551.
    NextBioi 29541.
    PROi P17036.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17036.
    Bgeei P17036.
    CleanExi HS_ZNF3.
    Genevestigatori P17036.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel Human cDNA clones with function of inhibiting cancer cell growth."
      Gu J.R., Wan D.F., Zhao X.T., Zhou X.M., Jiang H.Q., Zhang P.P., Qin W.X., Huang Y., Qiu X.K., Qian L.F., He L.P., Li H.N., Yu Y., Yu J., Han L.H.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-387 (ISOFORM 1).
      Tissue: Colon mucosa.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Ovary and Skin.
    5. "Members of the zinc finger protein gene family sharing a conserved N-terminal module."
      Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G.
      Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-250 (ISOFORM 1).
      Tissue: Teratocarcinoma.
    6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
      Thiesen H.-J.
      New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 340-395.
      Tissue: Lymphoid tissue.
    7. "Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation."
      Pannuti A., Lanfrancone L., Pascucci A., Pelicci P.-G., la Mantia G., Lania L.
      Nucleic Acids Res. 16:4227-4237(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 252-446.
      Tissue: Placenta.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiZNF3_HUMAN
    AccessioniPrimary (citable) accession number: P17036
    Secondary accession number(s): D6W5U0
    , P13683, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 158 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3