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P17036 (ZNF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 153. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 3
Alternative name(s):
Zinc finger protein HF.12
Zinc finger protein HZF3.1
Zinc finger protein KOX25
Gene names
Name:ZNF3
Synonyms:KOX25
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in cell differentiation and/or proliferation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 8 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-1640965,EBI-1640965
ZNF212Q9UDV64EBI-1640965,EBI-1640204

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17036-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17036-2)

The sequence of this isoform differs from the canonical sequence as follows:
     92-446: RETRTENDQE...TTELNIREST → WIHVCLTTQK...LASVEPPDTF

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Zinc finger protein 3
PRO_0000047368

Regions

Domain51 – 12373KRAB
Zinc finger200 – 22223C2H2-type 1
Zinc finger228 – 25023C2H2-type 2
Zinc finger256 – 27823C2H2-type 3
Zinc finger284 – 30623C2H2-type 4
Zinc finger312 – 33423C2H2-type 5
Zinc finger340 – 36223C2H2-type 6
Zinc finger368 – 39023C2H2-type 7
Zinc finger396 – 41823C2H2-type 8

Amino acid modifications

Modified residue1431Phosphoserine Ref.8

Natural variations

Alternative sequence92 – 446355RETRT…IREST → WIHVCLTTQKVMLAWLTGTL SVAKGLCSSELASVEPPDTF in isoform 2.
VSP_041156
Natural variant1021I → T.
Corresponds to variant rs11550034 [ dbSNP | Ensembl ].
VAR_052743

Experimental info

Sequence conflict211P → L in BAA91019. Ref.2
Sequence conflict252 – 2565GEKPY → IRDSG in CAA30269. Ref.7
Sequence conflict336 – 38752GEKPY…LIQHQ → EALPTFVTLIRLLPSVDPIV TNEAAFPAESLATIFALIWR LFCVHSLMFKKV in BAA91019. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2004. Version 3.
Checksum: EEF50906695779A6

FASTA44650,916
        10         20         30         40         50         60 
METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL VTFEDVAVYF 

        70         80         90        100        110        120 
IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ EISEDTRSHG VLLGRFQKDI 

       130        140        150        160        170        180 
SQGLKFKEAY EREVSLKRPL GNSPGERLNR KMPDFGQVTV EEKLTPRGER SEKYNDFGNS 

       190        200        210        220        230        240 
FTVNSNLISH QRLPVGDRPH KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS 

       250        260        270        280        290        300 
SHLIQHQRIH TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT 

       310        320        330        340        350        360 
HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS QSSHLYQHQR 

       370        380        390        400        410        420 
IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE CGKAFRYSSA LVRHQRIHTG 

       430        440 
EKPLNGIGMS KSSLRVTTEL NIREST 

« Hide

Isoform 2 [UniParc].

Checksum: EB7B1403D9614BAB
Show »

FASTA13114,627

References

« Hide 'large scale' references
[1]"Novel Human cDNA clones with function of inhibiting cancer cell growth."
Gu J.R., Wan D.F., Zhao X.T., Zhou X.M., Jiang H.Q., Zhang P.P., Qin W.X., Huang Y., Qiu X.K., Qian L.F., He L.P., Li H.N., Yu Y., Yu J., Han L.H.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-387 (ISOFORM 1).
Tissue: Colon mucosa.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary and Skin.
[5]"Members of the zinc finger protein gene family sharing a conserved N-terminal module."
Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G.
Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-250 (ISOFORM 1).
Tissue: Teratocarcinoma.
[6]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 340-395.
Tissue: Lymphoid tissue.
[7]"Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation."
Pannuti A., Lanfrancone L., Pascucci A., Pelicci P.-G., la Mantia G., Lania L.
Nucleic Acids Res. 16:4227-4237(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 252-446.
Tissue: Placenta.
[8]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF217988 mRNA. Translation: AAG17231.1.
AF193057 mRNA. Translation: AAG22485.1.
AK000223 mRNA. Translation: BAA91019.1.
AK297625 mRNA. Translation: BAH12633.1.
CH471091 Genomic DNA. Translation: EAW76605.1.
CH471091 Genomic DNA. Translation: EAW76606.1.
CH471091 Genomic DNA. Translation: EAW76608.1.
BC011887 mRNA. Translation: AAH11887.2.
BC013603 mRNA. Translation: AAH13603.2.
X60153 mRNA. Translation: CAB94195.1.
X52356 mRNA. Translation: CAA36582.1.
X07290 mRNA. Translation: CAA30269.1.
PIRS00754.
RefSeqNP_001265213.1. NM_001278284.1.
NP_001265216.1. NM_001278287.1.
NP_001265219.1. NM_001278290.1.
NP_060185.2. NM_017715.3.
NP_116313.3. NM_032924.4.
UniGeneHs.435302.

3D structure databases

ProteinModelPortalP17036.
SMRP17036. Positions 45-101, 141-425.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113383. 6 interactions.
IntActP17036. 4 interactions.
STRING9606.ENSP00000299667.

PTM databases

PhosphoSiteP17036.

Polymorphism databases

DMDM46577682.

Proteomic databases

PaxDbP17036.
PRIDEP17036.

Protocols and materials databases

DNASU7551.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299667; ENSP00000299667; ENSG00000166526. [P17036-1]
ENST00000303915; ENSP00000306372; ENSG00000166526. [P17036-1]
ENST00000413658; ENSP00000399951; ENSG00000166526. [P17036-2]
ENST00000424697; ENSP00000415358; ENSG00000166526. [P17036-1]
GeneID7551.
KEGGhsa:7551.
UCSCuc003usp.4. human. [P17036-2]
uc003usq.4. human. [P17036-1]

Organism-specific databases

CTD7551.
GeneCardsGC07M099661.
HGNCHGNC:13089. ZNF3.
HPAHPA003719.
MIM194510. gene.
601261. gene.
neXtProtNX_P17036.
PharmGKBPA37664.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
InParanoidP17036.
KOK09228.
OMAMGDRPHK.
OrthoDBEOG73JKWC.
PhylomeDBP17036.
TreeFamTF337732.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressP17036.
BgeeP17036.
CleanExHS_ZNF3.
GenevestigatorP17036.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF3. human.
GeneWikiZNF3.
GenomeRNAi7551.
NextBio29541.
PROP17036.
SOURCESearch...

Entry information

Entry nameZNF3_HUMAN
AccessionPrimary (citable) accession number: P17036
Secondary accession number(s): D6W5U0 expand/collapse secondary AC list , P13683, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 26, 2004
Last modified: April 16, 2014
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM