Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 3

Gene

ZNF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 222C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166526-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 3
Alternative name(s):
Zinc finger protein HF.12
Zinc finger protein HZF3.1
Zinc finger protein KOX25
Gene namesi
Name:ZNF3
Synonyms:KOX25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13089. ZNF3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166526.
PharmGKBiPA37664.

Polymorphism and mutation databases

DMDMi46577682.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473681 – 446Zinc finger protein 3Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143PhosphoserineCombined sources1
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei419PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17036.
MaxQBiP17036.
PaxDbiP17036.
PeptideAtlasiP17036.
PRIDEiP17036.

PTM databases

iPTMnetiP17036.
PhosphoSitePlusiP17036.

Expressioni

Gene expression databases

BgeeiENSG00000166526.
CleanExiHS_ZNF3.
ExpressionAtlasiP17036. baseline and differential.
GenevisibleiP17036. HS.

Organism-specific databases

HPAiHPA003719.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1640965,EBI-1640965
MTUS2Q5JR593EBI-1640965,EBI-742948
SSX2IPQ9Y2D83EBI-1640965,EBI-2212028
TRAF4Q9BUZ45EBI-1640965,EBI-3650647
ZNF212Q9UDV64EBI-1640965,EBI-1640204

Protein-protein interaction databases

BioGridi113383. 14 interactors.
IntActiP17036. 15 interactors.
STRINGi9606.ENSP00000299667.

Structurei

3D structure databases

ProteinModelPortaliP17036.
SMRiP17036.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 123KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 222C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133693.
HOVERGENiHBG018163.
InParanoidiP17036.
KOiK09228.
OMAiEKPLNVM.
OrthoDBiEOG091G02KC.
PhylomeDBiP17036.
TreeFamiTF337732.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17036-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL
60 70 80 90 100
VTFEDVAVYF IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ
110 120 130 140 150
EISEDTRSHG VLLGRFQKDI SQGLKFKEAY EREVSLKRPL GNSPGERLNR
160 170 180 190 200
KMPDFGQVTV EEKLTPRGER SEKYNDFGNS FTVNSNLISH QRLPVGDRPH
210 220 230 240 250
KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS SHLIQHQRIH
260 270 280 290 300
TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT
310 320 330 340 350
HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS
360 370 380 390 400
QSSHLYQHQR IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE
410 420 430 440
CGKAFRYSSA LVRHQRIHTG EKPLNGIGMS KSSLRVTTEL NIREST
Length:446
Mass (Da):50,916
Last modified:April 26, 2004 - v3
Checksum:iEEF50906695779A6
GO
Isoform 2 (identifier: P17036-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-446: RETRTENDQE...TTELNIREST → WIHVCLTTQK...LASVEPPDTF

Show »
Length:131
Mass (Da):14,627
Checksum:iEB7B1403D9614BAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21P → L in BAA91019 (PubMed:14702039).Curated1
Sequence conflicti252 – 256GEKPY → IRDSG in CAA30269 (PubMed:3380682).Curated5
Sequence conflicti336 – 387GEKPY…LIQHQ → EALPTFVTLIRLLPSVDPIV TNEAAFPAESLATIFALIWR LFCVHSLMFKKV in BAA91019 (PubMed:14702039).CuratedAdd BLAST52

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052743102I → T.Corresponds to variant rs11550034dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04115692 – 446RETRT…IREST → WIHVCLTTQKVMLAWLTGTL SVAKGLCSSELASVEPPDTF in isoform 2. 2 PublicationsAdd BLAST355

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217988 mRNA. Translation: AAG17231.1.
AF193057 mRNA. Translation: AAG22485.1.
AK000223 mRNA. Translation: BAA91019.1.
AK297625 mRNA. Translation: BAH12633.1.
CH471091 Genomic DNA. Translation: EAW76605.1.
CH471091 Genomic DNA. Translation: EAW76606.1.
CH471091 Genomic DNA. Translation: EAW76608.1.
BC011887 mRNA. Translation: AAH11887.2.
BC013603 mRNA. Translation: AAH13603.2.
X60153 mRNA. Translation: CAB94195.1.
X52356 mRNA. Translation: CAA36582.1.
X07290 mRNA. Translation: CAA30269.1.
CCDSiCCDS43618.1. [P17036-2]
CCDS43619.1. [P17036-1]
PIRiS00754.
RefSeqiNP_001265213.1. NM_001278284.1. [P17036-1]
NP_001265216.1. NM_001278287.1. [P17036-1]
NP_001265219.1. NM_001278290.1. [P17036-1]
NP_001305064.1. NM_001318135.1. [P17036-1]
NP_001305065.1. NM_001318136.1.
NP_001305066.1. NM_001318137.1.
NP_060185.2. NM_017715.3. [P17036-2]
NP_116313.3. NM_032924.4. [P17036-1]
UniGeneiHs.435302.

Genome annotation databases

EnsembliENST00000299667; ENSP00000299667; ENSG00000166526. [P17036-1]
ENST00000303915; ENSP00000306372; ENSG00000166526. [P17036-1]
ENST00000413658; ENSP00000399951; ENSG00000166526. [P17036-2]
ENST00000424697; ENSP00000415358; ENSG00000166526. [P17036-1]
GeneIDi7551.
KEGGihsa:7551.
UCSCiuc003usp.5. human. [P17036-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217988 mRNA. Translation: AAG17231.1.
AF193057 mRNA. Translation: AAG22485.1.
AK000223 mRNA. Translation: BAA91019.1.
AK297625 mRNA. Translation: BAH12633.1.
CH471091 Genomic DNA. Translation: EAW76605.1.
CH471091 Genomic DNA. Translation: EAW76606.1.
CH471091 Genomic DNA. Translation: EAW76608.1.
BC011887 mRNA. Translation: AAH11887.2.
BC013603 mRNA. Translation: AAH13603.2.
X60153 mRNA. Translation: CAB94195.1.
X52356 mRNA. Translation: CAA36582.1.
X07290 mRNA. Translation: CAA30269.1.
CCDSiCCDS43618.1. [P17036-2]
CCDS43619.1. [P17036-1]
PIRiS00754.
RefSeqiNP_001265213.1. NM_001278284.1. [P17036-1]
NP_001265216.1. NM_001278287.1. [P17036-1]
NP_001265219.1. NM_001278290.1. [P17036-1]
NP_001305064.1. NM_001318135.1. [P17036-1]
NP_001305065.1. NM_001318136.1.
NP_001305066.1. NM_001318137.1.
NP_060185.2. NM_017715.3. [P17036-2]
NP_116313.3. NM_032924.4. [P17036-1]
UniGeneiHs.435302.

3D structure databases

ProteinModelPortaliP17036.
SMRiP17036.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113383. 14 interactors.
IntActiP17036. 15 interactors.
STRINGi9606.ENSP00000299667.

PTM databases

iPTMnetiP17036.
PhosphoSitePlusiP17036.

Polymorphism and mutation databases

DMDMi46577682.

Proteomic databases

EPDiP17036.
MaxQBiP17036.
PaxDbiP17036.
PeptideAtlasiP17036.
PRIDEiP17036.

Protocols and materials databases

DNASUi7551.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299667; ENSP00000299667; ENSG00000166526. [P17036-1]
ENST00000303915; ENSP00000306372; ENSG00000166526. [P17036-1]
ENST00000413658; ENSP00000399951; ENSG00000166526. [P17036-2]
ENST00000424697; ENSP00000415358; ENSG00000166526. [P17036-1]
GeneIDi7551.
KEGGihsa:7551.
UCSCiuc003usp.5. human. [P17036-1]

Organism-specific databases

CTDi7551.
GeneCardsiZNF3.
HGNCiHGNC:13089. ZNF3.
HPAiHPA003719.
MIMi194510. gene.
601261. gene.
neXtProtiNX_P17036.
OpenTargetsiENSG00000166526.
PharmGKBiPA37664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133693.
HOVERGENiHBG018163.
InParanoidiP17036.
KOiK09228.
OMAiEKPLNVM.
OrthoDBiEOG091G02KC.
PhylomeDBiP17036.
TreeFamiTF337732.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166526-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF3. human.
GeneWikiiZNF3.
GenomeRNAii7551.
PROiP17036.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166526.
CleanExiHS_ZNF3.
ExpressionAtlasiP17036. baseline and differential.
GenevisibleiP17036. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF3_HUMAN
AccessioniPrimary (citable) accession number: P17036
Secondary accession number(s): D6W5U0
, P13683, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 26, 2004
Last modified: November 30, 2016
This is version 181 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.