P17036 (ZNF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 3

Alternative name(s):
Zinc finger protein HF.12
Zinc finger protein HZF3.1
Zinc finger protein KOX25

Gene names

Name:	ZNF3
Synonyms:	KOX25

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in cell differentiation and/or proliferation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 8 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW leukocyte activation Non-traceable author statement Ref.6. Source: UniProtKB multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Non-traceable author statement Ref.6. Source: UniProtKB sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB zinc ion binding Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-1640965,EBI-1640965
ZNF212	Q9UDV6	4	EBI-1640965,EBI-1640204

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P17036-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P17036-2)

The sequence of this isoform differs from the canonical sequence as follows:
     92-446: RETRTENDQE...TTELNIREST → WIHVCLTTQK...LASVEPPDTF

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Zinc finger protein 3		PRO_0000047368
Regions
	Domain	51 – 123	73	KRAB
	Zinc finger	200 – 222	23	C2H2-type 1
	Zinc finger	228 – 250	23	C2H2-type 2
	Zinc finger	256 – 278	23	C2H2-type 3
	Zinc finger	284 – 306	23	C2H2-type 4
	Zinc finger	312 – 334	23	C2H2-type 5
	Zinc finger	340 – 362	23	C2H2-type 6
	Zinc finger	368 – 390	23	C2H2-type 7
	Zinc finger	396 – 418	23	C2H2-type 8
Amino acid modifications
	Modified residue	143	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	92 – 446	355	RETRT…IREST → WIHVCLTTQKVMLAWLTGTL SVAKGLCSSELASVEPPDTF in isoform 2.		VSP_041156
	Natural variant	102	1	I → T. Corresponds to variant rs11550034 [ dbSNP | Ensembl ].		VAR_052743
Experimental info
	Sequence conflict	21	1	P → L in BAA91019. Ref.2
	Sequence conflict	252 – 256	5	GEKPY → IRDSG in CAA30269. Ref.7
	Sequence conflict	336 – 387	52	GEKPY…LIQHQ → EALPTFVTLIRLLPSVDPIV TNEAAFPAESLATIFALIWR LFCVHSLMFKKV in BAA91019. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 26, 2004. Version 3. Checksum: EEF50906695779A6	FASTA	446	50,916
	10 20 30 40 50 60 METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL VTFEDVAVYF 70 80 90 100 110 120 IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ EISEDTRSHG VLLGRFQKDI 130 140 150 160 170 180 SQGLKFKEAY EREVSLKRPL GNSPGERLNR KMPDFGQVTV EEKLTPRGER SEKYNDFGNS 190 200 210 220 230 240 FTVNSNLISH QRLPVGDRPH KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS 250 260 270 280 290 300 SHLIQHQRIH TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT 310 320 330 340 350 360 HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS QSSHLYQHQR 370 380 390 400 410 420 IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE CGKAFRYSSA LVRHQRIHTG 430 440 EKPLNGIGMS KSSLRVTTEL NIREST
	Isoform 2 [UniParc]. Checksum: EB7B1403D9614BAB	FASTA	131	14,627
	10 20 30 40 50 60 METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL VTFEDVAVYF 70 80 90 100 110 120 IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DWIHVCLTTQ KVMLAWLTGT LSVAKGLCSS 130 ELASVEPPDT F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel Human cDNA clones with function of inhibiting cancer cell growth." Gu J.R., Wan D.F., Zhao X.T., Zhou X.M., Jiang H.Q., Zhang P.P., Qin W.X., Huang Y., Qiu X.K., Qian L.F., He L.P., Li H.N., Yu Y., Yu J., Han L.H. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-387 (ISOFORM 1). Tissue: Colon mucosa.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Ovary and Skin.
[5]	"Members of the zinc finger protein gene family sharing a conserved N-terminal module." Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G. Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-250 (ISOFORM 1). Tissue: Teratocarcinoma.
[6]	"Multiple genes encoding zinc finger domains are expressed in human T cells." Thiesen H.-J. New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 340-395. Tissue: Lymphoid tissue.
[7]	"Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation." Pannuti A., Lanfrancone L., Pascucci A., Pelicci P.-G., la Mantia G., Lania L. Nucleic Acids Res. 16:4227-4237(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 252-446. Tissue: Placenta.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF217988 mRNA. Translation: AAG17231.1. AF193057 mRNA. Translation: AAG22485.1. AK000223 mRNA. Translation: BAA91019.1. AK297625 mRNA. Translation: BAH12633.1. CH471091 Genomic DNA. Translation: EAW76605.1. CH471091 Genomic DNA. Translation: EAW76606.1. CH471091 Genomic DNA. Translation: EAW76608.1. BC011887 mRNA. Translation: AAH11887.2. BC013603 mRNA. Translation: AAH13603.2. X60153 mRNA. Translation: CAB94195.1. X52356 mRNA. Translation: CAA36582.1. X07290 mRNA. Translation: CAA30269.1.
IPI	IPI00642617. IPI01010414.
PIR	S00754.
RefSeq	NP_060185.2. NM_017715.2. NP_116313.3. NM_032924.3.
UniGene	Hs.435302.
3D structure databases
ProteinModelPortal	P17036.
ModBase	Search...
Protein-protein interaction databases
IntAct	P17036. 4 interactions.
STRING	9606.ENSP00000299667.
PTM databases
PhosphoSite	P17036.
Polymorphism databases
DMDM	46577682.
Proteomic databases
PaxDb	P17036.
PRIDE	P17036.
Protocols and materials databases
DNASU	7551.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299667; ENSP00000299667; ENSG00000166526. ENST00000303915; ENSP00000306372; ENSG00000166526. ENST00000413658; ENSP00000399951; ENSG00000166526. ENST00000424697; ENSP00000415358; ENSG00000166526.
GeneID	7551.
KEGG	hsa:7551.
UCSC	uc003usp.3. human. uc003usq.3. human.
Organism-specific databases
CTD	7551.
GeneCards	GC07M099661.
HGNC	HGNC:13089. ZNF3.
HPA	HPA003719.
MIM	194510. gene. 601261. gene.
neXtProt	NX_P17036.
PharmGKB	PA37664.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG018163.
InParanoid	P17036.
KO	K09228.
OMA	QGLKFEE.
OrthoDB	EOG476K27.
PhylomeDB	P17036.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P17036.
Bgee	P17036.
CleanEx	HS_ZNF3.
Genevestigator	P17036.
GermOnline	ENSG00000166526. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 9 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 8 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 8 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF3. human.
GenomeRNAi	7551.
NextBio	29541.
SOURCE	Search...

Entry information

Entry name

ZNF3_HUMAN

Accession

Primary (citable) accession number: P17036
Secondary accession number(s): D6W5U0 , P13683, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	April 26, 2004
Last modified:	May 1, 2013
This is version 145 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.