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P17035

- ZNF28_HUMAN

UniProt

P17035 - ZNF28_HUMAN

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Protein

Zinc finger protein 28

Gene

ZNF28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri607 – 62923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri635 – 65723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri663 – 68523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri691 – 71323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 28
Alternative name(s):
Zinc finger protein KOX24
Gene namesi
Name:ZNF28
Synonyms:KOX24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13073. ZNF28.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Zinc finger protein 28PRO_0000047357Add
BLAST

Proteomic databases

PaxDbiP17035.
PRIDEiP17035.

PTM databases

PhosphoSiteiP17035.

Expressioni

Gene expression databases

BgeeiP17035.
CleanExiHS_ZNF28.
ExpressionAtlasiP17035. baseline and differential.
GenevestigatoriP17035.

Interactioni

Protein-protein interaction databases

BioGridi113406. 2 interactions.
STRINGi9606.ENSP00000397693.

Structurei

3D structure databases

ProteinModelPortaliP17035.
SMRiP17035. Positions 166-718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8174KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri607 – 62923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri635 – 65723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri663 – 68523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri691 – 71323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00690000102079.
HOVERGENiHBG018163.
InParanoidiP17035.
OMAiMERHRRI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17035.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P17035-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMKTFFS TGQGNTEAFH TGTLQRQASH HIGDFCFQKI EKDIHGFQFQ
110 120 130 140 150
WKEDETNDHA APMTEIKELT GSTGQHDQRH AGNKHIKDQL GLSFHSHLPE
160 170 180 190 200
LHIFQPEGKI GNQVEKSINN ASSVSTSQRI CCRPKTHISN KYGNNSLHSS
210 220 230 240 250
LLTQKRNVHM REKSFQCIES GKSFNCSSLL KKHQITHLEE KQCKCDVYGK
260 270 280 290 300
VFNQKRYLAC HRRSHIDEKP YKCNECGKIF GHNTSLFLHK ALHTADKPYE
310 320 330 340 350
CEECDKVFSR KSHLETHKII YTGGKPYKCK VCDKAFTCNS YLAKHTIIHT
360 370 380 390 400
GEKPYKCNEC GKVFNRLSTL ARHRRLHTGE KPYECEECEK VFSRKSHLER
410 420 430 440 450
HKRIHTGEKP YKCKVCDKAF AYNSYLAKHS IIHTGEKPYK CNECGKVFNQ
460 470 480 490 500
QSTLARHHRL HTAEKPYKCE ECDKVFRCKS HLERHRRIHT GEKPYKCKVC
510 520 530 540 550
DKAFRSDSCL TEHQRVHTGE KPYMCNECGK VFSTKANLAC HHKLHTAEKP
560 570 580 590 600
YKCEECEKVF SRKSHMERHR RIHTGEKPYK CKVCDKAFRR DSHLAQHQRV
610 620 630 640 650
HTGEKPYKCN ECGKTFRQTS SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL
660 670 680 690 700
VYHHRLHSGE KPYKCNECGK VFNQQAHLAQ HQRVHTGEKP YKCNECGKTF
710
SQMSNLVYHH RLHSGEKP
Length:718
Mass (Da):83,658
Last modified:November 30, 2010 - v5
Checksum:iCF602657CFEC8633
GO
Isoform 2 (identifier: P17035-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:665
Mass (Da):77,468
Checksum:i894C11EFBB370BB5
GO

Sequence cautioni

The sequence BAD18706.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651N → D in BAD18519. (PubMed:14702039)Curated
Sequence conflicti113 – 1131M → T in BAF85763. (PubMed:14702039)Curated
Sequence conflicti273 – 2731C → G in CAI46258. (PubMed:17974005)Curated
Sequence conflicti325 – 3251K → E in CAI45923. (PubMed:17974005)Curated
Sequence conflicti403 – 4031R → T in BAD18706. (PubMed:14702039)Curated
Sequence conflicti403 – 4031R → T in CAI46258. (PubMed:17974005)Curated
Sequence conflicti412 – 4121K → E in BAG65472. (PubMed:14702039)Curated
Sequence conflicti418 – 4181K → R in CAI46258. (PubMed:17974005)Curated
Sequence conflicti498 – 4981K → T in CAI45923. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791R → G.
Corresponds to variant rs13382164 [ dbSNP | Ensembl ].
VAR_036841
Natural varianti465 – 4651K → Q.2 Publications
Corresponds to variant rs10417163 [ dbSNP | Ensembl ].
VAR_036842
Natural varianti524 – 5241M → T.2 Publications
Corresponds to variant rs8107444 [ dbSNP | Ensembl ].
VAR_036843

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353Missing in isoform 2. 2 PublicationsVSP_029007Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131368 mRNA. Translation: BAD18519.1.
AK131574 mRNA. Translation: BAD18706.1. Different initiation.
AK293074 mRNA. Translation: BAF85763.1.
AK304704 mRNA. Translation: BAG65472.1.
CR933598 mRNA. Translation: CAI45923.1.
BX640767 mRNA. Translation: CAI46258.1.
AC008813 Genomic DNA. No translation available.
BC140720 mRNA. Translation: AAI40721.1.
X52355 mRNA. Translation: CAA36581.1.
CCDSiCCDS33093.2. [P17035-1]
PIRiI37964.
RefSeqiNP_008900.3. NM_006969.3. [P17035-1]
UniGeneiHs.732407.

Genome annotation databases

EnsembliENST00000438150; ENSP00000412143; ENSG00000198538. [P17035-2]
ENST00000457749; ENSP00000397693; ENSG00000198538. [P17035-1]
GeneIDi7576.
KEGGihsa:7576.
UCSCiuc002qac.3. human. [P17035-1]

Polymorphism databases

DMDMi313104321.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131368 mRNA. Translation: BAD18519.1 .
AK131574 mRNA. Translation: BAD18706.1 . Different initiation.
AK293074 mRNA. Translation: BAF85763.1 .
AK304704 mRNA. Translation: BAG65472.1 .
CR933598 mRNA. Translation: CAI45923.1 .
BX640767 mRNA. Translation: CAI46258.1 .
AC008813 Genomic DNA. No translation available.
BC140720 mRNA. Translation: AAI40721.1 .
X52355 mRNA. Translation: CAA36581.1 .
CCDSi CCDS33093.2. [P17035-1 ]
PIRi I37964.
RefSeqi NP_008900.3. NM_006969.3. [P17035-1 ]
UniGenei Hs.732407.

3D structure databases

ProteinModelPortali P17035.
SMRi P17035. Positions 166-718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113406. 2 interactions.
STRINGi 9606.ENSP00000397693.

PTM databases

PhosphoSitei P17035.

Polymorphism databases

DMDMi 313104321.

Proteomic databases

PaxDbi P17035.
PRIDEi P17035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000438150 ; ENSP00000412143 ; ENSG00000198538 . [P17035-2 ]
ENST00000457749 ; ENSP00000397693 ; ENSG00000198538 . [P17035-1 ]
GeneIDi 7576.
KEGGi hsa:7576.
UCSCi uc002qac.3. human. [P17035-1 ]

Organism-specific databases

CTDi 7576.
GeneCardsi GC19M053300.
HGNCi HGNC:13073. ZNF28.
neXtProti NX_P17035.
PharmGKBi PA37649.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00690000102079.
HOVERGENi HBG018163.
InParanoidi P17035.
OMAi MERHRRI.
OrthoDBi EOG7KSX7Q.
PhylomeDBi P17035.
TreeFami TF341892.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF28. human.
GenomeRNAii 7576.
NextBioi 29625.
PROi P17035.

Gene expression databases

Bgeei P17035.
CleanExi HS_ZNF28.
ExpressionAtlasi P17035. baseline and differential.
Genevestigatori P17035.

Family and domain databases

Gene3Di 3.30.160.60. 18 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLN-465 AND THR-524.
    Tissue: Cerebellum and Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-465 AND THR-524.
    Tissue: Rectum tumor and Seminoma.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-270 (ISOFORMS 1/2).
    Tissue: Lymphoid tissue.

Entry informationi

Entry nameiZNF28_HUMAN
AccessioniPrimary (citable) accession number: P17035
Secondary accession number(s): A8KAK9
, B4E3G0, B9EIK7, Q5H9V1, Q5HYM9, Q6ZML9, Q6ZN56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 133 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3