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P17035 (ZNF28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 28
Alternative name(s):
Zinc finger protein KOX24
Gene names
Name:ZNF28
Synonyms:KOX24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length718 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 18 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAD18706.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17035-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17035-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 718718Zinc finger protein 28
PRO_0000047357

Regions

Domain8 – 8174KRAB
Zinc finger215 – 23723C2H2-type 1; degenerate
Zinc finger243 – 26523C2H2-type 2; degenerate
Zinc finger271 – 29323C2H2-type 3
Zinc finger299 – 32123C2H2-type 4; degenerate
Zinc finger327 – 34923C2H2-type 5
Zinc finger355 – 37723C2H2-type 6
Zinc finger383 – 40523C2H2-type 7
Zinc finger411 – 43323C2H2-type 8
Zinc finger439 – 46123C2H2-type 9
Zinc finger467 – 48923C2H2-type 10
Zinc finger495 – 51723C2H2-type 11
Zinc finger523 – 54523C2H2-type 12
Zinc finger551 – 57323C2H2-type 13
Zinc finger579 – 60123C2H2-type 14
Zinc finger607 – 62923C2H2-type 15
Zinc finger635 – 65723C2H2-type 16
Zinc finger663 – 68523C2H2-type 17
Zinc finger691 – 71323C2H2-type 18

Natural variations

Alternative sequence1 – 5353Missing in isoform 2.
VSP_029007
Natural variant1791R → G.
Corresponds to variant rs13382164 [ dbSNP | Ensembl ].
VAR_036841
Natural variant4651K → Q. Ref.1 Ref.2
Corresponds to variant rs10417163 [ dbSNP | Ensembl ].
VAR_036842
Natural variant5241M → T. Ref.1 Ref.2
Corresponds to variant rs8107444 [ dbSNP | Ensembl ].
VAR_036843

Experimental info

Sequence conflict651N → D in BAD18519. Ref.1
Sequence conflict1131M → T in BAF85763. Ref.1
Sequence conflict2731C → G in CAI46258. Ref.2
Sequence conflict3251K → E in CAI45923. Ref.2
Sequence conflict4031R → T in BAD18706. Ref.1
Sequence conflict4031R → T in CAI46258. Ref.2
Sequence conflict4121K → E in BAG65472. Ref.1
Sequence conflict4181K → R in CAI46258. Ref.2
Sequence conflict4981K → T in CAI45923. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 5.
Checksum: CF602657CFEC8633

FASTA71883,658
        10         20         30         40         50         60 
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKTFFS 

        70         80         90        100        110        120 
TGQGNTEAFH TGTLQRQASH HIGDFCFQKI EKDIHGFQFQ WKEDETNDHA APMTEIKELT 

       130        140        150        160        170        180 
GSTGQHDQRH AGNKHIKDQL GLSFHSHLPE LHIFQPEGKI GNQVEKSINN ASSVSTSQRI 

       190        200        210        220        230        240 
CCRPKTHISN KYGNNSLHSS LLTQKRNVHM REKSFQCIES GKSFNCSSLL KKHQITHLEE 

       250        260        270        280        290        300 
KQCKCDVYGK VFNQKRYLAC HRRSHIDEKP YKCNECGKIF GHNTSLFLHK ALHTADKPYE 

       310        320        330        340        350        360 
CEECDKVFSR KSHLETHKII YTGGKPYKCK VCDKAFTCNS YLAKHTIIHT GEKPYKCNEC 

       370        380        390        400        410        420 
GKVFNRLSTL ARHRRLHTGE KPYECEECEK VFSRKSHLER HKRIHTGEKP YKCKVCDKAF 

       430        440        450        460        470        480 
AYNSYLAKHS IIHTGEKPYK CNECGKVFNQ QSTLARHHRL HTAEKPYKCE ECDKVFRCKS 

       490        500        510        520        530        540 
HLERHRRIHT GEKPYKCKVC DKAFRSDSCL TEHQRVHTGE KPYMCNECGK VFSTKANLAC 

       550        560        570        580        590        600 
HHKLHTAEKP YKCEECEKVF SRKSHMERHR RIHTGEKPYK CKVCDKAFRR DSHLAQHQRV 

       610        620        630        640        650        660 
HTGEKPYKCN ECGKTFRQTS SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL VYHHRLHSGE 

       670        680        690        700        710 
KPYKCNECGK VFNQQAHLAQ HQRVHTGEKP YKCNECGKTF SQMSNLVYHH RLHSGEKP 

« Hide

Isoform 2 [UniParc].

Checksum: 894C11EFBB370BB5
Show »

FASTA66577,468

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLN-465 AND THR-524.
Tissue: Cerebellum and Uterus.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-465 AND THR-524.
Tissue: Rectum tumor and Seminoma.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-270 (ISOFORMS 1/2).
Tissue: Lymphoid tissue.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK131368 mRNA. Translation: BAD18519.1.
AK131574 mRNA. Translation: BAD18706.1. Different initiation.
AK293074 mRNA. Translation: BAF85763.1.
AK304704 mRNA. Translation: BAG65472.1.
CR933598 mRNA. Translation: CAI45923.1.
BX640767 mRNA. Translation: CAI46258.1.
AC008813 Genomic DNA. No translation available.
BC140720 mRNA. Translation: AAI40721.1.
X52355 mRNA. Translation: CAA36581.1.
PIRI37964.
RefSeqNP_008900.3. NM_006969.3.
UniGeneHs.732407.

3D structure databases

ProteinModelPortalP17035.
SMRP17035. Positions 2-51, 170-718.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113406. 2 interactions.
STRING9606.ENSP00000397693.

PTM databases

PhosphoSiteP17035.

Polymorphism databases

DMDM313104321.

Proteomic databases

PaxDbP17035.
PRIDEP17035.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360272; ENSP00000353410; ENSG00000198538. [P17035-2]
ENST00000414252; ENSP00000444965; ENSG00000198538. [P17035-2]
ENST00000438150; ENSP00000412143; ENSG00000198538. [P17035-2]
ENST00000457749; ENSP00000397693; ENSG00000198538. [P17035-1]
GeneID7576.
KEGGhsa:7576.
UCSCuc002qac.3. human. [P17035-1]

Organism-specific databases

CTD7576.
GeneCardsGC19M053300.
HGNCHGNC:13073. ZNF28.
neXtProtNX_P17035.
PharmGKBPA37649.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
InParanoidP17035.
OMAMERHRRI.
OrthoDBEOG7KSX7Q.
PhylomeDBP17035.
TreeFamTF341892.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeP17035.
CleanExHS_ZNF28.
GenevestigatorP17035.

Family and domain databases

Gene3D3.30.160.60. 18 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7576.
NextBio29625.
PROP17035.

Entry information

Entry nameZNF28_HUMAN
AccessionPrimary (citable) accession number: P17035
Secondary accession number(s): A8KAK9 expand/collapse secondary AC list , B4E3G0, B9EIK7, Q5H9V1, Q5HYM9, Q6ZML9, Q6ZN56
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 126 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM