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Protein

Zinc finger protein 28

Gene

ZNF28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142396-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 28
Alternative name(s):
Zinc finger protein KOX24
Gene namesi
Name:ZNF28
Synonyms:KOX24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13073. ZNF28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198538.
PharmGKBiPA37649.

Polymorphism and mutation databases

BioMutaiZNF28.
DMDMi313104321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473571 – 718Zinc finger protein 28Add BLAST718

Proteomic databases

EPDiP17035.
MaxQBiP17035.
PaxDbiP17035.
PeptideAtlasiP17035.
PRIDEiP17035.

PTM databases

iPTMnetiP17035.
PhosphoSitePlusiP17035.

Expressioni

Gene expression databases

BgeeiENSG00000198538.
CleanExiHS_ZNF28.
ExpressionAtlasiP17035. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi113406. 2 interactors.
STRINGi9606.ENSP00000397693.

Structurei

3D structure databases

ProteinModelPortaliP17035.
SMRiP17035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 81KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOVERGENiHBG018163.
InParanoidiP17035.
OMAiRKSHMER.
OrthoDBiEOG091G02KC.
PhylomeDBiP17035.
TreeFamiTF341892.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17035-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMKTFFS TGQGNTEAFH TGTLQRQASH HIGDFCFQKI EKDIHGFQFQ
110 120 130 140 150
WKEDETNDHA APMTEIKELT GSTGQHDQRH AGNKHIKDQL GLSFHSHLPE
160 170 180 190 200
LHIFQPEGKI GNQVEKSINN ASSVSTSQRI CCRPKTHISN KYGNNSLHSS
210 220 230 240 250
LLTQKRNVHM REKSFQCIES GKSFNCSSLL KKHQITHLEE KQCKCDVYGK
260 270 280 290 300
VFNQKRYLAC HRRSHIDEKP YKCNECGKIF GHNTSLFLHK ALHTADKPYE
310 320 330 340 350
CEECDKVFSR KSHLETHKII YTGGKPYKCK VCDKAFTCNS YLAKHTIIHT
360 370 380 390 400
GEKPYKCNEC GKVFNRLSTL ARHRRLHTGE KPYECEECEK VFSRKSHLER
410 420 430 440 450
HKRIHTGEKP YKCKVCDKAF AYNSYLAKHS IIHTGEKPYK CNECGKVFNQ
460 470 480 490 500
QSTLARHHRL HTAEKPYKCE ECDKVFRCKS HLERHRRIHT GEKPYKCKVC
510 520 530 540 550
DKAFRSDSCL TEHQRVHTGE KPYMCNECGK VFSTKANLAC HHKLHTAEKP
560 570 580 590 600
YKCEECEKVF SRKSHMERHR RIHTGEKPYK CKVCDKAFRR DSHLAQHQRV
610 620 630 640 650
HTGEKPYKCN ECGKTFRQTS SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL
660 670 680 690 700
VYHHRLHSGE KPYKCNECGK VFNQQAHLAQ HQRVHTGEKP YKCNECGKTF
710
SQMSNLVYHH RLHSGEKP
Length:718
Mass (Da):83,658
Last modified:November 30, 2010 - v5
Checksum:iCF602657CFEC8633
GO
Isoform 2 (identifier: P17035-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:665
Mass (Da):77,468
Checksum:i894C11EFBB370BB5
GO

Sequence cautioni

The sequence BAD18706 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65N → D in BAD18519 (PubMed:14702039).Curated1
Sequence conflicti113M → T in BAF85763 (PubMed:14702039).Curated1
Sequence conflicti273C → G in CAI46258 (PubMed:17974005).Curated1
Sequence conflicti325K → E in CAI45923 (PubMed:17974005).Curated1
Sequence conflicti403R → T in BAD18706 (PubMed:14702039).Curated1
Sequence conflicti403R → T in CAI46258 (PubMed:17974005).Curated1
Sequence conflicti412K → E in BAG65472 (PubMed:14702039).Curated1
Sequence conflicti418K → R in CAI46258 (PubMed:17974005).Curated1
Sequence conflicti498K → T in CAI45923 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036841179R → G.Corresponds to variant rs13382164dbSNPEnsembl.1
Natural variantiVAR_036842465K → Q.2 PublicationsCorresponds to variant rs10417163dbSNPEnsembl.1
Natural variantiVAR_036843524M → T.2 PublicationsCorresponds to variant rs8107444dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0290071 – 53Missing in isoform 2. 2 PublicationsAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131368 mRNA. Translation: BAD18519.1.
AK131574 mRNA. Translation: BAD18706.1. Different initiation.
AK293074 mRNA. Translation: BAF85763.1.
AK304704 mRNA. Translation: BAG65472.1.
CR933598 mRNA. Translation: CAI45923.1.
BX640767 mRNA. Translation: CAI46258.1.
AC008813 Genomic DNA. No translation available.
BC140720 mRNA. Translation: AAI40721.1.
X52355 mRNA. Translation: CAA36581.1.
CCDSiCCDS33093.2. [P17035-1]
PIRiI37964.
RefSeqiNP_008900.3. NM_006969.3. [P17035-1]
XP_011525564.1. XM_011527262.2. [P17035-1]
UniGeneiHs.732407.

Genome annotation databases

EnsembliENST00000438150; ENSP00000412143; ENSG00000198538. [P17035-2]
ENST00000457749; ENSP00000397693; ENSG00000198538. [P17035-1]
GeneIDi7576.
KEGGihsa:7576.
UCSCiuc002qad.4. human. [P17035-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131368 mRNA. Translation: BAD18519.1.
AK131574 mRNA. Translation: BAD18706.1. Different initiation.
AK293074 mRNA. Translation: BAF85763.1.
AK304704 mRNA. Translation: BAG65472.1.
CR933598 mRNA. Translation: CAI45923.1.
BX640767 mRNA. Translation: CAI46258.1.
AC008813 Genomic DNA. No translation available.
BC140720 mRNA. Translation: AAI40721.1.
X52355 mRNA. Translation: CAA36581.1.
CCDSiCCDS33093.2. [P17035-1]
PIRiI37964.
RefSeqiNP_008900.3. NM_006969.3. [P17035-1]
XP_011525564.1. XM_011527262.2. [P17035-1]
UniGeneiHs.732407.

3D structure databases

ProteinModelPortaliP17035.
SMRiP17035.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113406. 2 interactors.
STRINGi9606.ENSP00000397693.

PTM databases

iPTMnetiP17035.
PhosphoSitePlusiP17035.

Polymorphism and mutation databases

BioMutaiZNF28.
DMDMi313104321.

Proteomic databases

EPDiP17035.
MaxQBiP17035.
PaxDbiP17035.
PeptideAtlasiP17035.
PRIDEiP17035.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438150; ENSP00000412143; ENSG00000198538. [P17035-2]
ENST00000457749; ENSP00000397693; ENSG00000198538. [P17035-1]
GeneIDi7576.
KEGGihsa:7576.
UCSCiuc002qad.4. human. [P17035-1]

Organism-specific databases

CTDi7576.
GeneCardsiZNF28.
HGNCiHGNC:13073. ZNF28.
neXtProtiNX_P17035.
OpenTargetsiENSG00000198538.
PharmGKBiPA37649.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOVERGENiHBG018163.
InParanoidiP17035.
OMAiRKSHMER.
OrthoDBiEOG091G02KC.
PhylomeDBiP17035.
TreeFamiTF341892.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142396-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF28. human.
GenomeRNAii7576.
PROiP17035.

Gene expression databases

BgeeiENSG00000198538.
CleanExiHS_ZNF28.
ExpressionAtlasiP17035. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF28_HUMAN
AccessioniPrimary (citable) accession number: P17035
Secondary accession number(s): A8KAK9
, B4E3G0, B9EIK7, Q5H9V1, Q5HYM9, Q6ZML9, Q6ZN56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 151 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.