P17035 (ZNF28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 28

Alternative name(s):
Zinc finger protein KOX24

Gene names

Name:	ZNF28
Synonyms:	KOX24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	718 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 18 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence BAD18706.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P17035-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P17035-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 718	718	Zinc finger protein 28		PRO_0000047357
Regions
	Domain	8 – 81	74	KRAB
	Zinc finger	215 – 237	23	C2H2-type 1; degenerate
	Zinc finger	243 – 265	23	C2H2-type 2; degenerate
	Zinc finger	271 – 293	23	C2H2-type 3
	Zinc finger	299 – 321	23	C2H2-type 4; degenerate
	Zinc finger	327 – 349	23	C2H2-type 5
	Zinc finger	355 – 377	23	C2H2-type 6
	Zinc finger	383 – 405	23	C2H2-type 7
	Zinc finger	411 – 433	23	C2H2-type 8
	Zinc finger	439 – 461	23	C2H2-type 9
	Zinc finger	467 – 489	23	C2H2-type 10
	Zinc finger	495 – 517	23	C2H2-type 11
	Zinc finger	523 – 545	23	C2H2-type 12
	Zinc finger	551 – 573	23	C2H2-type 13
	Zinc finger	579 – 601	23	C2H2-type 14
	Zinc finger	607 – 629	23	C2H2-type 15
	Zinc finger	635 – 657	23	C2H2-type 16
	Zinc finger	663 – 685	23	C2H2-type 17
	Zinc finger	691 – 713	23	C2H2-type 18
Natural variations
	Alternative sequence	1 – 53	53	Missing in isoform 2.		VSP_029007
	Natural variant	179	1	R → G. Corresponds to variant rs13382164 [ dbSNP | Ensembl ].		VAR_036841
	Natural variant	465	1	K → Q. Ref.1 Ref.2 Corresponds to variant rs10417163 [ dbSNP | Ensembl ].		VAR_036842
	Natural variant	524	1	M → T. Ref.1 Ref.2 Corresponds to variant rs8107444 [ dbSNP | Ensembl ].		VAR_036843
Experimental info
	Sequence conflict	65	1	N → D in BAD18519. Ref.1
	Sequence conflict	113	1	M → T in BAF85763. Ref.1
	Sequence conflict	273	1	C → G in CAI46258. Ref.2
	Sequence conflict	325	1	K → E in CAI45923. Ref.2
	Sequence conflict	403	1	R → T in BAD18706. Ref.1
	Sequence conflict	403	1	R → T in CAI46258. Ref.2
	Sequence conflict	412	1	K → E in BAG65472. Ref.1
	Sequence conflict	418	1	K → R in CAI46258. Ref.2
	Sequence conflict	498	1	K → T in CAI45923. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 5. Checksum: CF602657CFEC8633	FASTA	718	83,658
	10 20 30 40 50 60 MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKTFFS 70 80 90 100 110 120 TGQGNTEAFH TGTLQRQASH HIGDFCFQKI EKDIHGFQFQ WKEDETNDHA APMTEIKELT 130 140 150 160 170 180 GSTGQHDQRH AGNKHIKDQL GLSFHSHLPE LHIFQPEGKI GNQVEKSINN ASSVSTSQRI 190 200 210 220 230 240 CCRPKTHISN KYGNNSLHSS LLTQKRNVHM REKSFQCIES GKSFNCSSLL KKHQITHLEE 250 260 270 280 290 300 KQCKCDVYGK VFNQKRYLAC HRRSHIDEKP YKCNECGKIF GHNTSLFLHK ALHTADKPYE 310 320 330 340 350 360 CEECDKVFSR KSHLETHKII YTGGKPYKCK VCDKAFTCNS YLAKHTIIHT GEKPYKCNEC 370 380 390 400 410 420 GKVFNRLSTL ARHRRLHTGE KPYECEECEK VFSRKSHLER HKRIHTGEKP YKCKVCDKAF 430 440 450 460 470 480 AYNSYLAKHS IIHTGEKPYK CNECGKVFNQ QSTLARHHRL HTAEKPYKCE ECDKVFRCKS 490 500 510 520 530 540 HLERHRRIHT GEKPYKCKVC DKAFRSDSCL TEHQRVHTGE KPYMCNECGK VFSTKANLAC 550 560 570 580 590 600 HHKLHTAEKP YKCEECEKVF SRKSHMERHR RIHTGEKPYK CKVCDKAFRR DSHLAQHQRV 610 620 630 640 650 660 HTGEKPYKCN ECGKTFRQTS SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL VYHHRLHSGE 670 680 690 700 710 KPYKCNECGK VFNQQAHLAQ HQRVHTGEKP YKCNECGKTF SQMSNLVYHH RLHSGEKP
	Isoform 2 [UniParc]. Checksum: 894C11EFBB370BB5	FASTA	665	77,468
	10 20 30 40 50 60 MMKTFFSTGQ GNTEAFHTGT LQRQASHHIG DFCFQKIEKD IHGFQFQWKE DETNDHAAPM 70 80 90 100 110 120 TEIKELTGST GQHDQRHAGN KHIKDQLGLS FHSHLPELHI FQPEGKIGNQ VEKSINNASS 130 140 150 160 170 180 VSTSQRICCR PKTHISNKYG NNSLHSSLLT QKRNVHMREK SFQCIESGKS FNCSSLLKKH 190 200 210 220 230 240 QITHLEEKQC KCDVYGKVFN QKRYLACHRR SHIDEKPYKC NECGKIFGHN TSLFLHKALH 250 260 270 280 290 300 TADKPYECEE CDKVFSRKSH LETHKIIYTG GKPYKCKVCD KAFTCNSYLA KHTIIHTGEK 310 320 330 340 350 360 PYKCNECGKV FNRLSTLARH RRLHTGEKPY ECEECEKVFS RKSHLERHKR IHTGEKPYKC 370 380 390 400 410 420 KVCDKAFAYN SYLAKHSIIH TGEKPYKCNE CGKVFNQQST LARHHRLHTA EKPYKCEECD 430 440 450 460 470 480 KVFRCKSHLE RHRRIHTGEK PYKCKVCDKA FRSDSCLTEH QRVHTGEKPY MCNECGKVFS 490 500 510 520 530 540 TKANLACHHK LHTAEKPYKC EECEKVFSRK SHMERHRRIH TGEKPYKCKV CDKAFRRDSH 550 560 570 580 590 600 LAQHQRVHTG EKPYKCNECG KTFRQTSSLI IHRRLHTGEK PYKCNECGKT FSQMSSLVYH 610 620 630 640 650 660 HRLHSGEKPY KCNECGKVFN QQAHLAQHQR VHTGEKPYKC NECGKTFSQM SNLVYHHRLH SGEKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLN-465 AND THR-524. Tissue: Cerebellum and Uterus.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-465 AND THR-524. Tissue: Rectum tumor and Seminoma.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[5]	"Multiple genes encoding zinc finger domains are expressed in human T cells." Thiesen H.-J. New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-270 (ISOFORMS 1/2). Tissue: Lymphoid tissue.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK131368 mRNA. Translation: BAD18519.1. AK131574 mRNA. Translation: BAD18706.1. Different initiation. AK293074 mRNA. Translation: BAF85763.1. AK304704 mRNA. Translation: BAG65472.1. CR933598 mRNA. Translation: CAI45923.1. BX640767 mRNA. Translation: CAI46258.1. AC008813 Genomic DNA. No translation available. BC140720 mRNA. Translation: AAI40721.1. X52355 mRNA. Translation: CAA36581.1.
IPI	IPI00640476. IPI01014655.
PIR	I37964.
RefSeq	NP_008900.3. NM_006969.3.
UniGene	Hs.732407.
3D structure databases
ProteinModelPortal	P17035.
SMR	P17035. Positions 8-47, 166-718.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000397693.
PTM databases
PhosphoSite	P17035.
Polymorphism databases
DMDM	229485312.
Proteomic databases
PaxDb	P17035.
PRIDE	P17035.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360272; ENSP00000353410; ENSG00000198538. ENST00000414252; ENSP00000444965; ENSG00000198538. ENST00000438150; ENSP00000412143; ENSG00000198538. ENST00000457749; ENSP00000397693; ENSG00000198538.
GeneID	7576.
KEGG	hsa:7576.
UCSC	uc002qac.3. human.
Organism-specific databases
CTD	7576.
GeneCards	GC19M053300.
HGNC	HGNC:13073. ZNF28.
neXtProt	NX_P17035.
PharmGKB	PA37649.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG018163.
InParanoid	P17035.
OMA	MERHRRI.
OrthoDB	EOG46Q6S0.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P17035.
Bgee	P17035.
CleanEx	HS_ZNF28.
Genevestigator	P17035.
Family and domain databases
Gene3D	3.30.160.60. 18 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 18 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 15 hits. PS50157. ZINC_FINGER_C2H2_2. 18 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7576.
NextBio	29625.

Entry information

Entry name

ZNF28_HUMAN

Accession

Primary (citable) accession number: P17035
Secondary accession number(s): A8KAK9 , B4E3G0, B9EIK7, Q5H9V1, Q5HYM9, Q6ZML9, Q6ZN56

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 118 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.