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Protein

Zinc finger protein 37A

Gene

ZNF37A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 16823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 37A
Alternative name(s):
Zinc finger protein KOX21
Gene namesi
Name:ZNF37A
Synonyms:KOX21, ZNF37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13102. ZNF37A.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37677.

Polymorphism and mutation databases

BioMutaiZNF37A.
DMDMi85681861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Zinc finger protein 37APRO_0000047367Add
BLAST

Proteomic databases

MaxQBiP17032.
PaxDbiP17032.
PRIDEiP17032.

PTM databases

iPTMnetiP17032.
PhosphoSiteiP17032.

Expressioni

Inductioni

Down-regulated in cells with DM1 (Myotonic dystrophy type 1) mutation, via a mechanism that involves abnormal control of its mRNA stability by CUGBP1.1 Publication

Gene expression databases

BgeeiP17032.
CleanExiHS_ZNF37A.
GenevisibleiP17032. HS.

Organism-specific databases

HPAiHPA003172.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329141.

Structurei

3D structure databases

ProteinModelPortaliP17032.
SMRiP17032. Positions 3-49, 116-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 16823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17032.
KOiK09228.
OMAiIEYNECG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17032.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITSQGSVSF RDVTVGFTQE EWQHLDPAQR TLYRDVMLEN YSHLVSVGYC
60 70 80 90 100
IPKPEVILKL EKGEEPWILE EKFPSQSHLE LINTSRNYSI MKFNEFNKGG
110 120 130 140 150
KCFCDEKHEI IHSEEEPSEY NKNGNSFWLN EDLIWHQKIK NWEQSFEYNE
160 170 180 190 200
CGKAFPENSL FLVHKRGYTG QKTCKYTEHG KTCDMSFFIT HQQTHPRENH
210 220 230 240 250
YGNECGENIF EESILLEHQS VYPFSQKLNL TPIQRTHSIN NIIEYNECGT
260 270 280 290 300
FFSEKLVLHL QQRTHTGEKP YECHECGKTF TQKSAHTRHQ RTHTGGKPYE
310 320 330 340 350
CHECGKTFYK NSDLIKHQRI HTGERPYGCH ECGKSFSEKS TLTQHQRTHT
360 370 380 390 400
GEKPYECHEC GKTFSFKSVL TVHQKTHTGE KPYECYACGK AFLRKSDLIK
410 420 430 440 450
HQRIHTGEKP YECNECGKSF SEKSTLTKHL RTHTGEKPYE CIQCGKFFCY
460 470 480 490 500
YSGFTEHLRR HTGEKPFGCN ECGKTFRQKS ALIVHQRTHI RQKPYGCNQC
510 520 530 540 550
GKSFCVKSKL IAHHRTHTGE KPYECNVCGK SFYVKSKLTV HQRIHLGRNP
560
INVVNEGNYS G
Length:561
Mass (Da):65,418
Last modified:January 10, 2006 - v3
Checksum:i068789DC7DA04BC3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051D → N.
Corresponds to variant rs2021319 [ dbSNP | Ensembl ].
VAR_052753

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492195 mRNA. Translation: CAD37331.1.
AK092012 mRNA. Translation: BAG52465.1.
AL117339 Genomic DNA. Translation: CAI14947.1.
CH471072 Genomic DNA. Translation: EAW85885.1.
CH471072 Genomic DNA. Translation: EAW85886.1.
BC015858 mRNA. Translation: AAH15858.1.
X69115 mRNA. Translation: CAA48868.1.
X52352 mRNA. Translation: CAA36578.1.
CCDSiCCDS31183.1.
PIRiS30238.
RefSeqiNP_001007095.1. NM_001007094.2.
NP_001171572.1. NM_001178101.1.
NP_003412.1. NM_003421.2.
XP_005252638.1. XM_005252581.2.
XP_005252639.1. XM_005252582.2.
XP_005252640.1. XM_005252583.2.
XP_006717564.1. XM_006717501.2.
XP_011517957.1. XM_011519655.1.
XP_011517958.1. XM_011519656.1.
XP_011517959.1. XM_011519657.1.
XP_011517960.1. XM_011519658.1.
UniGeneiHs.292575.

Genome annotation databases

EnsembliENST00000351773; ENSP00000329141; ENSG00000075407.
ENST00000361085; ENSP00000354377; ENSG00000075407.
GeneIDi7587.
KEGGihsa:7587.
UCSCiuc001izk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492195 mRNA. Translation: CAD37331.1.
AK092012 mRNA. Translation: BAG52465.1.
AL117339 Genomic DNA. Translation: CAI14947.1.
CH471072 Genomic DNA. Translation: EAW85885.1.
CH471072 Genomic DNA. Translation: EAW85886.1.
BC015858 mRNA. Translation: AAH15858.1.
X69115 mRNA. Translation: CAA48868.1.
X52352 mRNA. Translation: CAA36578.1.
CCDSiCCDS31183.1.
PIRiS30238.
RefSeqiNP_001007095.1. NM_001007094.2.
NP_001171572.1. NM_001178101.1.
NP_003412.1. NM_003421.2.
XP_005252638.1. XM_005252581.2.
XP_005252639.1. XM_005252582.2.
XP_005252640.1. XM_005252583.2.
XP_006717564.1. XM_006717501.2.
XP_011517957.1. XM_011519655.1.
XP_011517958.1. XM_011519656.1.
XP_011517959.1. XM_011519657.1.
XP_011517960.1. XM_011519658.1.
UniGeneiHs.292575.

3D structure databases

ProteinModelPortaliP17032.
SMRiP17032. Positions 3-49, 116-553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329141.

PTM databases

iPTMnetiP17032.
PhosphoSiteiP17032.

Polymorphism and mutation databases

BioMutaiZNF37A.
DMDMi85681861.

Proteomic databases

MaxQBiP17032.
PaxDbiP17032.
PRIDEiP17032.

Protocols and materials databases

DNASUi7587.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351773; ENSP00000329141; ENSG00000075407.
ENST00000361085; ENSP00000354377; ENSG00000075407.
GeneIDi7587.
KEGGihsa:7587.
UCSCiuc001izk.4. human.

Organism-specific databases

CTDi7587.
GeneCardsiZNF37A.
HGNCiHGNC:13102. ZNF37A.
HPAiHPA003172.
MIMi616085. gene.
neXtProtiNX_P17032.
PharmGKBiPA37677.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17032.
KOiK09228.
OMAiIEYNECG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17032.
TreeFamiTF337898.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF37A. human.
GeneWikiiZNF37A.
GenomeRNAii7587.
PROiP17032.
SOURCEiSearch...

Gene expression databases

BgeeiP17032.
CleanExiHS_ZNF37A.
GenevisibleiP17032. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p."
    Guy J., Hearn T., Crosier M., Mudge J., Viggiano L., Koczan D., Thiesen H.-J., Bailey J.A., Horvath J.E., Eichler E.E., Earthrowl M.E., Deloukas P., French L., Rogers J., Bentley D., Jackson M.S.
    Genome Res. 13:159-172(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution."
    Tunnacliffe A., Liu L., Moore J.K., Leversha M.A., Jackson M.S., Ferguson-Smith M.A., Thiesen H.-J., Ponder B.A.
    Nucleic Acids Res. 21:1409-1417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 320-561.
  7. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 327-382.
    Tissue: Lymphoid tissue.
  8. "A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1."
    Gauthier M., Marteyn A., Denis J.A., Cailleret M., Giraud-Triboult K., Aubert S., Lecuyer C., Marie J., Furling D., Vernet R., Yanguas C., Baldeschi C., Pietu G., Peschanski M., Martinat C.
    Hum. Mol. Genet. 22:5188-5198(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZN37A_HUMAN
AccessioniPrimary (citable) accession number: P17032
Secondary accession number(s): B3KRQ3, D3DRZ3, Q96B88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.