P17031 (ZNF26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 26

Alternative name(s):
Zinc finger protein KOX20

Gene names

Name:	ZNF26
Synonyms:	KOX20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	533 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 13 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAH08211.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA91367.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 533	533	Zinc finger protein 26		PRO_0000047355
Regions
	Domain	14 – 85	72	KRAB
	Zinc finger	174 – 196	23	C2H2-type 1
	Zinc finger	202 – 224	23	C2H2-type 2
	Zinc finger	230 – 252	23	C2H2-type 3
	Zinc finger	258 – 280	23	C2H2-type 4
	Zinc finger	286 – 308	23	C2H2-type 5
	Zinc finger	314 – 336	23	C2H2-type 6
	Zinc finger	342 – 364	23	C2H2-type 7
	Zinc finger	370 – 392	23	C2H2-type 8
	Zinc finger	398 – 420	23	C2H2-type 9
	Zinc finger	426 – 448	23	C2H2-type 10
	Zinc finger	454 – 476	23	C2H2-type 11
	Zinc finger	482 – 504	23	C2H2-type 12
	Zinc finger	510 – 532	23	C2H2-type 13

Sequences

	Sequence		Length	Mass (Da)
	P17031 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: E7D64DFBE10D0282	FASTA	533	61,282
	10 20 30 40 50 60 MATSFRTASC WGLLSFKDIS MEFTWDEWQL LDSTQKYLYR DVILENYHNL ISVGYHGTKP 70 80 90 100 110 120 DLIFKLEQGE DPWIINAKIS RQSCPDGWEE WYQNNQDELE SIERSYACSV LGRLNLSKTH 130 140 150 160 170 180 DSSRQRLYNT RGKSLTQNSA PSRSYLRKNP DKFHGYEEPY FLKHQRAHSI EKNCVCSECG 190 200 210 220 230 240 KAFRCKSQLI VHLRIHTGER PYECSKCERA FSAKSNLNAH QRVHTGEKPY SCSECEKVFS 250 260 270 280 290 300 FRSQLIVHQE IHTGGKPYGC SECGKAYSWK SQLLLHQRSH TGVKPYECSE CGKAFSLKSP 310 320 330 340 350 360 FVVHQRTHTG VKPHKCSECG KAFRSKSYLL VHIRMHTGEK PYQCSDCGKA FNMKTQLIVH 370 380 390 400 410 420 QGVHTGNNPY QCGECGKAFG RKEQLTAHLR AHAGEKPYGC SECGKAFSSK SYLVIHRRTH 430 440 450 460 470 480 TGERPYECSL CERAFCGKSQ LIIHQRTHST EKPYECNECE KAYPRKASLQ IHQKTHSGEK 490 500 510 520 530 PFKCSECGKA FTQKSSLSEH QRVHTGEKPW KCSECGKSFC WNSGLRIHRK THK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Uterus.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-533.
[5]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 335-533.
[6]	"Multiple genes encoding zinc finger domains are expressed in human T cells." Thiesen H.-J. New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 454-509. Tissue: Lymphoid tissue.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC073911 Genomic DNA. No translation available. CH471218 Genomic DNA. Translation: EAW54803.1. BC008211 mRNA. Translation: AAH08211.1. Different initiation. BC046206 mRNA. Translation: AAH46206.1. AK000762 mRNA. Translation: BAA91367.1. Different initiation. BT006963 mRNA. Translation: AAP35609.1. X52351 mRNA. Translation: CAA36577.1.
IPI	IPI00156521.
PIR	I37960.
RefSeq	NP_062537.2. NM_019591.3. XP_003119263.1. XM_003119215.3.
UniGene	Hs.489608.
3D structure databases
ProteinModelPortal	P17031.
ModBase	Search...
Protein-protein interaction databases
IntAct	P17031. 1 interaction.
PTM databases
PhosphoSite	P17031.
Polymorphism databases
DMDM	215274195.
Proteomic databases
PaxDb	P17031.
PRIDE	P17031.
Protocols and materials databases
DNASU	7574.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328654; ENSP00000333725; ENSG00000198393.
GeneID	100287515. 7574.
KEGG	hsa:100287515. hsa:7574.
UCSC	uc001ull.1. human.
Organism-specific databases
CTD	7574.
GeneCards	GC00M7Y0093. GC12P133563.
HGNC	HGNC:13053. ZNF26.
HPA	HPA018329.
MIM	194537. gene.
neXtProt	NX_P17031.
Orphanet	88616. Autosomal recessive nonsyndromic intellectual deficit.
PharmGKB	PA37631.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	P17031.
KO	K09228.
OMA	FCERAFC.
OrthoDB	EOG4R502F.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P17031.
Bgee	P17031.
CleanEx	HS_ZNF26.
Genevestigator	P17031.
GermOnline	ENSG00000198393. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 13 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF26. human.
NextBio	20777266.
SOURCE	Search...

Entry information

Entry name

ZNF26_HUMAN

Accession

Primary (citable) accession number: P17031
Secondary accession number(s): Q86X57, Q9NWL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 132 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.