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Protein

Zinc finger protein 26

Gene

ZNF26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri174 – 19623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 26
Alternative name(s):
Zinc finger protein KOX20
Gene namesi
Name:ZNF26
Synonyms:KOX20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13053. ZNF26.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37631.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Zinc finger protein 26PRO_0000047355Add
BLAST

Proteomic databases

MaxQBiP17031.
PaxDbiP17031.
PRIDEiP17031.

PTM databases

PhosphoSiteiP17031.

Expressioni

Gene expression databases

BgeeiP17031.
CleanExiHS_ZNF26.
ExpressionAtlasiP17031. baseline and differential.
GenevestigatoriP17031.

Organism-specific databases

HPAiHPA018329.

Interactioni

Protein-protein interaction databases

BioGridi113404. 6 interactions.
IntActiP17031. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP17031.
SMRiP17031. Positions 14-56, 176-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri174 – 19623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17031.
KOiK09228.
OMAiFCERAFC.
PhylomeDBiP17031.
TreeFamiTF340593.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17031-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSFRTASC WGLLSFKDIS MEFTWDEWQL LDSTQKYLYR DVILENYHNL
60 70 80 90 100
ISVGYHGTKP DLIFKLEQGE DPWIINAKIS RQSCPDGWEE WYQNNQDELE
110 120 130 140 150
SIERSYACSV LGRLNLSKTH DSSRQRLYNT RGKSLTQNSA PSRSYLRKNP
160 170 180 190 200
DKFHGYEEPY FLKHQRAHSI EKNCVCSECG KAFRCKSQLI VHLRIHTGER
210 220 230 240 250
PYECSKCERA FSAKSNLNAH QRVHTGEKPY SCSECEKVFS FRSQLIVHQE
260 270 280 290 300
IHTGGKPYGC SECGKAYSWK SQLLLHQRSH TGVKPYECSE CGKAFSLKSP
310 320 330 340 350
FVVHQRTHTG VKPHKCSECG KAFRSKSYLL VHIRMHTGEK PYQCSDCGKA
360 370 380 390 400
FNMKTQLIVH QGVHTGNNPY QCGECGKAFG RKEQLTAHLR AHAGEKPYGC
410 420 430 440 450
SECGKAFSSK SYLVIHRRTH TGERPYECSL CERAFCGKSQ LIIHQRTHST
460 470 480 490 500
EKPYECNECE KAYPRKASLQ IHQKTHSGEK PFKCSECGKA FTQKSSLSEH
510 520 530
QRVHTGEKPW KCSECGKSFC WNSGLRIHRK THK
Length:533
Mass (Da):61,282
Last modified:November 25, 2008 - v3
Checksum:iE7D64DFBE10D0282
GO

Sequence cautioni

The sequence AAH08211.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91367.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073911 Genomic DNA. No translation available.
CH471218 Genomic DNA. Translation: EAW54803.1.
BC008211 mRNA. Translation: AAH08211.1. Different initiation.
BC046206 mRNA. Translation: AAH46206.1.
AK000762 mRNA. Translation: BAA91367.1. Different initiation.
BT006963 mRNA. Translation: AAP35609.1.
X52351 mRNA. Translation: CAA36577.1.
CCDSiCCDS31939.1.
PIRiI37960.
RefSeqiNP_062537.2. NM_019591.3.
UniGeneiHs.489608.

Genome annotation databases

EnsembliENST00000328654; ENSP00000333725; ENSG00000198393.
GeneIDi7574.
KEGGihsa:7574.
UCSCiuc001ull.2. human.

Polymorphism databases

DMDMi215274195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073911 Genomic DNA. No translation available.
CH471218 Genomic DNA. Translation: EAW54803.1.
BC008211 mRNA. Translation: AAH08211.1. Different initiation.
BC046206 mRNA. Translation: AAH46206.1.
AK000762 mRNA. Translation: BAA91367.1. Different initiation.
BT006963 mRNA. Translation: AAP35609.1.
X52351 mRNA. Translation: CAA36577.1.
CCDSiCCDS31939.1.
PIRiI37960.
RefSeqiNP_062537.2. NM_019591.3.
UniGeneiHs.489608.

3D structure databases

ProteinModelPortaliP17031.
SMRiP17031. Positions 14-56, 176-532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113404. 6 interactions.
IntActiP17031. 1 interaction.

PTM databases

PhosphoSiteiP17031.

Polymorphism databases

DMDMi215274195.

Proteomic databases

MaxQBiP17031.
PaxDbiP17031.
PRIDEiP17031.

Protocols and materials databases

DNASUi7574.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328654; ENSP00000333725; ENSG00000198393.
GeneIDi7574.
KEGGihsa:7574.
UCSCiuc001ull.2. human.

Organism-specific databases

CTDi7574.
GeneCardsiGC12P133563.
HGNCiHGNC:13053. ZNF26.
HPAiHPA018329.
MIMi194537. gene.
neXtProtiNX_P17031.
PharmGKBiPA37631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17031.
KOiK09228.
OMAiFCERAFC.
PhylomeDBiP17031.
TreeFamiTF340593.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF26. human.
GenomeRNAii7574.
NextBioi20777266.
PROiP17031.
SOURCEiSearch...

Gene expression databases

BgeeiP17031.
CleanExiHS_ZNF26.
ExpressionAtlasiP17031. baseline and differential.
GenevestigatoriP17031.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Uterus.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-533.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 335-533.
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 454-509.
    Tissue: Lymphoid tissue.

Entry informationi

Entry nameiZNF26_HUMAN
AccessioniPrimary (citable) accession number: P17031
Secondary accession number(s): Q86X57, Q9NWL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: February 4, 2015
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.