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P17031

- ZNF26_HUMAN

UniProt

P17031 - ZNF26_HUMAN

Protein

Zinc finger protein 26

Gene

ZNF26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri174 – 19623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri202 – 22423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri230 – 25223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri258 – 28023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 30823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri314 – 33623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47623C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri482 – 50423C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri510 – 53223C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 26
    Alternative name(s):
    Zinc finger protein KOX20
    Gene namesi
    Name:ZNF26
    Synonyms:KOX20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13053. ZNF26.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37631.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 533533Zinc finger protein 26PRO_0000047355Add
    BLAST

    Proteomic databases

    PaxDbiP17031.
    PRIDEiP17031.

    PTM databases

    PhosphoSiteiP17031.

    Expressioni

    Gene expression databases

    ArrayExpressiP17031.
    BgeeiP17031.
    CleanExiHS_ZNF26.
    GenevestigatoriP17031.

    Organism-specific databases

    HPAiHPA018329.

    Interactioni

    Protein-protein interaction databases

    IntActiP17031. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP17031.
    SMRiP17031. Positions 14-56, 105-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri174 – 19623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri202 – 22423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri230 – 25223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri258 – 28023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 30823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri314 – 33623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47623C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri482 – 50423C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri510 – 53223C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP17031.
    KOiK09228.
    OMAiFCERAFC.
    PhylomeDBiP17031.
    TreeFamiTF340593.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17031-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSFRTASC WGLLSFKDIS MEFTWDEWQL LDSTQKYLYR DVILENYHNL    50
    ISVGYHGTKP DLIFKLEQGE DPWIINAKIS RQSCPDGWEE WYQNNQDELE 100
    SIERSYACSV LGRLNLSKTH DSSRQRLYNT RGKSLTQNSA PSRSYLRKNP 150
    DKFHGYEEPY FLKHQRAHSI EKNCVCSECG KAFRCKSQLI VHLRIHTGER 200
    PYECSKCERA FSAKSNLNAH QRVHTGEKPY SCSECEKVFS FRSQLIVHQE 250
    IHTGGKPYGC SECGKAYSWK SQLLLHQRSH TGVKPYECSE CGKAFSLKSP 300
    FVVHQRTHTG VKPHKCSECG KAFRSKSYLL VHIRMHTGEK PYQCSDCGKA 350
    FNMKTQLIVH QGVHTGNNPY QCGECGKAFG RKEQLTAHLR AHAGEKPYGC 400
    SECGKAFSSK SYLVIHRRTH TGERPYECSL CERAFCGKSQ LIIHQRTHST 450
    EKPYECNECE KAYPRKASLQ IHQKTHSGEK PFKCSECGKA FTQKSSLSEH 500
    QRVHTGEKPW KCSECGKSFC WNSGLRIHRK THK 533
    Length:533
    Mass (Da):61,282
    Last modified:November 25, 2008 - v3
    Checksum:iE7D64DFBE10D0282
    GO

    Sequence cautioni

    The sequence AAH08211.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA91367.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073911 Genomic DNA. No translation available.
    CH471218 Genomic DNA. Translation: EAW54803.1.
    BC008211 mRNA. Translation: AAH08211.1. Different initiation.
    BC046206 mRNA. Translation: AAH46206.1.
    AK000762 mRNA. Translation: BAA91367.1. Different initiation.
    BT006963 mRNA. Translation: AAP35609.1.
    X52351 mRNA. Translation: CAA36577.1.
    CCDSiCCDS31939.1.
    PIRiI37960.
    RefSeqiNP_062537.2. NM_019591.3.
    UniGeneiHs.489608.

    Genome annotation databases

    EnsembliENST00000328654; ENSP00000333725; ENSG00000198393.
    GeneIDi7574.
    KEGGihsa:7574.
    UCSCiuc001ull.2. human.

    Polymorphism databases

    DMDMi215274195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073911 Genomic DNA. No translation available.
    CH471218 Genomic DNA. Translation: EAW54803.1 .
    BC008211 mRNA. Translation: AAH08211.1 . Different initiation.
    BC046206 mRNA. Translation: AAH46206.1 .
    AK000762 mRNA. Translation: BAA91367.1 . Different initiation.
    BT006963 mRNA. Translation: AAP35609.1 .
    X52351 mRNA. Translation: CAA36577.1 .
    CCDSi CCDS31939.1.
    PIRi I37960.
    RefSeqi NP_062537.2. NM_019591.3.
    UniGenei Hs.489608.

    3D structure databases

    ProteinModelPortali P17031.
    SMRi P17031. Positions 14-56, 105-532.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P17031. 1 interaction.

    PTM databases

    PhosphoSitei P17031.

    Polymorphism databases

    DMDMi 215274195.

    Proteomic databases

    PaxDbi P17031.
    PRIDEi P17031.

    Protocols and materials databases

    DNASUi 7574.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328654 ; ENSP00000333725 ; ENSG00000198393 .
    GeneIDi 7574.
    KEGGi hsa:7574.
    UCSCi uc001ull.2. human.

    Organism-specific databases

    CTDi 7574.
    GeneCardsi GC12P133563.
    HGNCi HGNC:13053. ZNF26.
    HPAi HPA018329.
    MIMi 194537. gene.
    neXtProti NX_P17031.
    PharmGKBi PA37631.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P17031.
    KOi K09228.
    OMAi FCERAFC.
    PhylomeDBi P17031.
    TreeFami TF340593.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF26. human.
    GenomeRNAii 7574.
    NextBioi 20777266.
    PROi P17031.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17031.
    Bgeei P17031.
    CleanExi HS_ZNF26.
    Genevestigatori P17031.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Uterus.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-533.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 335-533.
    6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
      Thiesen H.-J.
      New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 454-509.
      Tissue: Lymphoid tissue.

    Entry informationi

    Entry nameiZNF26_HUMAN
    AccessioniPrimary (citable) accession number: P17031
    Secondary accession number(s): Q86X57, Q9NWL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3