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Protein

Zinc finger protein 25

Gene

ZNF25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 25
Alternative name(s):
Zinc finger protein KOX19
Gene namesi
Name:ZNF25
Synonyms:KOX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13043. ZNF25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi219749.
OpenTargetsiENSG00000175395.
PharmGKBiPA37621.

Polymorphism and mutation databases

BioMutaiZNF25.
DMDMi33302620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473541 – 456Zinc finger protein 25Add BLAST456

Proteomic databases

MaxQBiP17030.
PaxDbiP17030.
PeptideAtlasiP17030.
PRIDEiP17030.

PTM databases

iPTMnetiP17030.
PhosphoSitePlusiP17030.

Expressioni

Gene expression databases

BgeeiENSG00000175395.
CleanExiHS_ZNF25.
GenevisibleiP17030. HS.

Organism-specific databases

HPAiHPA030190.

Interactioni

Protein-protein interaction databases

IntActiP17030. 1 interactor.
MINTiMINT-8373460.
STRINGi9606.ENSP00000302222.

Structurei

3D structure databases

ProteinModelPortaliP17030.
SMRiP17030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17030.
KOiK09228.
OMAiHRGFPED.
OrthoDBiEOG091G02KC.
PhylomeDBiP17030.
TreeFamiTF337898.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17030-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH
60 70 80 90 100
VNKPNAVFKL KQGKEPWILE VEFPHRGFPE DLWSIHDLEA RYQESQAGNS
110 120 130 140 150
RNGELTKHQK THTTEKACEC KECGKFFCQK SALIVHQHTH SKGKSYDCDK
160 170 180 190 200
CGKSFSKNED LIRHQKIHTR DKTYECKECK KIFYHLSSLS RHLRTHAGEK
210 220 230 240 250
PYECNQCEKS FYQKPHLTEH QKTHTGEKPF ECTECGKFFY VKAYLMVHQK
260 270 280 290 300
THTGEKPYEC KECGKAFSQK SHLTVHQRMH TGEKPYKCKE CGKFFSRNSH
310 320 330 340 350
LKTHQRSHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT
360 370 380 390 400
FYYKSDLTKH QRKHTGEKPY ECTECGKSFA VNSVLRLHQR THTGEKPYAC
410 420 430 440 450
KECGKSFSQK SHFIIHQRKH TGEKPYECQE CGETFIQKSQ LTAHQKTHTK

KRNAEK
Length:456
Mass (Da):53,545
Last modified:July 25, 2003 - v2
Checksum:i9B65561962CBD85D
GO
Isoform 2 (identifier: P17030-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-99: SQAGN → MWNFL

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):42,625
Checksum:iB2C9D8C2FCA76F84
GO

Sequence cautioni

The sequence AAH36038 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03556721E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_03556881D → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_052748453N → K.1 PublicationCorresponds to variant rs1208606dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0078461 – 94Missing in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_00784795 – 99SQAGN → MWNFL in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491696 mRNA. Translation: CAD36955.1.
AK056452 mRNA. Translation: BAB71187.1.
AL834125 mRNA. Translation: CAD38845.1.
AL117337 Genomic DNA. Translation: CAH73314.1.
BC036038 mRNA. Translation: AAH36038.1. Different initiation.
X52350 mRNA. Translation: CAA36576.1.
CCDSiCCDS7195.1. [P17030-1]
PIRiI37958.
RefSeqiNP_001316579.1. NM_001329650.1. [P17030-1]
NP_001316580.1. NM_001329651.1. [P17030-1]
NP_001316581.1. NM_001329652.1. [P17030-1]
NP_001316582.1. NM_001329653.1. [P17030-1]
NP_001316583.1. NM_001329654.1. [P17030-1]
NP_659448.1. NM_145011.3. [P17030-1]
UniGeneiHs.499429.

Genome annotation databases

EnsembliENST00000302609; ENSP00000302222; ENSG00000175395. [P17030-1]
GeneIDi219749.
KEGGihsa:219749.
UCSCiuc001ize.2. human. [P17030-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491696 mRNA. Translation: CAD36955.1.
AK056452 mRNA. Translation: BAB71187.1.
AL834125 mRNA. Translation: CAD38845.1.
AL117337 Genomic DNA. Translation: CAH73314.1.
BC036038 mRNA. Translation: AAH36038.1. Different initiation.
X52350 mRNA. Translation: CAA36576.1.
CCDSiCCDS7195.1. [P17030-1]
PIRiI37958.
RefSeqiNP_001316579.1. NM_001329650.1. [P17030-1]
NP_001316580.1. NM_001329651.1. [P17030-1]
NP_001316581.1. NM_001329652.1. [P17030-1]
NP_001316582.1. NM_001329653.1. [P17030-1]
NP_001316583.1. NM_001329654.1. [P17030-1]
NP_659448.1. NM_145011.3. [P17030-1]
UniGeneiHs.499429.

3D structure databases

ProteinModelPortaliP17030.
SMRiP17030.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17030. 1 interactor.
MINTiMINT-8373460.
STRINGi9606.ENSP00000302222.

PTM databases

iPTMnetiP17030.
PhosphoSitePlusiP17030.

Polymorphism and mutation databases

BioMutaiZNF25.
DMDMi33302620.

Proteomic databases

MaxQBiP17030.
PaxDbiP17030.
PeptideAtlasiP17030.
PRIDEiP17030.

Protocols and materials databases

DNASUi219749.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302609; ENSP00000302222; ENSG00000175395. [P17030-1]
GeneIDi219749.
KEGGihsa:219749.
UCSCiuc001ize.2. human. [P17030-1]

Organism-specific databases

CTDi219749.
DisGeNETi219749.
GeneCardsiZNF25.
HGNCiHGNC:13043. ZNF25.
HPAiHPA030190.
MIMi194528. gene.
neXtProtiNX_P17030.
OpenTargetsiENSG00000175395.
PharmGKBiPA37621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17030.
KOiK09228.
OMAiHRGFPED.
OrthoDBiEOG091G02KC.
PhylomeDBiP17030.
TreeFamiTF337898.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii219749.
PROiP17030.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175395.
CleanExiHS_ZNF25.
GenevisibleiP17030. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF25_HUMAN
AccessioniPrimary (citable) accession number: P17030
Secondary accession number(s): A9Z1X5
, Q8IYE3, Q8NDD6, Q96MU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 25, 2003
Last modified: November 30, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.