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Protein

Zinc finger protein 25

Gene

ZNF25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 25
Alternative name(s):
Zinc finger protein KOX19
Gene namesi
Name:ZNF25
Synonyms:KOX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000175395.15
HGNCiHGNC:13043 ZNF25
MIMi194528 gene
neXtProtiNX_P17030

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175395
PharmGKBiPA37621

Polymorphism and mutation databases

BioMutaiZNF25
DMDMi33302620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473541 – 456Zinc finger protein 25Add BLAST456

Proteomic databases

MaxQBiP17030
PaxDbiP17030
PeptideAtlasiP17030
PRIDEiP17030

PTM databases

iPTMnetiP17030
PhosphoSitePlusiP17030

Expressioni

Gene expression databases

BgeeiENSG00000175395
CleanExiHS_ZNF25
GenevisibleiP17030 HS

Organism-specific databases

HPAiHPA030190

Interactioni

Protein-protein interaction databases

BioGridi128572, 1 interactor
IntActiP17030, 2 interactors
MINTiP17030
STRINGi9606.ENSP00000302222

Structurei

3D structure databases

ProteinModelPortaliP17030
SMRiP17030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP17030
KOiK09228
OMAiHRGFPED
OrthoDBiEOG091G02KC
PhylomeDBiP17030
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17030-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH
60 70 80 90 100
VNKPNAVFKL KQGKEPWILE VEFPHRGFPE DLWSIHDLEA RYQESQAGNS
110 120 130 140 150
RNGELTKHQK THTTEKACEC KECGKFFCQK SALIVHQHTH SKGKSYDCDK
160 170 180 190 200
CGKSFSKNED LIRHQKIHTR DKTYECKECK KIFYHLSSLS RHLRTHAGEK
210 220 230 240 250
PYECNQCEKS FYQKPHLTEH QKTHTGEKPF ECTECGKFFY VKAYLMVHQK
260 270 280 290 300
THTGEKPYEC KECGKAFSQK SHLTVHQRMH TGEKPYKCKE CGKFFSRNSH
310 320 330 340 350
LKTHQRSHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT
360 370 380 390 400
FYYKSDLTKH QRKHTGEKPY ECTECGKSFA VNSVLRLHQR THTGEKPYAC
410 420 430 440 450
KECGKSFSQK SHFIIHQRKH TGEKPYECQE CGETFIQKSQ LTAHQKTHTK

KRNAEK
Length:456
Mass (Da):53,545
Last modified:July 25, 2003 - v2
Checksum:i9B65561962CBD85D
GO
Isoform 2 (identifier: P17030-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-99: SQAGN → MWNFL

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):42,625
Checksum:iB2C9D8C2FCA76F84
GO

Sequence cautioni

The sequence AAH36038 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03556721E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_03556881D → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_052748453N → K1 PublicationCorresponds to variant dbSNP:rs1208606Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0078461 – 94Missing in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_00784795 – 99SQAGN → MWNFL in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491696 mRNA Translation: CAD36955.1
AK056452 mRNA Translation: BAB71187.1
AL834125 mRNA Translation: CAD38845.1
AL117337 Genomic DNA No translation available.
BC036038 mRNA Translation: AAH36038.1 Different initiation.
X52350 mRNA Translation: CAA36576.1
CCDSiCCDS7195.1 [P17030-1]
PIRiI37958
RefSeqiNP_001316579.1, NM_001329650.1 [P17030-1]
NP_001316580.1, NM_001329651.1 [P17030-1]
NP_001316581.1, NM_001329652.1 [P17030-1]
NP_001316582.1, NM_001329653.1 [P17030-1]
NP_001316583.1, NM_001329654.1 [P17030-1]
NP_659448.1, NM_145011.3 [P17030-1]
UniGeneiHs.499429

Genome annotation databases

EnsembliENST00000302609; ENSP00000302222; ENSG00000175395 [P17030-1]
GeneIDi219749
KEGGihsa:219749
UCSCiuc001ize.2 human [P17030-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF25_HUMAN
AccessioniPrimary (citable) accession number: P17030
Secondary accession number(s): A9Z1X5
, Q8IYE3, Q8NDD6, Q96MU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 25, 2003
Last modified: April 25, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health