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Protein

Zinc finger protein 25

Gene

ZNF25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 25
Alternative name(s):
Zinc finger protein KOX19
Gene namesi
Name:ZNF25
Synonyms:KOX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13043. ZNF25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37621.

Polymorphism and mutation databases

BioMutaiZNF25.
DMDMi33302620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Zinc finger protein 25PRO_0000047354Add
BLAST

Proteomic databases

MaxQBiP17030.
PaxDbiP17030.
PeptideAtlasiP17030.
PRIDEiP17030.

PTM databases

iPTMnetiP17030.
PhosphoSiteiP17030.

Expressioni

Gene expression databases

BgeeiP17030.
CleanExiHS_ZNF25.
GenevisibleiP17030. HS.

Organism-specific databases

HPAiHPA030190.

Interactioni

Protein-protein interaction databases

IntActiP17030. 1 interaction.
MINTiMINT-8373460.
STRINGi9606.ENSP00000302222.

Structurei

3D structure databases

ProteinModelPortaliP17030.
SMRiP17030. Positions 8-50, 100-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17030.
KOiK09228.
OMAiHRGFPED.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17030.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17030-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH
60 70 80 90 100
VNKPNAVFKL KQGKEPWILE VEFPHRGFPE DLWSIHDLEA RYQESQAGNS
110 120 130 140 150
RNGELTKHQK THTTEKACEC KECGKFFCQK SALIVHQHTH SKGKSYDCDK
160 170 180 190 200
CGKSFSKNED LIRHQKIHTR DKTYECKECK KIFYHLSSLS RHLRTHAGEK
210 220 230 240 250
PYECNQCEKS FYQKPHLTEH QKTHTGEKPF ECTECGKFFY VKAYLMVHQK
260 270 280 290 300
THTGEKPYEC KECGKAFSQK SHLTVHQRMH TGEKPYKCKE CGKFFSRNSH
310 320 330 340 350
LKTHQRSHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT
360 370 380 390 400
FYYKSDLTKH QRKHTGEKPY ECTECGKSFA VNSVLRLHQR THTGEKPYAC
410 420 430 440 450
KECGKSFSQK SHFIIHQRKH TGEKPYECQE CGETFIQKSQ LTAHQKTHTK

KRNAEK
Length:456
Mass (Da):53,545
Last modified:July 25, 2003 - v2
Checksum:i9B65561962CBD85D
GO
Isoform 2 (identifier: P17030-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-99: SQAGN → MWNFL

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):42,625
Checksum:iB2C9D8C2FCA76F84
GO

Sequence cautioni

The sequence AAH36038.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_035567
Natural varianti81 – 811D → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_035568
Natural varianti453 – 4531N → K.1 Publication
Corresponds to variant rs1208606 [ dbSNP | Ensembl ].
VAR_052748

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_007846Add
BLAST
Alternative sequencei95 – 995SQAGN → MWNFL in isoform 2. 1 PublicationVSP_007847

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491696 mRNA. Translation: CAD36955.1.
AK056452 mRNA. Translation: BAB71187.1.
AL834125 mRNA. Translation: CAD38845.1.
AL117337 Genomic DNA. Translation: CAH73314.1.
BC036038 mRNA. Translation: AAH36038.1. Different initiation.
X52350 mRNA. Translation: CAA36576.1.
CCDSiCCDS7195.1. [P17030-1]
PIRiI37958.
RefSeqiNP_659448.1. NM_145011.2. [P17030-1]
XP_005252441.1. XM_005252384.1. [P17030-1]
XP_005252442.1. XM_005252385.1. [P17030-1]
XP_005252443.1. XM_005252386.1. [P17030-1]
UniGeneiHs.499429.

Genome annotation databases

EnsembliENST00000302609; ENSP00000302222; ENSG00000175395. [P17030-1]
GeneIDi219749.
KEGGihsa:219749.
UCSCiuc001ize.2. human. [P17030-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491696 mRNA. Translation: CAD36955.1.
AK056452 mRNA. Translation: BAB71187.1.
AL834125 mRNA. Translation: CAD38845.1.
AL117337 Genomic DNA. Translation: CAH73314.1.
BC036038 mRNA. Translation: AAH36038.1. Different initiation.
X52350 mRNA. Translation: CAA36576.1.
CCDSiCCDS7195.1. [P17030-1]
PIRiI37958.
RefSeqiNP_659448.1. NM_145011.2. [P17030-1]
XP_005252441.1. XM_005252384.1. [P17030-1]
XP_005252442.1. XM_005252385.1. [P17030-1]
XP_005252443.1. XM_005252386.1. [P17030-1]
UniGeneiHs.499429.

3D structure databases

ProteinModelPortaliP17030.
SMRiP17030. Positions 8-50, 100-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17030. 1 interaction.
MINTiMINT-8373460.
STRINGi9606.ENSP00000302222.

PTM databases

iPTMnetiP17030.
PhosphoSiteiP17030.

Polymorphism and mutation databases

BioMutaiZNF25.
DMDMi33302620.

Proteomic databases

MaxQBiP17030.
PaxDbiP17030.
PeptideAtlasiP17030.
PRIDEiP17030.

Protocols and materials databases

DNASUi219749.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302609; ENSP00000302222; ENSG00000175395. [P17030-1]
GeneIDi219749.
KEGGihsa:219749.
UCSCiuc001ize.2. human. [P17030-1]

Organism-specific databases

CTDi219749.
GeneCardsiZNF25.
HGNCiHGNC:13043. ZNF25.
HPAiHPA030190.
MIMi194528. gene.
neXtProtiNX_P17030.
PharmGKBiPA37621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17030.
KOiK09228.
OMAiHRGFPED.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17030.
TreeFamiTF337898.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii219749.
PROiP17030.
SOURCEiSearch...

Gene expression databases

BgeeiP17030.
CleanExiHS_ZNF25.
GenevisibleiP17030. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organisation, expression and evolution of Kruppel-type zinc finger genes in human chromosomal region 10p11.2-q11.2."
    Hearn T.
    Thesis (2000), University of Newcastle, United Kingdom
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-456 (ISOFORM 1), VARIANT LYS-453.
    Tissue: Testis.
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 230-285.
    Tissue: Lymphoid tissue.
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-21 AND GLY-81.

Entry informationi

Entry nameiZNF25_HUMAN
AccessioniPrimary (citable) accession number: P17030
Secondary accession number(s): A9Z1X5
, Q8IYE3, Q8NDD6, Q96MU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 25, 2003
Last modified: July 6, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.