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Protein

Zinc finger protein with KRAB and SCAN domains 1

Gene

ZKSCAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri377 – 399C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 1
Alternative name(s):
Zinc finger protein 139
Zinc finger protein 36
Zinc finger protein KOX18
Gene namesi
Name:ZKSCAN1
Synonyms:KOX18, ZNF139, ZNF36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106261.16
HGNCiHGNC:13101 ZKSCAN1
MIMi601260 gene
neXtProtiNX_P17029

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106261
PharmGKBiPA37676

Polymorphism and mutation databases

DMDMi85681856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477531 – 563Zinc finger protein with KRAB and SCAN domains 1Add BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei208PhosphoserineCombined sources1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17029
MaxQBiP17029
PaxDbiP17029
PeptideAtlasiP17029
PRIDEiP17029

PTM databases

iPTMnetiP17029
PhosphoSitePlusiP17029

Expressioni

Gene expression databases

BgeeiENSG00000106261
CleanExiHS_ZKSCAN1
ExpressionAtlasiP17029 baseline and differential
GenevisibleiP17029 HS

Organism-specific databases

HPAiHPA006672

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZSCAN32I3L3J23EBI-10199654,EBI-10178206

Protein-protein interaction databases

BioGridi113414, 31 interactors
IntActiP17029, 2 interactors
STRINGi9606.ENSP00000323148

Structurei

3D structure databases

ProteinModelPortaliP17029
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 138SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini227 – 300KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri377 – 399C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiP17029
KOiK09229
OMAiQVHGPEM
OrthoDBiEOG091G046Q
PhylomeDBiP17029
TreeFamiTF350830

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

P17029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSTLQDTPPP
60 70 80 90 100
DPEIFRQRFR RFCYQNTFGP REALSRLKEL CHQWLRPEIN TKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGMVPL DPVQESSSFD LHHEATQSHF KHSSRKPRLL QSRALPAAHI
210 220 230 240 250
PAPPHEGSPR DQAMASALFT ADSQAMVKIE DMAVSLILEE WGCQNLARRN
260 270 280 290 300
LSRDNRQENY GSAFPQGGEN RNENEESTSK AETSEDSASR GETTGRSQKE
310 320 330 340 350
FGEKRDQEGK TGERQQKNPE EKTRKEKRDS GPAIGKDKKT ITGERGPREK
360 370 380 390 400
GKGLGRSFSL SSNFTTPEEV PTGTKSHRCD ECGKCFTRSS SLIRHKIIHT
410 420 430 440 450
GEKPYECSEC GKAFSLNSNL VLHQRIHTGE KPHECNECGK AFSHSSNLIL
460 470 480 490 500
HQRIHSGEKP YECNECGKAF SQSSDLTKHQ RIHTGEKPYE CSECGKAFNR
510 520 530 540 550
NSYLILHRRI HTREKPYKCT KCGKAFTRSS TLTLHHRIHA RERASEYSPA
560
SLDAFGAFLK SCV
Length:563
Mass (Da):63,630
Last modified:January 10, 2006 - v3
Checksum:i9960C9E320554352
GO

Sequence cautioni

The sequence AAC50264 differs from that shown. Reason: Frameshift at position 241.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02483926V → A1 PublicationCorresponds to variant dbSNP:rs17851996Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074116 mRNA Translation: BAB84942.1
BX640646 mRNA Translation: CAE45792.1
CH236956 Genomic DNA Translation: EAL23861.1
CH471091 Genomic DNA Translation: EAW76613.1
BC022378 mRNA Translation: AAH22378.1
BC112224 mRNA Translation: AAI12225.1
BC113697 mRNA Translation: AAI13698.1
U09848 mRNA Translation: AAC50264.1 Frameshift.
X52349 mRNA Translation: CAA36575.1
CCDSiCCDS34698.1
PIRiI38616
RefSeqiNP_001333510.1, NM_001346581.1
NP_003430.1, NM_003439.3
XP_011514861.1, XM_011516559.2
UniGeneiHs.615360
Hs.633338
Hs.743424

Genome annotation databases

EnsembliENST00000324306; ENSP00000323148; ENSG00000106261
GeneIDi7586
KEGGihsa:7586
UCSCiuc003usk.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZKSC1_HUMAN
AccessioniPrimary (citable) accession number: P17029
Secondary accession number(s): A4D294
, P52745, Q2M1U1, Q8TBW5, Q8TEK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: April 25, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health