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Protein

Zinc finger protein with KRAB and SCAN domains 1

Gene

ZKSCAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri377 – 39923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 1
Alternative name(s):
Zinc finger protein 139
Zinc finger protein 36
Zinc finger protein KOX18
Gene namesi
Name:ZKSCAN1
Synonyms:KOX18, ZNF139, ZNF36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13101. ZKSCAN1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37676.

Polymorphism and mutation databases

DMDMi85681856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Zinc finger protein with KRAB and SCAN domains 1PRO_0000047753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources
Modified residuei208 – 2081PhosphoserineCombined sources
Cross-linki280 – 280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki339 – 339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki560 – 560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17029.
MaxQBiP17029.
PaxDbiP17029.
PRIDEiP17029.

PTM databases

iPTMnetiP17029.
PhosphoSiteiP17029.

Expressioni

Gene expression databases

BgeeiP17029.
CleanExiHS_ZKSCAN1.
ExpressionAtlasiP17029. baseline and differential.
GenevisibleiP17029. HS.

Organism-specific databases

HPAiHPA006672.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZSCAN32I3L3J23EBI-10199654,EBI-10178206

Protein-protein interaction databases

BioGridi113414. 27 interactions.
IntActiP17029. 1 interaction.
STRINGi9606.ENSP00000323148.

Structurei

3D structure databases

ProteinModelPortaliP17029.
SMRiP17029. Positions 50-138, 342-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 13883SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini227 – 30074KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri377 – 39923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP17029.
KOiK09229.
OMAiEKREQQG.
OrthoDBiEOG7SBNN6.
PhylomeDBiP17029.
TreeFamiTF350830.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSTLQDTPPP
60 70 80 90 100
DPEIFRQRFR RFCYQNTFGP REALSRLKEL CHQWLRPEIN TKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGMVPL DPVQESSSFD LHHEATQSHF KHSSRKPRLL QSRALPAAHI
210 220 230 240 250
PAPPHEGSPR DQAMASALFT ADSQAMVKIE DMAVSLILEE WGCQNLARRN
260 270 280 290 300
LSRDNRQENY GSAFPQGGEN RNENEESTSK AETSEDSASR GETTGRSQKE
310 320 330 340 350
FGEKRDQEGK TGERQQKNPE EKTRKEKRDS GPAIGKDKKT ITGERGPREK
360 370 380 390 400
GKGLGRSFSL SSNFTTPEEV PTGTKSHRCD ECGKCFTRSS SLIRHKIIHT
410 420 430 440 450
GEKPYECSEC GKAFSLNSNL VLHQRIHTGE KPHECNECGK AFSHSSNLIL
460 470 480 490 500
HQRIHSGEKP YECNECGKAF SQSSDLTKHQ RIHTGEKPYE CSECGKAFNR
510 520 530 540 550
NSYLILHRRI HTREKPYKCT KCGKAFTRSS TLTLHHRIHA RERASEYSPA
560
SLDAFGAFLK SCV
Length:563
Mass (Da):63,630
Last modified:January 10, 2006 - v3
Checksum:i9960C9E320554352
GO

Sequence cautioni

The sequence AAC50264.1 differs from that shown. Reason: Frameshift at position 241. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261V → A.1 Publication
Corresponds to variant rs17851996 [ dbSNP | Ensembl ].
VAR_024839

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074116 mRNA. Translation: BAB84942.1.
BX640646 mRNA. Translation: CAE45792.1.
CH236956 Genomic DNA. Translation: EAL23861.1.
CH471091 Genomic DNA. Translation: EAW76613.1.
BC022378 mRNA. Translation: AAH22378.1.
BC112224 mRNA. Translation: AAI12225.1.
BC113697 mRNA. Translation: AAI13698.1.
U09848 mRNA. Translation: AAC50264.1. Frameshift.
X52349 mRNA. Translation: CAA36575.1.
CCDSiCCDS34698.1.
PIRiI38616.
RefSeqiNP_003430.1. NM_003439.2.
XP_011514861.1. XM_011516559.1.
UniGeneiHs.615360.
Hs.633338.
Hs.743424.

Genome annotation databases

EnsembliENST00000324306; ENSP00000323148; ENSG00000106261.
GeneIDi7586.
KEGGihsa:7586.
UCSCiuc003usk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074116 mRNA. Translation: BAB84942.1.
BX640646 mRNA. Translation: CAE45792.1.
CH236956 Genomic DNA. Translation: EAL23861.1.
CH471091 Genomic DNA. Translation: EAW76613.1.
BC022378 mRNA. Translation: AAH22378.1.
BC112224 mRNA. Translation: AAI12225.1.
BC113697 mRNA. Translation: AAI13698.1.
U09848 mRNA. Translation: AAC50264.1. Frameshift.
X52349 mRNA. Translation: CAA36575.1.
CCDSiCCDS34698.1.
PIRiI38616.
RefSeqiNP_003430.1. NM_003439.2.
XP_011514861.1. XM_011516559.1.
UniGeneiHs.615360.
Hs.633338.
Hs.743424.

3D structure databases

ProteinModelPortaliP17029.
SMRiP17029. Positions 50-138, 342-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113414. 27 interactions.
IntActiP17029. 1 interaction.
STRINGi9606.ENSP00000323148.

PTM databases

iPTMnetiP17029.
PhosphoSiteiP17029.

Polymorphism and mutation databases

DMDMi85681856.

Proteomic databases

EPDiP17029.
MaxQBiP17029.
PaxDbiP17029.
PRIDEiP17029.

Protocols and materials databases

DNASUi7586.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324306; ENSP00000323148; ENSG00000106261.
GeneIDi7586.
KEGGihsa:7586.
UCSCiuc003usk.3. human.

Organism-specific databases

CTDi7586.
GeneCardsiZKSCAN1.
HGNCiHGNC:13101. ZKSCAN1.
HPAiHPA006672.
MIMi601260. gene.
neXtProtiNX_P17029.
PharmGKBiPA37676.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP17029.
KOiK09229.
OMAiEKREQQG.
OrthoDBiEOG7SBNN6.
PhylomeDBiP17029.
TreeFamiTF350830.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZKSCAN1. human.
GeneWikiiZKSCAN1.
GenomeRNAii7586.
PROiP17029.
SOURCEiSearch...

Gene expression databases

BgeeiP17029.
CleanExiHS_ZKSCAN1.
ExpressionAtlasiP17029. baseline and differential.
GenevisibleiP17029. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal kidney.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-26.
    Tissue: Brain and Lung.
  6. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
    Tommerup N., Vissing H.
    Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 240-563.
    Tissue: Insulinoma.
  7. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 405-460.
    Tissue: Lymphoid tissue.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  14. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-280 AND LYS-339, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."
    Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C.
    Cell Rep. 10:1778-1791(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-339 AND LYS-560, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZKSC1_HUMAN
AccessioniPrimary (citable) accession number: P17029
Secondary accession number(s): A4D294
, P52745, Q2M1U1, Q8TBW5, Q8TEK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.