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Protein

Zinc finger protein 24

Gene

ZNF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri251 – 27323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: InterPro
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 24
Alternative name(s):
Retinoic acid suppression protein A
Short name:
RSG-A
Zinc finger and SCAN domain-containing protein 3
Zinc finger protein 191
Zinc finger protein KOX17
Gene namesi
Name:ZNF24
Synonyms:KOX17, ZNF191, ZSCAN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:13032. ZNF24.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi286 – 2861K → A: Partial cytoplasmic accumulation. 1 Publication
Mutagenesisi290 – 2901R → A: Partial cytoplasmic accumulation. 1 Publication

Organism-specific databases

PharmGKBiPA37610.

Polymorphism and mutation databases

BioMutaiZNF24.
DMDMi160376173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Zinc finger protein 24PRO_0000047352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 1321Phosphoserine1 Publication
Modified residuei142 – 1421Phosphoserine1 Publication
Modified residuei274 – 2741Phosphoserine1 Publication
Modified residuei335 – 3351Phosphotyrosine1 Publication

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP17028.
PaxDbiP17028.
PRIDEiP17028.

PTM databases

PhosphoSiteiP17028.

Miscellaneous databases

PMAP-CutDBP17028.

Expressioni

Tissue specificityi

Expressed in many tissues except in heart.

Gene expression databases

BgeeiP17028.
CleanExiHS_ZNF24.
ExpressionAtlasiP17028. baseline and differential.
GenevisibleiP17028. HS.

Organism-specific databases

HPAiCAB025642.
HPA024062.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APLP1P516932EBI-707773,EBI-74648
DDX6P261963EBI-707773,EBI-351257
DZIP3Q86Y133EBI-707773,EBI-948630
LMO2P257913EBI-707773,EBI-739696
MID2Q9UJV3-23EBI-707773,EBI-10172526
PGBD1Q96JS33EBI-707773,EBI-10290053
TCAF1Q9Y4C23EBI-707773,EBI-750484
ZNF446Q96AF56EBI-707773,EBI-740232
ZNF483Q6P0883EBI-707773,EBI-10196963
ZSCAN21Q9Y5A63EBI-707773,EBI-10281938
ZSCAN32I3L3J25EBI-707773,EBI-10178206
ZSCAN32Q9NX653EBI-707773,EBI-739949

Protein-protein interaction databases

BioGridi113403. 66 interactions.
IntActiP17028. 50 interactions.
MINTiMINT-1373684.
STRINGi9606.ENSP00000261332.

Structurei

Secondary structure

1
368
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi47 – 5711Combined sources
Helixi60 – 623Combined sources
Beta strandi63 – 653Combined sources
Helixi66 – 8116Combined sources
Turni83 – 853Combined sources
Helixi88 – 10215Combined sources
Helixi106 – 1149Combined sources
Helixi120 – 13415Combined sources
Turni272 – 2754Combined sources
Beta strandi282 – 2843Combined sources
Beta strandi287 – 2904Combined sources
Helixi291 – 2999Combined sources
Helixi300 – 3023Combined sources
Beta strandi310 – 3123Combined sources
Beta strandi315 – 3184Combined sources
Helixi319 – 33012Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X6ENMR-A272-330[»]
3LHRX-ray1.90A/B46-136[»]
ProteinModelPortaliP17028.
SMRiP17028. Positions 46-136, 248-361.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17028.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 13483SCAN boxPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 30151Necessary and sufficient for nuclear localizationAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri251 – 27323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP17028.
KOiK09230.
OMAiILIIPNP.
OrthoDBiEOG7HF1JG.
PhylomeDBiP17028.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17028-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI
60 70 80 90 100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF
110 120 130 140 150
VAILPKELQT WVRDHHPENG EEAVTVLEDL ESELDDPGQP VSLRRRKREV
160 170 180 190 200
LVEDMVSQEE AQGLPSSELD AVENQLKWAS WELHSLRHCD DDGRTENGAL
210 220 230 240 250
APKQELPSAL ESHEVPGTLN MGVPQIFKYG ETCFPKGRFE RKRNPSRKKQ
260 270 280 290 300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV
310 320 330 340 350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL
360
FRHQRRHNAE KLLNVVKV
Length:368
Mass (Da):42,155
Last modified:October 23, 2007 - v4
Checksum:iB890EDC512493E0E
GO
Isoform 2 (identifier: P17028-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-193: DDDG → VIIP
     194-368: Missing.

Show »
Length:193
Mass (Da):22,382
Checksum:iA6A9515C74EA57E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti367 – 3671K → E in AAB37275 (Ref. 1) Curated
Sequence conflicti367 – 3671K → E in CAG29324 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti220 – 2201N → S.5 Publications
Corresponds to variant rs2032729 [ dbSNP | Ensembl ].
VAR_012017
Natural varianti331 – 3311G → W.
Corresponds to variant rs3568 [ dbSNP | Ensembl ].
VAR_012018

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei190 – 1934DDDG → VIIP in isoform 2. 1 PublicationVSP_039219
Alternative sequencei194 – 368175Missing in isoform 2. 1 PublicationVSP_039220Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68536 mRNA. Translation: AAB37275.1.
AF016052 Genomic DNA. Translation: AAB70216.1.
AF542097 mRNA. Translation: AAN40767.1.
AF038964 mRNA. Translation: AAD19827.1.
AK291246 mRNA. Translation: BAF83935.1.
BT006658 mRNA. Translation: AAP35304.1.
CR450328 mRNA. Translation: CAG29324.1.
AC116447 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01348.1.
CH471088 Genomic DNA. Translation: EAX01349.1.
BC003566 mRNA. Translation: AAH03566.1.
BC016801 mRNA. Translation: AAH16801.1.
X52348 mRNA. Translation: CAA36574.1.
CCDSiCCDS11912.1. [P17028-1]
PIRiI37956.
RefSeqiNP_008896.2. NM_006965.3. [P17028-1]
XP_005258398.1. XM_005258341.2. [P17028-1]
UniGeneiHs.514802.

Genome annotation databases

EnsembliENST00000261332; ENSP00000261332; ENSG00000172466. [P17028-1]
ENST00000399061; ENSP00000382015; ENSG00000172466. [P17028-1]
ENST00000589881; ENSP00000467655; ENSG00000172466. [P17028-2]
GeneIDi7572.
KEGGihsa:7572.
UCSCiuc002kys.2. human. [P17028-1]
uc002kyu.1. human. [P17028-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68536 mRNA. Translation: AAB37275.1.
AF016052 Genomic DNA. Translation: AAB70216.1.
AF542097 mRNA. Translation: AAN40767.1.
AF038964 mRNA. Translation: AAD19827.1.
AK291246 mRNA. Translation: BAF83935.1.
BT006658 mRNA. Translation: AAP35304.1.
CR450328 mRNA. Translation: CAG29324.1.
AC116447 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01348.1.
CH471088 Genomic DNA. Translation: EAX01349.1.
BC003566 mRNA. Translation: AAH03566.1.
BC016801 mRNA. Translation: AAH16801.1.
X52348 mRNA. Translation: CAA36574.1.
CCDSiCCDS11912.1. [P17028-1]
PIRiI37956.
RefSeqiNP_008896.2. NM_006965.3. [P17028-1]
XP_005258398.1. XM_005258341.2. [P17028-1]
UniGeneiHs.514802.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X6ENMR-A272-330[»]
3LHRX-ray1.90A/B46-136[»]
ProteinModelPortaliP17028.
SMRiP17028. Positions 46-136, 248-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113403. 66 interactions.
IntActiP17028. 50 interactions.
MINTiMINT-1373684.
STRINGi9606.ENSP00000261332.

PTM databases

PhosphoSiteiP17028.

Polymorphism and mutation databases

BioMutaiZNF24.
DMDMi160376173.

Proteomic databases

MaxQBiP17028.
PaxDbiP17028.
PRIDEiP17028.

Protocols and materials databases

DNASUi7572.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261332; ENSP00000261332; ENSG00000172466. [P17028-1]
ENST00000399061; ENSP00000382015; ENSG00000172466. [P17028-1]
ENST00000589881; ENSP00000467655; ENSG00000172466. [P17028-2]
GeneIDi7572.
KEGGihsa:7572.
UCSCiuc002kys.2. human. [P17028-1]
uc002kyu.1. human. [P17028-2]

Organism-specific databases

CTDi7572.
GeneCardsiGC18M032912.
HGNCiHGNC:13032. ZNF24.
HPAiCAB025642.
HPA024062.
MIMi194534. gene.
neXtProtiNX_P17028.
PharmGKBiPA37610.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP17028.
KOiK09230.
OMAiILIIPNP.
OrthoDBiEOG7HF1JG.
PhylomeDBiP17028.
TreeFamiTF338304.

Miscellaneous databases

ChiTaRSiZNF24. human.
EvolutionaryTraceiP17028.
GeneWikiiZNF24.
GenomeRNAii7572.
NextBioi29617.
PMAP-CutDBP17028.
PROiP17028.
SOURCEiSearch...

Gene expression databases

BgeeiP17028.
CleanExiHS_ZNF24.
ExpressionAtlasiP17028. baseline and differential.
GenevisibleiP17028. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Shi S., Yu L.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANT SER-220.
    Tissue: Liver.
  2. "Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB."
    Han Z.-G., Zhang Q.-H., Ye M., Kan L.-X., Gu B.-W., He K.-L., Shi S.-L., Zhou J., Fu G., Mao M., Chen S.-J., Yu L., Chen Z.
    J. Biol. Chem. 274:35741-35748(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT SER-220.
    Tissue: Bone marrow.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-220.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-220.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-220.
    Tissue: Lung and Testis.
  8. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 319-362 (ISOFORM 1).
    Tissue: Lymphoid tissue.
  9. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
    Gocke C.B., Yu H., Kang J.
    J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION.
  10. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24."
    Li J.Z., Chen X., Gong X.L., Hu H.Y., Shi D., Lu Y.M., Qiu L., Lu F., Hu Z.L., Zhang J.P.
    PLoS ONE 8:E79910-E79910(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-286 AND ARG-290.
  16. "Solution structures of the C2H2 type zinc finger domain of human zinc finger protein 24."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 272-330.

Entry informationi

Entry nameiZNF24_HUMAN
AccessioniPrimary (citable) accession number: P17028
Secondary accession number(s): O14754
, Q53YE4, Q6ICR5, Q8IZN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 23, 2007
Last modified: June 24, 2015
This is version 173 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.