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Protein

Zinc finger protein 24

Gene

ZNF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • myelination Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 24
Alternative name(s):
Retinoic acid suppression protein A
Short name:
RSG-A
Zinc finger and SCAN domain-containing protein 3
Zinc finger protein 191
Zinc finger protein KOX17
Gene namesi
Name:ZNF24
Synonyms:KOX17, ZNF191, ZSCAN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000172466.15
HGNCiHGNC:13032 ZNF24
MIMi194534 gene
neXtProtiNX_P17028

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi286K → A: Partial cytoplasmic accumulation. 1 Publication1
Mutagenesisi290R → A: Partial cytoplasmic accumulation. 1 Publication1

Organism-specific databases

DisGeNETi7572
OpenTargetsiENSG00000172466
PharmGKBiPA37610

Polymorphism and mutation databases

BioMutaiZNF24
DMDMi160376173

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473521 – 368Zinc finger protein 24Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei132PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei274PhosphoserineCombined sources1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei292PhosphoserineCombined sources1
Modified residuei335PhosphotyrosineCombined sources1
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17028
MaxQBiP17028
PaxDbiP17028
PeptideAtlasiP17028
PRIDEiP17028

PTM databases

iPTMnetiP17028
PhosphoSitePlusiP17028

Miscellaneous databases

PMAP-CutDBiP17028

Expressioni

Tissue specificityi

Expressed in many tissues except in heart.

Gene expression databases

BgeeiENSG00000172466
CleanExiHS_ZNF24
ExpressionAtlasiP17028 baseline and differential
GenevisibleiP17028 HS

Organism-specific databases

HPAiCAB025642
HPA024062

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113403, 74 interactors
IntActiP17028, 59 interactors
MINTiP17028
STRINGi9606.ENSP00000261332

Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 57Combined sources11
Helixi60 – 62Combined sources3
Beta strandi63 – 65Combined sources3
Helixi66 – 81Combined sources16
Turni83 – 85Combined sources3
Helixi88 – 102Combined sources15
Helixi106 – 114Combined sources9
Helixi120 – 134Combined sources15
Turni272 – 275Combined sources4
Beta strandi282 – 284Combined sources3
Beta strandi287 – 290Combined sources4
Helixi291 – 299Combined sources9
Helixi300 – 302Combined sources3
Beta strandi310 – 312Combined sources3
Beta strandi315 – 318Combined sources4
Helixi319 – 330Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X6ENMR-A272-330[»]
3LHRX-ray1.90A/B46-136[»]
ProteinModelPortaliP17028
SMRiP17028
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17028

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 301Necessary and sufficient for nuclear localizationAdd BLAST51

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiP17028
KOiK09230
OMAiILIIPNP
OrthoDBiEOG091G09O3
PhylomeDBiP17028
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17028-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI
60 70 80 90 100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF
110 120 130 140 150
VAILPKELQT WVRDHHPENG EEAVTVLEDL ESELDDPGQP VSLRRRKREV
160 170 180 190 200
LVEDMVSQEE AQGLPSSELD AVENQLKWAS WELHSLRHCD DDGRTENGAL
210 220 230 240 250
APKQELPSAL ESHEVPGTLN MGVPQIFKYG ETCFPKGRFE RKRNPSRKKQ
260 270 280 290 300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV
310 320 330 340 350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL
360
FRHQRRHNAE KLLNVVKV
Length:368
Mass (Da):42,155
Last modified:October 23, 2007 - v4
Checksum:iB890EDC512493E0E
GO
Isoform 2 (identifier: P17028-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-193: DDDG → VIIP
     194-368: Missing.

Show »
Length:193
Mass (Da):22,382
Checksum:iA6A9515C74EA57E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti367K → E in AAB37275 (Ref. 1) Curated1
Sequence conflicti367K → E in CAG29324 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012017220N → S5 PublicationsCorresponds to variant dbSNP:rs2032729Ensembl.1
Natural variantiVAR_012018331G → W. Corresponds to variant dbSNP:rs3568Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039219190 – 193DDDG → VIIP in isoform 2. 1 Publication4
Alternative sequenceiVSP_039220194 – 368Missing in isoform 2. 1 PublicationAdd BLAST175

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68536 mRNA Translation: AAB37275.1
AF016052 Genomic DNA Translation: AAB70216.1
AF542097 mRNA Translation: AAN40767.1
AF038964 mRNA Translation: AAD19827.1
AK291246 mRNA Translation: BAF83935.1
BT006658 mRNA Translation: AAP35304.1
CR450328 mRNA Translation: CAG29324.1
AC116447 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01348.1
CH471088 Genomic DNA Translation: EAX01349.1
BC003566 mRNA Translation: AAH03566.1
BC016801 mRNA Translation: AAH16801.1
X52348 mRNA Translation: CAA36574.1
CCDSiCCDS11912.1 [P17028-1]
CCDS77175.1 [P17028-2]
PIRiI37956
RefSeqiNP_001295052.1, NM_001308123.1 [P17028-2]
NP_008896.2, NM_006965.3 [P17028-1]
XP_005258398.1, XM_005258341.3 [P17028-1]
UniGeneiHs.514802

Genome annotation databases

EnsembliENST00000261332; ENSP00000261332; ENSG00000172466 [P17028-1]
ENST00000399061; ENSP00000382015; ENSG00000172466 [P17028-1]
ENST00000589881; ENSP00000467655; ENSG00000172466 [P17028-2]
GeneIDi7572
KEGGihsa:7572
UCSCiuc002kys.3 human [P17028-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF24_HUMAN
AccessioniPrimary (citable) accession number: P17028
Secondary accession number(s): O14754
, Q53YE4, Q6ICR5, Q8IZN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 202 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health