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P17027

- ZNF23_HUMAN

UniProt

P17027 - ZNF23_HUMAN

Protein

Zinc finger protein 23

Gene

ZNF23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 3 (28 Feb 2003)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation. May have a role in embryonic development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri168 – 19023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri196 – 21823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri252 – 27423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri476 – 49823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri504 – 52623C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri532 – 55423C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri560 – 58223C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri588 – 61023C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri616 – 63823C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 23
    Alternative name(s):
    Zinc finger protein 359
    Zinc finger protein 612
    Zinc finger protein KOX16
    Gene namesi
    Name:ZNF23
    Synonyms:KOX16, ZNF359, ZNF612
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:13023. ZNF23.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37602.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 643643Zinc finger protein 23PRO_0000047351Add
    BLAST

    Proteomic databases

    PaxDbiP17027.
    PRIDEiP17027.

    PTM databases

    PhosphoSiteiP17027.

    Expressioni

    Gene expression databases

    BgeeiP17027.
    CleanExiHS_ZNF23.
    GenevestigatoriP17027.

    Organism-specific databases

    HPAiHPA023534.

    Interactioni

    Protein-protein interaction databases

    BioGridi113402. 3 interactions.
    IntActiP17027. 2 interactions.
    STRINGi9606.ENSP00000349796.

    Structurei

    3D structure databases

    ProteinModelPortaliP17027.
    SMRiP17027. Positions 133-638.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 4343KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri168 – 19023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri196 – 21823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri252 – 27423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri476 – 49823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri504 – 52623C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri532 – 55423C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri560 – 58223C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri588 – 61023C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri616 – 63823C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP17027.
    KOiK09228.
    OMAiSVHSEGK.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiP17027.
    TreeFamiTF350833.

    Family and domain databases

    Gene3Di3.30.160.60. 17 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 16 hits.
    [Graphical view]
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 17 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P17027-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLENYGNVAS LGFPLLKPAV ISQLEGGSEL GGSSPLAAGT GLQGLQTDIQ    50
    TDNDLTKEMY EGKENVSFEL QRDFSQETDF SEASLLEKQQ EVHSAGNIKK 100
    EKSNTIDGTV KDETSPVEEC FFSQSSNSYQ CHTITGEQPS GCTGLGKSIS 150
    FDTKLVKHEI INSEERPFKC EELVEPFRCD SQLIQHQENN TEEKPYQCSE 200
    CGKAFSINEK LIWHQRLHSG EKPFKCVECG KSFSYSSHYI THQTIHSGEK 250
    PYQCKMCGKA FSVNGSLSRH QRIHTGEKPY QCKECGNGFS CSSAYITHQR 300
    VHTGEKPYEC NDCGKAFNVN AKLIQHQRIH TGEKPYECNE CGKGFRCSSQ 350
    LRQHQSIHTG EKPYQCKECG KGFNNNTKLI QHQRIHTGEK PYECTECGKA 400
    FSVKGKLIQH QRIHTGEKPY ECNECGKAFR CNSQFRQHLR IHTGEKPYEC 450
    NECGKAFSVN GKLMRHQRIH TGEKPFECNE CGRCFTSKRN LLDHHRIHTG 500
    EKPYQCKECG KAFSINAKLT RHQRIHTGEK PFKCMECEKA FSCSSNYIVH 550
    QRIHTGEKPF QCKECGKAFH VNAHLIRHQR SHTGEKPFRC VECGKGFSFS 600
    SDYIIHQTVH TWKKPYMCSV CGKAFRFSFQ LSQHQSVHSE GKS 643
    Length:643
    Mass (Da):73,059
    Last modified:February 28, 2003 - v3
    Checksum:iA86682E8A75F5A45
    GO
    Isoform 2 (identifier: P17027-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:585
    Mass (Da):67,160
    Checksum:iD3DD01C89F379A3C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501Q → E in CAB45722. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281S → G.
    Corresponds to variant rs2070832 [ dbSNP | Ensembl ].
    VAR_024195

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5858Missing in isoform 2. 2 PublicationsVSP_055936Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF507946 mRNA. Translation: AAM33359.1.
    BT007400 mRNA. Translation: AAP36064.1.
    AL080123 mRNA. Translation: CAB45722.1.
    AL833815 mRNA. Translation: CAD38678.1.
    AC010547 Genomic DNA. No translation available.
    BC007256 mRNA. Translation: AAH07256.1.
    BC048974 mRNA. Translation: AAH48974.1.
    X52347 mRNA. Translation: CAA36573.1.
    CCDSiCCDS10900.1.
    PIRiT12488.
    RefSeqiNP_666016.1. NM_145911.1.
    UniGeneiHs.656643.

    Genome annotation databases

    EnsembliENST00000357254; ENSP00000349796; ENSG00000167377.
    ENST00000393539; ENSP00000377171; ENSG00000167377.
    ENST00000428724; ENSP00000387673; ENSG00000167377.
    GeneIDi7571.
    KEGGihsa:7571.
    UCSCiuc002fad.3. human.

    Polymorphism databases

    DMDMi29840831.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF507946 mRNA. Translation: AAM33359.1 .
    BT007400 mRNA. Translation: AAP36064.1 .
    AL080123 mRNA. Translation: CAB45722.1 .
    AL833815 mRNA. Translation: CAD38678.1 .
    AC010547 Genomic DNA. No translation available.
    BC007256 mRNA. Translation: AAH07256.1 .
    BC048974 mRNA. Translation: AAH48974.1 .
    X52347 mRNA. Translation: CAA36573.1 .
    CCDSi CCDS10900.1.
    PIRi T12488.
    RefSeqi NP_666016.1. NM_145911.1.
    UniGenei Hs.656643.

    3D structure databases

    ProteinModelPortali P17027.
    SMRi P17027. Positions 133-638.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113402. 3 interactions.
    IntActi P17027. 2 interactions.
    STRINGi 9606.ENSP00000349796.

    PTM databases

    PhosphoSitei P17027.

    Polymorphism databases

    DMDMi 29840831.

    Proteomic databases

    PaxDbi P17027.
    PRIDEi P17027.

    Protocols and materials databases

    DNASUi 7571.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357254 ; ENSP00000349796 ; ENSG00000167377 .
    ENST00000393539 ; ENSP00000377171 ; ENSG00000167377 .
    ENST00000428724 ; ENSP00000387673 ; ENSG00000167377 .
    GeneIDi 7571.
    KEGGi hsa:7571.
    UCSCi uc002fad.3. human.

    Organism-specific databases

    CTDi 7571.
    GeneCardsi GC16M071481.
    HGNCi HGNC:13023. ZNF23.
    HPAi HPA023534.
    MIMi 194527. gene.
    neXtProti NX_P17027.
    PharmGKBi PA37602.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P17027.
    KOi K09228.
    OMAi SVHSEGK.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi P17027.
    TreeFami TF350833.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF23.
    GenomeRNAii 7571.
    NextBioi 29613.
    PROi P17027.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17027.
    CleanExi HS_ZNF23.
    Genevestigatori P17027.

    Family and domain databases

    Gene3Di 3.30.160.60. 17 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 16 hits.
    [Graphical view ]
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 17 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development."
      Zhou L., Zhu C., Luo K., Li Y., Pi H., Yuan W., Wang Y., Huang C., Liu M., Wu X.
      Biochem. Biophys. Res. Commun. 295:862-868(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-643 (ISOFORM 1).
      Tissue: Hippocampus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Muscle.
    6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
      Thiesen H.-J.
      New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 476-531 (ISOFORM 1).
      Tissue: Lymphoid tissue.

    Entry informationi

    Entry nameiZNF23_HUMAN
    AccessioniPrimary (citable) accession number: P17027
    Secondary accession number(s): Q8NDP5, Q96IT3, Q9UG42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: February 28, 2003
    Last modified: October 1, 2014
    This is version 144 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3