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P17027 (ZNF23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 23
Alternative name(s):
Zinc finger protein 359
Zinc finger protein 612
Zinc finger protein KOX16
Gene names
Name:ZNF23
Synonyms:KOX16, ZNF359, ZNF612
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation. May have a role in embryonic development.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 17 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 643643Zinc finger protein 23
PRO_0000047351

Regions

Domain1 – 4343KRAB
Zinc finger168 – 19023C2H2-type 1; degenerate
Zinc finger196 – 21823C2H2-type 2
Zinc finger224 – 24623C2H2-type 3
Zinc finger252 – 27423C2H2-type 4
Zinc finger280 – 30223C2H2-type 5
Zinc finger308 – 33023C2H2-type 6
Zinc finger336 – 35823C2H2-type 7
Zinc finger364 – 38623C2H2-type 8
Zinc finger392 – 41423C2H2-type 9
Zinc finger420 – 44223C2H2-type 10
Zinc finger448 – 47023C2H2-type 11
Zinc finger476 – 49823C2H2-type 12
Zinc finger504 – 52623C2H2-type 13
Zinc finger532 – 55423C2H2-type 14
Zinc finger560 – 58223C2H2-type 15
Zinc finger588 – 61023C2H2-type 16
Zinc finger616 – 63823C2H2-type 17

Natural variations

Natural variant281S → G.
Corresponds to variant rs2070832 [ dbSNP | Ensembl ].
VAR_024195

Experimental info

Sequence conflict501Q → E in CAB45722. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P17027 [UniParc].

Last modified February 28, 2003. Version 3.
Checksum: A86682E8A75F5A45

FASTA64373,059
        10         20         30         40         50         60 
MLENYGNVAS LGFPLLKPAV ISQLEGGSEL GGSSPLAAGT GLQGLQTDIQ TDNDLTKEMY 

        70         80         90        100        110        120 
EGKENVSFEL QRDFSQETDF SEASLLEKQQ EVHSAGNIKK EKSNTIDGTV KDETSPVEEC 

       130        140        150        160        170        180 
FFSQSSNSYQ CHTITGEQPS GCTGLGKSIS FDTKLVKHEI INSEERPFKC EELVEPFRCD 

       190        200        210        220        230        240 
SQLIQHQENN TEEKPYQCSE CGKAFSINEK LIWHQRLHSG EKPFKCVECG KSFSYSSHYI 

       250        260        270        280        290        300 
THQTIHSGEK PYQCKMCGKA FSVNGSLSRH QRIHTGEKPY QCKECGNGFS CSSAYITHQR 

       310        320        330        340        350        360 
VHTGEKPYEC NDCGKAFNVN AKLIQHQRIH TGEKPYECNE CGKGFRCSSQ LRQHQSIHTG 

       370        380        390        400        410        420 
EKPYQCKECG KGFNNNTKLI QHQRIHTGEK PYECTECGKA FSVKGKLIQH QRIHTGEKPY 

       430        440        450        460        470        480 
ECNECGKAFR CNSQFRQHLR IHTGEKPYEC NECGKAFSVN GKLMRHQRIH TGEKPFECNE 

       490        500        510        520        530        540 
CGRCFTSKRN LLDHHRIHTG EKPYQCKECG KAFSINAKLT RHQRIHTGEK PFKCMECEKA 

       550        560        570        580        590        600 
FSCSSNYIVH QRIHTGEKPF QCKECGKAFH VNAHLIRHQR SHTGEKPFRC VECGKGFSFS 

       610        620        630        640 
SDYIIHQTVH TWKKPYMCSV CGKAFRFSFQ LSQHQSVHSE GKS 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development."
Zhou L., Zhu C., Luo K., Li Y., Pi H., Yuan W., Wang Y., Huang C., Liu M., Wu X.
Biochem. Biophys. Res. Commun. 295:862-868(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-643.
Tissue: Hippocampus.
[5]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 476-531.
Tissue: Lymphoid tissue.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF507946 mRNA. Translation: AAM33359.1.
BT007400 mRNA. Translation: AAP36064.1.
BC007256 mRNA. Translation: AAH07256.1.
AL080123 mRNA. Translation: CAB45722.1.
X52347 mRNA. Translation: CAA36573.1.
PIRT12488.
RefSeqNP_666016.1. NM_145911.1.
UniGeneHs.656643.

3D structure databases

ProteinModelPortalP17027.
SMRP17027. Positions 111-643.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113402. 3 interactions.
IntActP17027. 2 interactions.
STRING9606.ENSP00000349796.

PTM databases

PhosphoSiteP17027.

Polymorphism databases

DMDM29840831.

Proteomic databases

PaxDbP17027.
PRIDEP17027.

Protocols and materials databases

DNASU7571.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357254; ENSP00000349796; ENSG00000167377.
ENST00000393539; ENSP00000377171; ENSG00000167377.
ENST00000417828; ENSP00000395712; ENSG00000167377.
GeneID7571.
KEGGhsa:7571.
UCSCuc002fad.3. human.

Organism-specific databases

CTD7571.
GeneCardsGC16M071481.
HGNCHGNC:13023. ZNF23.
HPAHPA023534.
MIM194527. gene.
neXtProtNX_P17027.
PharmGKBPA37602.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP17027.
KOK09228.
OMASVHSEGK.
OrthoDBEOG7KSX7Q.
PhylomeDBP17027.
TreeFamTF350833.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeP17027.
CleanExHS_ZNF23.
GenevestigatorP17027.

Family and domain databases

Gene3D3.30.160.60. 17 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF23.
GenomeRNAi7571.
NextBio29613.
PROP17027.
SOURCESearch...

Entry information

Entry nameZNF23_HUMAN
AccessionPrimary (citable) accession number: P17027
Secondary accession number(s): Q96IT3, Q9UG42
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 28, 2003
Last modified: April 16, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM