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Protein

Zinc finger protein 23

Gene

ZNF23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation. May have a role in embryonic development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri168 – 19023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri532 – 55423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri560 – 58223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri588 – 61023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri616 – 63823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 23
Alternative name(s):
Zinc finger protein 359
Zinc finger protein 612
Zinc finger protein KOX16
Gene namesi
Name:ZNF23
Synonyms:KOX16, ZNF359, ZNF612
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13023. ZNF23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37602.

Polymorphism and mutation databases

BioMutaiZNF23.
DMDMi29840831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Zinc finger protein 23PRO_0000047351Add
BLAST

Proteomic databases

MaxQBiP17027.
PaxDbiP17027.
PRIDEiP17027.

PTM databases

PhosphoSiteiP17027.

Expressioni

Gene expression databases

BgeeiP17027.
CleanExiHS_ZNF23.
ExpressionAtlasiP17027. baseline.
GenevisibleiP17027. HS.

Organism-specific databases

HPAiHPA023534.

Interactioni

Protein-protein interaction databases

BioGridi113402. 5 interactions.
IntActiP17027. 2 interactions.
STRINGi9606.ENSP00000349796.

Structurei

3D structure databases

ProteinModelPortaliP17027.
SMRiP17027. Positions 133-638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4343KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri168 – 19023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri532 – 55423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri560 – 58223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri588 – 61023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri616 – 63823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00790000122953.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17027.
KOiK09228.
OMAiQETDFSE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17027.
TreeFamiTF350833.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17027-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLENYGNVAS LGFPLLKPAV ISQLEGGSEL GGSSPLAAGT GLQGLQTDIQ
60 70 80 90 100
TDNDLTKEMY EGKENVSFEL QRDFSQETDF SEASLLEKQQ EVHSAGNIKK
110 120 130 140 150
EKSNTIDGTV KDETSPVEEC FFSQSSNSYQ CHTITGEQPS GCTGLGKSIS
160 170 180 190 200
FDTKLVKHEI INSEERPFKC EELVEPFRCD SQLIQHQENN TEEKPYQCSE
210 220 230 240 250
CGKAFSINEK LIWHQRLHSG EKPFKCVECG KSFSYSSHYI THQTIHSGEK
260 270 280 290 300
PYQCKMCGKA FSVNGSLSRH QRIHTGEKPY QCKECGNGFS CSSAYITHQR
310 320 330 340 350
VHTGEKPYEC NDCGKAFNVN AKLIQHQRIH TGEKPYECNE CGKGFRCSSQ
360 370 380 390 400
LRQHQSIHTG EKPYQCKECG KGFNNNTKLI QHQRIHTGEK PYECTECGKA
410 420 430 440 450
FSVKGKLIQH QRIHTGEKPY ECNECGKAFR CNSQFRQHLR IHTGEKPYEC
460 470 480 490 500
NECGKAFSVN GKLMRHQRIH TGEKPFECNE CGRCFTSKRN LLDHHRIHTG
510 520 530 540 550
EKPYQCKECG KAFSINAKLT RHQRIHTGEK PFKCMECEKA FSCSSNYIVH
560 570 580 590 600
QRIHTGEKPF QCKECGKAFH VNAHLIRHQR SHTGEKPFRC VECGKGFSFS
610 620 630 640
SDYIIHQTVH TWKKPYMCSV CGKAFRFSFQ LSQHQSVHSE GKS
Length:643
Mass (Da):73,059
Last modified:February 28, 2003 - v3
Checksum:iA86682E8A75F5A45
GO
Isoform 2 (identifier: P17027-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):67,160
Checksum:iD3DD01C89F379A3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501Q → E in CAB45722 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281S → G.
Corresponds to variant rs2070832 [ dbSNP | Ensembl ].
VAR_024195

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858Missing in isoform 2. 2 PublicationsVSP_055936Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507946 mRNA. Translation: AAM33359.1.
BT007400 mRNA. Translation: AAP36064.1.
AL080123 mRNA. Translation: CAB45722.1.
AL833815 mRNA. Translation: CAD38678.1.
AC010547 Genomic DNA. No translation available.
BC007256 mRNA. Translation: AAH07256.1.
BC048974 mRNA. Translation: AAH48974.1.
X52347 mRNA. Translation: CAA36573.1.
CCDSiCCDS10900.1. [P17027-1]
PIRiT12488.
RefSeqiNP_666016.1. NM_145911.2. [P17027-1]
UniGeneiHs.656643.

Genome annotation databases

EnsembliENST00000357254; ENSP00000349796; ENSG00000167377. [P17027-1]
ENST00000393539; ENSP00000377171; ENSG00000167377. [P17027-1]
ENST00000428724; ENSP00000387673; ENSG00000167377. [P17027-1]
ENST00000564528; ENSP00000462429; ENSG00000167377. [P17027-2]
GeneIDi7571.
KEGGihsa:7571.
UCSCiuc002fad.3. human. [P17027-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507946 mRNA. Translation: AAM33359.1.
BT007400 mRNA. Translation: AAP36064.1.
AL080123 mRNA. Translation: CAB45722.1.
AL833815 mRNA. Translation: CAD38678.1.
AC010547 Genomic DNA. No translation available.
BC007256 mRNA. Translation: AAH07256.1.
BC048974 mRNA. Translation: AAH48974.1.
X52347 mRNA. Translation: CAA36573.1.
CCDSiCCDS10900.1. [P17027-1]
PIRiT12488.
RefSeqiNP_666016.1. NM_145911.2. [P17027-1]
UniGeneiHs.656643.

3D structure databases

ProteinModelPortaliP17027.
SMRiP17027. Positions 133-638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113402. 5 interactions.
IntActiP17027. 2 interactions.
STRINGi9606.ENSP00000349796.

PTM databases

PhosphoSiteiP17027.

Polymorphism and mutation databases

BioMutaiZNF23.
DMDMi29840831.

Proteomic databases

MaxQBiP17027.
PaxDbiP17027.
PRIDEiP17027.

Protocols and materials databases

DNASUi7571.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357254; ENSP00000349796; ENSG00000167377. [P17027-1]
ENST00000393539; ENSP00000377171; ENSG00000167377. [P17027-1]
ENST00000428724; ENSP00000387673; ENSG00000167377. [P17027-1]
ENST00000564528; ENSP00000462429; ENSG00000167377. [P17027-2]
GeneIDi7571.
KEGGihsa:7571.
UCSCiuc002fad.3. human. [P17027-1]

Organism-specific databases

CTDi7571.
GeneCardsiGC16M071481.
HGNCiHGNC:13023. ZNF23.
HPAiHPA023534.
MIMi194527. gene.
neXtProtiNX_P17027.
PharmGKBiPA37602.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00790000122953.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17027.
KOiK09228.
OMAiQETDFSE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP17027.
TreeFamiTF350833.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF23.
GenomeRNAii7571.
NextBioi29613.
PROiP17027.
SOURCEiSearch...

Gene expression databases

BgeeiP17027.
CleanExiHS_ZNF23.
ExpressionAtlasiP17027. baseline.
GenevisibleiP17027. HS.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development."
    Zhou L., Zhu C., Luo K., Li Y., Pi H., Yuan W., Wang Y., Huang C., Liu M., Wu X.
    Biochem. Biophys. Res. Commun. 295:862-868(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-643 (ISOFORM 1).
    Tissue: Hippocampus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Muscle.
  6. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 476-531 (ISOFORM 1).
    Tissue: Lymphoid tissue.

Entry informationi

Entry nameiZNF23_HUMAN
AccessioniPrimary (citable) accession number: P17027
Secondary accession number(s): Q8NDP5, Q96IT3, Q9UG42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 28, 2003
Last modified: June 24, 2015
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.