ID   ZNF22_HUMAN             Reviewed;         224 AA.
AC   P17026; Q5T741; Q96FM4;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2002, sequence version 3.
DT   27-MAR-2024, entry version 212.
DE   RecName: Full=Zinc finger protein 22;
DE   AltName: Full=Zinc finger protein KOX15;
DE   AltName: Full=Zinc finger protein Krox-26;
GN   Name=ZNF22; Synonyms=KOX15, KROX26;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1421376;
RA   Wu B.Y., Hanley E.W., Turka L.A., Nabel G.J.;
RT   "Isolation of a cDNA clone encoding a zinc finger protein highly expressed
RT   in T-leukemia lines.";
RL   Blood 80:2571-2576(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=14630903; DOI=10.1177/154405910308201213;
RA   Gao Y., Kobayashi H., Ganss B.;
RT   "The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and
RT   maps to the locus for permanent tooth agenesis (He-Zhao deficiency).";
RL   J. Dent. Res. 82:1002-1007(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Blood, Brain, and Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-224.
RC   TISSUE=Placenta;
RX   PubMed=1946370; DOI=10.1073/pnas.88.21.9563;
RA   Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.;
RT   "Characterization and mapping of human genes encoding zinc finger
RT   proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 139-194.
RC   TISSUE=Lymphoid tissue;
RX   PubMed=2288909;
RA   Thiesen H.-J.;
RT   "Multiple genes encoding zinc finger domains are expressed in human T
RT   cells.";
RL   New Biol. 2:363-374(1990).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [11]
RP   VARIANT [LARGE SCALE ANALYSIS] LEU-129.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. May be
CC       involved in transcriptional regulation and may play a role in tooth
CC       formation (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P17026; P13569: CFTR; NbExp=2; IntAct=EBI-20803387, EBI-349854;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: In the embryo, expressed in developing craniofacial
CC       structures including dental epithelium of maxillary molar tooth organs,
CC       tongue epithelium and muscle, and craniofacial bone osteoblasts. In the
CC       adult, expressed in mesoderm-derived tissues such as skeletal muscle,
CC       heart, kidney and liver. Intermediate expression in spleen, thymus and
CC       brain. Low levels in endoderm-derived tissues such as intestine and
CC       colon. {ECO:0000269|PubMed:14630903}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; S50223; AAB24264.2; -; mRNA.
DR   EMBL; AY137767; AAN15804.1; -; Genomic_DNA.
DR   EMBL; BT009806; AAP88808.1; -; mRNA.
DR   EMBL; AK291508; BAF84197.1; -; mRNA.
DR   EMBL; AL353801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471160; EAW86632.1; -; Genomic_DNA.
DR   EMBL; BC010642; AAH10642.1; -; mRNA.
DR   EMBL; BC041139; AAH41139.1; -; mRNA.
DR   EMBL; BC053687; AAH53687.1; -; mRNA.
DR   EMBL; M77172; AAA36815.1; -; Genomic_DNA.
DR   EMBL; X52346; CAA36572.1; -; mRNA.
DR   CCDS; CCDS7211.1; -.
DR   PIR; A48927; A48927.
DR   RefSeq; NP_008894.2; NM_006963.4.
DR   AlphaFoldDB; P17026; -.
DR   SMR; P17026; -.
DR   BioGRID; 113401; 119.
DR   IntAct; P17026; 26.
DR   MINT; P17026; -.
DR   STRING; 9606.ENSP00000298299; -.
DR   iPTMnet; P17026; -.
DR   PhosphoSitePlus; P17026; -.
DR   BioMuta; ZNF22; -.
DR   DMDM; 20455530; -.
DR   EPD; P17026; -.
DR   jPOST; P17026; -.
DR   MassIVE; P17026; -.
DR   PaxDb; 9606-ENSP00000298299; -.
DR   PeptideAtlas; P17026; -.
DR   ProteomicsDB; 53427; -.
DR   Pumba; P17026; -.
DR   Antibodypedia; 13486; 91 antibodies from 19 providers.
DR   DNASU; 7570; -.
DR   Ensembl; ENST00000298299.4; ENSP00000298299.3; ENSG00000165512.5.
DR   GeneID; 7570; -.
DR   KEGG; hsa:7570; -.
DR   MANE-Select; ENST00000298299.4; ENSP00000298299.3; NM_006963.5; NP_008894.2.
DR   UCSC; uc001jbw.4; human.
DR   AGR; HGNC:13012; -.
DR   CTD; 7570; -.
DR   DisGeNET; 7570; -.
DR   GeneCards; ZNF22; -.
DR   HGNC; HGNC:13012; ZNF22.
DR   HPA; ENSG00000165512; Low tissue specificity.
DR   MIM; 194529; gene.
DR   neXtProt; NX_P17026; -.
DR   OpenTargets; ENSG00000165512; -.
DR   PharmGKB; PA37591; -.
DR   VEuPathDB; HostDB:ENSG00000165512; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT01100000263491; -.
DR   HOGENOM; CLU_002678_21_0_1; -.
DR   InParanoid; P17026; -.
DR   OMA; KTHLSSW; -.
DR   OrthoDB; 3023033at2759; -.
DR   PhylomeDB; P17026; -.
DR   TreeFam; TF350836; -.
DR   PathwayCommons; P17026; -.
DR   SignaLink; P17026; -.
DR   BioGRID-ORCS; 7570; 15 hits in 1194 CRISPR screens.
DR   ChiTaRS; ZNF22; human.
DR   GeneWiki; ZNF22; -.
DR   GenomeRNAi; 7570; -.
DR   Pharos; P17026; Tbio.
DR   PRO; PR:P17026; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; P17026; Protein.
DR   Bgee; ENSG00000165512; Expressed in ventricular zone and 208 other cell types or tissues.
DR   ExpressionAtlas; P17026; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:ARUK-UCL.
DR   GO; GO:0008270; F:zinc ion binding; TAS:ProtInc.
DR   GO; GO:0042476; P:odontogenesis; NAS:UniProtKB.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; NAS:UniProtKB.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23226:SF372; ZINC FINGER AND SCAN DOMAIN CONTAINING 2; 1.
DR   PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
DR   Genevisible; P17026; HS.
PE   1: Evidence at protein level;
KW   Acetylation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..224
FT                   /note="Zinc finger protein 22"
FT                   /id="PRO_0000047348"
FT   ZN_FING         55..77
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         83..105
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         111..133
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         139..161
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         167..189
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         18
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ERU3"
FT   MOD_RES         23
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ERU3"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:24275569"
FT   VARIANT         65
FT                   /note="S -> G (in dbSNP:rs3740093)"
FT                   /id="VAR_052747"
FT   VARIANT         129
FT                   /note="H -> L (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035566"
FT   CONFLICT        31
FT                   /note="Q -> E (in Ref. 1; AAB24264)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        216..224
FT                   /note="GRKSVAGLR -> EGSLWLVSVKYRAF (in Ref. 1; AAB24264)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   224 AA;  25915 MW;  61BE158D2CEAEE19 CRC64;
     MRLAKPKAGI SRSSSQGKAY ENKRKTGRQR QKWGMTIRFD SSFSRLRRSL DDKPYKCTEC
     EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGESF
     KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS
     HLRQHMKVHK EEKPRKTRGK NIRVKTHLPS WKAGTGRKSV AGLR
//