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P17026

- ZNF22_HUMAN

UniProt

P17026 - ZNF22_HUMAN

Protein

Zinc finger protein 22

Gene

ZNF22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (02 May 2002)
      Previous versions | rss
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    Functioni

    Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri55 – 7723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri83 – 10523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri111 – 13323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri167 – 18923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. zinc ion binding Source: ProtInc

    GO - Biological processi

    1. odontogenesis Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 22
    Alternative name(s):
    Zinc finger protein KOX15
    Zinc finger protein Krox-26
    Gene namesi
    Name:ZNF22
    Synonyms:KOX15, KROX26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:13012. ZNF22.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37591.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Zinc finger protein 22PRO_0000047348Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181N6-acetyllysineBy similarity
    Modified residuei23 – 231N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP17026.
    PaxDbiP17026.
    PeptideAtlasiP17026.
    PRIDEiP17026.

    PTM databases

    PhosphoSiteiP17026.

    Expressioni

    Tissue specificityi

    In the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen, thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon.1 Publication

    Gene expression databases

    BgeeiP17026.
    CleanExiHS_ZNF22.
    GenevestigatoriP17026.

    Organism-specific databases

    HPAiHPA016736.
    HPA054893.

    Interactioni

    Protein-protein interaction databases

    BioGridi113401. 2 interactions.
    STRINGi9606.ENSP00000298299.

    Structurei

    3D structure databases

    ProteinModelPortaliP17026.
    SMRiP17026. Positions 25-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri55 – 7723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri83 – 10523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri111 – 13323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri167 – 18923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP17026.
    OMAiTHLVSSW.
    OrthoDBiEOG7QG44V.
    PhylomeDBiP17026.
    TreeFamiTF350836.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17026-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLAKPKAGI SRSSSQGKAY ENKRKTGRQR QKWGMTIRFD SSFSRLRRSL    50
    DDKPYKCTEC EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ 100
    HRRIHTGEKP YKCDECGESF KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ 150
    SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS HLRQHMKVHK EEKPRKTRGK 200
    NIRVKTHLPS WKAGTGRKSV AGLR 224
    Length:224
    Mass (Da):25,915
    Last modified:May 2, 2002 - v3
    Checksum:i61BE158D2CEAEE19
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311Q → E in AAB24264. (PubMed:1421376)Curated
    Sequence conflicti216 – 2249GRKSVAGLR → EGSLWLVSVKYRAF in AAB24264. (PubMed:1421376)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651S → G.
    Corresponds to variant rs3740093 [ dbSNP | Ensembl ].
    VAR_052747
    Natural varianti129 – 1291H → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035566

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S50223 mRNA. Translation: AAB24264.2.
    AY137767 Genomic DNA. Translation: AAN15804.1.
    BT009806 mRNA. Translation: AAP88808.1.
    AK291508 mRNA. Translation: BAF84197.1.
    AL353801 Genomic DNA. Translation: CAI13068.1.
    CH471160 Genomic DNA. Translation: EAW86632.1.
    BC010642 mRNA. Translation: AAH10642.1.
    BC041139 mRNA. Translation: AAH41139.1.
    BC053687 mRNA. Translation: AAH53687.1.
    M77172 Genomic DNA. Translation: AAA36815.1.
    X52346 mRNA. Translation: CAA36572.1.
    CCDSiCCDS7211.1.
    PIRiA48927.
    RefSeqiNP_008894.2. NM_006963.4.
    UniGeneiHs.462693.
    Hs.655124.

    Genome annotation databases

    EnsembliENST00000298299; ENSP00000298299; ENSG00000165512.
    GeneIDi7570.
    KEGGihsa:7570.
    UCSCiuc001jbw.3. human.

    Polymorphism databases

    DMDMi20455530.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S50223 mRNA. Translation: AAB24264.2 .
    AY137767 Genomic DNA. Translation: AAN15804.1 .
    BT009806 mRNA. Translation: AAP88808.1 .
    AK291508 mRNA. Translation: BAF84197.1 .
    AL353801 Genomic DNA. Translation: CAI13068.1 .
    CH471160 Genomic DNA. Translation: EAW86632.1 .
    BC010642 mRNA. Translation: AAH10642.1 .
    BC041139 mRNA. Translation: AAH41139.1 .
    BC053687 mRNA. Translation: AAH53687.1 .
    M77172 Genomic DNA. Translation: AAA36815.1 .
    X52346 mRNA. Translation: CAA36572.1 .
    CCDSi CCDS7211.1.
    PIRi A48927.
    RefSeqi NP_008894.2. NM_006963.4.
    UniGenei Hs.462693.
    Hs.655124.

    3D structure databases

    ProteinModelPortali P17026.
    SMRi P17026. Positions 25-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113401. 2 interactions.
    STRINGi 9606.ENSP00000298299.

    PTM databases

    PhosphoSitei P17026.

    Polymorphism databases

    DMDMi 20455530.

    Proteomic databases

    MaxQBi P17026.
    PaxDbi P17026.
    PeptideAtlasi P17026.
    PRIDEi P17026.

    Protocols and materials databases

    DNASUi 7570.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298299 ; ENSP00000298299 ; ENSG00000165512 .
    GeneIDi 7570.
    KEGGi hsa:7570.
    UCSCi uc001jbw.3. human.

    Organism-specific databases

    CTDi 7570.
    GeneCardsi GC10P045496.
    HGNCi HGNC:13012. ZNF22.
    HPAi HPA016736.
    HPA054893.
    MIMi 194529. gene.
    neXtProti NX_P17026.
    PharmGKBi PA37591.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P17026.
    OMAi THLVSSW.
    OrthoDBi EOG7QG44V.
    PhylomeDBi P17026.
    TreeFami TF350836.

    Miscellaneous databases

    GeneWikii ZNF22.
    GenomeRNAii 7570.
    NextBioi 29609.
    PROi P17026.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17026.
    CleanExi HS_ZNF22.
    Genevestigatori P17026.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines."
      Wu B.Y., Hanley E.W., Turka L.A., Nabel G.J.
      Blood 80:2571-2576(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency)."
      Gao Y., Kobayashi H., Ganss B.
      J. Dent. Res. 82:1002-1007(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood, Brain and Colon.
    8. "Characterization and mapping of human genes encoding zinc finger proteins."
      Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.
      Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-224.
      Tissue: Placenta.
    9. "Multiple genes encoding zinc finger domains are expressed in human T cells."
      Thiesen H.-J.
      New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-194.
      Tissue: Lymphoid tissue.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-129.

    Entry informationi

    Entry nameiZNF22_HUMAN
    AccessioniPrimary (citable) accession number: P17026
    Secondary accession number(s): Q5T741, Q96FM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3