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P17026

- ZNF22_HUMAN

UniProt

P17026 - ZNF22_HUMAN

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Protein

Zinc finger protein 22

Gene
ZNF22, KOX15, KROX26
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 7723C2H2-type 1Add
BLAST
Zinc fingeri83 – 10523C2H2-type 2Add
BLAST
Zinc fingeri111 – 13323C2H2-type 3Add
BLAST
Zinc fingeri139 – 16123C2H2-type 4Add
BLAST
Zinc fingeri167 – 18923C2H2-type 5Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. zinc ion binding Source: ProtInc

GO - Biological processi

  1. odontogenesis Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 22
Alternative name(s):
Zinc finger protein KOX15
Zinc finger protein Krox-26
Gene namesi
Name:ZNF22
Synonyms:KOX15, KROX26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:13012. ZNF22.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37591.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Zinc finger protein 22PRO_0000047348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181N6-acetyllysine By similarity
Modified residuei23 – 231N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP17026.
PaxDbiP17026.
PeptideAtlasiP17026.
PRIDEiP17026.

PTM databases

PhosphoSiteiP17026.

Expressioni

Tissue specificityi

In the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen, thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon.1 Publication

Gene expression databases

BgeeiP17026.
CleanExiHS_ZNF22.
GenevestigatoriP17026.

Organism-specific databases

HPAiHPA016736.
HPA054893.

Interactioni

Protein-protein interaction databases

BioGridi113401. 2 interactions.
STRINGi9606.ENSP00000298299.

Structurei

3D structure databases

ProteinModelPortaliP17026.
SMRiP17026. Positions 25-196.

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 7723C2H2-type 1Add
BLAST
Zinc fingeri83 – 10523C2H2-type 2Add
BLAST
Zinc fingeri111 – 13323C2H2-type 3Add
BLAST
Zinc fingeri139 – 16123C2H2-type 4Add
BLAST
Zinc fingeri167 – 18923C2H2-type 5Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17026.
OMAiTHLVSSW.
OrthoDBiEOG7QG44V.
PhylomeDBiP17026.
TreeFamiTF350836.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17026-1 [UniParc]FASTAAdd to Basket

« Hide

MRLAKPKAGI SRSSSQGKAY ENKRKTGRQR QKWGMTIRFD SSFSRLRRSL    50
DDKPYKCTEC EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ 100
HRRIHTGEKP YKCDECGESF KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ 150
SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS HLRQHMKVHK EEKPRKTRGK 200
NIRVKTHLPS WKAGTGRKSV AGLR 224
Length:224
Mass (Da):25,915
Last modified:May 2, 2002 - v3
Checksum:i61BE158D2CEAEE19
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651S → G.
Corresponds to variant rs3740093 [ dbSNP | Ensembl ].
VAR_052747
Natural varianti129 – 1291H → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_035566

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311Q → E in AAB24264. 1 Publication
Sequence conflicti216 – 2249GRKSVAGLR → EGSLWLVSVKYRAF in AAB24264. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S50223 mRNA. Translation: AAB24264.2.
AY137767 Genomic DNA. Translation: AAN15804.1.
BT009806 mRNA. Translation: AAP88808.1.
AK291508 mRNA. Translation: BAF84197.1.
AL353801 Genomic DNA. Translation: CAI13068.1.
CH471160 Genomic DNA. Translation: EAW86632.1.
BC010642 mRNA. Translation: AAH10642.1.
BC041139 mRNA. Translation: AAH41139.1.
BC053687 mRNA. Translation: AAH53687.1.
M77172 Genomic DNA. Translation: AAA36815.1.
X52346 mRNA. Translation: CAA36572.1.
CCDSiCCDS7211.1.
PIRiA48927.
RefSeqiNP_008894.2. NM_006963.4.
UniGeneiHs.462693.
Hs.655124.

Genome annotation databases

EnsembliENST00000298299; ENSP00000298299; ENSG00000165512.
GeneIDi7570.
KEGGihsa:7570.
UCSCiuc001jbw.3. human.

Polymorphism databases

DMDMi20455530.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S50223 mRNA. Translation: AAB24264.2 .
AY137767 Genomic DNA. Translation: AAN15804.1 .
BT009806 mRNA. Translation: AAP88808.1 .
AK291508 mRNA. Translation: BAF84197.1 .
AL353801 Genomic DNA. Translation: CAI13068.1 .
CH471160 Genomic DNA. Translation: EAW86632.1 .
BC010642 mRNA. Translation: AAH10642.1 .
BC041139 mRNA. Translation: AAH41139.1 .
BC053687 mRNA. Translation: AAH53687.1 .
M77172 Genomic DNA. Translation: AAA36815.1 .
X52346 mRNA. Translation: CAA36572.1 .
CCDSi CCDS7211.1.
PIRi A48927.
RefSeqi NP_008894.2. NM_006963.4.
UniGenei Hs.462693.
Hs.655124.

3D structure databases

ProteinModelPortali P17026.
SMRi P17026. Positions 25-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113401. 2 interactions.
STRINGi 9606.ENSP00000298299.

PTM databases

PhosphoSitei P17026.

Polymorphism databases

DMDMi 20455530.

Proteomic databases

MaxQBi P17026.
PaxDbi P17026.
PeptideAtlasi P17026.
PRIDEi P17026.

Protocols and materials databases

DNASUi 7570.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298299 ; ENSP00000298299 ; ENSG00000165512 .
GeneIDi 7570.
KEGGi hsa:7570.
UCSCi uc001jbw.3. human.

Organism-specific databases

CTDi 7570.
GeneCardsi GC10P045496.
HGNCi HGNC:13012. ZNF22.
HPAi HPA016736.
HPA054893.
MIMi 194529. gene.
neXtProti NX_P17026.
PharmGKBi PA37591.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P17026.
OMAi THLVSSW.
OrthoDBi EOG7QG44V.
PhylomeDBi P17026.
TreeFami TF350836.

Miscellaneous databases

GeneWikii ZNF22.
GenomeRNAii 7570.
NextBioi 29609.
PROi P17026.
SOURCEi Search...

Gene expression databases

Bgeei P17026.
CleanExi HS_ZNF22.
Genevestigatori P17026.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines."
    Wu B.Y., Hanley E.W., Turka L.A., Nabel G.J.
    Blood 80:2571-2576(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency)."
    Gao Y., Kobayashi H., Ganss B.
    J. Dent. Res. 82:1002-1007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood, Brain and Colon.
  8. "Characterization and mapping of human genes encoding zinc finger proteins."
    Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.
    Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-224.
    Tissue: Placenta.
  9. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-194.
    Tissue: Lymphoid tissue.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-129.

Entry informationi

Entry nameiZNF22_HUMAN
AccessioniPrimary (citable) accession number: P17026
Secondary accession number(s): Q5T741, Q96FM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 2, 2002
Last modified: July 9, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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