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Protein

Zinc finger protein 22

Gene

ZNF22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 77C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri83 – 105C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri111 – 133C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri139 – 161C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 189C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • zinc ion binding Source: ProtInc

GO - Biological processi

  • odontogenesis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 22
Alternative name(s):
Zinc finger protein KOX15
Zinc finger protein Krox-26
Gene namesi
Name:ZNF22
Synonyms:KOX15, KROX26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165512.4.
HGNCiHGNC:13012. ZNF22.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7570.
OpenTargetsiENSG00000165512.
PharmGKBiPA37591.

Polymorphism and mutation databases

BioMutaiZNF22.
DMDMi20455530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473481 – 224Zinc finger protein 22Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18N6-acetyllysineBy similarity1
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP17026.
PaxDbiP17026.
PeptideAtlasiP17026.
PRIDEiP17026.

PTM databases

iPTMnetiP17026.
PhosphoSitePlusiP17026.

Expressioni

Tissue specificityi

In the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen, thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon.1 Publication

Gene expression databases

BgeeiENSG00000165512.
CleanExiHS_ZNF22.
ExpressionAtlasiP17026. baseline and differential.
GenevisibleiP17026. HS.

Organism-specific databases

HPAiHPA016736.
HPA054893.

Interactioni

Protein-protein interaction databases

BioGridi113401. 43 interactors.
STRINGi9606.ENSP00000298299.

Structurei

3D structure databases

ProteinModelPortaliP17026.
SMRiP17026.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 77C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri83 – 105C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri111 – 133C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri139 – 161C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 189C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139349.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17026.
OMAiRGKNIRA.
OrthoDBiEOG091G0I4B.
PhylomeDBiP17026.
TreeFamiTF350836.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 5 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.

Sequencei

Sequence statusi: Complete.

P17026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAKPKAGI SRSSSQGKAY ENKRKTGRQR QKWGMTIRFD SSFSRLRRSL
60 70 80 90 100
DDKPYKCTEC EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ
110 120 130 140 150
HRRIHTGEKP YKCDECGESF KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ
160 170 180 190 200
SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS HLRQHMKVHK EEKPRKTRGK
210 220
NIRVKTHLPS WKAGTGRKSV AGLR
Length:224
Mass (Da):25,915
Last modified:May 2, 2002 - v3
Checksum:i61BE158D2CEAEE19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31Q → E in AAB24264 (PubMed:1421376).Curated1
Sequence conflicti216 – 224GRKSVAGLR → EGSLWLVSVKYRAF in AAB24264 (PubMed:1421376).Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05274765S → G. Corresponds to variant dbSNP:rs3740093Ensembl.1
Natural variantiVAR_035566129H → L in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S50223 mRNA. Translation: AAB24264.2.
AY137767 Genomic DNA. Translation: AAN15804.1.
BT009806 mRNA. Translation: AAP88808.1.
AK291508 mRNA. Translation: BAF84197.1.
AL353801 Genomic DNA. No translation available.
CH471160 Genomic DNA. Translation: EAW86632.1.
BC010642 mRNA. Translation: AAH10642.1.
BC041139 mRNA. Translation: AAH41139.1.
BC053687 mRNA. Translation: AAH53687.1.
M77172 Genomic DNA. Translation: AAA36815.1.
X52346 mRNA. Translation: CAA36572.1.
CCDSiCCDS7211.1.
PIRiA48927.
RefSeqiNP_008894.2. NM_006963.4.
UniGeneiHs.462693.
Hs.655124.

Genome annotation databases

EnsembliENST00000298299; ENSP00000298299; ENSG00000165512.
GeneIDi7570.
KEGGihsa:7570.
UCSCiuc001jbw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF22_HUMAN
AccessioniPrimary (citable) accession number: P17026
Secondary accession number(s): Q5T741, Q96FM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 2, 2002
Last modified: September 27, 2017
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families