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UniProtKB - P17025 (ZN182_HUMAN)

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Protein

Zinc finger protein 182

Gene

ZNF182

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 592C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri598 – 620C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 182
Alternative name(s):
Zinc finger protein 21
Zinc finger protein KOX14
Gene namesi
Name:ZNF182
Synonyms:KOX14, ZNF21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13001. ZNF182.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7569.
OpenTargetsiENSG00000147118.
PharmGKBiPA37581.

Polymorphism and mutation databases

BioMutaiZNF182.
DMDMi85681865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473451 – 639Zinc finger protein 182Add BLAST639

Proteomic databases

EPDiP17025.
MaxQBiP17025.
PaxDbiP17025.
PeptideAtlasiP17025.
PRIDEiP17025.

PTM databases

iPTMnetiP17025.
PhosphoSitePlusiP17025.

Expressioni

Gene expression databases

BgeeiENSG00000147118.
CleanExiHS_ZNF182.
GenevisibleiP17025. HS.

Organism-specific databases

HPAiHPA059574.

Interactioni

Protein-protein interaction databases

BioGridi113400. 1 interactor.
STRINGi9606.ENSP00000306351.

Structurei

3D structure databases

ProteinModelPortaliP17025.
SMRiP17025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 98KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 592C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri598 – 620C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17025.
KOiK09228.
OMAiKKGLSLH.
OrthoDBiEOG091G02KC.
PhylomeDBiP17025.
TreeFamiTF350805.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17025-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPASASGED SGSFYSWQKA KREQGLVTFE DVAVDFTQEE WQYLNPPQRT 
        60         70         80         90        100
LYRDVMLETY SNLVFVGQQV TKPNLILKLE VEECPAEGKI PFWNFPEVCQ 
       110        120        130        140        150
VDEQIERQHQ DDQDKCLLMQ VGFSDKKTII TKSARDCHEF GNILHLSTNL 
       160        170        180        190        200
VASIQRPDKH ESFGNNMVDN LDLFSRSSAE NKYDNGCAKL FFHTEYEKTN 
       210        220        230        240        250
PGMKPYGYKE CGKGLRRKKG LSLHQRIKNG EKPFECTACR KTFSKKSHLI 
       260        270        280        290        300
VHWRTHTGEK PFGCTECGKA FSQKSQLIIH LRTHTGERPF ECPECGKAFR 
       310        320        330        340        350
EKSTVIIHYR THTGEKPYEC NECGKAFTQK SNLIVHQKTH TGEKTYECTK 
       360        370        380        390        400
CGESFIQKLD LIIHHSTHTG KKPHECNECK KTFSDKSTLI IHQRTHTGEK 
       410        420        430        440        450
PHKCTECGKS FNEKSTLIVH QRTHTGEKPY ECDVCGKTFT QKSNLGVHQR 
       460        470        480        490        500
THSGEKPFEC NECEKAFSQK SYLMLHQRGH TGEKPYECNE CEKAFSQKSY 
       510        520        530        540        550
LIIHQRTHTE EKPYKCNECG KAFREKSKLI IHQRIHTGEK PYECPVCWKA 
       560        570        580        590        600
FSQKSQLIIH QRTHTGEKPY ACTECGKAFR EKSTFTVHQR THTGEKPYKC 
       610        620        630 
TECGKAFTQK SNLIVHQRTH AGKKAHGRGH TRKSKFMAH
Length:639
Mass (Da):73,646
Last modified:January 10, 2006 - v2
Checksum:i6976EB14399390A5
GO
Isoform 2 (identifier: P17025-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MTPASASGEDSGSFYSWQKAKRE → MAKP

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):71,570
Checksum:i30F28986DF6A9331
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07783762N → S Found in a child with sporadic epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146965366Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430781 – 23MTPAS…KAKRE → MAKP in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122874 mRNA. Translation: BAG53772.1.
Z98304 Genomic DNA. Translation: CAC41951.1.
Z98304 Genomic DNA. Translation: CAM28265.1.
CH471164 Genomic DNA. Translation: EAW59334.1.
CH471164 Genomic DNA. Translation: EAW59335.1.
BC106875 mRNA. Translation: AAI06876.1.
BC114216 mRNA. Translation: AAI14217.1.
X52345 mRNA. Translation: CAA36571.1.
CCDSiCCDS35235.1. [P17025-2]
CCDS35236.1. [P17025-1]
PIRiI37953. S10402.
RefSeqiNP_001007089.1. NM_001007088.1. [P17025-2]
NP_001171570.1. NM_001178099.1. [P17025-1]
NP_008893.1. NM_006962.1. [P17025-1]
UniGeneiHs.189690.

Genome annotation databases

EnsembliENST00000376943; ENSP00000366142; ENSG00000147118. [P17025-2]
ENST00000396965; ENSP00000380165; ENSG00000147118. [P17025-1]
GeneIDi7569.
KEGGihsa:7569.
UCSCiuc004dis.4. human. [P17025-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN182_HUMAN
AccessioniPrimary (citable) accession number: P17025
Secondary accession number(s): A2IDD7, Q3KP67, Q96QH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: June 7, 2017
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families