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Protein

Zinc finger protein 182

Gene

ZNF182

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri570 – 59223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri598 – 62023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 182
Alternative name(s):
Zinc finger protein 21
Zinc finger protein KOX14
Gene namesi
Name:ZNF182
Synonyms:KOX14, ZNF21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13001. ZNF182.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37581.

Polymorphism and mutation databases

BioMutaiZNF182.
DMDMi85681865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Zinc finger protein 182PRO_0000047345Add
BLAST

Proteomic databases

MaxQBiP17025.
PaxDbiP17025.
PeptideAtlasiP17025.
PRIDEiP17025.

PTM databases

iPTMnetiP17025.
PhosphoSiteiP17025.

Expressioni

Gene expression databases

BgeeiENSG00000147118.
CleanExiHS_ZNF182.
GenevisibleiP17025. HS.

Organism-specific databases

HPAiHPA059574.

Interactioni

Protein-protein interaction databases

BioGridi113400. 1 interaction.
STRINGi9606.ENSP00000306351.

Structurei

3D structure databases

ProteinModelPortaliP17025.
SMRiP17025. Positions 27-67, 195-625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri570 – 59223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri598 – 62023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17025.
KOiK09228.
OMAiDKCLLMQ.
OrthoDBiEOG091G02KC.
PhylomeDBiP17025.
TreeFamiTF350805.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17025-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPASASGED SGSFYSWQKA KREQGLVTFE DVAVDFTQEE WQYLNPPQRT
60 70 80 90 100
LYRDVMLETY SNLVFVGQQV TKPNLILKLE VEECPAEGKI PFWNFPEVCQ
110 120 130 140 150
VDEQIERQHQ DDQDKCLLMQ VGFSDKKTII TKSARDCHEF GNILHLSTNL
160 170 180 190 200
VASIQRPDKH ESFGNNMVDN LDLFSRSSAE NKYDNGCAKL FFHTEYEKTN
210 220 230 240 250
PGMKPYGYKE CGKGLRRKKG LSLHQRIKNG EKPFECTACR KTFSKKSHLI
260 270 280 290 300
VHWRTHTGEK PFGCTECGKA FSQKSQLIIH LRTHTGERPF ECPECGKAFR
310 320 330 340 350
EKSTVIIHYR THTGEKPYEC NECGKAFTQK SNLIVHQKTH TGEKTYECTK
360 370 380 390 400
CGESFIQKLD LIIHHSTHTG KKPHECNECK KTFSDKSTLI IHQRTHTGEK
410 420 430 440 450
PHKCTECGKS FNEKSTLIVH QRTHTGEKPY ECDVCGKTFT QKSNLGVHQR
460 470 480 490 500
THSGEKPFEC NECEKAFSQK SYLMLHQRGH TGEKPYECNE CEKAFSQKSY
510 520 530 540 550
LIIHQRTHTE EKPYKCNECG KAFREKSKLI IHQRIHTGEK PYECPVCWKA
560 570 580 590 600
FSQKSQLIIH QRTHTGEKPY ACTECGKAFR EKSTFTVHQR THTGEKPYKC
610 620 630
TECGKAFTQK SNLIVHQRTH AGKKAHGRGH TRKSKFMAH
Length:639
Mass (Da):73,646
Last modified:January 10, 2006 - v2
Checksum:i6976EB14399390A5
GO
Isoform 2 (identifier: P17025-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MTPASASGEDSGSFYSWQKAKRE → MAKP

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):71,570
Checksum:i30F28986DF6A9331
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323MTPAS…KAKRE → MAKP in isoform 2. 1 PublicationVSP_043078Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122874 mRNA. Translation: BAG53772.1.
Z98304 Genomic DNA. Translation: CAC41951.1.
Z98304 Genomic DNA. Translation: CAM28265.1.
CH471164 Genomic DNA. Translation: EAW59334.1.
CH471164 Genomic DNA. Translation: EAW59335.1.
BC106875 mRNA. Translation: AAI06876.1.
BC114216 mRNA. Translation: AAI14217.1.
X52345 mRNA. Translation: CAA36571.1.
CCDSiCCDS35235.1. [P17025-2]
CCDS35236.1. [P17025-1]
PIRiI37953. S10402.
RefSeqiNP_001007089.1. NM_001007088.1. [P17025-2]
NP_001171570.1. NM_001178099.1. [P17025-1]
NP_008893.1. NM_006962.1. [P17025-1]
UniGeneiHs.189690.

Genome annotation databases

EnsembliENST00000305127; ENSP00000306351; ENSG00000147118. [P17025-1]
ENST00000376943; ENSP00000366142; ENSG00000147118. [P17025-2]
ENST00000396965; ENSP00000380165; ENSG00000147118. [P17025-1]
GeneIDi7569.
KEGGihsa:7569.
UCSCiuc004dis.4. human. [P17025-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122874 mRNA. Translation: BAG53772.1.
Z98304 Genomic DNA. Translation: CAC41951.1.
Z98304 Genomic DNA. Translation: CAM28265.1.
CH471164 Genomic DNA. Translation: EAW59334.1.
CH471164 Genomic DNA. Translation: EAW59335.1.
BC106875 mRNA. Translation: AAI06876.1.
BC114216 mRNA. Translation: AAI14217.1.
X52345 mRNA. Translation: CAA36571.1.
CCDSiCCDS35235.1. [P17025-2]
CCDS35236.1. [P17025-1]
PIRiI37953. S10402.
RefSeqiNP_001007089.1. NM_001007088.1. [P17025-2]
NP_001171570.1. NM_001178099.1. [P17025-1]
NP_008893.1. NM_006962.1. [P17025-1]
UniGeneiHs.189690.

3D structure databases

ProteinModelPortaliP17025.
SMRiP17025. Positions 27-67, 195-625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113400. 1 interaction.
STRINGi9606.ENSP00000306351.

PTM databases

iPTMnetiP17025.
PhosphoSiteiP17025.

Polymorphism and mutation databases

BioMutaiZNF182.
DMDMi85681865.

Proteomic databases

MaxQBiP17025.
PaxDbiP17025.
PeptideAtlasiP17025.
PRIDEiP17025.

Protocols and materials databases

DNASUi7569.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305127; ENSP00000306351; ENSG00000147118. [P17025-1]
ENST00000376943; ENSP00000366142; ENSG00000147118. [P17025-2]
ENST00000396965; ENSP00000380165; ENSG00000147118. [P17025-1]
GeneIDi7569.
KEGGihsa:7569.
UCSCiuc004dis.4. human. [P17025-1]

Organism-specific databases

CTDi7569.
GeneCardsiZNF182.
HGNCiHGNC:13001. ZNF182.
HPAiHPA059574.
MIMi314993. gene.
neXtProtiNX_P17025.
PharmGKBiPA37581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP17025.
KOiK09228.
OMAiDKCLLMQ.
OrthoDBiEOG091G02KC.
PhylomeDBiP17025.
TreeFamiTF350805.

Miscellaneous databases

GeneWikiiZNF182.
GenomeRNAii7569.
PROiP17025.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147118.
CleanExiHS_ZNF182.
GenevisibleiP17025. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN182_HUMAN
AccessioniPrimary (citable) accession number: P17025
Secondary accession number(s): A2IDD7, Q3KP67, Q96QH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: September 7, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.